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African cancers

Section edited by: Prof Twalib Ngoma  and Prof Henry R Wabinga.

This section will allow African oncologists to describe the current oncology issues along with their findings/achievements for those 'tropical' cancers, such as EBV-related Burkitt lymphoma and schistosomiasis-related bladder cancer, which are considered rare in the rest of the world.

  1. Content type: Research Article

    Ethiopia lies in the high-risk corridor of esophageal squamous cell carcinoma in East Africa, where individuals with this malignancy often do not report established risk factors, suggesting unidentified etiolo...

    Authors: Maria E. Leon, Endale Kassa, Abate Bane, Tufa Gemechu, Yared Tilahun, Nigatu Endalafer, Sandrine McKay-Chopin, Rosario N. Brancaccio, Gilles Ferro, Mathewos Assefa, Elizabeth Ward, Massimo Tommasino, Abraham Aseffa, Joachim Schüz, Ahmedin Jemal and Tarik Gheit

    Citation: Infectious Agents and Cancer 2019 14:19

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  2. Content type: Research Article

    Burkitt lymphoma (BL) is a relatively common cancer of childhood in tropical Africa, although its precise incidence and continent-wide geographic distribution have not been previously systematically studied.

    Authors: Lucia Hämmerl, Murielle Colombet, Rosemary Rochford, David Martin Ogwang and Donald Maxwell Parkin

    Citation: Infectious Agents and Cancer 2019 14:17

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  3. Content type: Research article

    The impact of South Africa’s high human immunodeficiency virus (HIV) burden on cancer risk is not fully understood, particularly in the context of antiretroviral treatment (ART) availability. We examined natio...

    Authors: Tafadzwa Dhokotera, Julia Bohlius, Adrian Spoerri, Matthias Egger, Jabulani Ncayiyana, Victor Olago, Elvira Singh and Mazvita Sengayi

    Citation: Infectious Agents and Cancer 2019 14:12

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  4. Content type: Research Article

    Cervical cancer is the second most prevalent cancer among women of child-bearing age in Ethiopia. The aim of this study was to determine human papilloma virus (HPV) genotype distribution among HIV-negative wom...

    Authors: Dawit Wolday, Muluken Derese, Solomon Gebressellassie, Bekure Tsegaye, Wondwossen Ergete, Yirgu Gebrehiwot, Orit Caplan, Dana G. Wolf and Shlomo Maayan

    Citation: Infectious Agents and Cancer 2018 13:28

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  5. Content type: Short Report

    Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospec...

    Authors: Takondwa Zuze, Matthew S. Painschab, Ryan Seguin, Evarista Kudowa, Bongani Kaimila, Edwards Kasonkanji, Tamiwe Tomoka, Bal Mukunda Dhungel, Maurice Mulenga, Maria Chikasema, Blessings Tewete, Asekanadziwa Ntangwanika, Sarah Chiyoyola, Fred Chimzimu, Coxcilly Kampani, Robert Krysiak…

    Citation: Infectious Agents and Cancer 2018 13:22

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  6. Content type: Research Article

    Despite the increasing incidence of laryngeal squamous cell carcinoma (LSCC) in Algeria, scarce information is available on the importance of the preventable etiological factors which may drive the disease. Re...

    Authors: Nora Kariche, Montserrat Torres Hortal, Samir Benyahia, Laia Alemany, Nabila Moulaï, Omar Clavero, Marleny Muñoz, Wahiba Ouahioune, Djamel Djennaoui, Chafia Touil-Boukoffa, Silvia de Sanjosé and Mehdi Bourouba

    Citation: Infectious Agents and Cancer 2018 13:8

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  7. Content type: Research Article

    Kaposi’s sarcoma (KS) is a common HIV-associated malignancy associated with disability, pain and poor outcomes. The cornerstone of its treatment is antiretroviral therapy, but advanced disease necessitates the...

    Authors: Vini Fardhdiani, Lucas Molfino, Ana Gabriela Zamudio, Rolanda Manuel, Gilda Luciano, Iza Ciglenecki, Barbara Rusch, Laurence Toutous Trellu and Matthew E Coldiron

    Citation: Infectious Agents and Cancer 2018 13:5

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  8. Content type: Research Article

    The oncogenic potential of Epstein-Barr virus (EBV) in breast cancer is being increasingly recognized. Despite some controversies regarding such role, new evidence is suggesting a culpability of EBV in breast ...

