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Cancer centers in low- and middle-income countries

Section edited by: Dr Kishor Bhatia and Dr Edward Trimble.

This section will provide a platform to showcase detailed features of institutes from low and middle income countries including; activities and resources for prevention, diagnosis, treatment and palliative care (available facilities, health care worker resources, outreach programs, collaborations, research projects, oncology-related training facilities, etc.); funding support from local government, foundations, or privately borne by patients; key features of the cancer center and its partnerships that contribute to its success; challenges, both universal and setting-specific, and how they are addressed; policy and practice implications including discussion of what could be adapted by others, what gaps need to be addressed, and what differences might arise in other settings.

  1. Content type: Research Article

    The pathogenesis of lung cancer is triggered by a combination of genetic and environmental factors, being the tobacco smoke the most important risk factor. Nevertheless, the incidence of lung cancer in non-smo...

    Authors: Estela Maria Silva, Vânia Sammartino Mariano, Paula Roberta Aguiar Pastrez, Miguel Cordoba Pinto, Emily Montosa Nunes, Laura Sichero, Luisa Lina Villa, Cristovam Scapulatempo-Neto, Kari Juhani Syrjanen and Adhemar Longatto-Filho

    Citation: Infectious Agents and Cancer 2019 14:18

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  2. Content type: Research Article

    Despite the high prevalences of Human Papilloma Virus (HPV) infections and cervical cancer in Nigeria, utilization of the HPV vaccine as a highly effective preventive measure remains low. The aim of this study...

    Authors: Adaobi I. Bisi-Onyemaechi, Ugo N. Chikani and Obinna Nduagubam

    Citation: Infectious Agents and Cancer 2018 13:29

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  3. Content type: Research Article

    Non-Hodgkin lymphoma (NHL) is the most common cancer in people with HIV. Although 95% of HIV patients are in developing countries like Peru, the majority of these studies have been conducted in developed count...

    Authors: Luis Ernesto Cuellar, Andrea Anampa-Guzmán, Alexis Manuel Holguín, Juan Velarde, Diana Portillo-Alvarez, Marco Antonio Zuñiga-Ninaquispe, Esther Rosa Luna-Reyes, Jule Vásquez, Joanne Marie Jeter and Karen Marie Winkfield

    Citation: Infectious Agents and Cancer 2018 13:27

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  4. Content type: Research Article

    Aberrant glycosylation is a characteristic of tumour cells. The expression of certain glycan structures has been associated with poor prognosis. In cervical carcinoma, changes in the expression levels of some ...

    Authors: Miguel Aco-Tlachi, Ricardo Carreño-López, Patricia L. Martínez-Morales, Paola Maycotte, Adriana Aguilar-Lemarroy, Luis Felipe Jave-Suárez, Gerardo Santos-López, Julio Reyes-Leyva and Verónica Vallejo-Ruiz

    Citation: Infectious Agents and Cancer 2018 13:25

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  5. Content type: Research Article

    The impact of different anti-virus regimens on prognosis of Chronic hepatitis B (CHB) related cirrhosis remains to be explored. We aim to investigate whether CHB-related HCC patients receiving nucleoside analo...

    Authors: Jing Sun, Yanfang Li, Yanna Wang, Yanyan Liu, Youde Liu and Xiumei Wang

    Citation: Infectious Agents and Cancer 2018 13:17

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  6. Content type: Research Article

    This study aimed to evaluate trends and predictors of survival after cancer diagnosis in persons living with HIV in the Caribbean, Central, and South America network for HIV epidemiology cohort.

    Authors: Valeria I. Fink, Cathy A. Jenkins, Jessica L. Castilho, Anna K. Person, Bryan E. Shepherd, Beatriz Grinsztejn, Juliana Netto, Brenda Crabtree-Ramirez, Claudia P. Cortés, Denis Padgett, Karu Jayathilake, Catherine McGowan and Pedro Cahn

    Citation: Infectious Agents and Cancer 2018 13:16

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  7. Content type: Research Article

    Cervical cancer (CC) is the leading cause of morbidity and mortality from cancer in Nepalese women. Nearly all cases of CC are caused by infection with certain genotypes of human papillomavirus (HPV). Data on ...

