Human papillomavirus genome variants and head and neck cancers: a perspective

Human papillomaviruses (HPV) cause infections that are responsible for diverse clinical manifestations from benign conditions to invasive cancer. As different HPV types are associated with variable pathogenic ...

Authors: Jean-Damien Combes and Silvia Franceschi

Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications

The Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies. In order to maintain its persistence in host cells and promote...

Authors: Silvia Giunco, Maria Raffaella Petrara, Manuela Zangrossi, Andrea Celeghin and Anita De Rossi

Role of BK human polyomavirus in cancer

Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of the...

Authors: Jorge Levican, Mónica Acevedo, Oscar León, Aldo Gaggero and Francisco Aguayo

Immunogenicity of a Fap2 peptide mimotope of Fusobacterium nucleatum and its potential use in the diagnosis of colorectal cancer

The role of Fusobacterium nucleatum Fap2 protein in the development of colorectal cancer has recently been explained. Fap2, when bound to the human inhibitory receptor, TIGIT, inhibits the cytotoxic activity of n...

Authors: Leonardo A. Guevarra Jr, Andrea Claudine F. Afable, Patricia Joyce O. Belza, Karen Joy S. Dy, Scott Justin Q. Lee, Teresa T. Sy-Ortin and Pia Marie S. P. Albano

Cellular prognostic markers in hepatitis-related hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and accounts for about 6% of all new cancers diagnosed worldwide. Moreover, it is the third and the fifth leading cause of death from ...

Authors: A. Petrizzo, A. Mauriello, M. L. Tornesello, F. M. Buonaguro, M. Tagliamonte and L. Buonaguro

The role of bacteria in cancer therapy – enemies in the past, but allies at present

In recent decades, bacteria’s therapeutic role has aroused attention in medicinal and pharmaceutical research. While bacteria are considered among the primary agents for causing cancer, recent research has sho...

Authors: Shiyu Song, Miza S. Vuai and Mintao Zhong

Comparative assessment of HPV, alcohol and tobacco etiological fractions in Algerian patients with laryngeal squamous cell carcinoma

Despite the increasing incidence of laryngeal squamous cell carcinoma (LSCC) in Algeria, scarce information is available on the importance of the preventable etiological factors which may drive the disease. Re...

Authors: Nora Kariche, Montserrat Torres Hortal, Samir Benyahia, Laia Alemany, Nabila Moulaï, Omar Clavero, Marleny Muñoz, Wahiba Ouahioune, Djamel Djennaoui, Chafia Touil-Boukoffa, Silvia de Sanjosé and Mehdi Bourouba

Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection

Hepatocellular carcinoma (HCC) can develop in patients who are negative for the hepatitis B surface antigen (HBsAg) in serum but positive for hepatitis B virus (HBV) DNA in the liver, referred to as occult HBV...

Authors: Yuri Hatazawa, Yoshihiko Yano, Rina Okada, Toshihito Tanahashi, Hiroki Hayashi, Hirotaka Hirano, Akihiro Minami, Yuki Kawano, Motofumi Tanaka, Takumi Fukumoto, Yoshiki Murakami, Masaru Yoshida and Yoshitake Hayashi

Prevalence of human papillomavirus infection among Iranian women using COBAS HPV DNA testing

Persistent infection with High Risk Human Papillomavirus (HR HPV) types plays a major role in the development of cervical cancer. Therefore, the detection of HR HPV types is an essential part of cervical cance...

Authors: Farzane Jamdar, Farah Farzaneh, Fariba Navidpour, Sarang Younesi, Payam Balvayeh, Maryamsadat Hosseini and Robabeh Ghodssi-Ghasemabadi

HIV-associated Kaposi’s sarcoma in Maputo, Mozambique: outcomes in a specialized treatment center, 2010–2015

Kaposi’s sarcoma (KS) is a common HIV-associated malignancy associated with disability, pain and poor outcomes. The cornerstone of its treatment is antiretroviral therapy, but advanced disease necessitates the...

Authors: Vini Fardhdiani, Lucas Molfino, Ana Gabriela Zamudio, Rolanda Manuel, Gilda Luciano, Iza Ciglenecki, Barbara Rusch, Laurence Toutous Trellu and Matthew E Coldiron

Human papillomavirus genotype distribution in cervical cancer biopsies from Nepalese women

Cervical cancer (CC) is the leading cause of morbidity and mortality from cancer in Nepalese women. Nearly all cases of CC are caused by infection with certain genotypes of human papillomavirus (HPV). Data on ...

Authors: Sunil Kumar Sah, Joaquin V. González, Sadina Shrestha, Anurag Adhikari, Krishna Das Manandhar, Shyam Babu Yadav, David A. Stein, Birendra Prasad Gupta and María Alejandra Picconi

Dissecting the mechanisms and molecules underlying the potential carcinogenicity of red and processed meat in colorectal cancer (CRC): an overview on the current state of knowledge

Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous du...

Authors: Marco Cascella, Sabrina Bimonte, Antonio Barbieri, Vitale Del Vecchio, Domenico Caliendo, Vincenzo Schiavone, Roberta Fusco, Vincenza Granata, Claudio Arra and Arturo Cuomo

HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan

Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype...

