Articles

Genetic variability in E6, E7 and L1 genes of Human Papillomavirus 62 and its prevalence in Mexico

Human papillomavirus (HPV) is the main etiological agent of cervical cancer, the third most common cancer among women globally and the second most frequent in Mexico. Persistent infection with high-risk HPV ge...

Authors: Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, María Teresa Magaña-Torres, María Guadalupe López-Cardona, Yelda Aurora Leal-Herrera, Patricia Piña-Sánchez, Luis Felipe Jave-Suárez and Adriana Aguilar-Lemarroy

Worldwide malaria incidence and cancer mortality are inversely associated

Investigations on the effects of malaria infection on cancer mortality are limited except for the incidence of Burkitt’s lymphoma (BL) in African children. Our previous murine lung cancer model study demonstra...

Authors: Li Qin, Changzhong Chen, Lili Chen, Ran Xue, Ming Ou-Yang, Chengzhi Zhou, Siting Zhao, Zhengxiang He, Yu Xia, Jianxing He, Pinghua Liu, Nanshan Zhong and Xiaoping Chen

An update on the management of breast cancer in Africa

There is limited information about the challenges of cancer management and attempts at improving outcomes in Africa. Even though South and North Africa are better resourceds to tackle the burden of breast canc...

Authors: V. Vanderpuye, S. Grover, N. Hammad, PoojaPrabhakar, H. Simonds, F. Olopade and D. C. Stefan

Safety of new DAAs for chronic HCV infection in a real life experience: role of a surveillance network based on clinician and hospital pharmacist

Direct Antiviral Agents (DAAs) for HCV therapy represents a step ahead in the cure of chronic hepatitis C. Notwithstanding the promising results in several clinical trials, few data are available on adverse ef...

Authors: A. Nappi, A. Perrella, P. Bellopede, A. Lanza, A. Izzi, M. Spatarella and C. Sbreglia

Randomized trial evaluating self-sampling for HPV DNA based tests for cervical cancer screening in Nigeria

Cervical cancer incidence and mortality rates in Sub-Saharan Africa (SSA) remain high due to several factors including low levels of uptake of cervical cancer screening. Self-collection of cervicovaginal sampl...

Authors: Fatima Modibbo, K. C. Iregbu, James Okuma, Annemiek Leeman, Annemieke Kasius, Maurits de Koning, Wim Quint and Clement Adebamowo

Review on the role of the human Polyomavirus JC in the development of tumors

Almost one fifth of human cancers worldwide are associated with infectious agents, either bacteria or viruses, and this makes the possible association between infections and tumors a relevant research issue. W...

Authors: Serena Delbue, Manola Comar and Pasquale Ferrante

Hepatitis C virus seroprevalence in the general female population of 9 countries in Europe, Asia and Africa

New oral treatments with very high cure rates have the potential to revolutionize global management of hepatitis C virus (HCV), but population-based data on HCV infection are missing in many low and middle-inc...

Authors: Gary M. Clifford, Tim Waterboer, Bolormaa Dondog, You Lin Qiao, Dimitri Kordzaia, Doudja Hammouda, Namory Keita, Nahid Khodakarami, Syed Ahsan Raza, Ang Tshering Sherpa, Witold Zatonski, Michael Pawlita, Martyn Plummer and Silvia Franceschi

Human papillomavirus genotypes associated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China

The mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China.

Authors: Jin Zhao, Zhong Guo, Qiang Wang, Tianbin Si, Shuyan Pei, Chenjing Wang, Hongmei Qu, Jianbin Zhong, Ying Ma, Cong Nie and Dan Zhang

Clinical and prognostic analysis of 78 patients with human immuno-deficiency virus associated non-Hodgkin’s lymphoma in Chinese population

Human Immuno-deficiency Virus (HIV) associated non-Hodgkin’s lymphoma (NHL) was a special group of disease, which manifests distinct clinical features and prognosis as compared with NHLs in patients without HI...

