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Clinical oncology

Section edited by: Prof Serigne Magueye Gueye and Prof Jan Vermorken. 

The clinical oncology section represents an opportunity to share experiences and information among worldwide oncologists and to identify and develop diagnostic as well as therapeutic protocols, which are globally valid in the current global village. Potential topics include, but are not limited to: epidemiology, pathology and pathogenesis of cancers and clinical studies

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  1. Content type: Research Article

    The impact of different anti-virus regimens on prognosis of Chronic hepatitis B (CHB) related cirrhosis remains to be explored. We aim to investigate whether CHB-related HCC patients receiving nucleoside analo...

    Authors: Ping Zhang, Qingli Liu, Mei Yuan and Lina Wang

    Citation: Infectious Agents and Cancer 2018 13:30

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  2. Content type: Research Article

    High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role o...

    Authors: Clorinda Annunziata, Giovanni Stellato, Stefano Greggi, Veronica Sanna, Maria Pia Curcio, Simona Losito, Gerardo Botti, Luigi Buonaguro, Franco Maria Buonaguro and Maria Lina Tornesello

    Citation: Infectious Agents and Cancer 2018 13:26

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  3. Content type: Research Article

    Helicobacter pylori (H. pylori) infection has been recognized as a significant threat for gastric cancer. However, studies that investigated the oncogenic factors and antimicrobial resistance of H. pylori in Egyp...

    Authors: Doaa M. Al-Eraky, Omneya M. Helmy, Yasser M. Ragab, Zeinab Abdul-Khalek, Eman A. El-Seidi and Mohammed A. Ramadan

    Citation: Infectious Agents and Cancer 2018 13:24

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  4. Content type: Review

    Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the ...

    Authors: Vincenza Granata, Roberta Fusco, Salvatore Filice, Orlando Catalano, Mauro Piccirillo, Raffaele Palaia, Francesco Izzo and Antonella Petrillo

    Citation: Infectious Agents and Cancer 2018 13:23

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  5. Content type: Research Article

    The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in Western countries and this has been attributed to human papillomavirus (HPV) infection. p16 expression is a marker for HPV infe...

    Authors: Lee Fah Yap, Sook Ling Lai, Anthony Rhodes, Hans Prakash Sathasivam, Maizaton Atmadini Abdullah, Kin-Choo Pua, Pathmanathan Rajadurai, Phaik-Leng Cheah, Selvam Thavaraj, Max Robinson and Ian C. Paterson

    Citation: Infectious Agents and Cancer 2018 13:21

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  6. Content type: Research Article

    Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line choices regarding the treatment of chronic hepatits B. The impact of the two antiviral agents on prognosis of Chronic h...

    Authors: Min Zhang, Dexin Wang, Haidong Liu and Hui Li

    Citation: Infectious Agents and Cancer 2018 13:19

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  7. Content type: Research Article

    Hepatitis B virus (HBV) is one of the most prevalent and serious infections worldwide. HBV reactivation is a serious complication for lymphoma patients who are being treated with rituximab-containing regimen. ...

    Authors: Mubarak M. Al-Mansour, Saif A. Alghamdi, Musab A. Alsubaie, Abdullah A. Alesa and Muhammad A. Khan

    Citation: Infectious Agents and Cancer 2018 13:18

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  8. Content type: Research Article

    A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related d...

    Authors: Noelia López, Aureli Torné, Agustín Franco, María San-Martin, Elisabet Viayna, Carmen Barrull and Nuria Perulero

    Citation: Infectious Agents and Cancer 2018 13:15

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  9. Content type: Review

    The Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies. In order to maintain its persistence in host cells and promote...

    Authors: Silvia Giunco, Maria Raffaella Petrara, Manuela Zangrossi, Andrea Celeghin and Anita De Rossi

    Citation: Infectious Agents and Cancer 2018 13:14

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  10. Content type: Review

    Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of the...

