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Clinical oncology

Section edited by: Prof Serigne Magueye Gueye and Prof Jan Vermorken. 

The clinical oncology section represents an opportunity to share experiences and information among worldwide oncologists and to identify and develop diagnostic as well as therapeutic protocols, which are globally valid in the current global village. Potential topics include, but are not limited to: epidemiology, pathology and pathogenesis of cancers and clinical studies

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  1. Sinonasal inverted papillomas (SIP) and sinonasal squamous cell carcinomas (SNSCC) are sinonasal tumors with unclear etiology and pathogenesis. Epstein-Barr virus (EBV) has been detected in these tumors but in...

    Authors: Thawaree Nukpook, Tipaya Ekalaksananan, Watchareporn Teeramatwanich, Natcha Patarapadungkit, Surachat Chaiwiriyakul, Patravoot Vatanasapt, Sirinart Aromseree and Chamsai Pientong

    Citation: Infectious Agents and Cancer 2020 15:43

    Content type: Research Article

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  2. EBV produces miRNAs with important functions in cancer growth, tumor invasion and host immune surveillance. The discovery of EBV miR-BARTs is recent, and most of their functions are still unknown. Nonetheless,...

    Authors: Valli De Re, Laura Caggiari, Mariangela De Zorzi, Valentina Fanotto, Gianmaria Miolo, Fabio Puglisi, Renato Cannizzaro, Vincenzo Canzonieri, Agostino Steffan, Piero Farruggia, Egesta Lopci, Emanuele S. G. d’Amore, Roberta Burnelli, Lara Mussolin and Maurizio Mascarin

    Citation: Infectious Agents and Cancer 2020 15:42

    Content type: Review

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  3. The anatomical complexity of the oropharynx and the difficulty in reaching its distal portion have always conditioned the surgical accessibility.

    Authors: Fraco Ionna, Agostino Guida, Luigi Califano, Gaetano Motta, Giovanni Salzano, Ettore Pavone, Corrado Aversa, Francesco Longo, Salvatore Villano, Ludovica Marcella Ponzo, Pierluigi Franco, Simona Losito, Franco Maria Buonaguro, Maria Lina Tornesello and Maria Grazia Maglione

    Citation: Infectious Agents and Cancer 2020 15:40

    Content type: Research Article

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  4. Information on HPV-associated sinonasal squamous cell carcinoma (SNSCC) is very limited in China. The aim of this study was to determine the prevalence of HPV in a large cohort of SNSCC patients in China.

    Authors: Chunyan Hu, Huatao Quan, Li Yan, Ji Sun, Lin Lan and Shengzi Wang

    Citation: Infectious Agents and Cancer 2020 15:36

    Content type: Research Article

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  5. Hepatitis C virus (HCV) represents a major risk factor for hepatocellular carcinoma (HCC) development and anti-HCV therapy is a significant measure to reduce the incidence of HCC, however development of HCC in...

    Authors: Javeria Khalid, Mohammad Umar, Tofeeq Ur-Rehman, Mashhood Ali and Gul Majid Khan

    Citation: Infectious Agents and Cancer 2020 15:35

    Content type: Research Article

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  6. To investigate high-risk HPV (hr-HPV) genotype distributions and the association between hr-HPV infection with severity of the cervical lesions in women with normal cytology.

    Authors: Zhiling Wang, Ting Liu, Yunjian Wang, Ying Gu, Hui Wang, Jingkang Liu, Baoxia Cui and Xingsheng Yang

    Citation: Infectious Agents and Cancer 2020 15:34

    Content type: Research Article

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  7. There has been limited research on the comparison of squamous cell carcinoma (SCC) and adenocarcinoma (AC) of cervical cancer and that lack of information may have significant bearing on the treatment of patie...

    Authors: Tian Tian, Xing Gong, Xudong Gao, Yanqing Li, Wen Ju and Yiqin Ai

    Citation: Infectious Agents and Cancer 2020 15:33

    Content type: Research Article

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  8. Viral infections can reduce early cancer development through enhancement of cancer immunosurveillance. This study was performed to analyse this effect of viral infection in a mouse model of solid tumor.

