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Clinical oncology

Section edited by: Prof Serigne Magueye Gueye and Prof Jan Vermorken. 

The clinical oncology section represents an opportunity to share experiences and information among worldwide oncologists and to identify and develop diagnostic as well as therapeutic protocols, which are globally valid in the current global village. Potential topics include, but are not limited to: epidemiology, pathology and pathogenesis of cancers and clinical studies

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  1. The conception that serological hepatitis markers determined surgical prognosis of hepatocellular carcinoma (HCC) associated with hepatitis B (HBV) or hepatitis C (HCV) has been well defined. However, little i...

    Authors: Xiu-Tao Fu, Ying-Hong Shi, Jian Zhou, Yuan-Fei Peng, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Kang Song, Jia Fan and Zhen-Bin Ding
    Citation: Infectious Agents and Cancer 2017 12:28
  2. Primary hepatocellular carcinoma (HCC) mainly develops in subjects chronically infected with hepatitis B (HBV) and C (HCV) viruses through a multistep process characterized by the accumulation of genetic alter...

    Authors: Francesca Pezzuto, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello
    Citation: Infectious Agents and Cancer 2017 12:27
  3. The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis.

    Authors: Kasper Ingerslev, Estrid Hogdall, Tine Henrichsen Schnack, Wojciech Skovrider-Ruminski, Claus Hogdall and Jan Blaakaer
    Citation: Infectious Agents and Cancer 2017 12:25
  4. Mouse mammary tumour viruses (MMTVs) may have a role in a subset of human breast cancers. MMTV positive human breast cancers have similar histological characteristics to neuroendocrine breast cancers and to MM...

    Authors: Lawson JS, Ngan CC, Glenn WK and Tran DD
    Citation: Infectious Agents and Cancer 2017 12:24

    The Correction to this article has been published in Infectious Agents and Cancer 2017 12:51

  5. Liver Imaging Reporting and Data System (LI-RADS) is a system for interpreting and reporting of imaging features on multidetector computed tomography (MDCT) and magnetic resonance (MR) studies in patients at r...

    Authors: Vincenza Granata, Roberta Fusco, Antonio Avallone, Orlando Catalano, Francesco Filice, Maddalena Leongito, Raffaele Palaia, Francesco Izzo and Antonella Petrillo
    Citation: Infectious Agents and Cancer 2017 12:23
  6. Helicobacter pylori (H. pylori) represents a key factor in the etiology of autoimmune atrophic gastritis (AAG), duodenal ulcer (DU) and gastric cancer (GC). The aim of this study was t...

    Authors: Valli De Re, Ombretta Repetto, Stefania Zanussi, Mariateresa Casarotto, Laura Caggiari, Vincenzo Canzonieri and Renato Cannizzaro
    Citation: Infectious Agents and Cancer 2017 12:22
  7. Blastocystis, a genetically diverse intestinal parasite with controversial pathogenic potential, has increasingly been incriminated for diarrheal illness in immunocompromised individua...

    Authors: Amr Mohamed Mohamed, Mona Abdelfattah Ahmed, Sabah Abdelghany Ahmed, Sherif Ahmed Al-Semany, Saad Saed Alghamdi and Dina Abdulla Zaglool
    Citation: Infectious Agents and Cancer 2017 12:21
  8. In addition to cervical cancer, human papillomavirus (HPV) is responsible for a significant proportion of cancers and precancerous lesions of the vulva, vagina, anus, penis, head and neck, as well as genital w...

    Authors: Susanne Hartwig, Jean Lacau St Guily, Géraldine Dominiak-Felden, Laia Alemany and Silvia de Sanjosé
    Citation: Infectious Agents and Cancer 2017 12:19
  9. Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack o...

    Authors: Madina Shaimerdenova, Orynbassar Karapina, Damel Mektepbayeva, Kenneth Alibek and Dana Akilbekova
    Citation: Infectious Agents and Cancer 2017 12:18
  10. Direct Antiviral Agents (DAAs) for HCV therapy represents a step ahead in the cure of chronic hepatitis C. Notwithstanding the promising results in several clinical trials, few data are available on adverse ef...

    Authors: A. Nappi, A. Perrella, P. Bellopede, A. Lanza, A. Izzi, M. Spatarella and C. Sbreglia
    Citation: Infectious Agents and Cancer 2017 12:12
  11. The mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China.

