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Table 3 Cancer incidence in patients with tuberculosis according to type, sex and aetiology

From: Non-pulmonary cancer risk following tuberculosis: a nationwide retrospective cohort study in Lithuania

Type of cancer

ICD-O

Men

Women

Exp

Obs

SIR (95% CI)

Exp

Obs

SIR (95% CI)

All but NMS

C00–96, excl. C44

710.6

1285

1.89 (1.79–2.00)

224.7

298

1.34 (1.19–1.50)

All but NMS & lung

C00–96, excl. C44, C33–34

567.4

850

1.50 (1.40–1.60)

214.6

255

1.19 (1.05–1.34)

 Mouth, pharynx

C01–14

30.0

116

3.98 (3.28–4.77)

2.0

6

3.05 (1.12–6.64)

 Oesophagus

C15

15.5

60

4.01 (3.06–5.16)

0.8

3

3.72 (0.77–10.90)

 Stomach

C16

47.8

75

1.65 (1.30–2.07)

11.7

16

1.38 (0.79–2.24)

 Colon

C18

31.8

35

1.16 (0.81–1.62)

12.9

5

0.39 (0.13–0.92)

 Rectum

C19–21

31.8

37

1.23 (0.87–1.70)

10.0

6

0.61 (0.22–1.32)

 Liver

C22

9.0

19

2.23 (1.34–3.48)

2.1

2

0.98 (0.12–3.52)

 Pancreas

C25

21.6

33

1.60 (1.10–2.25)

6.2

9

1.47 (0.67–2.79)

 Larynx

C32

19.7

49

2.58 (1.91–3.42)

0.4

4

10.88 (2.95–27.7)

 Bone, mesothelial & soft tissue

C40–41, C45, C47, C49

5.0

11

2.29 (1.14–4.09)

1.8

3

1.64 (0.34–4.82)

 Melanoma

C43

8.9

4

0.46 (0.13–1.19)

6.1

3

0.50 (0.10–1.45)

 Breast

C50

 

-

 

51.9

50

0.96 (0.72–1.27)

 Cervix uteri

C53

 

-

 

19.7

51

2.60 (1.93–3.42)

 Corpus uteri

C54, C55

 

-

 

19.9

13

0.66 (0.35–1.13)

 Ovary

C56

 

-

 

14.9

16

1.08 (0.62–1.76)

 Prostate

C61

219.2

184

0.88 (0.76–1.02)

-

  

 Kidney

C64

36.8

34

0.96 (0.67–1.34)

9.1

12

1.34 (0.69–2.33)

 Bladder

C67

25.6

44

1.83 (1.33–2.46)

2.9

4

1.39 (0.38–3.57)

 Brain, CNS

C70–72

11.3

15

1.37 (0.76–2.25)

4.8

2

0.42 (0.05–1.52)

 Thyroid

C73

4.8

2

0.43 (0.05–1.55)

10.9

8

0.74 (0.32–1.47)

 HL

C81

2.0

6

2.98 (1.09–6.49)

1.0

2

1.98 (0.24–7.15)

 NHL & other LHT

C82–85, C88, C90, C96

18.7

22

1.23 (0.77–1.86)

8.0

12

1.51 (0.78–2.64)

 Leukaemias

C91–95

16.0

33

2.17 (1.49–3.05)

6.0

8

1.35 (0.58–2.66)

 Other

 

35.4

71

2.00 (1.57–2.53)

12.7

20

1.58 (0.96–2.43)

Cancers by aetiology

 Alcohol-related

C01–15, C18–22, C32, C50

131.7

316

2.40 (2.14–2.68)

79.7

76

0.95 (0.75–1.19)

 Smoking-related

C01–16, C18–22, C25, C30–32, C34, C53, C56, C64–68

257.0

502

1.95 (1.79–2.13)

91.8

134

1.46 (1.22–1.73)

 Haematological

C81–85, C88, C90–96

35.2

61

1.73 (1.33–2.23)

14.9

22

1.48 (0.93–2.24)

 Hormone-related

C18–21, C50, C54–56, C61, C62, C73

276.8

263

0.95 (0.84–1.07)

119.8

98

0.82 (0.66–0.997)

  1. Exp expected cases, Obs observed cases, SIR standardized incidence ratio, CI confidence interval, NMS non-melanoma skin, HL Hodgkin lymphoma, NHL Non-Hodgkin lymphoma, LHT lympho-, haematopoietic tissue