Skip to main content

Non-pulmonary cancer risk following tuberculosis: a nationwide retrospective cohort study in Lithuania



Lithuania remains one of the highest tuberculosis burden countries in Europe. Epidemiological studies have long pointed to infections as important factors of cancer aetiology, but the association between tuberculosis and the risk of non-pulmonary cancers has rarely been tested and results have been inconsistent. The aim of this population-based cohort study was to examine the risk of cancer among patients diagnosed with tuberculosis using data from Lithuanian Tuberculosis, Cancer and Resident’s Registries.


The study cohort included 21,986 tuberculosis patients yielding 1583 cancers diagnosed during follow-up (1998–2012). Standardized incidence ratios (SIRs) and 95% confidence intervals (95% CIs) were calculated to compare the incidence of cancer among cohort participants with the general population for overall, non-pulmonary, site-specific cancers, as well as for subgroups of smoking-related, alcohol-related, hormone-related and haematological cancers.


The SIRs of all cancers combined were 1.89, 95% CI: 1.79–2.00 in men and 1.34, 95% CI: 1.19–1.50 in women. Risk was increased 3-fold within the first year following diagnosis; it decreased during later years, although remained significantly elevated for ≥5 years. Elevated long-term increased risks persisted for non-pulmonary cancers overall, and for cancers of mouth and pharynx, oesophagus, stomach, larynx, cervix uteri and leukaemias. Tuberculosis was associated with a decreased risk of melanoma. Increased risks were observed for smoking-related cancers in men (SIR 1.95, 95% CI: 1.79–2.13) and women (SIR 1.46, 95% CI: 1.22–1.73), alcohol-related cancers in men (SIR 2.40; 95% CI: 2.14–2.68) and haematological cancers in men (SIR 1.73, 95% CI: 1.33–2.23). The risk of hormone-related cancers was 18% lower (SIR = 0.82, 95% CI: 0.66–0.997) among women, the inverse association was weaker among men (SIR = 0.95, 95% CI: 0.84–1.07).


The risk of total and several non-pulmonary cancers was elevated in a cohort of tuberculosis patients. The recommendation for the awareness of this association among physicians is warranted. Analysis suggests a reduction in risk of hormone-related cancers and melanoma.


The latest World Health Organization (WHO) global tuberculosis report shows 10.4 million new tuberculosis cases and 1.4 million deaths due to tuberculosis worldwide in 2015 [1]. With 1600 new cases (56 cases per 100,000 population) in 2015 Lithuania remains among the countries with the highest incidence of tuberculosis in Europe, although due to recent decrease in rates it is no longer in the WHO’s list of high tuberculosis burden countries [1]. The incidence of cancer of several types in Lithuania is among the highest in the world [2].

In addition to smoking or environmental factors, a growing number of bacterial and parasitic infections have been associated with development of cancer [3]. Former analyses observed an increased risk of lung cancer in tuberculosis cohorts, although conclusions with regards to confounding effects of smoking were inconsistent [4,5,6,7]. Recently the association between tuberculosis infection and certain non-pulmonary malignancies (multiple myeloma [8]; myeloid leukaemia [4], leukaemia [9], Non-Hodgkin lymphoma [4, 10, 11], Hodgkin lymphoma [11, 12], melanoma [13], as well as oesophageal [4, 9], kidney and bladder [8, 9], liver [4, 9] and other cancers [8, 9]) has been reported; however, the evidence remains inconclusive due to the low incidence of cancer following tuberculosis, small sample size or short follow-up. Previous studies led to the suggestion that inflammation caused by Mycobacterium tuberculosis infection, could induce genetic damage promoting carcinogenesis [14]. Prior tuberculosis might also indicate the immune deficiency and increased risk for cancer as a result. In addition, chronic immune stimulation and certain infectious diseases have been shown to have a protective effect against cancer, although studies have been inconsistent [11, 15, 16]. Detailed investigation of association between tuberculosis and cancer is important for elucidating the role of this chronic infection in occurrence of cancer as well as for developing an effective cancer prevention strategy.

In this analysis, we aimed to investigate association between tuberculosis infection and risk of overall and site-specific non-pulmonary cancer using a population-based national cohort data.


