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Clinical oncology

Section edited by: Prof Serigne Magueye Gueye and Prof Jan Vermorken. 

The clinical oncology section represents an opportunity to share experiences and information among worldwide oncologists and to identify and develop diagnostic as well as therapeutic protocols, which are globally valid in the current global village. Potential topics include, but are not limited to: epidemiology, pathology and pathogenesis of cancers and clinical studies

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  1. Triple-Negative Breast Cancer (TNBC), represents a subtype of breast cancer in which the estrogens receptor (ER) negative, the progesterone receptor (PR) negative and the human epidermal growth factor receptor...

    Authors: Sabrina Bimonte, Marco Cascella, Antonio Barbieri, Claudio Arra and Arturo Cuomo

    Citation: Infectious Agents and Cancer 2020 15:2

    Content type: Review

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  2. Given the paucity of data and widely variable rates that have been reported, the main objective of this study was to examine the prevalence of HPV-positivity in oropharyngeal squamous cell carcinoma (OPSCC) in...

    Authors: Christopher A. Maroun, Karine Al Feghali, Henri Traboulsi, Helene Dabbous, Fatmeh Abbas, Gabriel Dunya, Georges Ziade, Rami Mahfouz, Bassem Youssef, Hani Tamim, Fady Geara, Ibrahim Khalifeh and Roger V. Moukarbel

    Citation: Infectious Agents and Cancer 2020 15:1

    Content type: Research Article

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  3. The aim of this study was to investigate the prognostic significance of the serum γ-glutamyltransferase (γ-GT)-to-prealbumin ratio (GPR) and whether combining this ratio with other parameters can lead to an im...

    Authors: Q. Wang, P. Zhao, N. He, J. P. Sun, K. Li, C. R. Zang, Y. N. Zhao, Y. Zhao and Y. H. Zhang

    Citation: Infectious Agents and Cancer 2019 14:49

    Content type: Research Article

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  4. Earlier we suggested a new hypothesis of the possible evolutionary role of hereditary tumors (Kozlov, Evolution by tumor Neofunctionalization, 2014), and described a new class of genes – tumor specifically exp...

    Authors: E. A. Matyunina, A. V. Emelyanov, T. V. Kurbatova, A. A. Makashov, I. V. Mizgirev and A. P. Kozlov

    Citation: Infectious Agents and Cancer 2019 14:46

    Content type: Research Article

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  5. Although the Kaposi sarcoma (KS) is one of the AIDS defining entity and seen in almost one third of HIV infected patients with low CD4 cell counts, it is not uncommon in HIV seronegative persons, but genital K...

    Authors: Abdulaziz Alamri and B. K. Adiga

    Citation: Infectious Agents and Cancer 2019 14:45

    Content type: Short Report

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  6. Infections classified as group 1 biological carcinogens include the helminthiases caused by Schistosoma haematobium and Opisthorchis viverrini. The molecular mediators underlying the infection with these parasite...

    Authors: Maria João Gouveia, Paul J. Brindley, Gabriel Rinaldi, Fátima Gärtner, José M. C. da Costa and Nuno Vale

    Citation: Infectious Agents and Cancer 2019 14:41

    Content type: Research Article

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  7. To compare liver-specific EOB-GD-DTPA and liver-non-specific Gd-BT-DO3A MR, in hepatocellular carcinoma (HCC) and liver colorectal metastases.

    Authors: Vincenza Granata, Roberta Fusco, Francesca Maio, Antonio Avallone, Guglielmo Nasti, Raffaele Palaia, Vittorio Albino, Roberto Grassi, Francesco Izzo and Antonella Petrillo

    Citation: Infectious Agents and Cancer 2019 14:40

    Content type: Research Article

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  8. Persistent infection with human papillomaviruses (HPVs) has been associated with cervical intraepithelial neoplasia (CIN) and cervical cancer. However, why only a fraction of HPV cases progress to cancer is st...