    Authors: Mohamed F. Mandour, Pyone Pyone Soe, Catherine Uyttenhove, Jacques Van Snick, Etienne Marbaix and Jean-Paul Coutelier

    Citation: Infectious Agents and Cancer 2020 15:30

    Content type: Research Article

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  9. The detection of the Epstein–Barr capsid antigen (VCA) immunoglobulin A (IgA) is widely used in the diagnosis of nasopharyngeal carcinoma (NPC), but a reference standard for evaluating the presence of VCA-IgA ...

    Authors: Hao Chen, Qiaohua Zhong, Xiaobin Wu, Yanling Ding, Qi Chen, Ning Xue, Yiwei Xu and Shulin Chen

    Citation: Infectious Agents and Cancer 2020 15:25

    Content type: Research Article

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  10. The cause of epithelial ovarian cancer (EOC) is not elucidated. Viral infection may induce chronic inflammatory infection and play a role in the pathogenesis of cancers. Some viruses are considered to be oncom...

    Authors: Min Yin, Aiping Chen, Fei Zhao, Xuechao Ji, Chuan Li and Guangning Wang

    Citation: Infectious Agents and Cancer 2020 15:23

    Content type: Research Article

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  11. Infection with human papillomaviruses (HPVs) can cause benign and malignant tumours in the anogenital tract and the oropharynx both in men and women. The aim of the presented study was to investigate cervical,...

    Authors: Maria Nasioutziki, Kimon Chatzistamatiou, Panagiotis-Dimitrios Loufopoulos, Eleftherios Vavoulidis, Nikolaos Tsampazis, George-Chrysostomos Pratilas, Anastasios Liberis, Vasiliki Karpa, Evanggelos Parcharidis, Angelos Daniilidis, Konstantinos Spanos and Konstantinos Dinas

    Citation: Infectious Agents and Cancer 2020 15:22

    Content type: Research Article

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  12. Hepatocellular carcinoma is a primary liver malignancy in which the risk of development is always multifunctional. Interleukin-6 is a proinflammatory and multifunctional cytokine, which plays an important role...

    Authors: Faisal Adnan, Najeeb Ullah Khan, Aqib Iqbal, Ijaz Ali, Arnolfo Petruzziello, Rocco Sabatino, Annunziata Guzzo, Giovanna Loquercio, Gerardo Botti, Sanaullah Khan, Muhammad Naeem and Muhammad Ismail Khan

    Citation: Infectious Agents and Cancer 2020 15:21

    Content type: Research Article

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  13. Vulvar squamous cell carcinoma (VSCC) is a rare malignancy of the female genital tract. We aimed to determine the mucosal high-risk human papillomavirus (HPV)-attributable fraction of VSCCs from Italian women ...

    Authors: Mario Preti, John Charles Rotondo, Dana Holzinger, Leonardo Micheletti, Niccolò Gallio, Sandrine McKay-Chopin, Christine Carreira, Sebastiana Silvana Privitera, Reiko Watanabe, Ruediger Ridder, Michael Pawlita, Chiara Benedetto, Massimo Tommasino and Tarik Gheit

    Citation: Infectious Agents and Cancer 2020 15:20

    Content type: Research Article

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  14. Persistence of human papillomavirus (HPV) infections is associated with squamous cell carcinomas of different human anatomic sites. Several studies have suggested a potential role for HPV infection, particular...

    Authors: Sandra F. Martins, Vânia Mariano, Mesquita Rodrigues and Adhemar Longatto-Filho

    Citation: Infectious Agents and Cancer 2020 15:17

    Content type: Research Article

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  15. Cervical cancer is the most common malignancy of the female lower genital tract. In our previous study, we found that TLR4 promotes cervical cancer cell growth in vitro. The aim of this study was to further ex...

    Authors: Ninghong Jiang, Feng Xie, Limei Chen, Fang Chen and Long Sui

    Citation: Infectious Agents and Cancer 2020 15:12

    Content type: Research Article

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  16. The efficacy of cervical cancer screening programs is dependent on the participation rate. To increase participation among women not attending cervical cancer screening, self-collected samples for detection of...