    Authors: Jin Zhao, Zhong Guo, Qiang Wang, Tianbin Si, Shuyan Pei, Chenjing Wang, Hongmei Qu, Jianbin Zhong, Ying Ma, Cong Nie and Dan Zhang
    Citation: Infectious Agents and Cancer 2017 12:8
  12. Human Immuno-deficiency Virus (HIV) associated non-Hodgkin’s lymphoma (NHL) was a special group of disease, which manifests distinct clinical features and prognosis as compared with NHLs in patients without HI...

    Authors: Yang Shen, Renfang Zhang, Li Liu, Yinzhong Shen, Wei Song, Tangkai Qi, Yang Tang, Zhenyan Wang, Liqian Guan and Hongzhou Lu
    Citation: Infectious Agents and Cancer 2017 12:7
  13. An association between HPV infection and progression to anal squamous intraepithelial lesions (ASIL) has been established, specifically in high-risk populations such as HIV-infected men. In this population, an...

    Authors: Celia M. Limia, Yudira Soto, Yanara García, Orestes Blanco, Vivian Kourí, María V. López, María E. Toledo, Lissette Pérez, Yoanna Baños, Yaniris Caturla and Francisco Aguayo
    Citation: Infectious Agents and Cancer 2017 12:5
  14. An infectious aetiology for prostate cancer has been conjectured for decades but the evidence gained from questionnaire-based and sero-epidemiological studies is weak and inconsistent, and a causal association...

    Authors: Melissa A. Yow, Sepehr N. Tabrizi, Gianluca Severi, Damien M. Bolton, John Pedersen, Graham G. Giles and Melissa C. Southey
    Citation: Infectious Agents and Cancer 2017 12:4
  15. There is substantial evidence that a virus homologous to mouse mammary tumor virus (MMTV) may have a role in human breast cancer. The present study indicates that those who developed breast cancer associated w...

    Authors: Teiko Nartey, Chiara M. Mazzanti, Stella Melana, Wendy K. Glenn, Generoso Bevilacqua, James F. Holland, Noel J. Whitaker, James S. Lawson and Beatriz G.T. Pogo
    Citation: Infectious Agents and Cancer 2017 12:1

    The Erratum to this article has been published in Infectious Agents and Cancer 2017 12:16

  16. Animal models of para-renal cancer can provide useful information for the evaluation of tumor response to loco-regional therapy experiments in solid tumors. The aim of our study was to establish a rabbit para-...

    Authors: Sabrina Bimonte, Maddalena Leongito, Mauro Piccirillo, Maria Luisa Tamma, Marianna Vallifuoco, Adele Bracco, Antonio Mancini, Daniele Di Napoli, Sigismondo Castaldo, Santolo Cozzolino, Francesca Iacobellis, Roberto Grassi, Vincenza Granata, Secondo Lastoria, Steven Curley and Francesco Izzo
    Citation: Infectious Agents and Cancer 2016 11:62
  17. Human Papillomavirus is the major etiological agent in the development of cervical cancer but not a sufficient cause. Despite significant research, the underlying mechanisms of progression from a low-grade squ...

    Authors: Rashmirani Senapati, Nihar Nalini Senapati and Bhagirathi Dwibedi
    Citation: Infectious Agents and Cancer 2016 11:59
  18. Ductal adenocarcinoma of the pancreas is one of the most aggressive forms of cancer, with only a minority of cases being resectable at the moment of their diagnosis. The accurate detection and characterization...

    Authors: Vincenza Granata, Roberta Fusco, Orlando Catalano, Sergio Venanzio Setola, Elisabetta de Lutio di Castelguidone, Mauro Piccirillo, Raffaele Palaia, Roberto Grassi, Francesco Granata, Francesco Izzo and Antonella Petrillo
    Citation: Infectious Agents and Cancer 2016 11:57
  19. The incidence of hepatocellular carcinoma (HCC) and its association with hepatitis C (HCV) and hepatitis B virus (HBV) infections, FIB-4 index and liver enzymes was assessed in an area of the province of Naple...

    Authors: Mario Fusco, Pierluca Piselli, Saverio Virdone, Pietro Di Cicco, Paola Scognamiglio, Paolo De Paoli, Valerio Ciullo, Diana Verdirosi, Michele D’Orazio, Luigino Dal Maso, Enrico Girardi, Silvia Franceschi and Diego Serraino
    Citation: Infectious Agents and Cancer 2016 11:54
  20. Hepatitis C virus (HCV) infection is a major public health burden in Europe, causing an increasing level of liver-related morbidity and mortality, characterized by several regional variations in the genotypes ...