Authors: Dauren Adilbay, Galim Adilbayev, Gulzhan Kidirbayeva, Viktoria Shipilova, Zhanat Sadyk, Gulsum Koyanbekova, Ekaterina Sokolenko and Jan Klozar

Could Mycobacterium avium subspecies paratuberculosis cause Crohn’s disease, ulcerative colitis…and colorectal cancer?

Infectious agents are known causes of human cancers. Schistosoma japonicum and Schistosoma mansoni cause a percentage of colorectal cancers in countries where the respective Schistosoma species are prevalent. Col...

Authors: Ellen S. Pierce

Association of Epstein - Barr virus and breast cancer in Eritrea

The oncogenic potential of Epstein-Barr virus (EBV) in breast cancer is being increasingly recognized. Despite some controversies regarding such role, new evidence is suggesting a culpability of EBV in breast ...

Authors: Ghimja Fessahaye, Ahmed M. Elhassan, Elwaleed M. Elamin, Ameera A. M. Adam, Anghesom Ghebremedhin and Muntaser E. Ibrahim

Cervical cancer patients presentation and survival in the only oncology referral hospital, Ethiopia: a retrospective cohort study

Women infected with Human Immune Deficiency Virus (HIV) are assumed to be at higher risk of developing Cervical Cancer (CC). This is due to a rapid progression of pre-invasive to invasive lesions. However, evi...

Authors: Muluken Gizaw, Adamu Addissie, Sefonias Getachew, Wondimu Ayele, Israel Mitiku, Ulrike Moelle, Tigist Yusuf, Mathias Begoihn, Mathewos Assefa, Ahmedin Jemal and Eva Johanna Kantelhardt

Characterization of hormonal receptors and human epidermal growth factor receptor-2 in tissues of women with breast cancer at Muhimbili National Hospital, Dar es salaam, Tanzania

Breast cancer is a leading cause of morbidity and deaths among women worldwide. In Tanzania there is no published data on human epidermal growth receptor-2 (HER2/neu) expression in breast carcinoma. Hormonal r...

Authors: Amos Rodger Mwakigonja, Nyanda Elias Lushina and Ally Mwanga

Factors associated with the high prevalence of oesophageal cancer in Western Kenya: a review

Oesophageal carcinoma (OC) is highly prevalent in Western Kenya especially among the members of the Kalenjin community who reside in the Northern and Southern areas of the Rift Valley. Previous authors have su...

Authors: Gabriel Kigen, Naftali Busakhala, Zipporah Kamuren, Hillary Rono, Wilfred Kimalat and Evangeline Njiru

Prevalence of HPV infection in hypopharyngeal and laryngeal squamous cell carcinoma at Thailand's largest tertiary referral center

Following the well-established relationship between human papillomavirus (HPV) and cervical carcinoma, the carcinogenicity of this virus has also been confirmed in subsets of head and neck carcinoma (HNCA), bu...

Authors: Warut Pongsapich, Nitathip Eakkasem, Sontana Siritantikorn, Paveena Pithuksurachai, Kshidej Bongsabhikul and Cheerasook Chongkolwatana

A systematic review on multiparametric MR imaging in prostate cancer detection

Literature data suggest that multi-parametric Magnetic Resonance Imaging (MRI), including morphologic T2-weigthed images (T2-MRI) and functional approaches such as Dynamic Contrast Enhanced-MRI (DCE-MRI), Diff...

Authors: Roberta Fusco, Mario Sansone, Vincenza Granata, Sergio Venanzio Setola and Antonella Petrillo

T- and NK-cell populations with regulatory phenotype and markers of apoptosis in circulating lymphocytes of patients with CIN3 or microcarcinoma of the cervix: evidence for potential mechanisms of immune suppression

Processes and mechanisms responsible for systemic immune suppression in early-stage cervical cancer remain substantially underinvestigated. In this work, we focused on studying the frequencies of circulating r...

Authors: Olga V. Kurmyshkina, Pavel I. Kovchur, Ludmila V. Schegoleva and Tatyana O. Volkova

Multiple oncogenic viruses are present in human breast tissues before development of virus associated breast cancer

Multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and Epstein Barr virus, have been identified as separate infectious pathogens in human breast canc...

Authors: James S. Lawson and Wendy K. Glenn

HPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors?

Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Currently, Human papillomavirus (HPV) is suggested as a potential risk factor for esophageal cancer (EC) in addition to the classic...

Authors: Allini Mafra da Costa, José Humberto Tavares Guerreiro Fregnani, Paula Roberta Aguiar Pastrez, Vânia Sammartino Mariano, Estela Maria Silva, Cristovam Scapulatempo Neto, Denise Peixoto Guimarães, Luisa Lina Villa, Laura Sichero, Kari Juhani Syrjanen and Adhemar Longatto-Filho

Integration of human papillomavirus 16 in esophageal carcinoma samples

Esophageal carcinoma (EC) is one of the major cancers in China. In 1982, Syrjanen first hypothesized the relationship between human papillomavirus (HPV) infection and the development of esophageal cancer. Sinc...

Authors: Shuying Li, Haie Shen, Zhanjun Liu, Ning Li, Suxian Yang, Ke Zhang and Jintao Li

Correction to: mouse mammary tumour virus (MMTV) and human breast cancer with neuroendocrine differentiation

Authors: J. S. Lawson, C. C. Ngan, W. K. Glenn and D. D. Tran