    Authors: Avalon Ernstson, Annika Urdell, Ola Forslund and Christer Borgfeldt

    Citation: Infectious Agents and Cancer 2020 15:10

    Content type: Research Article

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  17. Cervical cancer is the fourth most common malignant tumor in women worldwide. The persistent infection of high-risk Human Papillomavirus (hrHPV) is considered to be the primary cause of this disease. As an inn...

    Authors: Xubin Liu, Hanyu Ma, Lingyan Fei, Mengjie Jiang, Meng Xia, Lihong Bai, Xufang Pi, Shangwu Chen and Li Yu

    Citation: Infectious Agents and Cancer 2020 15:6

    Content type: Research Article

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  18. Co-existence of hepatocellular carcinoma (HCC) and cystic echinococcus (CE) is extremely rare. Echinococcus granulosus may exhibit a protective effect against cancer. Herein, this study aimed to evaluate the poss...

    Authors: Ran Bo, Aimaiti Yasen, Yingmei Shao, Wenbao Zhang, Renyong Lin, Tiemin Jiang, Hao Wen, Hui Xiao and Tuerganaili Aji

    Citation: Infectious Agents and Cancer 2020 15:5

    Content type: Research Article

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  19. Triple-Negative Breast Cancer (TNBC), represents a subtype of breast cancer in which the estrogens receptor (ER) negative, the progesterone receptor (PR) negative and the human epidermal growth factor receptor...

    Authors: Sabrina Bimonte, Marco Cascella, Antonio Barbieri, Claudio Arra and Arturo Cuomo

    Citation: Infectious Agents and Cancer 2020 15:2

    Content type: Review

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  20. Given the paucity of data and widely variable rates that have been reported, the main objective of this study was to examine the prevalence of HPV-positivity in oropharyngeal squamous cell carcinoma (OPSCC) in...

    Authors: Christopher A. Maroun, Karine Al Feghali, Henri Traboulsi, Helene Dabbous, Fatmeh Abbas, Gabriel Dunya, Georges Ziade, Rami Mahfouz, Bassem Youssef, Hani Tamim, Fady Geara, Ibrahim Khalifeh and Roger V. Moukarbel

    Citation: Infectious Agents and Cancer 2020 15:1

    Content type: Research Article

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  21. The aim of this study was to investigate the prognostic significance of the serum γ-glutamyltransferase (γ-GT)-to-prealbumin ratio (GPR) and whether combining this ratio with other parameters can lead to an im...

    Authors: Q. Wang, P. Zhao, N. He, J. P. Sun, K. Li, C. R. Zang, Y. N. Zhao, Y. Zhao and Y. H. Zhang

    Citation: Infectious Agents and Cancer 2019 14:49

    Content type: Research Article

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  22. Earlier we suggested a new hypothesis of the possible evolutionary role of hereditary tumors (Kozlov, Evolution by tumor Neofunctionalization, 2014), and described a new class of genes – tumor specifically exp...

    Authors: E. A. Matyunina, A. V. Emelyanov, T. V. Kurbatova, A. A. Makashov, I. V. Mizgirev and A. P. Kozlov

    Citation: Infectious Agents and Cancer 2019 14:46

    Content type: Research Article

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    The Correction to this article has been published in Infectious Agents and Cancer 2020 15:3

  23. Although the Kaposi sarcoma (KS) is one of the AIDS defining entity and seen in almost one third of HIV infected patients with low CD4 cell counts, it is not uncommon in HIV seronegative persons, but genital K...

    Authors: Abdulaziz Alamri and B. K. Adiga

    Citation: Infectious Agents and Cancer 2019 14:45

    Content type: Short Report

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  24. Infections classified as group 1 biological carcinogens include the helminthiases caused by Schistosoma haematobium and Opisthorchis viverrini. The molecular mediators underlying the infection with these parasite...

    Authors: Maria João Gouveia, Paul J. Brindley, Gabriel Rinaldi, Fátima Gärtner, José M. C. da Costa and Nuno Vale

    Citation: Infectious Agents and Cancer 2019 14:41

    Content type: Research Article

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  25. To compare liver-specific EOB-GD-DTPA and liver-non-specific Gd-BT-DO3A MR, in hepatocellular carcinoma (HCC) and liver colorectal metastases.

    Authors: Vincenza Granata, Roberta Fusco, Francesca Maio, Antonio Avallone, Guglielmo Nasti, Raffaele Palaia, Vittorio Albino, Roberto Grassi, Francesco Izzo and Antonella Petrillo

    Citation: Infectious Agents and Cancer 2019 14:40

    Content type: Research Article

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  26. Persistent infection with human papillomaviruses (HPVs) has been associated with cervical intraepithelial neoplasia (CIN) and cervical cancer. However, why only a fraction of HPV cases progress to cancer is st...

    Authors: Junwei Zhao, Qin Zhan, Junhan Guo, Min Liu, Yetian Ruan, Tailin Zhu, Lingfei Han and Fang Li

    Citation: Infectious Agents and Cancer 2019 14:38

    Content type: Research Article

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  27. It has been reported that lncRNA MAGI2-AS3 can promote many types of cancer, such as breast cancer and bladder cancer, by regulating cell behaviors, such a proliferation, invasion, and migration. However, its ...

    Authors: Qifang Liu, Shuang Liu, Xiaoying Wang, Jin Zhang and Kuiran Liu

    Citation: Infectious Agents and Cancer 2019 14:37

    Content type: Research Article

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  28. Hepatitis B caused by HBV is a serious public health hazard prevalent worldwide including Bangladesh. Few scattered molecular studies of HBV have been reported in Bangladesh. This study aimed to analyze the ge...

    Authors: Md. Golzar Hossain and Keiji Ueda

    Citation: Infectious Agents and Cancer 2019 14:33

    Content type: Review

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  29. The possible role of Epstein-Barr virus (EBV) in the pathogenesis of thymic epithelial tumors (TET) remains controversial. This study aimed to determine the prevalence of EBV in TET. We conducted a systematic ...

    Authors: Guofei Zhang, Zipu Yu, Gang Shen, Ying Chai and Chengxiao Liang

    Citation: Infectious Agents and Cancer 2019 14:32

    Content type: Review

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  30. Human herpesvirus-6 (HHV-6) is a ubiquitous double-stranded DNA virus that can cause roseola infantum, encephalitis, and seizure disorders. Several studies have shown an association between HHV-6 and cancer bu...

    Authors: Michael J. Wells, Steven Jacobson and Paul H. Levine

    Citation: Infectious Agents and Cancer 2019 14:31

    Content type: Review

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  31. Microecology is an emerging discipline in recent years. The female reproductive tract is an important microecological region, and its microecological environment can directly affect women’s cervical health. Th...

    Authors: Yuejuan Liang, Mengjie Chen, Lu Qin, Bing Wan and He Wang

    Citation: Infectious Agents and Cancer 2019 14:29

    Content type: Review

    Published on:

    The Correction to this article has been published in Infectious Agents and Cancer 2019 14:47

  32. This study estimated genital warts prevalence, genital-warts-related healthcare resource use and costs, and self-reported human-papillomavirus-related psychosocial impact among male and female patients aged 18...

    Authors: Lani Buenconsejo, Smita Kothari-Talwar, Karen Yee, Amit Kulkarni, Nuria Lara, Montserrat Roset, Anna R. Giuliano and Suzanne Garland

    Citation: Infectious Agents and Cancer 2019 14:26

    Content type: Research Article

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  33. Bacterial infection may be involved in the entire process of tissue carcinogenesis by directly or indirectly affecting the occurrence and development of tumors. Porphyromonas gingivalis (P.gingivalis) is an impor...

    Authors: Xiao-bo Liu, Zi-ye Gao, Chuan-tao Sun, Hui Wen, Bo Gao, Sheng-bao Li and Qiang Tong

    Citation: Infectious Agents and Cancer 2019 14:23

    Content type: Review

    Published on:

  34. Human Papilloma Virus (HPV) genotypes concordance among sexual couples has been evaluated in many investigations with considerable variations in the concordance. However, no such study has carried out between ...

    Authors: Mehrdad Davarmanesh, Mehrouz Dezfulian, Mohammad Javad Gharavi, Sarang Younesi, Pourandokht Saadati, Mohammad Mehdi Taheri Amin and Seyed Mohammad Jazayeri

    Citation: Infectious Agents and Cancer 2019 14:22

    Content type: Research Article

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  35. Platelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection. Several studies and clinical findings have demonstrated that the PRP can accelerate the regenera...

    Authors: Antonio Barbieri, Sabrina Bimonte, Giovanna Loquercio, Domenica Rea, Marco Cascella, Annamaria Anniciello, Antonio Luciano, Giuseppe Palma, Gaetano Di Costanzo, Azzaro Rosa, Pasquale Giuliano and Claudio Arra

    Citation: Infectious Agents and Cancer 2019 14:21

    Content type: Short Report

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  36. B7-H4 is among the B7 family members which may serve as a new targetable immune checkpoint molecule. It was reported that high level of serum B7-H4 level may be correlated with lymphoma. Nevertheless, the role...

    Authors: Ying Jiang, Gangli Cai, Jun Lin, Jing Zhang, Zhilei Bo, Ying Li, Chun Wang and Yin Tong

    Citation: Infectious Agents and Cancer 2019 14:20

    Content type: Research Article

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  37. Cervical cancer is a common cancer among women worldwide and is closely related to high-risk human papillomavirus infection (HR-HPV). The immune microenvironment is thought to play an essential role in viral i...

    Authors: Bohan Li, Ling Zhang, Jianguo Zhao, Guichun Tan, Wenwen Zhang, Na Zhang, Jing Tian and Pengpeng Qu

    Citation: Infectious Agents and Cancer 2019 14:16

    Content type: Research Article

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  38. New strategies are needed to combat the high incidence of cervical cancer in resource-limited settings such as sub-Saharan Africa. Screening for high-risk human papillomavirus (hrHPV) DNA is sensitive for pre-...

    Authors: Miriam Nakalembe, Philippa Makanga, Frank Mubiru, Megan Swanson, Jeffrey Martin and Megan Huchko

    Citation: Infectious Agents and Cancer 2019 14:14

    Content type: Research Article

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  39. To evaluate the correlation of serum PIVKA-II levels and development of portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) patients.

    Authors: Tao Li, Yuanzi Yu, Juan Liu, Xiangguo Tian, Meng Kong, Lei Wu, Shaocan Tang, Shengqing Gu, Jingfang Zhao, Yi Cui and Jinhua Hu

    Citation: Infectious Agents and Cancer 2019 14:13

    Content type: Research article

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  40. The impact of different anti-virus regimens on prognosis of Chronic hepatitis B (CHB) related cirrhosis remains to be explored. We aim to investigate whether CHB-related HCC patients receiving nucleoside analo...

    Authors: Ping Zhang, Qingli Liu, Mei Yuan and Lina Wang

    Citation: Infectious Agents and Cancer 2018 13:30

    Content type: Research Article

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  41. High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role o...

    Authors: Clorinda Annunziata, Giovanni Stellato, Stefano Greggi, Veronica Sanna, Maria Pia Curcio, Simona Losito, Gerardo Botti, Luigi Buonaguro, Franco Maria Buonaguro and Maria Lina Tornesello

    Citation: Infectious Agents and Cancer 2018 13:26

    Content type: Research Article

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  42. Helicobacter pylori (H. pylori) infection has been recognized as a significant threat for gastric cancer. However, studies that investigated the oncogenic factors and antimicrobial resistance of H. pylori in Egyp...

    Authors: Doaa M. Al-Eraky, Omneya M. Helmy, Yasser M. Ragab, Zeinab Abdul-Khalek, Eman A. El-Seidi and Mohammed A. Ramadan

    Citation: Infectious Agents and Cancer 2018 13:24

    Content type: Research Article

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  43. Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the ...

    Authors: Vincenza Granata, Roberta Fusco, Salvatore Filice, Orlando Catalano, Mauro Piccirillo, Raffaele Palaia, Francesco Izzo and Antonella Petrillo

    Citation: Infectious Agents and Cancer 2018 13:23

    Content type: Review

    Published on:

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