Articles

Endemic Kaposi sarcoma in HIV-negative children and adolescents: an evaluation of overlapping and distinct clinical features in comparison with HIV-related disease

Endemic Kaposi sarcoma (KS) was first described in African children over fifty years ago, but has recently been overshadowed by HIV-related disease. We aimed to evaluate the similarities and differences betwee...

Authors: Nader Kim El-Mallawany, Jimmy Villiera, William Kamiyango, Erin C. Peckham-Gregory, Michael E. Scheurer, Carl E. Allen, Casey L. McAtee, Alejandra Legarreta, Dirk P. Dittmer, Carrie L. Kovarik, Elizabeth Y. Chiao, Stephen C. Martin, Nmazuo W. Ozuah, Parth S. Mehta and Peter N. Kazembe

Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in keratinizing versus non- keratinizing squamous cell carcinoma of the oropharynx

Oral and oropharyngeal squamous cell carcinomas (OSCC and OPSCC) represent the majority of head and neck squamous cell carcinomas (HNSCC). Human papillomavirus (HPV) is an important etiologic factor together w...

Authors: Francesco Broccolo, Giulia Ciccarese, Agostino Rossi, Luca Anselmi, Francesco Drago and Antonio Toniolo

Human papillomavirus E5 protein, the undercover culprit of tumorigenesis

Human papillomavirus (HPV) is the most common viral infection of the reproductive tract worldwide. It has been well documented that the HPV oncoproteins E6 and E7 play important roles in cancer progression and...

Authors: Nima Hemmat and Hossein Bannazadeh Baghi

Tenofovir disoproxil fumarate reduce incidence of HCC development in CHB-patients with compensated cirrhosis

The impact of different anti-virus regimens on prognosis of Chronic hepatitis B (CHB) related cirrhosis remains to be explored. We aim to investigate whether CHB-related HCC patients receiving nucleoside analo...

Authors: Ping Zhang, Qingli Liu, Mei Yuan and Lina Wang

Reducing incidence of cervical cancer: knowledge and attitudes of caregivers in Nigerian city to human papilloma virus vaccination

Despite the high prevalences of Human Papilloma Virus (HPV) infections and cervical cancer in Nigeria, utilization of the HPV vaccine as a highly effective preventive measure remains low. The aim of this study...

Authors: Adaobi I. Bisi-Onyemaechi, Ugo N. Chikani and Obinna Nduagubam

HPV genotype distribution among women with normal and abnormal cervical cytology presenting in a tertiary gynecology referral Clinic in Ethiopia

Cervical cancer is the second most prevalent cancer among women of child-bearing age in Ethiopia. The aim of this study was to determine human papilloma virus (HPV) genotype distribution among HIV-negative wom...

Authors: Dawit Wolday, Muluken Derese, Solomon Gebressellassie, Bekure Tsegaye, Wondwossen Ergete, Yirgu Gebrehiwot, Orit Caplan, Dana G. Wolf and Shlomo Maayan

Prognostic factors in HIV-positive patients with non-Hodgkin lymphoma: a Peruvian experience

Non-Hodgkin lymphoma (NHL) is the most common cancer in people with HIV. Although 95% of HIV patients are in developing countries like Peru, the majority of these studies have been conducted in developed count...

Authors: Luis Ernesto Cuellar, Andrea Anampa-Guzmán, Alexis Manuel Holguín, Juan Velarde, Diana Portillo-Alvarez, Marco Antonio Zuñiga-Ninaquispe, Esther Rosa Luna-Reyes, Jule Vásquez, Joanne Marie Jeter and Karen Marie Winkfield

Prevalence of “unclassified” HPV genotypes among women with abnormal cytology

High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role o...

Authors: Clorinda Annunziata, Giovanni Stellato, Stefano Greggi, Veronica Sanna, Maria Pia Curcio, Simona Losito, Gerardo Botti, Luigi Buonaguro, Franco Maria Buonaguro and Maria Lina Tornesello

Glycogene expression profiles based on microarray data from cervical carcinoma HeLa cells with partially silenced E6 and E7 HPV oncogenes

Aberrant glycosylation is a characteristic of tumour cells. The expression of certain glycan structures has been associated with poor prognosis. In cervical carcinoma, changes in the expression levels of some ...