Authors: Yang Shen, Renfang Zhang, Li Liu, Yinzhong Shen, Wei Song, Tangkai Qi, Yang Tang, Zhenyan Wang, Liqian Guan and Hongzhou Lu

The surgical pathology laboratory in Mwanza, Tanzania: a survey on the reproducibility of diagnoses after the first years of autonomous activity

In 2000, an Italian non-governmental organisation (NGO) began a 9-year project to establish a surgical pathology laboratory at the Bugando Medical Centre (BMC) in Mwanza, Tanzania, a country with a low Human D...

Authors: R. Tumino, P. F. Rambau, F. Callea, L. Leoncini, R. Monaco, J. Kahima, V. Stracca Pansa, L. Viberti, D. Amadori, P. Giovenali and K. A. Mteta

Human papillomavirus infection in anal intraepithelial lesions from HIV infected Cuban men

An association between HPV infection and progression to anal squamous intraepithelial lesions (ASIL) has been established, specifically in high-risk populations such as HIV-infected men. In this population, an...

Authors: Celia M. Limia, Yudira Soto, Yanara García, Orestes Blanco, Vivian Kourí, María V. López, María E. Toledo, Lissette Pérez, Yoanna Baños, Yaniris Caturla and Francisco Aguayo

Characterisation of microbial communities within aggressive prostate cancer tissues

An infectious aetiology for prostate cancer has been conjectured for decades but the evidence gained from questionnaire-based and sero-epidemiological studies is weak and inconsistent, and a causal association...

Authors: Melissa A. Yow, Sepehr N. Tabrizi, Gianluca Severi, Damien M. Bolton, John Pedersen, Graham G. Giles and Melissa C. Southey

Frequency of Chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16/Ki-67 dual-staining

Chlamydia trachomatis (Ct) is not a disease subject to mandatory reporting in Brazil, and the prevalence rate of this genital infection varies according to the region in which studies ...

Authors: R. Robial, A. Longatto-Filho, C. M. Roteli-Martins, M. F. Silveira, D. Stauffert, G. G. Ribeiro, I. M. Linhares, M. Tacla, M. A. Zonta and E. C. Baracat

Multiple HPV infections in female sex workers in Western Kenya: implications for prophylactic vaccines within this sub population

Whilst the imputed role of High Risk (HR) HPV infection in the development of cervical lesions and cancer has been established, the high number of HPV genotypes that Female Sex workers (FSW) harbour warrants ...

Authors: Sonia Menon, Davy van den Broeck, Rodolfo Rossi, Emilomo Ogbe and Hillary Mabeya

Mouse mammary tumor-like virus (MMTV) is present in human breast tissue before development of virally associated breast cancer

There is substantial evidence that a virus homologous to mouse mammary tumor virus (MMTV) may have a role in human breast cancer. The present study indicates that those who developed breast cancer associated w...

Authors: Teiko Nartey, Chiara M. Mazzanti, Stella Melana, Wendy K. Glenn, Generoso Bevilacqua, James F. Holland, Noel J. Whitaker, James S. Lawson and Beatriz G.T. Pogo

African Organization for Research and Training in Cancer: position and vision for cancer research on the African Continent

The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa including informa...

Authors: J. Olufemi Ogunbiyi, D. Cristina Stefan and Timothy R. Rebbeck

Induction of VX2 para-renal carcinoma in rabbits: generation of animal model for loco-regional treatments of solid tumors

Animal models of para-renal cancer can provide useful information for the evaluation of tumor response to loco-regional therapy experiments in solid tumors. The aim of our study was to establish a rabbit para-...

Authors: Sabrina Bimonte, Maddalena Leongito, Mauro Piccirillo, Maria Luisa Tamma, Marianna Vallifuoco, Adele Bracco, Antonio Mancini, Daniele Di Napoli, Sigismondo Castaldo, Santolo Cozzolino, Francesca Iacobellis, Roberto Grassi, Vincenza Granata, Secondo Lastoria, Steven Curley and Francesco Izzo

Human papillomavirus genotypes and HPV-16 variants distribution among Tunisian women with normal cytology and squamous intraepithelial lesions

Little is known about the epidemiological characteristics of papillomavirus (HPV) infection among North African countries. Herein, we conducted a molecular epidemiological study to investigate prevalence of HP...