    Authors: Ghimja Fessahaye, Ahmed M. Elhassan, Elwaleed M. Elamin, Ameera A. M. Adam, Anghesom Ghebremedhin and Muntaser E. Ibrahim

    Citation: Infectious Agents and Cancer 2017 12:62

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  9. Content type: Research Article

    Breast cancer is a leading cause of morbidity and deaths among women worldwide. In Tanzania there is no published data on human epidermal growth receptor-2 (HER2/neu) expression in breast carcinoma. Hormonal r...

    Authors: Amos Rodger Mwakigonja, Nyanda Elias Lushina and Ally Mwanga

    Citation: Infectious Agents and Cancer 2017 12:60

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  10. Content type: Research Article

    Cervical cancer is the fourth most common cancer in women worldwide with highest incidence reported in Eastern Africa in 2012. The primary goal of this study was to study the expression of p16INK4a in squamous ce...

    Authors: Hina Sarwath, Devendra Bansal, Nazik Elmalaika Husain, Mahmoud Mohamed, Ali A. Sultan and Shahinaz Bedri

    Citation: Infectious Agents and Cancer 2017 12:50

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  11. Content type: Short Report

    Lymphoma is highly associated with HIV in sub-Saharan Africa (SSA), which contributes to worse outcomes relative to resource-rich settings, and frequent failure of first-line chemotherapy. However, there are n...

    Authors: Bongani Kaimila, Toon van der Gronde, Christopher Stanley, Edwards Kasonkanji, Maria Chikasema, Blessings Tewete, Paula Fox and Satish Gopal

    Citation: Infectious Agents and Cancer 2017 12:45

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  12. Content type: Research Article

    Sexually transmitted infections (STIs) remain an important public health problem with approximately half a billion new cases annually among persons aged 15–49 years. Epidemiological data on STIs among women of...

    Authors: Themba G. Ginindza, Cristina D. Stefan, Joyce M. Tsoka-Gwegweni, Xolisile Dlamini, Pauline E. Jolly, Elisabete Weiderpass, Nathalie Broutet and Benn Sartorius

    Citation: Infectious Agents and Cancer 2017 12:29

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  13. Content type: Research Article

    HPV infections are ubiquitous and particularly common among sexually active young women. However, there are regional and national variations in age-specific HPV prevalence, which have implications for cervical...

    Authors: Adolf K. Awua, Richard M. K. Adanu, Edwin K. Wiredu, Edwin A. Afari and Alberto Severini

    Citation: Infectious Agents and Cancer 2017 12:26

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  14. Content type: Research Article

    Aflatoxin B1 (AFB1) contamination of food is very high in most sub-Saharan African countries. AFB1 is known to cause hepatocellular carcinoma (HCC) by inducing mutation in the tumour suppressor gene TP53. The num...

    Authors: Patrick W. Narkwa, David J. Blackbourn and Mohamed Mutocheluh

    Citation: Infectious Agents and Cancer 2017 12:17

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  15. Content type: Review

    There is limited information about the challenges of cancer management and attempts at improving outcomes in Africa. Even though South and North Africa are better resourceds to tackle the burden of breast canc...

    Authors: V. Vanderpuye, S. Grover, N. Hammad, PoojaPrabhakar, H. Simonds, F. Olopade and D. C. Stefan

    Citation: Infectious Agents and Cancer 2017 12:13

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  16. Content type: Research Article

    Cervical cancer incidence and mortality rates in Sub-Saharan Africa (SSA) remain high due to several factors including low levels of uptake of cervical cancer screening. Self-collection of cervicovaginal sampl...

    Authors: Fatima Modibbo, K. C. Iregbu, James Okuma, Annemiek Leeman, Annemieke Kasius, Maurits de Koning, Wim Quint and Clement Adebamowo

    Citation: Infectious Agents and Cancer 2017 12:11

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  17. Content type: Position Statement

    The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa including informa...