Authors: Miguel Aco-Tlachi, Ricardo Carreño-López, Patricia L. Martínez-Morales, Paola Maycotte, Adriana Aguilar-Lemarroy, Luis Felipe Jave-Suárez, Gerardo Santos-López, Julio Reyes-Leyva and Verónica Vallejo-Ruiz

Prevalence of CagA and antimicrobial sensitivity of H. pylori isolates of patients with gastric cancer in Egypt

Helicobacter pylori (H. pylori) infection has been recognized as a significant threat for gastric cancer. However, studies that investigated the oncogenic factors and antimicrobial resistance of H. pylori in Egyp...

Authors: Doaa M. Al-Eraky, Omneya M. Helmy, Yasser M. Ragab, Zeinab Abdul-Khalek, Eman A. El-Seidi and Mohammed A. Ramadan

The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC

Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the ...

Authors: Vincenza Granata, Roberta Fusco, Salvatore Filice, Orlando Catalano, Mauro Piccirillo, Raffaele Palaia, Francesco Izzo and Antonella Petrillo

Plasmablastic lymphoma in Malawi

Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospec...

Authors: Takondwa Zuze, Matthew S. Painschab, Ryan Seguin, Evarista Kudowa, Bongani Kaimila, Edwards Kasonkanji, Tamiwe Tomoka, Bal Mukunda Dhungel, Maurice Mulenga, Maria Chikasema, Blessings Tewete, Asekanadziwa Ntangwanika, Sarah Chiyoyola, Fred Chimzimu, Coxcilly Kampani, Robert Krysiak…

Clinico-pathological features of oropharyngeal squamous cell carcinomas in Malaysia with reference to HPV infection

The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in Western countries and this has been attributed to human papillomavirus (HPV) infection. p16 expression is a marker for HPV infe...

Authors: Lee Fah Yap, Sook Ling Lai, Anthony Rhodes, Hans Prakash Sathasivam, Maizaton Atmadini Abdullah, Kin-Choo Pua, Pathmanathan Rajadurai, Phaik-Leng Cheah, Selvam Thavaraj, Max Robinson and Ian C. Paterson

Prognostic factors in patients with HBV-related hepatocellular carcinoma following hepatic resection

To analyze prognostic factors following hepatic resection in patients with HBV-related hepatocellular carcinoma.

Authors: Narongsak Rungsakulkij, Wikran Suragul, Somkit Mingphruedhi, Pongsatorn Tangtawee, Paramin Muangkaew and Suraida Aeesoa

Tenofovir decrease hepatocellular carcinoma recurrence in chronic hepatitis B patients after liver resection

Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line choices regarding the treatment of chronic hepatits B. The impact of the two antiviral agents on prognosis of Chronic h...

Authors: Min Zhang, Dexin Wang, Haidong Liu and Hui Li

Negative effect of hepatitis in overall and progression-free survival among patients with diffuse large B-cell lymphoma

Hepatitis B virus (HBV) is one of the most prevalent and serious infections worldwide. HBV reactivation is a serious complication for lymphoma patients who are being treated with rituximab-containing regimen. ...

Authors: Mubarak M. Al-Mansour, Saif A. Alghamdi, Musab A. Alsubaie, Abdullah A. Alesa and Muhammad A. Khan

Comparison of anti-HBV regimen with or without adefovir on hepatocellular carcinoma development of Chronic hepatitis B patients with compensated cirrhosis: a retrospective cohort study

The impact of different anti-virus regimens on prognosis of Chronic hepatitis B (CHB) related cirrhosis remains to be explored. We aim to investigate whether CHB-related HCC patients receiving nucleoside analo...

Authors: Jing Sun, Yanfang Li, Yanna Wang, Yanyan Liu, Youde Liu and Xiumei Wang

Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America

This study aimed to evaluate trends and predictors of survival after cancer diagnosis in persons living with HIV in the Caribbean, Central, and South America network for HIV epidemiology cohort.

Authors: Valeria I. Fink, Cathy A. Jenkins, Jessica L. Castilho, Anna K. Person, Bryan E. Shepherd, Beatriz Grinsztejn, Juliana Netto, Brenda Crabtree-Ramirez, Claudia P. Cortés, Denis Padgett, Karu Jayathilake, Catherine McGowan and Pedro Cahn

Epidemiologic and economic burden of HPV diseases in Spain: implication of additional 5 types from the 9-valent vaccine

A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related d...

Authors: Noelia López, Aureli Torné, Agustín Franco, María San-Martin, Elisabet Viayna, Carmen Barrull and Nuria Perulero

Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications

The Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies. In order to maintain its persistence in host cells and promote...