    Authors: Junwei Zhao, Qin Zhan, Junhan Guo, Min Liu, Yetian Ruan, Tailin Zhu, Lingfei Han and Fang Li

    Citation: Infectious Agents and Cancer 2019 14:38

    Content type: Research Article

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  9. It has been reported that lncRNA MAGI2-AS3 can promote many types of cancer, such as breast cancer and bladder cancer, by regulating cell behaviors, such a proliferation, invasion, and migration. However, its ...

    Authors: Qifang Liu, Shuang Liu, Xiaoying Wang, Jin Zhang and Kuiran Liu

    Citation: Infectious Agents and Cancer 2019 14:37

    Content type: Research Article

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  10. Hepatitis B caused by HBV is a serious public health hazard prevalent worldwide including Bangladesh. Few scattered molecular studies of HBV have been reported in Bangladesh. This study aimed to analyze the ge...

    Authors: Md. Golzar Hossain and Keiji Ueda

    Citation: Infectious Agents and Cancer 2019 14:33

    Content type: Review

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  11. The possible role of Epstein-Barr virus (EBV) in the pathogenesis of thymic epithelial tumors (TET) remains controversial. This study aimed to determine the prevalence of EBV in TET. We conducted a systematic ...

    Authors: Guofei Zhang, Zipu Yu, Gang Shen, Ying Chai and Chengxiao Liang

    Citation: Infectious Agents and Cancer 2019 14:32

    Content type: Review

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  12. Human herpesvirus-6 (HHV-6) is a ubiquitous double-stranded DNA virus that can cause roseola infantum, encephalitis, and seizure disorders. Several studies have shown an association between HHV-6 and cancer bu...

    Authors: Michael J. Wells, Steven Jacobson and Paul H. Levine

    Citation: Infectious Agents and Cancer 2019 14:31

    Content type: Review

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  13. Microecology is an emerging discipline in recent years. The female reproductive tract is an important microecological region, and its microecological environment can directly affect women’s cervical health. Th...

    Authors: Yuejuan Liang, Mengjie Chen, Lu Qin, Bing Wan and He Wang

    Citation: Infectious Agents and Cancer 2019 14:29

    Content type: Review

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    The Correction to this article has been published in Infectious Agents and Cancer 2019 14:47

  14. This study estimated genital warts prevalence, genital-warts-related healthcare resource use and costs, and self-reported human-papillomavirus-related psychosocial impact among male and female patients aged 18...

    Authors: Lani Buenconsejo, Smita Kothari-Talwar, Karen Yee, Amit Kulkarni, Nuria Lara, Montserrat Roset, Anna R. Giuliano and Suzanne Garland

    Citation: Infectious Agents and Cancer 2019 14:26

    Content type: Research Article

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  15. Bacterial infection may be involved in the entire process of tissue carcinogenesis by directly or indirectly affecting the occurrence and development of tumors. Porphyromonas gingivalis (P.gingivalis) is an impor...

    Authors: Xiao-bo Liu, Zi-ye Gao, Chuan-tao Sun, Hui Wen, Bo Gao, Sheng-bao Li and Qiang Tong

    Citation: Infectious Agents and Cancer 2019 14:23

    Content type: Review

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  16. Human Papilloma Virus (HPV) genotypes concordance among sexual couples has been evaluated in many investigations with considerable variations in the concordance. However, no such study has carried out between ...

    Authors: Mehrdad Davarmanesh, Mehrouz Dezfulian, Mohammad Javad Gharavi, Sarang Younesi, Pourandokht Saadati, Mohammad Mehdi Taheri Amin and Seyed Mohammad Jazayeri

    Citation: Infectious Agents and Cancer 2019 14:22

    Content type: Research Article

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  17. Platelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection. Several studies and clinical findings have demonstrated that the PRP can accelerate the regenera...