Authors: R. Ghedira, W. Mahfoudh, S. Hadhri, S. Gabbouj, I. Bouanene, H. Khairi, A. Chaieb, R. Khelifa, N. Bouaouina, S. Remadi, A. A. Elmi, D. Bansal, A. A. Sultan, R. Faleh, A. Zakhama, L. Chouchane…

Erratum to: Molecular Detection of Epstein - Barr virus in Nasopharyngeal Carcinoma among Sudanese population

Authors: Ali Edris, Mona Ali Mohamed, Nouh S. Mohamed and Emmanuel E. Siddig

Molecular mechanisms of HPV mediated neoplastic progression

Human Papillomavirus is the major etiological agent in the development of cervical cancer but not a sufficient cause. Despite significant research, the underlying mechanisms of progression from a low-grade squ...

Authors: Rashmirani Senapati, Nihar Nalini Senapati and Bhagirathi Dwibedi

Changing Patterns of lung, liver, and head and neck non-AIDS-defining cancers relative to HIV status in Tanzania between 2002-2014

Tanzania, like other low-income countries, has an increasing cancer burden that remains underestimated. Infection-associated malignancies, particularly HIV-infection, represent a great proportion of cancer bur...

Authors: Julee A. Campbell, Amr S. Soliman, Crispin Kahesa, Sioban D. Harlow and Diwani Msemo

Multidetector computer tomography in the pancreatic adenocarcinoma assessment: an update

Ductal adenocarcinoma of the pancreas is one of the most aggressive forms of cancer, with only a minority of cases being resectable at the moment of their diagnosis. The accurate detection and characterization...

Authors: Vincenza Granata, Roberta Fusco, Orlando Catalano, Sergio Venanzio Setola, Elisabetta de Lutio di Castelguidone, Mauro Piccirillo, Raffaele Palaia, Roberto Grassi, Francesco Granata, Francesco Izzo and Antonella Petrillo

Invasive cervical cancers in the United States, Botswana and Kenya: HPV type distribution and health policy implications

More deaths occur in African women from invasive cervical cancer (ICC) than from any other malignancy. ICC is caused by infection with oncogenic types of human papillomavirus (HPV). Co-infection with the human...

Authors: Aaron Ermel, Brahim Qadadri, Yan Tong, Omenge Orang’o, Benson Macharia, Doreen Ramogola-Masire, Nicola M. Zetola and Darron R. Brown

Molecular Detection of Epstein - Barr virus in Nasopharyngeal Carcinoma among Sudanese population

Nasopharyngeal carcinoma (NPC) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatme...

Authors: Ali Edris, Mona Ali Mohamed, Nouh S. Mohamed and Emmanuel E. Siddig

Infection with hepatitis viruses, FIB-4 index and risk of hepatocellular carcinoma in southern Italy: a population-based cohort study

The incidence of hepatocellular carcinoma (HCC) and its association with hepatitis C (HCV) and hepatitis B virus (HBV) infections, FIB-4 index and liver enzymes was assessed in an area of the province of Naple...

Authors: Mario Fusco, Pierluca Piselli, Saverio Virdone, Pietro Di Cicco, Paola Scognamiglio, Paolo De Paoli, Valerio Ciullo, Diana Verdirosi, Michele D’Orazio, Luigino Dal Maso, Enrico Girardi, Silvia Franceschi and Diego Serraino

Hepatitis C virus (HCV) genotypes distribution: an epidemiological up-date in Europe

Hepatitis C virus (HCV) infection is a major public health burden in Europe, causing an increasing level of liver-related morbidity and mortality, characterized by several regional variations in the genotypes ...