Study population

The study was performed using new cases of tuberculosis diagnosed from January 1, 1998 to December 31, 2012; they were identified at the Lithuanian Tuberculosis registry, which covers the entire population. For each individual, information on date of birth, sex, date of diagnosis, diagnosis codes according to ICD-10 (International Statistical Classification of Diseases, 10th Revision) was obtained. In all, 30,594 individuals were available for analysis. Since the occurrence of cancer is rare in the youngest age groups, and diagnoses of the disease are less reliable for those in old age [17] only individuals of 25 to 75 years old at tuberculosis diagnosis were included. More detailed information about the study has been published elsewhere [7]. We excluded records due to age (19.8%), cancer other than non-melanoma skin cancer before start of follow-up (4.8%), unknown vital status (3.1%), duplicates or insufficient data (0.4%), and not being a Lithuanian citizen (0.03%). The final number of participants, included in the current analysis, was 21,986. For patients with multiple cancers, each non-melanoma skin cancer diagnosis was considered as an individual event.

Case ascertainment

For each subject, date of entry into cohort was the date of diagnosis of tuberculosis, and date of exit was the date of diagnosis of cancer other than non-melanoma skin cancer, death, emigration, or 31 December 2012, whichever occurred first. We identified cases of cancer from the Lithuanian Cancer Registry (LCR). The LCR has population-based information available since 1978; data since the year 1988 have been included in ‘Cancer Incidence in Five Continents’ [18]. Dates of death and emigration were ascertained by linkage to the Lithuanian Residents’ Register Service. The linkages were performed using an individual personal identification number. For calculation of Standardized incidence ratios (SIRs), cancer incidence and population data were obtained from the LCR and Lithuanian Department of Statistics.

Data analysis

We calculated SIRs of total and site-specific non-pulmonary cancer in the tuberculosis cohort, based on person-days of ‘follow-up’. Expected numbers were obtained by multiplying Lithuanian national cancer incidence rates according to sex-, age- (5-year groups) and calendar period (1998–2002, 2003–2007 and 2008–2012), by corresponding stratum-specific number of person-days of follow-up accrued in the cohort. Then these stratum-specific expected numbers were summed across all strata in the cohort to obtain the expected total number of people with lung cancer in the cohort. We calculated SIRs by dividing the observed number of events by that expected. We calculated 95% confidence intervals (95% CI) for the SIRs assuming a Poisson distribution. Stratified analysis was performed according to the years since tuberculosis diagnosis and sex. SIRs were computed for total, non-pulmonary, tobacco-related [19], alcohol-related [19], haematological, hormone-related [20, 21] and site-specific cancers.

Analyses were performed using SPSS 19. All tests were two-tailed, and P value below 0.05 was considered statistically significant.


A total of 21,986 patients (70.3% male) with tuberculosis were enrolled in the study (Table 1). The mean age at tuberculosis diagnosis was 47.1 years. The percent of smokers was 63.8% among total population, 78.0% among men and 30.2% among women. Among patients with tuberculosis, 59.3% were unemployed and only 6.4% had high school education. We followed the cohort for a total of 136,816 person-years. During the follow-up we observed 1583 cancers. There were 62 persons having two cancers.

Table 1 Characteristics of cohort members

Total cancer SIR among tuberculosis patients, compared with the general population was 1.76, 95% CI: 1.67–1.85 (Table 2). When lung cancer was excluded, all-time SIR was 1.41, 95% CI: 1.33–1.50. Short-term and long-term risks of non-pulmonary cancer were significantly increased, SIR = 2.03, 95% CI: 1.75–2.34 within first 1 year after diagnosis, 1.38, 95% CI: 1.25–1.52 during 1–4 years and 1.29, 95% CI: 1.18–1.41 during ≥5 years of follow-up (Table 2).

Table 2 Cancer incidence in patients with tuberculosis according to time since tuberculosis diagnosis

Analysis by cancer type revealed high risks of mouth and pharynx, oesophagus, stomach, liver, pancreas, larynx and bladder cancer (Table 2). Tuberculosis was also positively associated with leukaemias, Hodgkin lymphoma, bone, mesothelial & soft tissue as well as “other” cancers. In addition, results revealed reduced risk of melanoma, SIR = 0.48, 95% CI: 0.19–0.96. Risk of most non-pulmonary cancers was significantly increased within the first year. Elevated long-term risks (≥5 years) persisted for cancers of the mouth and pharynx (SIR = 3.24, 95% CI: 2.36–4.33), oesophagus (SIR = 3.57, 95% CI: 2.33–5.23), stomach (SIR = 1.67, 95% CI: 1.22–2.23), larynx (SIR = 1.96, 95% CI: 1.14–3.14), cervix uteri (SIR = 2.73, 95% CI: 1.77–4.03), leukaemias (SIR = 1.90, 95% CI: 1.16–2.93) and for “other” cancers (SIR = 1.50, 95% CI: 1.04–2.10).

