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Clinical oncology

Section edited by: Prof Serigne Magueye Gueye and Prof Jan Vermorken. 

The clinical oncology section represents an opportunity to share experiences and information among worldwide oncologists and to identify and develop diagnostic as well as therapeutic protocols, which are globally valid in the current global village. Potential topics include, but are not limited to: epidemiology, pathology and pathogenesis of cancers and clinical studies

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  1. The identification of effective prognosis biomarkers for nasopharyngeal carcinoma (NPC) is crucial to improve treatment and patient outcomes. In the present study, we have attempted to evaluate the correlation...

    Authors: Amina Gihbid, Raja Benzeid, Abdellah Faouzi, Jalal Nourlil, Nezha Tawfiq, Nadia Benchakroun, Amal Guensi, Karima Bendahhou, Abdellatif Benider, Naima El Benna, Imane Chaoui, Rachida Cadi, Mohammed El Mzibri and Meriem Khyatti

    Citation: Infectious Agents and Cancer 2021 16:15

    Content type: Research Article

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  2. Frequent mutations in the nuclear receptor binding SET domain protein 1 (NSD1) gene have been observed in head and neck squamous cell carcinomas (HNSCC). NSD1 encodes a histone 3 lysine-36 methyltransferase. NSD1

    Authors: Steven F. Gameiro, Farhad Ghasemi, Peter Y. F. Zeng, Neil Mundi, Christopher J. Howlett, Paul Plantinga, John W. Barrett, Anthony C. Nichols and Joe S. Mymryk

    Citation: Infectious Agents and Cancer 2021 16:13

    Content type: Research Article

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  3. Mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with chronic antigen stimulation: auto-antigens or of microbial origin. Only one study suggested association between Achromobacter xylosox...

    Authors: Raphaël Borie, Valérie Caro, Hilario Nunes, Marianne Kambouchner, Aurélie Cazes, Martine Antoine, Bruno Crestani, Karen Leroy, Christiane Copie-Bergman, Aurelia Kwasiborski, Christophe Hennequin, Mathias Vandenbogaert, Véronique Hourdel and Jacques Cadranel

    Citation: Infectious Agents and Cancer 2021 16:10

    Content type: Short Report

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  4. The medical community has been deeply involved in fighting the Coronavirus disease 2019 (COVID-19) pandemic and, as a consequence, the care of non-COVID-19 patients has been impacted. However, the treatment of...

    Authors: Francesco Longo, Eleonora M. C. Trecca, Aurelio D’Ecclesia, Chiara Copelli, Karim Tewfik, Alfonso Manfuso, Nicola Pederneschi, Annalisa Mastromatteo, Matteo Aldo Russo, Antonio Pansini, Luca M. Lacerenza, Pier Gerardo Marano and Lazzaro Cassano

    Citation: Infectious Agents and Cancer 2021 16:9

    Content type: Review

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  5. Human Cytomegalovirus (HCMV) is the most important viral pathogen in people undergoing bone marrow transplantation (BMT). HCMV detection in the early stages makes is possible to save the patients’ lives throug...

    Authors: Mehrdad Payandeh, Mohammad Hossein Zamanian, Bizhan Nomanpour, Mohammad Soroush Farhadi, Alireza Janbakhsh, Mosayeb Rostamian, Azam Elahi, Somayeh Jafari and Mohammad Dehghannejad

    Citation: Infectious Agents and Cancer 2021 16:8

    Content type: Research Article

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  6. The etiology of prostate cancer (PCa) is multiple and complex. Among the causes recently cited are chronic infections engendered by microorganisms that often go unnoticed. A typical illustration of such a case...

    Authors: Osama Mohammed Saed Abdul-Wahab, Mishari H. Al-Shyarba, Boutheina Ben Abdelmoumen Mardassi, Nessrine Sassi, Majed Saad Shaya Al Fayi, Hassan Otifi, Abdullah Hassan Al Murea, Béhija Mlik and Elhem Yacoub

    Citation: Infectious Agents and Cancer 2021 16:6

    Content type: Research Article

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  7. The aim was to evaluate the hepatitis C virus (HCV) cascade of care in the general population (GP) and in two high-risk populations: patients with diabetes mellitus (DM) and substance users (AS) in treatment i...