Authors: Silvia Giunco, Maria Raffaella Petrara, Manuela Zangrossi, Andrea Celeghin and Anita De Rossi

Human papillomavirus genome variants and head and neck cancers: a perspective

Human papillomaviruses (HPV) cause infections that are responsible for diverse clinical manifestations from benign conditions to invasive cancer. As different HPV types are associated with variable pathogenic ...

Authors: Jean-Damien Combes and Silvia Franceschi

Role of BK human polyomavirus in cancer

Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of the...

Authors: Jorge Levican, Mónica Acevedo, Oscar León, Aldo Gaggero and Francisco Aguayo

Immunogenicity of a Fap2 peptide mimotope of Fusobacterium nucleatum and its potential use in the diagnosis of colorectal cancer

The role of Fusobacterium nucleatum Fap2 protein in the development of colorectal cancer has recently been explained. Fap2, when bound to the human inhibitory receptor, TIGIT, inhibits the cytotoxic activity of n...

Authors: Leonardo A. Guevarra Jr, Andrea Claudine F. Afable, Patricia Joyce O. Belza, Karen Joy S. Dy, Scott Justin Q. Lee, Teresa T. Sy-Ortin and Pia Marie S. P. Albano

Cellular prognostic markers in hepatitis-related hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and accounts for about 6% of all new cancers diagnosed worldwide. Moreover, it is the third and the fifth leading cause of death from ...

Authors: A. Petrizzo, A. Mauriello, M. L. Tornesello, F. M. Buonaguro, M. Tagliamonte and L. Buonaguro

The role of bacteria in cancer therapy – enemies in the past, but allies at present

In recent decades, bacteria’s therapeutic role has aroused attention in medicinal and pharmaceutical research. While bacteria are considered among the primary agents for causing cancer, recent research has sho...

Authors: Shiyu Song, Miza S. Vuai and Mintao Zhong

Comparative assessment of HPV, alcohol and tobacco etiological fractions in Algerian patients with laryngeal squamous cell carcinoma

Despite the increasing incidence of laryngeal squamous cell carcinoma (LSCC) in Algeria, scarce information is available on the importance of the preventable etiological factors which may drive the disease. Re...

Authors: Nora Kariche, Montserrat Torres Hortal, Samir Benyahia, Laia Alemany, Nabila Moulaï, Omar Clavero, Marleny Muñoz, Wahiba Ouahioune, Djamel Djennaoui, Chafia Touil-Boukoffa, Silvia de Sanjosé and Mehdi Bourouba

Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection

Hepatocellular carcinoma (HCC) can develop in patients who are negative for the hepatitis B surface antigen (HBsAg) in serum but positive for hepatitis B virus (HBV) DNA in the liver, referred to as occult HBV...

Authors: Yuri Hatazawa, Yoshihiko Yano, Rina Okada, Toshihito Tanahashi, Hiroki Hayashi, Hirotaka Hirano, Akihiro Minami, Yuki Kawano, Motofumi Tanaka, Takumi Fukumoto, Yoshiki Murakami, Masaru Yoshida and Yoshitake Hayashi

Prevalence of human papillomavirus infection among Iranian women using COBAS HPV DNA testing

Persistent infection with High Risk Human Papillomavirus (HR HPV) types plays a major role in the development of cervical cancer. Therefore, the detection of HR HPV types is an essential part of cervical cance...

Authors: Farzane Jamdar, Farah Farzaneh, Fariba Navidpour, Sarang Younesi, Payam Balvayeh, Maryamsadat Hosseini and Robabeh Ghodssi-Ghasemabadi

HIV-associated Kaposi’s sarcoma in Maputo, Mozambique: outcomes in a specialized treatment center, 2010–2015

Kaposi’s sarcoma (KS) is a common HIV-associated malignancy associated with disability, pain and poor outcomes. The cornerstone of its treatment is antiretroviral therapy, but advanced disease necessitates the...

Authors: Vini Fardhdiani, Lucas Molfino, Ana Gabriela Zamudio, Rolanda Manuel, Gilda Luciano, Iza Ciglenecki, Barbara Rusch, Laurence Toutous Trellu and Matthew E Coldiron

Human papillomavirus genotype distribution in cervical cancer biopsies from Nepalese women

Cervical cancer (CC) is the leading cause of morbidity and mortality from cancer in Nepalese women. Nearly all cases of CC are caused by infection with certain genotypes of human papillomavirus (HPV). Data on ...