Authors: Arnolfo Petruzziello, Samantha Marigliano, Giovanna Loquercio and Carmela Cacciapuoti

Radiological assessment of anal cancer: an overview and update

Anal cancer is uncommon neoplasm with an incidence of 2 new cases per 100,000 per year in the USA, accounting approximately 0.4 % of all tumors and 2.5 % of gastrointestinal malignancies. An early detection of...

Authors: Vincenza Granata, Roberta Fusco, Alfonso Reginelli, Luca Roberto, Francesco Granata, Daniela Rega, Antonio Rotondo, Roberto Grassi, Francesco Izzo and Antonella Petrillo

Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo

Chronic Hepatitis B infection is a major health problem in Republic of Congo therefore molecular analysis of HBV strains is important to detect the patients at high risk of disease progression.

Authors: Brunel Monic Angounda, Gildas Hoffman Ngouloubi, Amélia Bokilo Dzia, Luc Magloire Anicet Boumba, Warda Baha, Donatien Moukassa, Gabriel Ahombo, Moulay Mustapha Ennaji and Jean-Rosaire Ibara

Molecular analysis of human Papillomavirus detected among women positive for cervical lesions by visual inspection with acetic acid/Lugol’s iodine (VIA/VILI) in Libreville, Gabon

The human papillomavirus (HPV) is the causative agent of cervical cancer, which is the leading cancer-related cause of death for women in Sub-Saharan Africa. In 2013, the Gabonese Ministry of Health and the Sy...

Authors: Pamela Boundzanga Moussavou, Ismaël Hervé Koumakpayi, Andriniaina Andy Nkili-Meyong, Ingrid Labouba, Ulrich Bisvigou, Junie K. Chansi, Corinne Engohan-Aloghe, Frederic Dissanami, Nathalie Ambounda, Anne-Sophie Delannoy-Vieillard, Laure Diancourt, Dieudonne Nkoghe, Eric M. Leroy, Ernest Belembaogo and Nicolas Berthet

Prevalence of human papillomavirus in saliva of women with HPV genital lesions

The human papilloma viruses (HPVs) are DNA viruses associated with benign and malignant lesions of skin and mucous membranes. The HPVs has been implicated as the cause of virtually all cervical cancers worldwi...

Authors: Giuseppa Visalli, Monica Currò, Alessio Facciolà, Romana Riso, Placido Mondello, Pasqualina Laganà, Angela Di Pietro, Isa Picerno and Pasquale Spataro

HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients

HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity...

Authors: Bianca Rivera-Peña, Francisco J. Ruíz-Fullana, Germán L. Vélez-Reyes, Rosa J. Rodriguez-Benitez, María J. Marcos-Martínez, Juan Trinidad-Pinedo and Adriana Báez

Fulminant anaplastic large cell lymphoma (ALCL) concomitant with primary cytomegalovirus (CMV) infection, and human herpes virus 8 (HHV-8) infection together with Epstein-Barr-virus (EBV) reactivation in a patient with asymptomatic HIV-infection

Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV ...

Authors: Sven Grützmeier, Anna Porwit, Corinna Schmitt, Eric Sandström, Börje Åkerlund and Ingemar Ernberg

Salivary and serum IL-10, TNF-α, TGF-β, VEGF levels in oropharyngeal squamous cell carcinoma and correlation with HPV and EBV infections

Each year approximately 6,000 new cases of head and neck cancer are registered in Poland. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) have been associated with tumour formation. Cytokines have been...

Authors: Małgorzata Polz-Dacewicz, Małgorzata Strycharz-Dudziak, Jakub Dworzański, Agnieszka Stec and Joanna Kocot

Variability of high risk HPV genotypes among HIV infected women in Mwanza, Tanzania- the need for evaluation of current vaccine effectiveness in developing countries

High risk (HR) human papilloma Virus (HPV) genotypes have been associated with cervical cancer. In Tanzania there is a limited data on the epidemiology of HPV and genotypes distribution among HIV infected wome...