    Authors: Sunil Kumar Sah, Joaquin V. González, Sadina Shrestha, Anurag Adhikari, Krishna Das Manandhar, Shyam Babu Yadav, David A. Stein, Birendra Prasad Gupta and María Alejandra Picconi

    Citation: Infectious Agents and Cancer 2018 13:4

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  8. Content type: Research Article

    Following the well-established relationship between human papillomavirus (HPV) and cervical carcinoma, the carcinogenicity of this virus has also been confirmed in subsets of head and neck carcinoma (HNCA), bu...

    Authors: Warut Pongsapich, Nitathip Eakkasem, Sontana Siritantikorn, Paveena Pithuksurachai, Kshidej Bongsabhikul and Cheerasook Chongkolwatana

    Citation: Infectious Agents and Cancer 2017 12:58

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  9. Content type: Research Article

    Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Currently, Human papillomavirus (HPV) is suggested as a potential risk factor for esophageal cancer (EC) in addition to the classic...

    Authors: Allini Mafra da Costa, José Humberto Tavares Guerreiro Fregnani, Paula Roberta Aguiar Pastrez, Vânia Sammartino Mariano, Estela Maria Silva, Cristovam Scapulatempo Neto, Denise Peixoto Guimarães, Luisa Lina Villa, Laura Sichero, Kari Juhani Syrjanen and Adhemar Longatto-Filho

    Citation: Infectious Agents and Cancer 2017 12:54

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  10. Content type: Research Article

    Esophageal carcinoma (EC) is one of the major cancers in China. In 1982, Syrjanen first hypothesized the relationship between human papillomavirus (HPV) infection and the development of esophageal cancer. Sinc...

    Authors: Shuying Li, Haie Shen, Zhanjun Liu, Ning Li, Suxian Yang, Ke Zhang and Jintao Li

    Citation: Infectious Agents and Cancer 2017 12:53

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  11. Content type: Research Article

    Direct-acting antivirals have been used for decompensated cirrhotic patients with hepatitis C virus (HCV) infection. However, the benefits in Chinese patients with decompensated cirrhosis are unclear.

    Authors: Fanpu Ji, Wenjun Wang, Shuangsuo Dang, Shengbang Wang, Burong Li, Dan Bai, Wenxue Zhao, Hong Deng, Changyin Tian and Zongfang Li

    Citation: Infectious Agents and Cancer 2017 12:48

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  12. Content type: Research Article

    In recent years, saprophytic bacteria have been emerging as potential human pathogens causing life-threatening infections in patients with malignancies. However, evidence is lacking concerning such bacteria, p...

    Authors: Balew Arega, Yimtubezinash Wolde-Amanuel, Kelemework Adane, Ezra Belay, Abdulaziz Abubeker and Daniel Asrat

    Citation: Infectious Agents and Cancer 2017 12:40

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  13. Content type: Research Article

    Lymphoma is a leading cause of cancer-related death among human immunodeficiency virus (HIV)-infected individuals in the current era of potent anti-retroviral therapy (ART). Globally, mortality after HIV-assoc...

    Authors: Olugbenga Akindele Silas, Chad J. Achenbach, Lifang Hou, Robert L. Murphy, Julie O. Egesie, Solomon A. Sagay, Oche O. Agbaji, Patricia E. Agaba, Jonah Musa, Agabus N. Manasseh, Ezra D. Jatau, Ayuba M. Dauda, Maxwell O. Akanbi and Barnabas M. Mandong

    Citation: Infectious Agents and Cancer 2017 12:34

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    The Erratum to this article has been published in Infectious Agents and Cancer 2017 12:37

  14. Content type: Short Report

    Little information on the prevalence of Kaposi’s sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia.

    Authors: Tiejun Zhang, Zhenqiu Liu, Jun Wang, Veenu Minhas, Charles Wood, Gary M. Clifford, Na He and Silvia Franceschi

    Citation: Infectious Agents and Cancer 2017 12:32

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  15. Content type: Research Article

    Human mammary tumor virus (HMTV) is 90–95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors. HMTV (MMTV-like) sequences were reported to be present in human bre...

    Authors: Thar Htet San, Masayoshi Fujisawa, Soichiro Fushimi, Teizo Yoshimura, Toshiaki Ohara, Lamin Soe, Ngu Wah Min, Ohnmar Kyaw, Xu Yang and Akihiro Matsukawa

    Citation: Infectious Agents and Cancer 2017 12:20

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  16. Content type: Research Article

    Human papillomavirus (HPV) is the main etiological agent of cervical cancer, the third most common cancer among women globally and the second most frequent in Mexico. Persistent infection with high-risk HPV ge...