    Authors: Arnolfo Petruzziello, Samantha Marigliano, Giovanna Loquercio and Carmela Cacciapuoti
    Citation: Infectious Agents and Cancer 2016 11:53
  21. The human papilloma viruses (HPVs) are DNA viruses associated with benign and malignant lesions of skin and mucous membranes. The HPVs has been implicated as the cause of virtually all cervical cancers worldwi...

    Authors: Giuseppa Visalli, Monica Currò, Alessio Facciolà, Romana Riso, Placido Mondello, Pasqualina Laganà, Angela Di Pietro, Isa Picerno and Pasquale Spataro
    Citation: Infectious Agents and Cancer 2016 11:48
  22. Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV ...

    Authors: Sven Grützmeier, Anna Porwit, Corinna Schmitt, Eric Sandström, Börje Åkerlund and Ingemar Ernberg
    Citation: Infectious Agents and Cancer 2016 11:46
  23. Each year approximately 6,000 new cases of head and neck cancer are registered in Poland. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) have been associated with tumour formation. Cytokines have been...

    Authors: Małgorzata Polz-Dacewicz, Małgorzata Strycharz-Dudziak, Jakub Dworzański, Agnieszka Stec and Joanna Kocot
    Citation: Infectious Agents and Cancer 2016 11:45
  24. Persistent infection of high-risk human papillomaviruses 16 (HPV16) has been considered as the leading cause of cervical cancer. In this study we assessed HPV16 sequence variation and genetic diversity of HPV1...

    Authors: Hongchang He, Hongtao Li, Peiwen Fan, Junling Zhu, Zhenzhen Pan, Huan Pan, Dan Wu, Xianxian Ren, Xiaoqing Guo, Dongmei Li, Zemin Pan and Renfu Shao
    Citation: Infectious Agents and Cancer 2016 11:44
  25. Preanalytical conditions determine the reliability and validity of bioassays. Therefore, the analytic performances of biological tests need to be determined when preanalytical steps differ from those recommend...

    Authors: David Guenat, Sophie Launay, Didier Riethmuller, Christiane Mougin and Jean-Luc Prétet
    Citation: Infectious Agents and Cancer 2016 11:41
  26. Primary effusion lymphoma is a rare distinct large B-cell neoplasm that is associated with Kaposi’s sarcoma–associated herpesvirus (KSHV) infection. Over recent years, 9 KSHV-positive/Epstein-Barr virus (EBV)-...

    Authors: Madori Osawa, Sohtaro Mine, Shinichiro Ota, Kengo Kato, Tsuyoshi Sekizuka, Makoto Kuroda, Michiyo Kataoka, Hitomi Fukumoto, Yuko Sato, Takayuki Kanno, Hideki Hasegawa, Keiji Ueda, Masashi Fukayama, Takuya Maeda, Soichiro Kanoh, Akihiko Kawana…
    Citation: Infectious Agents and Cancer 2016 11:37
  27. Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide with high morbidity, mortality and increasing incidence. It is of note that the main curative therapies for HCC are hepatic resection ...

    Authors: Sabrina Bimonte, Maddalena Leongito, Mauro Piccirillo, Cristina de Angelis, Claudia Pivonello, Vincenza Granata and Francesco Izzo
    Citation: Infectious Agents and Cancer 2016 11:38
  28. Glioblastoma (GBM) is a fatal CNS malignancy, representing 50 % of all gliomas with approximately 12–18 months survival time after initial diagnosis. Recently, the human herpesvirus cytomegalovirus (CMV) has b...

    Authors: Cheng-Te Major Lin, Emily C. Leibovitch, M. Isabel Almira-Suarez and Steven Jacobson
    Citation: Infectious Agents and Cancer 2016 11:32
  29. The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive ...

    Authors: A. P. Kozlov
    Citation: Infectious Agents and Cancer 2016 11:34
  30. High-risk human papillomavirus (HPV) has been suspected to play a role in the carcinogenesis of epithelial ovarian cancer (EOC). However, results from previous studies are conflicting. In most of these studies...

    Authors: Kasper Ingerslev, Estrid Hogdall, Wojciech Skovrider-Ruminski, Tine Henrichsen Schnack, Mona Aarenstrup Karlsen, Lotte Nedergaard, Claus Hogdall and Jan Blaakær
    Citation: Infectious Agents and Cancer 2016 11:39
  31. To assess the correlation of H. pylori infection with mitochondrial microsatellite instability (mtMSI) and IL-8 in gastric carcinogenesis.

    Authors: Xianlong Ling, Haoxiang Zhang, Caifei Shen, Wu Yan, Pu Wang, Ji Feng, Zhihong Peng, Guiyong Peng, Wensheng Chen and Dianchun Fang
    Citation: Infectious Agents and Cancer 2016 11:30
  32. We have previously reported the case of an immunocompetent female patient with a primary cutaneous CD30+ anaplastic large-cell lymphoma (PCALCL) located on her upper right eyelid characterized by the presence ...

    Authors: Elisabetta Caselli, Alessandro Borghi, Martina Maritati, Roberta Gafà, Giovanni Lanza, Dario Di Luca, Annarosa Virgili and Carlo Contini
    Citation: Infectious Agents and Cancer 2016 11:31
  33. Hepatitis C virus (HCV) has been consistently associated to non-Hodgkin lymphoma (NHL); conversely, few studies have evaluated a comprehensive serological panel of hepatitis B virus (HBV) in NHL etiology.

    Authors: Martina Taborelli, Jerry Polesel, Maurizio Montella, Massimo Libra, Rosamaria Tedeschi, Monica Battiston, Michele Spina, Francesco Di Raimondo, Antonio Pinto, Anna Crispo, Maria Grimaldi, Silvia Franceschi, Luigino Dal Maso and Diego Serraino
    Citation: Infectious Agents and Cancer 2016 11:27
  34. Prostate cancer is the most common cancer among men in Western countries but the exact pathogenic mechanism of the disease is still largely unknown. An infectious etiology and infection-induced inflammation ha...

    Authors: Sabina Davidsson, Paula Mölling, Jennifer R. Rider, Magnus Unemo, Mats G. Karlsson, Jessica Carlsson, Swen-Olof Andersson, Fredrik Elgh, Bo Söderquist and Ove Andrén
    Citation: Infectious Agents and Cancer 2016 11:26

    The Erratum to this article has been published in Infectious Agents and Cancer 2016 11:36

  35. Intravesical instillation of bacille Calmette-Guérin (BCG) has been established as efficient therapy for superficial bladder carcinoma. Overall, intravesical BCG is well tolerated and results in complications ...

    Authors: C. Colomba, P. Di Carlo, G. Guadagnino, L. Siracusa, M. Trizzino, C. Gioè and A. Cascio
    Citation: Infectious Agents and Cancer 2016 11:25
  36. The association between high risk human papillomaviruses (HPV) and cervical cancer has been firmly established. HPV genome is present in nearly all cases of cervical cancer and detection of viral DNA could the...

    Authors: Marianna Tortora, Clorinda Annunziata, Giuseppina Liguori, Simona Losito, Gerardo Botti, Stefano Greggi, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello
    Citation: Infectious Agents and Cancer 2016 11:22
  37. Human papillomavirus (HPV) prevalence in head and neck squamous cell carcinomas (HNSCC) diverges geographically. The reliability of using p16INK4a expression as a marker of viral infection is controversial in HNS...

    Authors: Julio C. Betiol, Laura Sichero, Henrique O. de Olival Costa, Leandro L. de Matos, Maria A. Andreoli, Silvaneide Ferreira, Sheila F. Faraj, Evandro S. de Mello, João S. Sobrinho, Lenine G. Brandão, Claudio R. Cernea, Marco A. Kulcsar, Fabio R. Pinto, Antonio J. Gonçalves, Marcelo B. Menezes, Leonardo Silva…
    Citation: Infectious Agents and Cancer 2016 11:20
  38. Human papilloma virus (HPV) is a known causative factor in oropharyngeal squamous cell cancer (OPC). In this prospective study, we sought to define the risk of HPV transmission between OPC patients and their s...

    Authors: Anne S. Tsao, Vassiliki Papadimitrakopoulou, Heather Lin, Ming Guo, J. Jack Lee, F. Christopher Holsinger, Waun Ki Hong and Erich M. Sturgis
    Citation: Infectious Agents and Cancer 2016 11:21
  39. This article evaluates a single institute’s radiotherapy management of OSSN, a previously regarded as rare malignancy, for possible future development of strategies to clearly define the role of adjuvant radio...

    Authors: Ntokozo Ndlovu, Sandra Ndarukwa, Webster Kadzatsa and Simbarashe Rusakaniko
    Citation: Infectious Agents and Cancer 2016 11:18
  40. p16INK4A expression has been used as a surrogate marker for human papillomavirus (HPV) infection in cervical cancer and head and neck cancer. p53 has also been reported as a feasible marker to identify HPV-positi...

    Authors: Lianghai Wang, Jing Li, Jun Hou, Man Li, Xiaobin Cui, Shugang Li, Xiaodan Yu, Zhiyu Zhang, Weihua Liang, Jinfang Jiang, Lijuan Pang, Yunzhao Chen, Jin Zhao and Feng Li
    Citation: Infectious Agents and Cancer 2016 11:19
  41. The association of human papillomavirus (HPV) types to neoplastic lesions increase as a function of their oncogenicity and the duration of the infection since lesion severity progresses from low-grade to high-...

    Authors: Raúl DelaRosa-Martínez, Mireya Sánchez-Garza and Rubén López-Revilla
    Citation: Infectious Agents and Cancer 2016 11:16
  42. Organized cervical cancer screening services are presently lacking in Nigeria contributing to late presentation and diagnosis of invasive cervical cancer cases (ICCs) at advanced stages in most gynecologic uni...

    Authors: Jonah Musa, Joseph Nankat, Chad J. Achenbach, Iornum H. Shambe, Babafemi O. Taiwo, Barnabas Mandong, Patrick H. Daru, Robert L. Murphy and Atiene S. Sagay
    Citation: Infectious Agents and Cancer 2016 11:15
  43. Insulin resistance is considered to be an important factor in the progression of fibrosis and the enhancement of the risk of hepatocellular carcinoma (HCC) for chronic hepatitis C patients. The aim of this stu...

    Authors: Takeo Hayashi, Eiichi Ogawa, Norihiro Furusyo, Masayuki Murata and Jun Hayashi
    Citation: Infectious Agents and Cancer 2016 11:9
  44. We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi’s sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseli...

    Authors: Anna Maria Cattelan, Adriana Mattiolo, Angela Grassi, Maria Assunta Piano, Lolita Sasset, Marco Trevenzoli, Paola Zanovello and Maria Luisa Calabrò
    Citation: Infectious Agents and Cancer 2016 11:5
  45. Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas g...

    Authors: Shegan Gao, Shuoguo Li, Zhikun Ma, Shuo Liang, Tanyou Shan, Mengxi Zhang, Xiaojuan Zhu, Pengfei Zhang, Gang Liu, Fuyou Zhou, Xiang Yuan, Ruinuo Jia, Jan Potempa, David A. Scott, Richard J. Lamont, Huizhi Wang…
    Citation: Infectious Agents and Cancer 2016 11:3
  46. Human Papillomavirus (HPV) is well known pathogen that can cause benign and malignant tumors in humans, yet there is very little information regarding HPV types prevalent in Pakistan.

    Authors: Abdullah Abdullah, Muhammad Qasim, Muhammad Shafiq, Muhammad Ijaz, Shamsa Parveen, Shahnaz Murtaza, Qamar Javed, Salman Akbar Malik, Shahida Husain Tarar, Sajid Mehmood, Abdul Sami, Syed Muhammad Saqlan Naqvi and Muhammad Zeeshan Hyder
    Citation: Infectious Agents and Cancer 2016 11:1
  47. Simple epithelial keratins appear early during embryonic development and are expressed in non-stratified, ductal and pseudo-stratified epithelial tissues. CK19, the lowest molecular weight keratin, is also exp...

    Authors: Angela Santoro, Giuseppe Pannone, Rossella Ninivaggi, Massimo Petruzzi, Andrea Santarelli, Giuseppe Maria Russo, Silvia Lepore, Michele Pietrafesa, Ilaria Laurenzana, Rosalia Leonardi, Paolo Bucci, Maria Iole Natalicchio, Alberta Lucchese, Silvana Papagerakis and Pantaleo Bufo
    Citation: Infectious Agents and Cancer 2015 10:46

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