Authors: Fridolin Mujuni, Mariam M. Mirambo, Peter Rambau, Korn Klaus, Muller Andreas, Dismas Matovelo, Mtebe Majigo, Christa Kasang and Stephen E. Mshana

Variants of human papillomaviruses 16 (HPV16) in Uigur women in Xinjiang, China

Persistent infection of high-risk human papillomaviruses 16 (HPV16) has been considered as the leading cause of cervical cancer. In this study we assessed HPV16 sequence variation and genetic diversity of HPV1...

Authors: Hongchang He, Hongtao Li, Peiwen Fan, Junling Zhu, Zhenzhen Pan, Huan Pan, Dan Wu, Xianxian Ren, Xiaoqing Guo, Dongmei Li, Zemin Pan and Renfu Shao

Validation of Novaprep^® HQ+ liquid-based cytology medium for high-risk human papillomavirus detection by hc2

Preanalytical conditions determine the reliability and validity of bioassays. Therefore, the analytic performances of biological tests need to be determined when preanalytical steps differ from those recommend...

Authors: David Guenat, Sophie Launay, Didier Riethmuller, Christiane Mougin and Jean-Luc Prétet

Establishing and characterizing a new primary effusion lymphoma cell line harboring Kaposi’s sarcoma–associated herpesvirus

Primary effusion lymphoma is a rare distinct large B-cell neoplasm that is associated with Kaposi’s sarcoma–associated herpesvirus (KSHV) infection. Over recent years, 9 KSHV-positive/Epstein-Barr virus (EBV)-...

Authors: Madori Osawa, Sohtaro Mine, Shinichiro Ota, Kengo Kato, Tsuyoshi Sekizuka, Makoto Kuroda, Michiyo Kataoka, Hitomi Fukumoto, Yuko Sato, Takayuki Kanno, Hideki Hasegawa, Keiji Ueda, Masashi Fukayama, Takuya Maeda, Soichiro Kanoh, Akihiko Kawana…

Human papillomavirus genotypes distribution in cervical cancer cases in Gabon

Cervical cancer is a real public health problem in African countries. The relation between HPV and cervical cancer is well established. However, it is known that the distribution of HPV genotypes differ geogra...

Authors: Samira Zoa-Assoumou, Angelique Ndjoyi-Mbiguino, Barthelemy Mabika Mabika, Ernest Belembaogo, Abdelkim Khattabi and My Mustapha Ennaji

Diversity of high risk human papilloma viruses in women treated with antiretroviral and in healthy controls and discordance with cervical dysplasia in the South of Benin

High risk oncologic Human Papilloma Virus (HPV) is one of the leading causes of cervical cancer worldwide. We investigated HPV genotypes among women living or not with Human Immuno-deficiency Virus (HIV) in tw...

Authors: Callinice D. Capo-chichi, Blanche Aguida, Nicodème W. Chabi, Jocelyn Acapko-Ezin, Jonas Sossah-Hiffo, Vidéhouénou K. Agossou, Toussain Anagbla, Marcel Zannou, Fabien Houngbé and Ambaliou Sanni

Hepatitis B virus X protein mediated suppression of miRNA-122 expression enhances hepatoblastoma cell proliferation through cyclin G1-p53 axis

Hepatitis B virus (HBV) X protein (HBx) reported to be associated with pathogenesis of hepatocellular carcinoma (HCC) and miR-122 expression is down regulated in HCC. Previous studies reported miR-122 targets ...

Authors: Manikankana Bandopadhyay, Neelakshi Sarkar, Sibnarayan Datta, Dipanwita Das, Ananya Pal, Rajesh Panigrahi, Arup Banerjee, Chinmay K. Panda, Chandrima Das, Shekhar Chakrabarti and Runu Chakravarty

Radio-frequency ablation-based studies on VX2rabbit models for HCC treatment

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide with high morbidity, mortality and increasing incidence. It is of note that the main curative therapies for HCC are hepatic resection ...