    Authors: Antonio Barbieri, Sabrina Bimonte, Giovanna Loquercio, Domenica Rea, Marco Cascella, Annamaria Anniciello, Antonio Luciano, Giuseppe Palma, Gaetano Di Costanzo, Azzaro Rosa, Pasquale Giuliano and Claudio Arra

    Citation: Infectious Agents and Cancer 2019 14:21

    Content type: Short Report

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  18. B7-H4 is among the B7 family members which may serve as a new targetable immune checkpoint molecule. It was reported that high level of serum B7-H4 level may be correlated with lymphoma. Nevertheless, the role...

    Authors: Ying Jiang, Gangli Cai, Jun Lin, Jing Zhang, Zhilei Bo, Ying Li, Chun Wang and Yin Tong

    Citation: Infectious Agents and Cancer 2019 14:20

    Content type: Research Article

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  19. Cervical cancer is a common cancer among women worldwide and is closely related to high-risk human papillomavirus infection (HR-HPV). The immune microenvironment is thought to play an essential role in viral i...

    Authors: Bohan Li, Ling Zhang, Jianguo Zhao, Guichun Tan, Wenwen Zhang, Na Zhang, Jing Tian and Pengpeng Qu

    Citation: Infectious Agents and Cancer 2019 14:16

    Content type: Research Article

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  20. New strategies are needed to combat the high incidence of cervical cancer in resource-limited settings such as sub-Saharan Africa. Screening for high-risk human papillomavirus (hrHPV) DNA is sensitive for pre-...

    Authors: Miriam Nakalembe, Philippa Makanga, Frank Mubiru, Megan Swanson, Jeffrey Martin and Megan Huchko

    Citation: Infectious Agents and Cancer 2019 14:14

    Content type: Research Article

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  21. To evaluate the correlation of serum PIVKA-II levels and development of portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) patients.

    Authors: Tao Li, Yuanzi Yu, Juan Liu, Xiangguo Tian, Meng Kong, Lei Wu, Shaocan Tang, Shengqing Gu, Jingfang Zhao, Yi Cui and Jinhua Hu

    Citation: Infectious Agents and Cancer 2019 14:13

    Content type: Research article

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  22. The impact of different anti-virus regimens on prognosis of Chronic hepatitis B (CHB) related cirrhosis remains to be explored. We aim to investigate whether CHB-related HCC patients receiving nucleoside analo...

    Authors: Ping Zhang, Qingli Liu, Mei Yuan and Lina Wang

    Citation: Infectious Agents and Cancer 2018 13:30

    Content type: Research Article

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  23. High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role o...

    Authors: Clorinda Annunziata, Giovanni Stellato, Stefano Greggi, Veronica Sanna, Maria Pia Curcio, Simona Losito, Gerardo Botti, Luigi Buonaguro, Franco Maria Buonaguro and Maria Lina Tornesello

    Citation: Infectious Agents and Cancer 2018 13:26

    Content type: Research Article

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  24. Helicobacter pylori (H. pylori) infection has been recognized as a significant threat for gastric cancer. However, studies that investigated the oncogenic factors and antimicrobial resistance of H. pylori in Egyp...

    Authors: Doaa M. Al-Eraky, Omneya M. Helmy, Yasser M. Ragab, Zeinab Abdul-Khalek, Eman A. El-Seidi and Mohammed A. Ramadan

    Citation: Infectious Agents and Cancer 2018 13:24

    Content type: Research Article

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  25. Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the ...

    Authors: Vincenza Granata, Roberta Fusco, Salvatore Filice, Orlando Catalano, Mauro Piccirillo, Raffaele Palaia, Francesco Izzo and Antonella Petrillo

    Citation: Infectious Agents and Cancer 2018 13:23

    Content type: Review

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  26. The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in Western countries and this has been attributed to human papillomavirus (HPV) infection. p16 expression is a marker for HPV infe...

    Authors: Lee Fah Yap, Sook Ling Lai, Anthony Rhodes, Hans Prakash Sathasivam, Maizaton Atmadini Abdullah, Kin-Choo Pua, Pathmanathan Rajadurai, Phaik-Leng Cheah, Selvam Thavaraj, Max Robinson and Ian C. Paterson

    Citation: Infectious Agents and Cancer 2018 13:21

    Content type: Research Article

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  27. Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line choices regarding the treatment of chronic hepatits B. The impact of the two antiviral agents on prognosis of Chronic h...

