Table 2 Cancer incidence in patients with tuberculosis according to time since tuberculosis diagnosis
Type of cancer | ICD-O | Time since tuberculosis diagnosis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 year | 1–4 years | ≥5 years | Total | ||||||||||
Exp | Obs | SIR (95% CI) | Exp | Obs | SIR (95% CI) | Exp | Obs | SIR (95% CI) | Exp | Obs | SIR (95% CI) | ||
All but NMS | C00–96, excl. C44 | 107.7 | 347 | 3.22 (2.89–3.58) | 377.0 | 625 | 1.74 (1.60–1.88) | 450.5 | 611 | 1.36 (1.25–1.47) | 935.2 | 1583 | 1.76 (1.67–1.85) |
All but NMS & lung | C00–96, excl. C44, C33, C34 | 91.6 | 186 | 2.03 (1.75–2.34) | 310.9 | 429 | 1.38 (1.25–1.52) | 379.6 | 490 | 1.29 (1.18–1.41) | 782.1 | 1105 | 1.41 (1.33–1.50) |
Mouth, pharynx | C01–14 | 4.3 | 20 | 4.65 (2.84–7.18) | 13.8 | 57 | 4.27 (3.24–5.54) | 13.9 | 45 | 3.24 (2.36–4.33) | 32.0 | 122 | 3.92 (3.25–4.68) |
Oesophagus | C15 | 2.1 | 9 | 4.28 (1.96–8.13) | 7.0 | 28 | 4.22 (2.80–6.10) | 7.3 | 26 | 3.57 (2.33–5.23) | 16.4 | 63 | 3.99 (3.07–5.11) |
Stomach | C16 | 7.6 | 16 | 2.11 (1.21–3.44) | 24.9 | 30 | 1.28 (0.86–1.83) | 27.0 | 45 | 1.67 (1.22–2.23) | 59.4 | 91 | 1.60 (1.29–1.96) |
Colon | C18 | 4.9 | 2 | 0.41 (0.05–1.47) | 17.4 | 20 | 1.21 (0.74–1.87) | 22.3 | 18 | 0.81 (0.48–1.27) | 44.7 | 40 | 0.93 (0.67–1.27) |
Rectum | C19–21 | 4.8 | 6 | 1.25 (0.46–2.75) | 16.7 | 14 | 0.89 (0.49–1.48) | 20.2 | 23 | 1.14 (0.72–1.71) | 41.7 | 43 | 1.08 (0.78–1.45) |
Liver | C22 | 1.2 | 3 | 2.47 (0.51–7.25) | 4.3 | 9 | 2.20 (1.01–4.19) | 5.5 | 9 | 1.63 (0.74–3.09) | 11.1 | 21 | 1.98 (1.23–3.03) |
Pancreas | C25 | 3.3 | 10 | 3.00 (1.44–5.52) | 11.3 | 16 | 1.50 (0.86–2.43) | 13.2 | 16 | 1.21 (0.69–1.97) | 27.8 | 42 | 1.57 (1.13–2.12) |
Larynx | C32 | 2.7 | 14 | 5.17 (2.82–8.67) | 8.7 | 22 | 2.67 (1.67–4.04) | 8.7 | 17 | 1.96 (1.14–3.14) | 20.0 | 53 | 2.74 (2.05–3.59) |
Bone, mesothelial & soft tissue | C40–41, C45, C47, C49 | 0.9 | 4 | 4.43 (1.21–11.40) | 2.9 | 4 | 1.44 (0.39–3.68) | 3.1 | 6 | 1.97 (0.72–4.28) | 6.8 | 14 | 2.11 (1.15–3.54) |
Melanoma | C43 | 1.7 | 1 | 0.58 (0.02–3.22) | 6.0 | 3 | 0.51 (0.11–1.50) | 7.3 | 3 | 0.41 (0.08–1.20) | 15.0 | 7 | 0.48 (0.19–0.96) |
Breasta | C50 | 5.7 | 3 | 0.53 (0.11–1.55) | 20.3 | 15 | 0.74 (0.41–1.22) | 25.9 | 32 | 1.21 (0.83–1.70) | 51.9 | 50 | 0.96 (0.72–1.27) |
Cervix uteri | C53 | 2.4 | 6 | 2.51 (0.92–5.44) | 8.2 | 20 | 2.43 (1.48–3.75) | 9.2 | 25 | 2.73 (1.77–4.03) | 19.7 | 51 | 2.60 (1.93–3.42) |
Corpus uteri | C54, C55 | 2.1 | 5 | 2.36 (0.77–5.50) | 7.5 | 2 | 0.26 (0.03–0.95) | 10.3 | 6 | 0.58 (0.21–1.27) | 19.9 | 13 | 0.66 (0.35–1.13) |
Ovary | C56 | 1.7 | 5 | 2.95 (0.96–6.86) | 5.8 | 2 | 0.34 (0.04–1.23) | 7.4 | 9 | 1.22 (0.56–2.32) | 14.9 | 16 | 1.08 (0.62–1.76) |
Prostate | C61 | 20.9 | 16 | 0.76 (0.44–1.24) | 84.0 | 66 | 0.83 (0.64–1.05) | 114.2 | 102 | 0.89 (0.73–1.08) | 219.2 | 184 | 0.88 (0.76–1.02) |
Kidney | C64 | 5.6 | 12 | 2.13 (1.10–3.72) | 19.0 | 20 | 1.10 (0.67–1.70) | 21.2 | 14 | 0.66 (0.36–1.11) | 45.9 | 46 | 1.04 (0.76–1.38) |
Bladder | C67 | 3.5 | 14 | 3.95 (2.16–6.62) | 11.7 | 19 | 1.77 (1.06–2.76) | 13.3 | 15 | 1.13 (0.63–1.87) | 28.5 | 48 | 1.79 (1.32–2.37) |
Brain, CNS | C70–72 | 2.1 | 3 | 1.45 (0.30–4.26) | 6.8 | 9 | 1.36 (0.62–2.59) | 7.3 | 5 | 0.69 (0.22–1.60) | 16.1 | 17 | 1.08 (0.63–1.73) |
Thyroid | C73 | 1.8 | 1 | 0.57 (0.01–3.15) | 6.3 | 2 | 0.32 (0.04–1.16) | 7.6 | 7 | 0.92 (0.37–1.90) | 15.6 | 10 | 0.65 (0.31–1.19) |
HL | C81 | 0.5 | 2 | 4.13 (0.50–14.90) | 1.4 | 4 | 2.83 (0.77–7.25) | 1.2 | 2 | 1.74 (0.21–6.30) | 3.1 | 8 | 2.65 (1.14–5.22) |
NHL & other LHT | C82–85, C88, C90, C96 | 3.0 | 8 | 2.71 (1.17–5.34) | 10.6 | 15 | 1.46 (0.82–2.41) | 13.2 | 11 | 0.84 (0.42–1.49) | 26.7 | 34 | 1.31 (0.91–1.84) |
Leukaemias | C91–95 | 2.6 | 3 | 1.16 (0.24–3.39) | 8.8 | 18 | 2.14 (1.27–3.38) | 10.6 | 20 | 1.90 (1.16–2.93) | 22.0 | 41 | 1.94 (1.39–2.63) |
Other |  | 6.0 | 23 | 3.84 (2.43–5.76) | 19.5 | 34 | 1.75 (1.21–2.44) | 22.7 | 34 | 1.50 (1.04–2.10) | 48.1 | 91 | 1.79 (1.43–2.21) |