Authors: Sunil Kumar Sah, Joaquin V. González, Sadina Shrestha, Anurag Adhikari, Krishna Das Manandhar, Shyam Babu Yadav, David A. Stein, Birendra Prasad Gupta and María Alejandra Picconi

Dissecting the mechanisms and molecules underlying the potential carcinogenicity of red and processed meat in colorectal cancer (CRC): an overview on the current state of knowledge

Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous du...

Authors: Marco Cascella, Sabrina Bimonte, Antonio Barbieri, Vitale Del Vecchio, Domenico Caliendo, Vincenzo Schiavone, Roberta Fusco, Vincenza Granata, Claudio Arra and Arturo Cuomo

HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan

Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype...

Authors: Dauren Adilbay, Galim Adilbayev, Gulzhan Kidirbayeva, Viktoria Shipilova, Zhanat Sadyk, Gulsum Koyanbekova, Ekaterina Sokolenko and Jan Klozar

Could Mycobacterium avium subspecies paratuberculosis cause Crohn’s disease, ulcerative colitis…and colorectal cancer?

Infectious agents are known causes of human cancers. Schistosoma japonicum and Schistosoma mansoni cause a percentage of colorectal cancers in countries where the respective Schistosoma species are prevalent. Col...

Authors: Ellen S. Pierce

Association of Epstein - Barr virus and breast cancer in Eritrea

The oncogenic potential of Epstein-Barr virus (EBV) in breast cancer is being increasingly recognized. Despite some controversies regarding such role, new evidence is suggesting a culpability of EBV in breast ...

Authors: Ghimja Fessahaye, Ahmed M. Elhassan, Elwaleed M. Elamin, Ameera A. M. Adam, Anghesom Ghebremedhin and Muntaser E. Ibrahim

Cervical cancer patients presentation and survival in the only oncology referral hospital, Ethiopia: a retrospective cohort study

Women infected with Human Immune Deficiency Virus (HIV) are assumed to be at higher risk of developing Cervical Cancer (CC). This is due to a rapid progression of pre-invasive to invasive lesions. However, evi...

Authors: Muluken Gizaw, Adamu Addissie, Sefonias Getachew, Wondimu Ayele, Israel Mitiku, Ulrike Moelle, Tigist Yusuf, Mathias Begoihn, Mathewos Assefa, Ahmedin Jemal and Eva Johanna Kantelhardt

Characterization of hormonal receptors and human epidermal growth factor receptor-2 in tissues of women with breast cancer at Muhimbili National Hospital, Dar es salaam, Tanzania

Breast cancer is a leading cause of morbidity and deaths among women worldwide. In Tanzania there is no published data on human epidermal growth receptor-2 (HER2/neu) expression in breast carcinoma. Hormonal r...

Authors: Amos Rodger Mwakigonja, Nyanda Elias Lushina and Ally Mwanga

Factors associated with the high prevalence of oesophageal cancer in Western Kenya: a review

Oesophageal carcinoma (OC) is highly prevalent in Western Kenya especially among the members of the Kalenjin community who reside in the Northern and Southern areas of the Rift Valley. Previous authors have su...

Authors: Gabriel Kigen, Naftali Busakhala, Zipporah Kamuren, Hillary Rono, Wilfred Kimalat and Evangeline Njiru

Prevalence of HPV infection in hypopharyngeal and laryngeal squamous cell carcinoma at Thailand's largest tertiary referral center

Following the well-established relationship between human papillomavirus (HPV) and cervical carcinoma, the carcinogenicity of this virus has also been confirmed in subsets of head and neck carcinoma (HNCA), bu...

Authors: Warut Pongsapich, Nitathip Eakkasem, Sontana Siritantikorn, Paveena Pithuksurachai, Kshidej Bongsabhikul and Cheerasook Chongkolwatana

A systematic review on multiparametric MR imaging in prostate cancer detection

Literature data suggest that multi-parametric Magnetic Resonance Imaging (MRI), including morphologic T2-weigthed images (T2-MRI) and functional approaches such as Dynamic Contrast Enhanced-MRI (DCE-MRI), Diff...

Authors: Roberta Fusco, Mario Sansone, Vincenza Granata, Sergio Venanzio Setola and Antonella Petrillo

T- and NK-cell populations with regulatory phenotype and markers of apoptosis in circulating lymphocytes of patients with CIN3 or microcarcinoma of the cervix: evidence for potential mechanisms of immune suppression

Processes and mechanisms responsible for systemic immune suppression in early-stage cervical cancer remain substantially underinvestigated. In this work, we focused on studying the frequencies of circulating r...