    Authors: Min Zhang, Dexin Wang, Haidong Liu and Hui Li

    Citation: Infectious Agents and Cancer 2018 13:19

    Content type: Research Article

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  28. Hepatitis B virus (HBV) is one of the most prevalent and serious infections worldwide. HBV reactivation is a serious complication for lymphoma patients who are being treated with rituximab-containing regimen. ...

    Authors: Mubarak M. Al-Mansour, Saif A. Alghamdi, Musab A. Alsubaie, Abdullah A. Alesa and Muhammad A. Khan

    Citation: Infectious Agents and Cancer 2018 13:18

    Content type: Research Article

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  29. A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related d...

    Authors: Noelia López, Aureli Torné, Agustín Franco, María San-Martin, Elisabet Viayna, Carmen Barrull and Nuria Perulero

    Citation: Infectious Agents and Cancer 2018 13:15

    Content type: Research Article

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  30. The Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies. In order to maintain its persistence in host cells and promote...

    Authors: Silvia Giunco, Maria Raffaella Petrara, Manuela Zangrossi, Andrea Celeghin and Anita De Rossi

    Citation: Infectious Agents and Cancer 2018 13:14

    Content type: Review

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  31. Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of the...

    Authors: Jorge Levican, Mónica Acevedo, Oscar León, Aldo Gaggero and Francisco Aguayo

    Citation: Infectious Agents and Cancer 2018 13:12

    Content type: Review

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  32. The role of Fusobacterium nucleatum Fap2 protein in the development of colorectal cancer has recently been explained. Fap2, when bound to the human inhibitory receptor, TIGIT, inhibits the cytotoxic activity of n...

    Authors: Leonardo A. Guevarra Jr, Andrea Claudine F. Afable, Patricia Joyce O. Belza, Karen Joy S. Dy, Scott Justin Q. Lee, Teresa T. Sy-Ortin and Pia Marie S. P. Albano

    Citation: Infectious Agents and Cancer 2018 13:11

    Content type: Research Article

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  33. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and accounts for about 6% of all new cancers diagnosed worldwide. Moreover, it is the third and the fifth leading cause of death from ...

    Authors: A. Petrizzo, A. Mauriello, M. L. Tornesello, F. M. Buonaguro, M. Tagliamonte and L. Buonaguro

    Citation: Infectious Agents and Cancer 2018 13:10

    Content type: Review

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  34. Hepatocellular carcinoma (HCC) can develop in patients who are negative for the hepatitis B surface antigen (HBsAg) in serum but positive for hepatitis B virus (HBV) DNA in the liver, referred to as occult HBV...

    Authors: Yuri Hatazawa, Yoshihiko Yano, Rina Okada, Toshihito Tanahashi, Hiroki Hayashi, Hirotaka Hirano, Akihiro Minami, Yuki Kawano, Motofumi Tanaka, Takumi Fukumoto, Yoshiki Murakami, Masaru Yoshida and Yoshitake Hayashi

    Citation: Infectious Agents and Cancer 2018 13:7

    Content type: Research Article

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  35. Persistent infection with High Risk Human Papillomavirus (HR HPV) types plays a major role in the development of cervical cancer. Therefore, the detection of HR HPV types is an essential part of cervical cance...

    Authors: Farzane Jamdar, Farah Farzaneh, Fariba Navidpour, Sarang Younesi, Payam Balvayeh, Maryamsadat Hosseini and Robabeh Ghodssi-Ghasemabadi

    Citation: Infectious Agents and Cancer 2018 13:6

    Content type: Research Article

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  36. Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous du...

    Authors: Marco Cascella, Sabrina Bimonte, Antonio Barbieri, Vitale Del Vecchio, Domenico Caliendo, Vincenzo Schiavone, Roberta Fusco, Vincenza Granata, Claudio Arra and Arturo Cuomo

    Citation: Infectious Agents and Cancer 2018 13:3

    Content type: Review

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  37. Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype...