    Authors: Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, María Teresa Magaña-Torres, María Guadalupe López-Cardona, Yelda Aurora Leal-Herrera, Patricia Piña-Sánchez, Luis Felipe Jave-Suárez and Adriana Aguilar-Lemarroy

    Citation: Infectious Agents and Cancer 2017 12:15

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  17. Content type: Research Article

    Investigations on the effects of malaria infection on cancer mortality are limited except for the incidence of Burkitt’s lymphoma (BL) in African children. Our previous murine lung cancer model study demonstra...

    Authors: Li Qin, Changzhong Chen, Lili Chen, Ran Xue, Ming Ou-Yang, Chengzhi Zhou, Siting Zhao, Zhengxiang He, Yu Xia, Jianxing He, Pinghua Liu, Nanshan Zhong and Xiaoping Chen

    Citation: Infectious Agents and Cancer 2017 12:14

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  18. Content type: Research Article

    New oral treatments with very high cure rates have the potential to revolutionize global management of hepatitis C virus (HCV), but population-based data on HCV infection are missing in many low and middle-inc...

    Authors: Gary M. Clifford, Tim Waterboer, Bolormaa Dondog, You Lin Qiao, Dimitri Kordzaia, Doudja Hammouda, Namory Keita, Nahid Khodakarami, Syed Ahsan Raza, Ang Tshering Sherpa, Witold Zatonski, Michael Pawlita, Martyn Plummer and Silvia Franceschi

    Citation: Infectious Agents and Cancer 2017 12:9

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  19. Content type: Methodology

    In 2000, an Italian non-governmental organisation (NGO) began a 9-year project to establish a surgical pathology laboratory at the Bugando Medical Centre (BMC) in Mwanza, Tanzania, a country with a low Human D...

    Authors: R. Tumino, P. F. Rambau, F. Callea, L. Leoncini, R. Monaco, J. Kahima, V. Stracca Pansa, L. Viberti, D. Amadori, P. Giovenali and K. A. Mteta

    Citation: Infectious Agents and Cancer 2017 12:6

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  20. Content type: Research Article

    Chlamydia trachomatis (Ct) is not a disease subject to mandatory reporting in Brazil, and the prevalence rate of this genital infection varies according to the region in which studies ...

    Authors: R. Robial, A. Longatto-Filho, C. M. Roteli-Martins, M. F. Silveira, D. Stauffert, G. G. Ribeiro, I. M. Linhares, M. Tacla, M. A. Zonta and E. C. Baracat

    Citation: Infectious Agents and Cancer 2017 12:3

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  21. Content type: Research Article

    Whilst the imputed role of High Risk (HR) HPV infection in the development of cervical lesions and cancer has been established, the high number of HPV genotypes that Female Sex workers (FSW) harbour warrants ...

    Authors: Sonia Menon, Davy van den Broeck, Rodolfo Rossi, Emilomo Ogbe and Hillary Mabeya

    Citation: Infectious Agents and Cancer 2017 12:2

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    The Correction to this article has been published in Infectious Agents and Cancer 2019 14:1

  22. Content type: Research Article

    Nasopharyngeal carcinoma (NPC) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatme...

    Authors: Ali Edris, Mona Ali Mohamed, Nouh S. Mohamed and Emmanuel E. Siddig

    Citation: Infectious Agents and Cancer 2016 11:55

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    The Erratum to this article has been published in Infectious Agents and Cancer 2016 11:60

  23. Content type: Research Article

    HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity...

    Authors: Bianca Rivera-Peña, Francisco J. Ruíz-Fullana, Germán L. Vélez-Reyes, Rosa J. Rodriguez-Benitez, María J. Marcos-Martínez, Juan Trinidad-Pinedo and Adriana Báez

    Citation: Infectious Agents and Cancer 2016 11:47

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  24. Content type: Research Article

    Hepatitis B virus (HBV) X protein (HBx) reported to be associated with pathogenesis of hepatocellular carcinoma (HCC) and miR-122 expression is down regulated in HCC. Previous studies reported miR-122 targets ...

    Authors: Manikankana Bandopadhyay, Neelakshi Sarkar, Sibnarayan Datta, Dipanwita Das, Ananya Pal, Rajesh Panigrahi, Arup Banerjee, Chinmay K. Panda, Chandrima Das, Shekhar Chakrabarti and Runu Chakravarty

    Citation: Infectious Agents and Cancer 2016 11:40

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  25. Content type: Research Article

    HPV is the major etiological factor in the causal pathway for cervical cancer, which is the leading cancer among women in sub-Saharan Africa. HIV is associated with a higher prevalence and a broader range of h...

    Authors: Sonia Simone Menon, Rodolfo Rossi, Ronald Harebottle, Hillary Mabeya and Davy vanden Broeck

    Citation: Infectious Agents and Cancer 2016 11:17

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  26. Content type: Research Article

    Most women in developing countries have never attended cervical screening programmes and often little information exists on type-specific human papillomavirus (HPV) prevalence among these populations. Self-sam...

    Authors: Pierre Vassilakos, Rosa Catarino, Stephanie Bougel, Maria Munoz, Caroline Benski, Ulrike Meyer-Hamme, Jeromine Jinoro, Josea Lea Heriniainasolo and Patrick Petignat

    Citation: Infectious Agents and Cancer 2016 11:13

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  27. Content type: Short Report

    We earlier proposed a genetic model for gallbladder carcinogenesis and its dissemination cascade. However, the association of gallbladder cancer and ‘inflammatory stimulus’ to drive the initial cascade in the ...

    Authors: Prajish Iyer, Savio George Barreto, Bikram Sahoo, Pratik Chandrani, Mukta R. Ramadwar, Shailesh V. Shrikhande and Amit Dutt

    Citation: Infectious Agents and Cancer 2016 11:12

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  28. Content type: Research Article

    The association of human papillomavirus (HPV) with cervical cancer is well established.

    Authors: Mohamed A. Youssef, Lobna Abdelsalam, Reem Abdelhameed Harfoush, Iman Mamdouh Talaat, Eman Elkattan, Abeer Mohey, Rana M. A. Abdella, Marwa Salah Farhan, Hany Ahmed Foad, Abeer Mostafa Elsayed, Naglaa A. Elkinaai, Doaa Ghaith, Mohamed Elsayed Rashed, Mohamed Abd-El Ghafar, Yasser Khamis and Ahmed N. Hosni

    Citation: Infectious Agents and Cancer 2016 11:6

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  29. Content type: Research Article

    Human Papillomavirus (HPV) infections have been shown to be a necessary risk factor for the development of cervical cancer. However, HPV genotype distribution varies geographically, both in type and relative p...

    Authors: A. K. Awua, S. T. Sackey, Y. D. Osei, R. H. Asmah and E. K. Wiredu

    Citation: Infectious Agents and Cancer 2016 11:4

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  30. Content type: Meeting Report

    According to the World Health Organisation (WHO), deaths from non-communicable diseases (NCDs) will increase globally, with the largest increase being on the African continent. On our continent, projections ha...

    Authors: D. C. Stefan, N. Masalu, L. Ngendahayo, D. Amadori, M. Botteghi, M. Mendy, N. A. Othieno-Aabinya, T. Ngoma, F. Asirwa, O. Balogun, W. Ngwa, E. Vuhahula and A Adesina

    Citation: Infectious Agents and Cancer 2015 10:48

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  31. Content type: Research Article

    Data on Human PapillomaVirus (HPV) infection are scarce in Morocco. The objective of the study was to determine the prevalence of HPV and cervical cytology abnormalities in women from the Souss area, Morocco.

    Authors: Essaada Belglaiaa, Hicham Elannaz, Bouchra Mouaouya, Mohamed Aksim, Mariette Mercier, Jean-Luc Prétet, Said Chouham and Christiane Mougin

    Citation: Infectious Agents and Cancer 2015 10:44

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  32. Content type: Research Article

    The aberrant expression of miR-23b is involved in the development and progression of cancer. The aim of this study was to evaluate the potential role of methylation in the silencing of miR-23b in cervical canc...

    Authors: Gabriela Elizabeth Campos-Viguri, Hilda Jiménez-Wences, Oscar Peralta-Zaragoza, Gricenda Torres-Altamirano, Diana Guillermina Soto-Flores, Daniel Hernández-Sotelo, Luz Del Carmen Alarcón-Romero, Marco Antonio Jiménez-López, Berenice Illades-Aguiar and Gloria Fernández-Tilapa

    Citation: Infectious Agents and Cancer 2015 10:42

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  33. Content type: Research Article

    Sub-Saharan countries including Nigeria have the highest burden of Human Papillomavirus (HPV) infection in the world. Most studies on HPV surveillance in Nigeria were done in the southern part of the country. ...

    Authors: Mohammed Mohammed Manga, Adeola Fowotade, Yusuf Mohammed Abdullahi, Aliyu Usman El-nafaty, Danladi Bojude Adamu, Hamidu Umar Pindiga, Rasheed Ajani Bakare and Abimbola Olu Osoba

    Citation: Infectious Agents and Cancer 2015 10:39

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  34. Content type: Research Article

    Prostate cancer causes the highest number of cancer-related deaths in Jamaican men. It is not known whether rural-dwelling men present with worse disease than urban-dwelling men at initial presentation. Since ...

    Authors: William D. Aiken, Kieron S. Jones, Camille Ragin and Kenneth James

    Citation: Infectious Agents and Cancer 2015 10:32

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  35. Content type: Letter to the Editor

    NRLP1 (rs12150220, rs9889625, rs9900356, rs6502867, rs2670660) and NLRP3 (rs35829419, rs10754558) polymorphisms have been analyzed in 69 subjects with documented asbestos exposure and dea...

    Authors: Violetta Borelli, Ronal R Moura, Elisa Trevisan and Sergio Crovella

    Citation: Infectious Agents and Cancer 2015 10:26

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  36. Content type: Short Report

    Human papillomavirus (HPV) infection is associated with cervical cancer, the most frequent cancer in women from northern Brazil. Assessment of the short-term impact of HPV vaccination depends on the availabili...

    Authors: Rodrigo Covre Vieira, Jeniffer do Socorro Valente Monteiro, Estéfane Primo Manso, Maria Renata Mendonça dos Santos, Mihoko Yamamoto Tsutsumi, Edna Aoba Yassui Ishikawa, Stephen Francis Ferrari, Karla Valéria Batista Lima and Maísa Silva de Sousa

    Citation: Infectious Agents and Cancer 2015 10:21

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  37. Content type: Research Article

    In Tanzania, 5.1% of adults aged 15-49 are infected with HIV. While rates of HIV-related malignancies have declined globally with antiretroviral therapy (ART), including Tanzania, rates of non-AIDS-defining ca...

    Authors: Clare Meernik, Amr S Soliman, Twalib Ngoma, Crispin Kahesa, Julius Mwaiselage and Sofia D Merajver

    Citation: Infectious Agents and Cancer 2014 9:42

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  38. Content type: Research article

    Human papillomavirus (HPV) infection is a prerequisite of cervical cancer, the leading cause of cancer mortality in Ethiopian women today. Data on Ethiopian cervical HPV prevalence and genotype distribution ar...

    Authors: Sami-Ramzi Leyh-Bannurah, Christof Prugger, Maurits NC de Koning, Hartmut Goette and Ralph J Lellé

    Citation: Infectious Agents and Cancer 2014 9:33

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  39. Content type: Research article

    The main cause of cervical cancer in the world is high risks human papillomavirus infection (mainly represented by HPV-16 and HPV-18), that are associated to the development of malign transformation of the epi...

    Authors: Bruna Pedroso Tamegão-Lopes, Edivaldo Costa Sousa-Júnior, Fabio Passetti, Carlos Gil Ferreira, Wyller Alencar de Mello and Rodrigo Vellasco Duarte Silvestre

    Citation: Infectious Agents and Cancer 2014 9:25

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  40. Content type: Review

    Cervical cancer is one of the major causes of morbidity and mortality in women in Zimbabwe. This is mainly due to the high prevalence of high-risk human papillomavirus (HPV) genotypes in the population. So far...

    Authors: Nyasha Chin'ombe, Natasha L Sebata, Vurayai Ruhanya and Hilda T Matarira

    Citation: Infectious Agents and Cancer 2014 9:16

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  41. Content type: Research article

    Human papillomavirus (HPV) is often present in oropharyngeal cancers. Head and neck tumors have been examined for other molecular markers including p53 and annexin A1 (ANXA1). Here, we investigated the prevale...

    Authors: Cleberson Jean dos Santos Queiroz, Cíntia Mara de Amorim Gomes Nakata, Egle Solito and Amílcar Sabino Damazo

    Citation: Infectious Agents and Cancer 2014 9:13

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