    Authors: J. Olufemi Ogunbiyi, D. Cristina Stefan and Timothy R. Rebbeck

    Citation: Infectious Agents and Cancer 2016 11:63

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  18. Content type: Research Article

    Little is known about the epidemiological characteristics of papillomavirus (HPV) infection among North African countries. Herein, we conducted a molecular epidemiological study to investigate prevalence of HP...

    Authors: R. Ghedira, W. Mahfoudh, S. Hadhri, S. Gabbouj, I. Bouanene, H. Khairi, A. Chaieb, R. Khelifa, N. Bouaouina, S. Remadi, A. A. Elmi, D. Bansal, A. A. Sultan, R. Faleh, A. Zakhama, L. Chouchane…

    Citation: Infectious Agents and Cancer 2016 11:61

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  19. Content type: Research Article

    Tanzania, like other low-income countries, has an increasing cancer burden that remains underestimated. Infection-associated malignancies, particularly HIV-infection, represent a great proportion of cancer bur...

    Authors: Julee A. Campbell, Amr S. Soliman, Crispin Kahesa, Sioban D. Harlow and Diwani Msemo

    Citation: Infectious Agents and Cancer 2016 11:58

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  20. Content type: Research Article

    More deaths occur in African women from invasive cervical cancer (ICC) than from any other malignancy. ICC is caused by infection with oncogenic types of human papillomavirus (HPV). Co-infection with the human...

    Authors: Aaron Ermel, Brahim Qadadri, Yan Tong, Omenge Orang’o, Benson Macharia, Doreen Ramogola-Masire, Nicola M. Zetola and Darron R. Brown

    Citation: Infectious Agents and Cancer 2016 11:56

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  21. Content type: Research Article

    Chronic Hepatitis B infection is a major health problem in Republic of Congo therefore molecular analysis of HBV strains is important to detect the patients at high risk of disease progression.

    Authors: Brunel Monic Angounda, Gildas Hoffman Ngouloubi, Amélia Bokilo Dzia, Luc Magloire Anicet Boumba, Warda Baha, Donatien Moukassa, Gabriel Ahombo, Moulay Mustapha Ennaji and Jean-Rosaire Ibara

    Citation: Infectious Agents and Cancer 2016 11:51

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  22. Content type: Research Article

    The human papillomavirus (HPV) is the causative agent of cervical cancer, which is the leading cancer-related cause of death for women in Sub-Saharan Africa. In 2013, the Gabonese Ministry of Health and the Sy...

    Authors: Pamela Boundzanga Moussavou, Ismaël Hervé Koumakpayi, Andriniaina Andy Nkili-Meyong, Ingrid Labouba, Ulrich Bisvigou, Junie K. Chansi, Corinne Engohan-Aloghe, Frederic Dissanami, Nathalie Ambounda, Anne-Sophie Delannoy-Vieillard, Laure Diancourt, Dieudonne Nkoghe, Eric M. Leroy, Ernest Belembaogo and Nicolas Berthet

    Citation: Infectious Agents and Cancer 2016 11:50

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  23. Content type: Research Article

    High risk (HR) human papilloma Virus (HPV) genotypes have been associated with cervical cancer. In Tanzania there is a limited data on the epidemiology of HPV and genotypes distribution among HIV infected wome...

    Authors: Fridolin Mujuni, Mariam M. Mirambo, Peter Rambau, Korn Klaus, Muller Andreas, Dismas Matovelo, Mtebe Majigo, Christa Kasang and Stephen E. Mshana

    Citation: Infectious Agents and Cancer 2016 11:49

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  24. Content type: Research Article

    Cervical cancer is a real public health problem in African countries. The relation between HPV and cervical cancer is well established. However, it is known that the distribution of HPV genotypes differ geogra...

    Authors: Samira Zoa-Assoumou, Angelique Ndjoyi-Mbiguino, Barthelemy Mabika Mabika, Ernest Belembaogo, Abdelkim Khattabi and My Mustapha Ennaji

    Citation: Infectious Agents and Cancer 2016 11:42

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  25. Content type: Research Article

    High risk oncologic Human Papilloma Virus (HPV) is one of the leading causes of cervical cancer worldwide. We investigated HPV genotypes among women living or not with Human Immuno-deficiency Virus (HIV) in tw...