    Authors: Dauren Adilbay, Galim Adilbayev, Gulzhan Kidirbayeva, Viktoria Shipilova, Zhanat Sadyk, Gulsum Koyanbekova, Ekaterina Sokolenko and Jan Klozar

    Citation: Infectious Agents and Cancer 2018 13:2

    Content type: Research Article

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  38. Women infected with Human Immune Deficiency Virus (HIV) are assumed to be at higher risk of developing Cervical Cancer (CC). This is due to a rapid progression of pre-invasive to invasive lesions. However, evi...

    Authors: Muluken Gizaw, Adamu Addissie, Sefonias Getachew, Wondimu Ayele, Israel Mitiku, Ulrike Moelle, Tigist Yusuf, Mathias Begoihn, Mathewos Assefa, Ahmedin Jemal and Eva Johanna Kantelhardt

    Citation: Infectious Agents and Cancer 2017 12:61

    Content type: Research Article

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  39. Oesophageal carcinoma (OC) is highly prevalent in Western Kenya especially among the members of the Kalenjin community who reside in the Northern and Southern areas of the Rift Valley. Previous authors have su...

    Authors: Gabriel Kigen, Naftali Busakhala, Zipporah Kamuren, Hillary Rono, Wilfred Kimalat and Evangeline Njiru

    Citation: Infectious Agents and Cancer 2017 12:59

    Content type: Review

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  40. Literature data suggest that multi-parametric Magnetic Resonance Imaging (MRI), including morphologic T2-weigthed images (T2-MRI) and functional approaches such as Dynamic Contrast Enhanced-MRI (DCE-MRI), Diff...

    Authors: Roberta Fusco, Mario Sansone, Vincenza Granata, Sergio Venanzio Setola and Antonella Petrillo

    Citation: Infectious Agents and Cancer 2017 12:57

    Content type: Review

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  41. Processes and mechanisms responsible for systemic immune suppression in early-stage cervical cancer remain substantially underinvestigated. In this work, we focused on studying the frequencies of circulating r...

    Authors: Olga V. Kurmyshkina, Pavel I. Kovchur, Ludmila V. Schegoleva and Tatyana O. Volkova

    Citation: Infectious Agents and Cancer 2017 12:56

    Content type: Research Article

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  42. Multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and Epstein Barr virus, have been identified as separate infectious pathogens in human breast canc...

    Authors: James S. Lawson and Wendy K. Glenn

    Citation: Infectious Agents and Cancer 2017 12:55

    Content type: Research Article

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  43. Hepatocellular carcinoma (HCC) is one of the major cause for cancer in the world. Aim of this case-control study was to investigate the distribution pattern of HCV genotypes among HCC patients and suggest whet...

    Authors: Arnolfo Petruzziello, Samantha Marigliano, Giovanna Loquercio, Nicola Coppola, Mauro Piccirillo, Maddalena Leongito, Rosa Azzaro, Francesco Izzo and Gerardo Botti

    Citation: Infectious Agents and Cancer 2017 12:52

    Content type: Research article

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  44. The introduction of cART has changed the morbidity and mortality patterns affecting HIV-infected (HIV+) individuals. The risk of breast cancer in HIV+ patients has now approached the general population risk. Howe...

    Authors: Francesca Caccuri, Francesca Giordano, Ines Barone, Pietro Mazzuca, Cinzia Giagulli, Sebastiano Andò, Arnaldo Caruso and Stefania Marsico

    Citation: Infectious Agents and Cancer 2017 12:49

    Content type: Research Article

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  45. To evaluate the diagnostic efficacy of prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) for early stage hepatitis virus B (HBV) related hepatocellular carcinoma (HCC).

    Authors: Xiumei Wang, Weiwei Zhang, Youde Liu, Wenjing Gong, Ping Sun, Xiangshuo Kong, Miaomiao Yang and Zhihua Wang

    Citation: Infectious Agents and Cancer 2017 12:47

    Content type: Research Article

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