The SIRs of total and most site-specific cancers were higher in men than in women (Table 3). Among men with tuberculosis SIR’s were substantially increased for mouth and pharynx, oesophagus, stomach, liver, larynx, bladder, bone, mesothelial and soft tissue cancer, Hodgkin lymphoma, leukaemias and “other” cancer. In contrast, there was reduced incidence of prostate cancer, SIR 0.88, 95% CI: 0.76–1.02. Women were at increased risk of cancer of mouth and pharynx, larynx and cervix uteri, and at reduced risk of cancer of colon, SIR 0.39, 95% CI: 0.13–0.92. High risks of tobacco-related cancers were observed among men (SIR = 1.95, 95% CI: 1.79–2.13) and women (SIR = 1.46, 95% CI: 1.22–1.73). Alcohol-related cancers showed an increased SIR of 2.40, 95% CI: 2.14–2.68 among men, whereas among women there was no increase in risk. An elevated SIR of haematological cancers was also seen for men (SIR = 1.73, 95% CI: 1.33–2.23), it showed a not statistically significant increase in women (SIR = 1.48, 95% CI: 0.93–2.24). The risk of hormone-related cancers was 18% lower (SIR = 0.82, 95% CI: 0.66–0.997) among women, the inverse association was weaker among men (SIR = 0.95, 95% CI: 0.84–1.07).

Table 3 Cancer incidence in patients with tuberculosis according to type, sex and aetiology


This study, based on a large retrospective cohort, has found a higher than expected risk of cancers of most types in men and women with tuberculosis. Increased risks of tobacco-related cancers, alcohol-related cancers and haematological cancers were observed. The risk of hormone-related cancers and melanoma was lower. Risk remained increased for ≥5 years for most smoking- and alcohol-related cancers, cancer of cervix uteri and leukaemias.

Our data on the 1.8-fold increased risk of overall cancer and 1.4-fold increased risk of non-pulmonary cancer among tuberculosis patients are in line with results from previous studies and reviews [4, 9, 22, 23].. In a Danish nationwide cohort study, comparing cancer risk in tuberculosis patients and the general population, the SIR for all cancers was 1.52, 95% CI: 1.45–1.59, whereas for non-pulmonary cancer it was 1.29, 95% CI: 1.22–1.36 [4]. Tuberculosis infection was also associated with increased long-term risk of tobacco-related and haematological malignancies. The incidence of cancer was also increased in the Taiwan Latent Tuberculosis Infection Cohort [8] and in the Estonian population-based cohort where the standardized mortality ratio for all cancers was 2.85, 95% CI: 2.17–3.68 for men and 3.80, 95% CI: 2.22–6.09 for women [22]. Another population-based study in Taiwan found that after a tuberculosis diagnosis the risk was 2.1-fold for total cancer and 1.7-fold for non-pulmonary cancer [9].

Several studies have reported an increased risk of Hodgkin or non-Hodgkin lymphoma in individuals with a history of tuberculosis [9,10,11,12]. In addition, significantly elevated long-term risks for leukaemia were observed [4, 9]. Similarly, the elevated SIRs for Hodgkin lymphoma as well as leukaemia were found in our study. Tuberculosis was associated with markedly increased long-term risk of cervical cancer in our study. Our analysis also revealed reduced risk of melanoma among patients with tuberculosis, in contrast with Taiwanese study results, where melanoma risk among men was significantly increased, particularly during <1 year after tuberculosis diagnosis [9]. Our data are in agreement with case-control study performed by Kölmel KF et al. in six European countries and Israel, where significantly lower Odds ratios of melanoma were found for pulmonary tuberculosis, as well as other infections and BCG vaccination [13].