    Authors: Callinice D. Capo-chichi, Blanche Aguida, Nicodème W. Chabi, Jocelyn Acapko-Ezin, Jonas Sossah-Hiffo, Vidéhouénou K. Agossou, Toussain Anagbla, Marcel Zannou, Fabien Houngbé and Ambaliou Sanni

    Citation: Infectious Agents and Cancer 2016 11:43

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  26. Content type: Review

    Cancer is typically classified as a leading non-communicable disease; however, infectious agents, such as Helicobacter pylori (H. pylori), hepatitis B virus (HBV), hepatitis C virus (HCV) and human papilloma viru...

    Authors: Wafaa Mohamed Hussein, Wagida A. Anwar, Mohammed Attaleb, Loubna Mazini, Asta Försti, Roxana-Delia Trimbitas and Meriem Khyatti

    Citation: Infectious Agents and Cancer 2016 11:35

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  27. Content type: Research Article

    Vulvar cancer is a rare gynaecological cancer. In Burkina Faso, the diagnosis of vulvar cancers is delayed and the prognosis is poor. However, no specific study on vulvar cancers has been conducted at the mome...

    Authors: Nayi Zongo, Nina Korsaga-Somé, Amandine Banata Gang-Ny, Edgar Ouangré, Maurice Zida, Aimé Sosthène Ouédraogo, Aboubacar Hirrhum Bambara, Augustin Tozoula Bambara, Si Simon Traore, Pascal Niamba, Adama Traoré and Ahmadou Dem

    Citation: Infectious Agents and Cancer 2016 11:33

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  28. Content type: Research Article

    Breast cancer is the commonest female malignancy globally and the second (after uterine cervix) in sub-Saharan Africa including Tanzania. Prognostic indicators reportedly influence post-mastectomy adjuvant the...

    Authors: Amos R. Mwakigonja, Happiness Rabiel, Naboth A. Mbembati and Leonard E. K. Lema

    Citation: Infectious Agents and Cancer 2016 11:28

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  29. Content type: Research Article

    Human herpesvirus-8 (HHV-8), the etiologic agent of Kaposi sarcoma (KS), establishes lifelong latent infection with periodic lytic replication (“shedding”) at mucosal sites, especially the oropharynx. Patterns...

    Authors: Rachel A. Bender Ignacio, Jason D. Goldman, Amalia S. Magaret, Stacy Selke, Meei-Li Huang, Soren Gantt, Christine Johnston, Warren T. Phipps, Joshua T. Schiffer, Richard A. Zuckerman, R. Scott McClelland, Connie Celum, Larry Corey, Anna Wald and Corey Casper

    Citation: Infectious Agents and Cancer 2016 11:7

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  30. Content type: Research Article

    The identification of suited early detection tests is one among the multiple requirements to reduce cervical cancer incidence in developing countries.

    Authors: Caroline Wangari Ngugi, Dietmar Schmidt, Karanja Wanyoro, Hamadi Boga, Peter Wanzala, Anne Muigai, John Mbithi, Magnus von Knebel Doeberitz and Miriam Reuschenbach

    Citation: Infectious Agents and Cancer 2015 10:25

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  31. Content type: Short report

    The etiology of primary cutaneous anaplastic large-cell CD30+ lymphoma is largely unknown, and although an infectious involvement has been suspected, the implication of infectious agents in its pathogenesis is...

    Authors: Alessandro Borghi, Elisabetta Caselli, Dario Di Luca, Adolfo Sebastiani, Paolo Perri, Silva Seraceni, Carlo Contini and Annarosa Virgili

    Citation: Infectious Agents and Cancer 2013 8:41

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  32. Content type: Editorial

    Infectious Agents and Cancer is introducing a new section of Clinical Oncology with the main objective of stimulating debate through articles published in the section. Infectious diseases have been the major caus...

    Authors: Franco M Buonaguro, Serigne N Gueye, Henry R Wabinga, Twalib A Ngoma, Jan B Vermorken and Sam M Mbulaiteye

    Citation: Infectious Agents and Cancer 2013 8:39

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