    Authors: Olivera Djuric, Marco Massari, Marta Ottone, Giorgia Collini, Pamela Mancuso, Massimo Vicentini, Antonio Nicolaci, Angela Zannini, Alessandro Zerbini, Valeria Manicardi, Loreta A. Kondili and Paolo Giorgi Rossi

    Citation: Infectious Agents and Cancer 2021 16:5

    Content type: Research Article

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  8. COVID-19 has caused great concern for patients with underlying medical conditions. We aimed to determine the prognosis of patients with current or previous cancer with either a PCR-confirmed COVID-19 infection...

    Authors: Majid Sorouri, Amir Kasaeian, Helia Mojtabavi, Amir Reza Radmard, Shadi Kolahdoozan, Amir Anushiravani, Bardia Khosravi, Seyed Mohammad Pourabbas, Masoud Eslahi, Azin Sirusbakht, Marjan Khodabakhshi, Fatemeh Motamedi, Fatemeh Azizi, Reza Ghanbari, Zeynab Rajabi, Ali Reza Sima…

    Citation: Infectious Agents and Cancer 2020 15:74

    Content type: Research Article

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  9. Coronavirus disease 19 (COVID-19) is an infection caused by the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The pandemic spread of SARS-CoV-2 has resulted in significant health, economi...

    Authors: Christine Cassidy, Danielle Dever, Laura Stanbery, Gerald Edelman, Lance Dworkin and John Nemunaitis

    Citation: Infectious Agents and Cancer 2020 15:73

    Content type: Review

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  10. The solid transport media is a small size card that allows fast, easy DNA extraction from a variety of biological samples. In 2016 we developed a solid media transport card; for that pilot study to control the...

    Authors: Hui Du, Xianzhi Duan, Yan Liu, Bin Shi, Wei Zhang, Chun Wang, Xinfen Qu, Juncui Bao, Jingran Li, Chao Zhao, Jing Jiang, Juan Liu, Kejia Wu, Aimin Xiao, Lvfang Duan, Xia Huang…

    Citation: Infectious Agents and Cancer 2020 15:72

    Content type: Research Article

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  11. To explore the value of alpha fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) in diagnosis of HBV-related hepatocellular carcinoma (HCC) and their relationship with vascu...

    Authors: Yuan-Quan Si, Xiu-Qin Wang, Gang Fan, Chang-Yin Wang, Yuan-Wen Zheng, Xie Song, Cui-Cui Pan, Fu-Lu Chu, Zhan-Feng Liu, Bing-Ru Lu and Zhi-Ming Lu

    Citation: Infectious Agents and Cancer 2020 15:70

    Content type: Research Article

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  12. This study was performed to evaluate the significance of positive resection margins (RMs) with the loop electrosurgical excision procedure combined with cold coagulation (LEEP with CC) as a definitive treatmen...

    Authors: Eun Jung Yang, Nae Ry Kim, Ji Yeon Choi, Wook Youn Kim and Sun Joo Lee

    Citation: Infectious Agents and Cancer 2020 15:58

    Content type: Research Article

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  13. Hepatocellular carcinoma (HCC) is one of the cancers of highest incidence and mortality worldwide. The proliferation and invasion of tumor cells are the main reason for poor prognosis after HCC surgery. Long n...

    Authors: Quan Liu, Xuxu Yu, Minjie Yang, Xiangke Li, Xuejia Zhai, Yujin Lian, Zhong Chen, Qingxia Fan, Lijie Song and Wencai Li

    Citation: Infectious Agents and Cancer 2020 15:55

    Content type: Research Article

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  14. Oral squamous cell carcinoma (OSCC) is the most common type of head and neck squamous cell carcinoma (HNSCC), and the effect of zymosan (ZYM), a component of the yeast cell wall, on oral cancer remains unclear...

    Authors: Xu Chen, Qingqiong Luo, Jieying Ding, Meng Yang, Ruiyang Zhang and Fuxiang Chen

    Citation: Infectious Agents and Cancer 2020 15:51

    Content type: Research Article

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  15. Breast cancer is reported as one of the most common cancers among females worldwide. Infectious agents especially viruses have been considered as role players in the development of breast cancer. Although some...

    Authors: Alireza Khatami, Ali Pormohammad, Rana Farzi, Hassan Saadati, Maryam Mehrabi, Seyed Jalal Kiani and Saied Ghorbani

    Citation: Infectious Agents and Cancer 2020 15:48

    Content type: Review

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  16. HPV causes specific cell-mediated immunity in the cervix. Mononuclear cells such as helper T cells (CD4+), cytotoxic T cells (CD8+), and dendritic cells play a critical role in the initiation of the HPV-specif...

    Authors: Ceyda Sancakli Usta, Eren Altun, Selim Afsar, Cagla Bahar Bulbul, Akin Usta and Ertan Adalı

    Citation: Infectious Agents and Cancer 2020 15:47

    Content type: Research Article

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  17. Women living with human immunodeficiency virus (WLWH), especially those living in low- and middle-income countries (LMIC), are at increased risk of cervical cancer. The optimal cervical-cancer screening strate...

    Authors: Philip E. Castle, Rogers Ajeh, Anastase Dzudie, Ernestine Kendowo, Norbert Fuhngwa, Andre Gaetan Simo-Wambo, Denis Nsame, Enow Orock, Tiffany M. Hebert, Amanda J. Pierz, Daniel Murokora, Kathryn Anastos and Adebola Adedimeji

    Citation: Infectious Agents and Cancer 2020 15:45

    Content type: Short Report

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  18. Sinonasal inverted papillomas (SIP) and sinonasal squamous cell carcinomas (SNSCC) are sinonasal tumors with unclear etiology and pathogenesis. Epstein-Barr virus (EBV) has been detected in these tumors but in...

    Authors: Thawaree Nukpook, Tipaya Ekalaksananan, Watchareporn Teeramatwanich, Natcha Patarapadungkit, Surachat Chaiwiriyakul, Patravoot Vatanasapt, Sirinart Aromseree and Chamsai Pientong

    Citation: Infectious Agents and Cancer 2020 15:43

    Content type: Research Article

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  19. EBV produces miRNAs with important functions in cancer growth, tumor invasion and host immune surveillance. The discovery of EBV miR-BARTs is recent, and most of their functions are still unknown. Nonetheless,...

    Authors: Valli De Re, Laura Caggiari, Mariangela De Zorzi, Valentina Fanotto, Gianmaria Miolo, Fabio Puglisi, Renato Cannizzaro, Vincenzo Canzonieri, Agostino Steffan, Piero Farruggia, Egesta Lopci, Emanuele S. G. d’Amore, Roberta Burnelli, Lara Mussolin and Maurizio Mascarin

    Citation: Infectious Agents and Cancer 2020 15:42

    Content type: Review

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  20. The anatomical complexity of the oropharynx and the difficulty in reaching its distal portion have always conditioned the surgical accessibility.

    Authors: Fraco Ionna, Agostino Guida, Luigi Califano, Gaetano Motta, Giovanni Salzano, Ettore Pavone, Corrado Aversa, Francesco Longo, Salvatore Villano, Ludovica Marcella Ponzo, Pierluigi Franco, Simona Losito, Franco Maria Buonaguro, Maria Lina Tornesello and Maria Grazia Maglione

    Citation: Infectious Agents and Cancer 2020 15:40

    Content type: Research Article

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  21. Information on HPV-associated sinonasal squamous cell carcinoma (SNSCC) is very limited in China. The aim of this study was to determine the prevalence of HPV in a large cohort of SNSCC patients in China.

    Authors: Chunyan Hu, Huatao Quan, Li Yan, Ji Sun, Lin Lan and Shengzi Wang

    Citation: Infectious Agents and Cancer 2020 15:36

    Content type: Research Article

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  22. Hepatitis C virus (HCV) represents a major risk factor for hepatocellular carcinoma (HCC) development and anti-HCV therapy is a significant measure to reduce the incidence of HCC, however development of HCC in...

    Authors: Javeria Khalid, Mohammad Umar, Tofeeq Ur-Rehman, Mashhood Ali and Gul Majid Khan

    Citation: Infectious Agents and Cancer 2020 15:35

    Content type: Research Article

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  23. To investigate high-risk HPV (hr-HPV) genotype distributions and the association between hr-HPV infection with severity of the cervical lesions in women with normal cytology.

    Authors: Zhiling Wang, Ting Liu, Yunjian Wang, Ying Gu, Hui Wang, Jingkang Liu, Baoxia Cui and Xingsheng Yang

    Citation: Infectious Agents and Cancer 2020 15:34

    Content type: Research Article

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  24. There has been limited research on the comparison of squamous cell carcinoma (SCC) and adenocarcinoma (AC) of cervical cancer and that lack of information may have significant bearing on the treatment of patie...

    Authors: Tian Tian, Xing Gong, Xudong Gao, Yanqing Li, Wen Ju and Yiqin Ai

    Citation: Infectious Agents and Cancer 2020 15:33

    Content type: Research Article

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  25. Viral infections can reduce early cancer development through enhancement of cancer immunosurveillance. This study was performed to analyse this effect of viral infection in a mouse model of solid tumor.

    Authors: Mohamed F. Mandour, Pyone Pyone Soe, Catherine Uyttenhove, Jacques Van Snick, Etienne Marbaix and Jean-Paul Coutelier

    Citation: Infectious Agents and Cancer 2020 15:30

    Content type: Research Article

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  26. The detection of the Epstein–Barr capsid antigen (VCA) immunoglobulin A (IgA) is widely used in the diagnosis of nasopharyngeal carcinoma (NPC), but a reference standard for evaluating the presence of VCA-IgA ...

    Authors: Hao Chen, Qiaohua Zhong, Xiaobin Wu, Yanling Ding, Qi Chen, Ning Xue, Yiwei Xu and Shulin Chen

    Citation: Infectious Agents and Cancer 2020 15:25

    Content type: Research Article

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  27. The cause of epithelial ovarian cancer (EOC) is not elucidated. Viral infection may induce chronic inflammatory infection and play a role in the pathogenesis of cancers. Some viruses are considered to be oncom...

    Authors: Min Yin, Aiping Chen, Fei Zhao, Xuechao Ji, Chuan Li and Guangning Wang

    Citation: Infectious Agents and Cancer 2020 15:23

    Content type: Research Article

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  28. Infection with human papillomaviruses (HPVs) can cause benign and malignant tumours in the anogenital tract and the oropharynx both in men and women. The aim of the presented study was to investigate cervical,...

    Authors: Maria Nasioutziki, Kimon Chatzistamatiou, Panagiotis-Dimitrios Loufopoulos, Eleftherios Vavoulidis, Nikolaos Tsampazis, George-Chrysostomos Pratilas, Anastasios Liberis, Vasiliki Karpa, Evanggelos Parcharidis, Angelos Daniilidis, Konstantinos Spanos and Konstantinos Dinas

    Citation: Infectious Agents and Cancer 2020 15:22

    Content type: Research Article

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  29. Hepatocellular carcinoma is a primary liver malignancy in which the risk of development is always multifunctional. Interleukin-6 is a proinflammatory and multifunctional cytokine, which plays an important role...

    Authors: Faisal Adnan, Najeeb Ullah Khan, Aqib Iqbal, Ijaz Ali, Arnolfo Petruzziello, Rocco Sabatino, Annunziata Guzzo, Giovanna Loquercio, Gerardo Botti, Sanaullah Khan, Muhammad Naeem and Muhammad Ismail Khan

    Citation: Infectious Agents and Cancer 2020 15:21

    Content type: Research Article

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  30. Vulvar squamous cell carcinoma (VSCC) is a rare malignancy of the female genital tract. We aimed to determine the mucosal high-risk human papillomavirus (HPV)-attributable fraction of VSCCs from Italian women ...

    Authors: Mario Preti, John Charles Rotondo, Dana Holzinger, Leonardo Micheletti, Niccolò Gallio, Sandrine McKay-Chopin, Christine Carreira, Sebastiana Silvana Privitera, Reiko Watanabe, Ruediger Ridder, Michael Pawlita, Chiara Benedetto, Massimo Tommasino and Tarik Gheit

    Citation: Infectious Agents and Cancer 2020 15:20

    Content type: Research Article

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  31. Persistence of human papillomavirus (HPV) infections is associated with squamous cell carcinomas of different human anatomic sites. Several studies have suggested a potential role for HPV infection, particular...

    Authors: Sandra F. Martins, Vânia Mariano, Mesquita Rodrigues and Adhemar Longatto-Filho

    Citation: Infectious Agents and Cancer 2020 15:17

    Content type: Research Article

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  32. Cervical cancer is the most common malignancy of the female lower genital tract. In our previous study, we found that TLR4 promotes cervical cancer cell growth in vitro. The aim of this study was to further ex...

    Authors: Ninghong Jiang, Feng Xie, Limei Chen, Fang Chen and Long Sui

    Citation: Infectious Agents and Cancer 2020 15:12

    Content type: Research Article

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  33. The efficacy of cervical cancer screening programs is dependent on the participation rate. To increase participation among women not attending cervical cancer screening, self-collected samples for detection of...

    Authors: Avalon Ernstson, Annika Urdell, Ola Forslund and Christer Borgfeldt

    Citation: Infectious Agents and Cancer 2020 15:10

    Content type: Research Article

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  34. Cervical cancer is the fourth most common malignant tumor in women worldwide. The persistent infection of high-risk Human Papillomavirus (hrHPV) is considered to be the primary cause of this disease. As an inn...

    Authors: Xubin Liu, Hanyu Ma, Lingyan Fei, Mengjie Jiang, Meng Xia, Lihong Bai, Xufang Pi, Shangwu Chen and Li Yu

    Citation: Infectious Agents and Cancer 2020 15:6

    Content type: Research Article

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  35. Co-existence of hepatocellular carcinoma (HCC) and cystic echinococcus (CE) is extremely rare. Echinococcus granulosus may exhibit a protective effect against cancer. Herein, this study aimed to evaluate the poss...

    Authors: Ran Bo, Aimaiti Yasen, Yingmei Shao, Wenbao Zhang, Renyong Lin, Tiemin Jiang, Hao Wen, Hui Xiao and Tuerganaili Aji

    Citation: Infectious Agents and Cancer 2020 15:5

    Content type: Research Article

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  36. Triple-Negative Breast Cancer (TNBC), represents a subtype of breast cancer in which the estrogens receptor (ER) negative, the progesterone receptor (PR) negative and the human epidermal growth factor receptor...

    Authors: Sabrina Bimonte, Marco Cascella, Antonio Barbieri, Claudio Arra and Arturo Cuomo

    Citation: Infectious Agents and Cancer 2020 15:2

    Content type: Review

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  37. Given the paucity of data and widely variable rates that have been reported, the main objective of this study was to examine the prevalence of HPV-positivity in oropharyngeal squamous cell carcinoma (OPSCC) in...

    Authors: Christopher A. Maroun, Karine Al Feghali, Henri Traboulsi, Helene Dabbous, Fatmeh Abbas, Gabriel Dunya, Georges Ziade, Rami Mahfouz, Bassem Youssef, Hani Tamim, Fady Geara, Ibrahim Khalifeh and Roger V. Moukarbel

    Citation: Infectious Agents and Cancer 2020 15:1

    Content type: Research Article

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  38. The aim of this study was to investigate the prognostic significance of the serum γ-glutamyltransferase (γ-GT)-to-prealbumin ratio (GPR) and whether combining this ratio with other parameters can lead to an im...

    Authors: Q. Wang, P. Zhao, N. He, J. P. Sun, K. Li, C. R. Zang, Y. N. Zhao, Y. Zhao and Y. H. Zhang

    Citation: Infectious Agents and Cancer 2019 14:49

    Content type: Research Article

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  39. Earlier we suggested a new hypothesis of the possible evolutionary role of hereditary tumors (Kozlov, Evolution by tumor Neofunctionalization, 2014), and described a new class of genes – tumor specifically exp...

    Authors: E. A. Matyunina, A. V. Emelyanov, T. V. Kurbatova, A. A. Makashov, I. V. Mizgirev and A. P. Kozlov

    Citation: Infectious Agents and Cancer 2019 14:46

    Content type: Research Article

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    The Correction to this article has been published in Infectious Agents and Cancer 2020 15:3

  40. Although the Kaposi sarcoma (KS) is one of the AIDS defining entity and seen in almost one third of HIV infected patients with low CD4 cell counts, it is not uncommon in HIV seronegative persons, but genital K...

    Authors: Abdulaziz Alamri and B. K. Adiga

    Citation: Infectious Agents and Cancer 2019 14:45

    Content type: Short Report

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  41. Infections classified as group 1 biological carcinogens include the helminthiases caused by Schistosoma haematobium and Opisthorchis viverrini. The molecular mediators underlying the infection with these parasite...

    Authors: Maria João Gouveia, Paul J. Brindley, Gabriel Rinaldi, Fátima Gärtner, José M. C. da Costa and Nuno Vale

    Citation: Infectious Agents and Cancer 2019 14:41

    Content type: Research Article

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