The mechanism underlying the increase of the long-term risk of cancer following tuberculosis is still not clear. Certain infectious episodes including tuberculosis may potentially trigger the development of Hodgkin lymphoma [12]. Previous studies have also supported an underlying immune deficiency many years prior to cancer diagnosis as a primary phenomenon for haematological cancers [12, 24]. Tuberculosis may induce a prolonged inflammatory response hence, inflammation may explain the increased long-term cancer risk. Occurrence of cervical cancer after tuberculosis has previously been reported rarely. There is a possibility that patients with human papilloma virus infection have a higher chance to encounter tuberculosis. In addition, it has been suggested that the Mycobacterium tuberculosis infection mediates down regulation of dendritic cells function and thereby facilitates the suppression of the host’s immunity against infectious pathogens and cervical cancer [25]. It has also been suggested that diverse microbial stimuli induce a defence against cancer: both vaccinations and previous episodes of having a severe infectious disease may induce a protective mechanism, possibly an infection-related Th1-cell activation that prevents the development of melanoma [13, 15]. The long-term increased risk may also be due to certain lifestyle factors, such as smoking or alcohol abuse that are strong risk factors for both tuberculosis and cancer [7, 14, 26,27,28,29,30,31]. E.g., most people with tuberculosis were tobacco smokers (64%) or heavy alcohol users (35%) in our study and we observed elevated all-term SIRs for smoking- or alcohol-related cancers, thus it is plausible that tobacco smoking and alcohol intake are important shared risk factors. Finally, malnutrition is a risk factor for tuberculosis and low body mass index (BMI) is prevalent in tuberculosis patients [32, 33]. There is substantial evidence that obesity increases the risks of breast, endometrial, ovarian cancer, malignant melanoma as well as some other cancers; its influence is most likely mediated through hormonal mechanisms [20]. Low body weight could possibly explain a reduced risk of hormone-related cancers or melanoma in the present study.

The strengths of our study include the use of nationwide population-based registers and the cohort setting which reduced selection bias at baseline. The study also has limitations. There was no appropriate control group to compare the incidence of cancer. It is possible, that patients with tuberculosis differ from the general population with respect to lifestyle factors, like use of tobacco or alcohol. As these factors have been found to be risk factors for various cancer types, confounding by them is likely [27, 28, 34]. In addition, it is possible that the study cohort included individuals with cancer, because tumours may have been interpreted as tuberculosis lesion prior to cancer diagnosis. There is also a potential for bias due to reverse causality, if occult cancer caused a weakening of immunity and malnutrition, resulting in Mycobacterium tuberculosis infection or reactivation [35]. Thus, tuberculosis may become clinically apparent earlier than cancer, even though cancer preceded tuberculosis reactivation. Bias from closer medical surveillance received by individuals with tuberculosis than healthy individuals is likely to have had an effect, especially within the first year. However, a reduced risk for melanoma, colon, breast, prostate and thyroid cancer suggests that reverse causality or higher diagnostic activity are unlikely to play major role.


The overall and non-pulmonary cancer risk was elevated in a cohort of tuberculosis patients in relation to the general Lithuanian population. High risks were observed for smoking- and alcohol-related cancers, haematological cancers and cancer of cervix uteri. In addition, we found reduced risk for hormone-related cancers and melanoma. This retrospective study provides suggestion that tuberculosis may be associated with a risk of some non-pulmonary cancers; however, the possibility of confounding effects cannot be completely ruled out. Further studies are needed to determine the role of potential underlying mechanisms in non-pulmonary cancer development among tuberculosis patients. The recommendation for the awareness of this association among physicians remains warranted.


95% CI:

95% Confidence Interval


Body mass index


International Statistical Classification of Diseases, 10th Revision


Lithuanian Cancer Registry


Standardized incidence ratio


World Health Organization


  1. World Health Organization. Global tuberculosis report 2016. World Health Organization, 2016. (accessed 7 Nov 2016).

  2. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86. doi:10.1002/ijc.29210.

    Article  CAS  PubMed  Google Scholar 

  3. Samaras V, Rafailidis PI, Mourtzoukou EG, Peppas G, Falagas ME. Chronic bacterial and parasitic infections and cancer: a review. J Infect Dev Ctries. 2010;4(5):267–81.

    PubMed  Google Scholar 

  4. Simonsen DF, Farkas DK, Søgaard M, Horsburgh CR, Sørensen HT, Thomsen RW. Tuberculosis and risk of cancer: a Danish nationwide cohort study. Int J Tuberc Lung Dis. 2014;18(10):1211–9.

    Article  CAS  PubMed  Google Scholar 

  5. Hong S, Mok Y, Jeon C, Jee SH, Samet JM. Tuberculosis, smoking and risk for lung cancer incidence and mortality. Int J Cancer. 2016;139(11):2447–55.