Authors: Sabrina Bimonte, Maddalena Leongito, Mauro Piccirillo, Cristina de Angelis, Claudia Pivonello, Vincenza Granata and Francesco Izzo

A review of the infection-associated cancers in North African countries

Cancer is typically classified as a leading non-communicable disease; however, infectious agents, such as Helicobacter pylori (H. pylori), hepatitis B virus (HBV), hepatitis C virus (HCV) and human papilloma viru...

Authors: Wafaa Mohamed Hussein, Wagida A. Anwar, Mohammed Attaleb, Loubna Mazini, Asta Försti, Roxana-Delia Trimbitas and Meriem Khyatti

Cancer of the vulva in Burkina Faso: a hospital-based case series

Vulvar cancer is a rare gynaecological cancer. In Burkina Faso, the diagnosis of vulvar cancers is delayed and the prognosis is poor. However, no specific study on vulvar cancers has been conducted at the mome...

Authors: Nayi Zongo, Nina Korsaga-Somé, Amandine Banata Gang-Ny, Edgar Ouangré, Maurice Zida, Aimé Sosthène Ouédraogo, Aboubacar Hirrhum Bambara, Augustin Tozoula Bambara, Si Simon Traore, Pascal Niamba, Adama Traoré and Ahmadou Dem

Human herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls

Glioblastoma (GBM) is a fatal CNS malignancy, representing 50 % of all gliomas with approximately 12–18 months survival time after initial diagnosis. Recently, the human herpesvirus cytomegalovirus (CMV) has b...

Authors: Cheng-Te Major Lin, Emily C. Leibovitch, M. Isabel Almira-Suarez and Steven Jacobson

Expression of evolutionarily novel genes in tumors

The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive ...

Authors: A. P. Kozlov

High-risk HPV is not associated with epithelial ovarian cancer in a Caucasian population

High-risk human papillomavirus (HPV) has been suspected to play a role in the carcinogenesis of epithelial ovarian cancer (EOC). However, results from previous studies are conflicting. In most of these studies...

Authors: Kasper Ingerslev, Estrid Hogdall, Wojciech Skovrider-Ruminski, Tine Henrichsen Schnack, Mona Aarenstrup Karlsen, Lotte Nedergaard, Claus Hogdall and Jan Blaakær

H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis

To assess the correlation of H. pylori infection with mitochondrial microsatellite instability (mtMSI) and IL-8 in gastric carcinogenesis.

Authors: Xianlong Ling, Haoxiang Zhang, Caifei Shen, Wu Yan, Pu Wang, Ji Feng, Zhihong Peng, Guiyong Peng, Wensheng Chen and Dianchun Fang

Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection

We have previously reported the case of an immunocompetent female patient with a primary cutaneous CD30+ anaplastic large-cell lymphoma (PCALCL) located on her upper right eyelid characterized by the presence ...

Authors: Elisabetta Caselli, Alessandro Borghi, Martina Maritati, Roberta Gafà, Giovanni Lanza, Dario Di Luca, Annarosa Virgili and Carlo Contini

The pattern of prognostic and risk indicators among women with breast cancer undergoing modified radical mastectomy in Dar es Salaam, Tanzania

Breast cancer is the commonest female malignancy globally and the second (after uterine cervix) in sub-Saharan Africa including Tanzania. Prognostic indicators reportedly influence post-mastectomy adjuvant the...

Authors: Amos R. Mwakigonja, Happiness Rabiel, Naboth A. Mbembati and Leonard E. K. Lema

Hepatitis B and C viruses and risk of non-Hodgkin lymphoma: a case-control study in Italy

Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology.

Authors: Martina Taborelli, Jerry Polesel, Maurizio Montella, Massimo Libra, Rosamaria Tedeschi, Monica Battiston, Michele Spina, Francesco Di Raimondo, Antonio Pinto, Anna Crispo, Maria Grimaldi, Silvia Franceschi, Luigino Dal Maso and Diego Serraino