    Authors: Jorge Levican, Mónica Acevedo, Oscar León, Aldo Gaggero and Francisco Aguayo

    Citation: Infectious Agents and Cancer 2018 13:12

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  11. Content type: Research Article

    The role of Fusobacterium nucleatum Fap2 protein in the development of colorectal cancer has recently been explained. Fap2, when bound to the human inhibitory receptor, TIGIT, inhibits the cytotoxic activity of n...

    Authors: Leonardo A. Guevarra Jr, Andrea Claudine F. Afable, Patricia Joyce O. Belza, Karen Joy S. Dy, Scott Justin Q. Lee, Teresa T. Sy-Ortin and Pia Marie S. P. Albano

    Citation: Infectious Agents and Cancer 2018 13:11

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  12. Content type: Review

    Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and accounts for about 6% of all new cancers diagnosed worldwide. Moreover, it is the third and the fifth leading cause of death from ...

    Authors: A. Petrizzo, A. Mauriello, M. L. Tornesello, F. M. Buonaguro, M. Tagliamonte and L. Buonaguro

    Citation: Infectious Agents and Cancer 2018 13:10

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  13. Content type: Research Article

    Hepatocellular carcinoma (HCC) can develop in patients who are negative for the hepatitis B surface antigen (HBsAg) in serum but positive for hepatitis B virus (HBV) DNA in the liver, referred to as occult HBV...

    Authors: Yuri Hatazawa, Yoshihiko Yano, Rina Okada, Toshihito Tanahashi, Hiroki Hayashi, Hirotaka Hirano, Akihiro Minami, Yuki Kawano, Motofumi Tanaka, Takumi Fukumoto, Yoshiki Murakami, Masaru Yoshida and Yoshitake Hayashi

    Citation: Infectious Agents and Cancer 2018 13:7

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  14. Content type: Research Article

    Persistent infection with High Risk Human Papillomavirus (HR HPV) types plays a major role in the development of cervical cancer. Therefore, the detection of HR HPV types is an essential part of cervical cance...

    Authors: Farzane Jamdar, Farah Farzaneh, Fariba Navidpour, Sarang Younesi, Payam Balvayeh, Maryamsadat Hosseini and Robabeh Ghodssi-Ghasemabadi

    Citation: Infectious Agents and Cancer 2018 13:6

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  15. Content type: Review

    Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous du...

    Authors: Marco Cascella, Sabrina Bimonte, Antonio Barbieri, Vitale Del Vecchio, Domenico Caliendo, Vincenzo Schiavone, Roberta Fusco, Vincenza Granata, Claudio Arra and Arturo Cuomo

    Citation: Infectious Agents and Cancer 2018 13:3

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  16. Content type: Research Article

    Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype...

    Authors: Dauren Adilbay, Galim Adilbayev, Gulzhan Kidirbayeva, Viktoria Shipilova, Zhanat Sadyk, Gulsum Koyanbekova, Ekaterina Sokolenko and Jan Klozar

    Citation: Infectious Agents and Cancer 2018 13:2

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  17. Content type: Research Article

    Women infected with Human Immune Deficiency Virus (HIV) are assumed to be at higher risk of developing Cervical Cancer (CC). This is due to a rapid progression of pre-invasive to invasive lesions. However, evi...

    Authors: Muluken Gizaw, Adamu Addissie, Sefonias Getachew, Wondimu Ayele, Israel Mitiku, Ulrike Moelle, Tigist Yusuf, Mathias Begoihn, Mathewos Assefa, Ahmedin Jemal and Eva Johanna Kantelhardt

    Citation: Infectious Agents and Cancer 2017 12:61

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  18. Content type: Review

    Oesophageal carcinoma (OC) is highly prevalent in Western Kenya especially among the members of the Kalenjin community who reside in the Northern and Southern areas of the Rift Valley. Previous authors have su...

    Authors: Gabriel Kigen, Naftali Busakhala, Zipporah Kamuren, Hillary Rono, Wilfred Kimalat and Evangeline Njiru

    Citation: Infectious Agents and Cancer 2017 12:59

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  19. Content type: Review

    Literature data suggest that multi-parametric Magnetic Resonance Imaging (MRI), including morphologic T2-weigthed images (T2-MRI) and functional approaches such as Dynamic Contrast Enhanced-MRI (DCE-MRI), Diff...

    Authors: Roberta Fusco, Mario Sansone, Vincenza Granata, Sergio Venanzio Setola and Antonella Petrillo

    Citation: Infectious Agents and Cancer 2017 12:57

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  20. Content type: Research Article

    Processes and mechanisms responsible for systemic immune suppression in early-stage cervical cancer remain substantially underinvestigated. In this work, we focused on studying the frequencies of circulating r...

    Authors: Olga V. Kurmyshkina, Pavel I. Kovchur, Ludmila V. Schegoleva and Tatyana O. Volkova

    Citation: Infectious Agents and Cancer 2017 12:56

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  21. Content type: Research Article

    Multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and Epstein Barr virus, have been identified as separate infectious pathogens in human breast canc...

    Authors: James S. Lawson and Wendy K. Glenn

    Citation: Infectious Agents and Cancer 2017 12:55

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  22. Content type: Research article

    Hepatocellular carcinoma (HCC) is one of the major cause for cancer in the world. Aim of this case-control study was to investigate the distribution pattern of HCV genotypes among HCC patients and suggest whet...

    Authors: Arnolfo Petruzziello, Samantha Marigliano, Giovanna Loquercio, Nicola Coppola, Mauro Piccirillo, Maddalena Leongito, Rosa Azzaro, Francesco Izzo and Gerardo Botti

    Citation: Infectious Agents and Cancer 2017 12:52

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  23. Content type: Research Article

    The introduction of cART has changed the morbidity and mortality patterns affecting HIV-infected (HIV+) individuals. The risk of breast cancer in HIV+ patients has now approached the general population risk. Howe...

    Authors: Francesca Caccuri, Francesca Giordano, Ines Barone, Pietro Mazzuca, Cinzia Giagulli, Sebastiano Andò, Arnaldo Caruso and Stefania Marsico

    Citation: Infectious Agents and Cancer 2017 12:49

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  24. Content type: Research Article

    To evaluate the diagnostic efficacy of prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) for early stage hepatitis virus B (HBV) related hepatocellular carcinoma (HCC).

    Authors: Xiumei Wang, Weiwei Zhang, Youde Liu, Wenjing Gong, Ping Sun, Xiangshuo Kong, Miaomiao Yang and Zhihua Wang

    Citation: Infectious Agents and Cancer 2017 12:47

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  25. Content type: Research Article

    Although high risk HPVs are associated with an increased risk of prostate cancer it is not known if they have a causal role. The purpose of this study is to investigate the potential role of human papilloma vi...

    Authors: Wendy K. Glenn, Christopher C. Ngan, Timothy G. Amos, Richard J. Edwards, Joshua Swift, Louise Lutze-Mann, Fei Shang, Noel J. Whitaker and James S. Lawson

    Citation: Infectious Agents and Cancer 2017 12:46

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  26. Content type: Research Article

    Human papillomavirus genotypes 52 and 58 (HPV52/58) are frequently detected in patients with cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC) in East Asian countries including Japan....

    Authors: Yuri Tenjimbayashi, Mamiko Onuki, Yusuke Hirose, Seiichiro Mori, Yoshiyuki Ishii, Takamasa Takeuchi, Nobutaka Tasaka, Toyomi Satoh, Tohru Morisada, Takashi Iwata, Shingo Miyamoto, Koji Matsumoto, Akihiko Sekizawa and Iwao Kukimoto

    Citation: Infectious Agents and Cancer 2017 12:44

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  27. Content type: Research Article

    Although analysis of the Human papillomavirus (HPV) genotype spread in a particular area has a crucial impact on public health and prevention programmes, there is a lack of epidemiological data regarding HPV i...

    Authors: Luisa Galati, Cinzia Peronace, Maria Teresa Fiorillo, Rosanna Masciari, Cristina Giraldi, Salvatore Nisticò, Pasquale Minchella, Vincenzo Maiolo, Giorgio Settimo Barreca, Nadia Marascio, Angelo Giuseppe Lamberti, Aida Giancotti, Maria Gabriella Lepore, Francesca Greco, Maria Vittoria Mauro, Annelisa Borelli…

    Citation: Infectious Agents and Cancer 2017 12:43

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  28. Content type: Research Article

    The role of interleukin (IL) 17A in chronic liver diseases had been extensively studied, but the function of IL-17F, which shares a high degree of homology with IL-17A, in the progression of chronic hepatic di...

    Authors: Ming-Sian Wu, Chun-Hsiang Wang, Fan-Chen Tseng, Hsuan-Ju Yang, Yin-Chiu Lo, Yi-Ping Kuo, De-Jiun Tsai, Wan-Ting Tsai and Guann-Yi Yu

    Citation: Infectious Agents and Cancer 2017 12:42

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  29. Content type: Research Article

    Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein–Barr virus (EBV) has been associated with approximately 1...

    Authors: Célia Nogueira, Marta Mota, Rui Gradiz, Maria Augusta Cipriano, Francisco Caramelo, Hugo Cruz, Ana Alarcão, Francisco Castro e Sousa, Fernando Oliveira, Fernando Martinho, João Moura Pereira, Paulo Figueiredo and Maximino Leitão

    Citation: Infectious Agents and Cancer 2017 12:41

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  30. Content type: Research Article

    The role of human cytomegalovirus (HCMV) in the development of breast carcinoma is questionable. The aim of this study was to evaluate the expression of the immediate early antigen (IE) of HCMV in breast carci...

    Authors: Fereshteh Mohammadizadeh and Fatemeh Mahmudi

    Citation: Infectious Agents and Cancer 2017 12:39

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  31. Content type: Research Article

    Electrochemotherapy (ECT) has shown to be an effective treatment for cutaneous and subcutaneous Kaposi sarcoma (KS) lesions. However, no study has investigated the impact of ECT treatment on the kinetics of hu...

    Authors: Noemy Starita, Gianluca Di Monta, Andrea Cerasuolo, Ugo Marone, Anna Maria Anniciello, Gerardo Botti, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello

    Citation: Infectious Agents and Cancer 2017 12:35

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  32. Content type: Review

    Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia characterized by cognitive and memory impairment. One of the mechanism involved in the pathogenesis of AD, is the o...

    Authors: Marco Cascella, Sabrina Bimonte, Maria Rosaria Muzio, Vincenzo Schiavone and Arturo Cuomo

    Citation: Infectious Agents and Cancer 2017 12:36

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  33. Content type: Research Article

    Lithuania remains one of the highest tuberculosis burden countries in Europe. Epidemiological studies have long pointed to infections as important factors of cancer aetiology, but the association between tuber...

    Authors: Ruta Everatt, Irena Kuzmickiene, Edita Davidaviciene and Saulius Cicenas

    Citation: Infectious Agents and Cancer 2017 12:33

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  34. Content type: Research Article

    Though TRAIL has been hailed as a promising drug for tumour treatment, it has been observed that many tumour cells have developed escape mechanisms against TRAIL-induced apoptosis. As a receptor of LPS, TLR 4,...

    Authors: Katharina Beyer, Lars Ivo Partecke, Felicitas Roetz, Herbert Fluhr, Frank Ulrich Weiss, Claus-Dieter Heidecke and Wolfram von Bernstorff

    Citation: Infectious Agents and Cancer 2017 12:30

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  35. Content type: Research Article

    The association between Epstein-Barr virus (EBV) and the development of head and neck cancer was reported by many researchers. The aim of the present study was to detect EBV DNA and EBV antibodies in 110 Polis...

    Authors: Sylwia Fołtyn, Małgorzata Strycharz-Dudziak, Bartłomiej Drop, Anastazja Boguszewska and Małgorzata Polz-Dacewicz

    Citation: Infectious Agents and Cancer 2017 12:31

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  36. Content type: Research Article

    The conception that serological hepatitis markers determined surgical prognosis of hepatocellular carcinoma (HCC) associated with hepatitis B (HBV) or hepatitis C (HCV) has been well defined. However, little i...

    Authors: Xiu-Tao Fu, Ying-Hong Shi, Jian Zhou, Yuan-Fei Peng, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Kang Song, Jia Fan and Zhen-Bin Ding

    Citation: Infectious Agents and Cancer 2017 12:28

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  37. Content type: Review

    Primary hepatocellular carcinoma (HCC) mainly develops in subjects chronically infected with hepatitis B (HBV) and C (HCV) viruses through a multistep process characterized by the accumulation of genetic alter...

    Authors: Francesca Pezzuto, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello

    Citation: Infectious Agents and Cancer 2017 12:27

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  38. Content type: Review

    The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis.

    Authors: Kasper Ingerslev, Estrid Hogdall, Tine Henrichsen Schnack, Wojciech Skovrider-Ruminski, Claus Hogdall and Jan Blaakaer

    Citation: Infectious Agents and Cancer 2017 12:25

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  39. Content type: Research Article

    Mouse mammary tumour viruses (MMTVs) may have a role in a subset of human breast cancers. MMTV positive human breast cancers have similar histological characteristics to neuroendocrine breast cancers and to MM...

    Authors: Lawson JS, Ngan CC, Glenn WK and Tran DD

    Citation: Infectious Agents and Cancer 2017 12:24

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    The Correction to this article has been published in Infectious Agents and Cancer 2017 12:51

  40. Content type: Review

    Liver Imaging Reporting and Data System (LI-RADS) is a system for interpreting and reporting of imaging features on multidetector computed tomography (MDCT) and magnetic resonance (MR) studies in patients at r...

    Authors: Vincenza Granata, Roberta Fusco, Antonio Avallone, Orlando Catalano, Francesco Filice, Maddalena Leongito, Raffaele Palaia, Francesco Izzo and Antonella Petrillo

    Citation: Infectious Agents and Cancer 2017 12:23

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  41. Content type: Research Article

    Helicobacter pylori (H. pylori) represents a key factor in the etiology of autoimmune atrophic gastritis (AAG), duodenal ulcer (DU) and gastric cancer (GC). The aim of this study was t...

    Authors: Valli De Re, Ombretta Repetto, Stefania Zanussi, Mariateresa Casarotto, Laura Caggiari, Vincenzo Canzonieri and Renato Cannizzaro

    Citation: Infectious Agents and Cancer 2017 12:22

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  42. Content type: Research Article

    Blastocystis, a genetically diverse intestinal parasite with controversial pathogenic potential, has increasingly been incriminated for diarrheal illness in immunocompromised individua...

    Authors: Amr Mohamed Mohamed, Mona Abdelfattah Ahmed, Sabah Abdelghany Ahmed, Sherif Ahmed Al-Semany, Saad Saed Alghamdi and Dina Abdulla Zaglool

    Citation: Infectious Agents and Cancer 2017 12:21

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  43. Content type: Research Article

    In addition to cervical cancer, human papillomavirus (HPV) is responsible for a significant proportion of cancers and precancerous lesions of the vulva, vagina, anus, penis, head and neck, as well as genital w...

    Authors: Susanne Hartwig, Jean Lacau St Guily, Géraldine Dominiak-Felden, Laia Alemany and Silvia de Sanjosé

    Citation: Infectious Agents and Cancer 2017 12:19

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  44. Content type: Research Article

    Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack o...

    Authors: Madina Shaimerdenova, Orynbassar Karapina, Damel Mektepbayeva, Kenneth Alibek and Dana Akilbekova

    Citation: Infectious Agents and Cancer 2017 12:18

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  45. Content type: Research Article

    Direct Antiviral Agents (DAAs) for HCV therapy represents a step ahead in the cure of chronic hepatitis C. Notwithstanding the promising results in several clinical trials, few data are available on adverse ef...

    Authors: A. Nappi, A. Perrella, P. Bellopede, A. Lanza, A. Izzi, M. Spatarella and C. Sbreglia

    Citation: Infectious Agents and Cancer 2017 12:12

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