    Article  CAS  PubMed  Google Scholar 

  6. Brenner DR, McLaughlin JR, Hung RJ. Previous lung diseases and lung cancer risk: a systematic review and meta-analysis. PLoS One. 2011;6(3):e1747. doi:10.1371/journal.pone.0017479.9.

    Article  Google Scholar 

  7. Everatt R, Kuzmickiene I, Davidaviciene E, Cicenas S. Incidence of lung cancer among patients with tuberculosis: a nationwide cohort study in Lithuania. Int J Tuberc Lung Dis. 2016;20(6):757–63.

    Article  CAS  PubMed  Google Scholar 

  8. Su VY, Yen YF, Pan SW, Chuang PH, Feng JY, Chou KT, et al. Latent tuberculosis infection and the risk of subsequent cancer. Medicine. 2016;95(4):e2352. doi:10.1097/MD.0000000000002352.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Kuo SC, Hu YW, Liu CJ, Lee YT, Chen YT, Chen TL, et al. Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study. Br J Cancer. 2013;109:229–34.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Askling J, Ekbom A. Risk of non-Hodgkin’s lymphoma following tuberculosis. Br J Cancer. 2001;84(1):113–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Tavani A, La Vecchia C, Franceschi S, Serraino D, Carbone A. Medical history and risk of Hodgkin's and non-Hodgkin's lymphomas. Eur J Cancer Prev. 2000;9(1):59–64.

    Article  CAS  PubMed  Google Scholar 

  12. Kristinsson SY, Gao Y, Björkholm M, Lund SH, Sjöberg J, Caporaso N, et al. Hodgkin lymphoma risk following infectious and chronic inflammatory diseases: a large population-based case-control study from Sweden. Int J Hematol. 2015;101(6):563–8.

    Article  PubMed  Google Scholar 

  13. Kölmel KF, Pfahlberg A, Mastrangelo G, Niin M, Botev IN, Seebacher C, et al. Infections and melanoma risk: results of a multicentre EORTC case-control study. European Organization for Research and Treatment of Cancer. Melanoma res. 1999;9(5):511–9.

    Article  PubMed  Google Scholar 

  14. Schottenfeld D, Beebe-Dimmer J. Chronic inflammation: a common and important factor in the pathogenesis of neoplasia. CA Cancer J Clin. 2006;56(2):69–83.

    Article  PubMed  Google Scholar 

  15. Krone B, Kölmel KF, Grange JM, Mastrangelo G, Henz BM, Botev IN, et al. Impact of vaccinations and infectious diseases on the risk of melanoma - evaluation of an EORTC case-control study. Eur J Cancer. 2003;39(16):2372–8.

    Article  CAS  PubMed  Google Scholar 

  16. Holla S, Ghorpade DS, Singh V, Bansal K, Balaji KN. Mycobacterium bovis BCG promotes tumor cell survival from tumor necrosis factor-α-induced apoptosis. Mol Cancer. 2014;13:210. doi:10.1186/1476-4598-13-210.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Fallah M, Kharazmi E. Correction for under-ascertainment in cancer cases in the very elderly (aged 75+): external reference method. Cancer Causes Control. 2008;19(7):739–49.

    Article  PubMed  Google Scholar 

  18. Forman D, Bray F, Brewster DH, Gombe Mbalawa C, Kohler B, Piñeros M, et al., editors. Cancer incidence in five continents. Vol. X. IARC scientific publication no. 164. Lyon: International Agency for Research on Cancer; 2014.

    Google Scholar 

  19. International agency for research on cancer (IARC). IARC monographs on the evaluation of carcinogenic risks to humans. A review of human carcinogens: personal habits and indoor combustions, vol. Volume 100E. Lyon: IARC; 2012.

    Google Scholar 

  20. Stewart BW, Wild CP, editors. World cancer report 2014. Lyon: IARC; 2014.

    Google Scholar 

  21. Zadnik V, Krajc M. Epidemiological trends of hormone-related cancers in Slovenia. Arh Hig Rada Toksikol. 2016;67:83–92.

    Article  PubMed  Google Scholar 

  22. Blöndal K, Rahu K, Altraja A, Viiklepp P, Rahu M. Overall and cause-specific mortality among patients with tuberculosis and multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2013;17(7):961–8.