Authors: Olga V. Kurmyshkina, Pavel I. Kovchur, Ludmila V. Schegoleva and Tatyana O. Volkova

Multiple oncogenic viruses are present in human breast tissues before development of virus associated breast cancer

Multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and Epstein Barr virus, have been identified as separate infectious pathogens in human breast canc...

Authors: James S. Lawson and Wendy K. Glenn

HPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors?

Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Currently, Human papillomavirus (HPV) is suggested as a potential risk factor for esophageal cancer (EC) in addition to the classic...

Authors: Allini Mafra da Costa, José Humberto Tavares Guerreiro Fregnani, Paula Roberta Aguiar Pastrez, Vânia Sammartino Mariano, Estela Maria Silva, Cristovam Scapulatempo Neto, Denise Peixoto Guimarães, Luisa Lina Villa, Laura Sichero, Kari Juhani Syrjanen and Adhemar Longatto-Filho

Integration of human papillomavirus 16 in esophageal carcinoma samples

Esophageal carcinoma (EC) is one of the major cancers in China. In 1982, Syrjanen first hypothesized the relationship between human papillomavirus (HPV) infection and the development of esophageal cancer. Sinc...

Authors: Shuying Li, Haie Shen, Zhanjun Liu, Ning Li, Suxian Yang, Ke Zhang and Jintao Li

Hepatitis C Virus (HCV) genotypes distribution among hepatocellular carcinoma patients in Southern Italy: a three year retrospective study

Hepatocellular carcinoma (HCC) is one of the major cause for cancer in the world. Aim of this case-control study was to investigate the distribution pattern of HCV genotypes among HCC patients and suggest whet...

Authors: Arnolfo Petruzziello, Samantha Marigliano, Giovanna Loquercio, Nicola Coppola, Mauro Piccirillo, Maddalena Leongito, Rosa Azzaro, Francesco Izzo and Gerardo Botti

Correction to: mouse mammary tumour virus (MMTV) and human breast cancer with neuroendocrine differentiation

Authors: J. S. Lawson, C. C. Ngan, W. K. Glenn and D. D. Tran

Introduction of p16^INK4a as a surrogate biomarker for HPV in women with invasive cervical cancer in Sudan

Cervical cancer is the fourth most common cancer in women worldwide with highest incidence reported in Eastern Africa in 2012. The primary goal of this study was to study the expression of p16^INK4a in squamous ce...

Authors: Hina Sarwath, Devendra Bansal, Nazik Elmalaika Husain, Mahmoud Mohamed, Ali A. Sultan and Shahinaz Bedri

HIV-1 matrix protein p17 and its variants promote human triple negative breast cancer cell aggressiveness

The introduction of cART has changed the morbidity and mortality patterns affecting HIV-infected (HIV⁺) individuals. The risk of breast cancer in HIV⁺ patients has now approached the general population risk. Howe...

Authors: Francesca Caccuri, Francesca Giordano, Ines Barone, Pietro Mazzuca, Cinzia Giagulli, Sebastiano Andò, Arnaldo Caruso and Stefania Marsico

Outcomes after sofosbuvir-containing regimens for hepatitis C virus in patients with decompensated cirrhosis: a real-world study

Direct-acting antivirals have been used for decompensated cirrhotic patients with hepatitis C virus (HCV) infection. However, the benefits in Chinese patients with decompensated cirrhosis are unclear.

Authors: Fanpu Ji, Wenjun Wang, Shuangsuo Dang, Shengbang Wang, Burong Li, Dan Bai, Wenxue Zhao, Hong Deng, Changyin Tian and Zongfang Li

Diagnostic value of prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) for early stage HBV related hepatocellular carcinoma

To evaluate the diagnostic efficacy of prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) for early stage hepatitis virus B (HBV) related hepatocellular carcinoma (HCC).

Authors: Xiumei Wang, Weiwei Zhang, Youde Liu, Wenjing Gong, Ping Sun, Xiangshuo Kong, Miaomiao Yang and Zhihua Wang

High risk human papilloma viruses (HPVs) are present in benign prostate tissues before development of HPV associated prostate cancer

Although high risk HPVs are associated with an increased risk of prostate cancer it is not known if they have a causal role. The purpose of this study is to investigate the potential role of human papilloma vi...

Authors: Wendy K. Glenn, Christopher C. Ngan, Timothy G. Amos, Richard J. Edwards, Joshua Swift, Louise Lutze-Mann, Fei Shang, Noel J. Whitaker and James S. Lawson