    Article  PubMed  Google Scholar 

  23. Falagas ME, Kouranos VD, Athanassa Z, Kopterides P. Tuberculosis and malignancy. Q J med. 2010;103:461–87.

    Article  CAS  Google Scholar 

  24. Mbulaiteye SM, Biggar RJ, Goedert JJ, Engels EA. Immune deficiency and risk for malignancy among persons with AIDS. J Acquir Immune Defic Syndr. 2003;32:527–33.

    Article  PubMed  Google Scholar 

  25. Manickam A, Sivanandham M. Mycobacterium bovis BCG and purified protein derivative-induced reduction in the CD80 expression and the antigen up-take function of dendritic cells from patients with cervical cancer. Eur J Obstet Gynecol Reprod Biol. 2011;159(2):413–7.

    Article  CAS  PubMed  Google Scholar 

  26. Rehm J, Samokhvalov AV, Neuman MG, Room R, Parry C, Lönnroth K, et al. The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review. BMC Public Health. 2009;9:450. doi:10.1186/1471-2458-9-450.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Everatt R, Kuzmickienė I, Virvičiūtė D, Tamošiūnas A. Cigarette smoking, educational level and total and site-specific cancer: a cohort study in men in Lithuania. Eur J Cancer Prev. 2014;23(6):579–86.

    Article  CAS  PubMed  Google Scholar 

  28. Everatt R, Tamosiunas A, Virviciute D, Kuzmickiene I, Reklaitiene R. Consumption of alcohol and risk of cancer among men: a 30 year cohort study in Lithuania. Eur J Epidemiol. 2013;28(5):383–92.

    Article  PubMed  Google Scholar 

  29. Waitt CJ, Squire SB. A systematic review of risk factors for death in adults during and after tuberculosis treatment. Int J Tuberc Lung Dis. 2011;5:871–85.

    Article  Google Scholar 

  30. Cogliano VJ, Baan R, Straif K, Grosse Y, Lauby-Secretan B, El Ghissassi F, et al. Preventable exposures associated with human cancers. J Natl Cancer Inst. 2011;103(24):1827–39.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Marais BJ, Lönnroth K, Lawn SD, Migliori GB, Mwaba P, Glaziou P, et al. Tuberculosis comorbidity with communicable and non-communicable diseases: integrating health services and control efforts. Lancet Infect Dis. 2013;13(5):436–48.

    Article  PubMed  Google Scholar 

  32. Kumari P, Meena LS. Factors affecting susceptibility to Mycobacterium tuberculosis: a close view of immunological defence mechanism. Appl Biochem Biotechnol. 2014;174(8):2663–73.

    Article  CAS  PubMed  Google Scholar 

  33. Hayashi S, Takeuchi M, Hatsuda K, Ogata K, Kurata M, Nakayama T, et al. The impact of nutrition and glucose intolerance on the development of tuberculosis in Japan. Int J Tuberc Lung Dis. 2014;18(1):84–8.

    Article  CAS  PubMed  Google Scholar 

  34. McKenzie F, Biessy C, Ferrari P, Freisling H, Rinaldi S, Chajès V, et al. Healthy lifestyle and risk of cancer in the European prospective investigation into cancer and nutrition cohort study. Medicine (Baltimore). 2016;95(16):e2850. doi:10.1097/MD.0000000000002850.

    Article  Google Scholar 

  35. Vento S, Lanzafame M. Tuberculosis and cancer: a complex and dangerous liaison. Lancet Oncol. 2011;12(6):520–2.

    Article  PubMed  Google Scholar 

Download references


The authors wish to thank the Lithuanian Tuberculosis Registry, the Lithuanian Cancer Registry and the Lithuanian Residents’ Register Service for making data available.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Availability of data and materials

The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request.

Authors’ contributions

The study was designed and coordinated by RE and ED. Data acquisition and cleaning was performed by IK, ED, RE. IK and RE prepared the final database, analyzed and interpreted the data and prepared the manuscript. SC contributed to the initial study idea, study design, critically revised the article. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Not applicable.

Ethics approval and consent to participate

The current study was approved by the Regional Biomedical Research Ethical Committee (No. 158200–14–736-252) and Lithuanian Data Protection Agency (2014–11-05 No. 2R-5434 (2.6–1.)). Obtaining a patient consent is not mandatory for this type of study in Lithuania.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ruta Everatt.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Everatt, R., Kuzmickiene, I., Davidaviciene, E. et al. Non-pulmonary cancer risk following tuberculosis: a nationwide retrospective cohort study in Lithuania. Infect Agents Cancer 12, 33 (2017).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: