Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917.
Article
CAS
PubMed
Google Scholar
O’Rorke MA, Ellison MV, Murray LJ, Moran M, James J, Anderson LA. Human papillomavirus related head and neck cancer survival: A systematic review and meta-analysis. Oral Oncol. 2012;48(12):1191–201.
Article
PubMed
Google Scholar
American Medical Association. ICD-10-CM 2016: The Complete Official Codebook. 2016 ed. Chicago: American Medical Association; 2016.
Google Scholar
Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the US population ages 20–44 years. Cancer. 2005;103(9):1843–49.
Article
PubMed
Google Scholar
Báez A. Genetic and environmental factors in head and neck cancer genesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008;26(2):174–200.
Article
PubMed
Google Scholar
Pulte D, Brenner H. Changes in Survival in Head and Neck Cancers in the Late 20th and Early 21st Century: A Period Analysis. Oncologist. 2010;15(9):994–1001.
Article
PubMed
PubMed Central
Google Scholar
Figueroa NR, Ortiz KJ, Pérez N, Villanueva E, Traverso M, Torres CR, et al. Cancer in Puerto Rico, 2004–2009. San Juan: Puerto Rico Central Cancer Registry; 2012.
Google Scholar
Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin S, et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 1988;48(11):3282–7.
CAS
PubMed
Google Scholar
Saracci R. The interactions of tobacco smoking and other agents in cancer etiology. Epidemiol Rev. 1987;9:175–93.
CAS
PubMed
Google Scholar
Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, et al. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst. 2007;99(10):777–89.
Article
PubMed
Google Scholar
Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000;92(9):709–20.
Article
CAS
PubMed
Google Scholar
Mork J, Lie AK, Glattre E, Hallmans G, Jellum E, Koskela P, et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med. 2001;344(15):1125–31.
Article
CAS
PubMed
Google Scholar
Báez A, Almodóvar JI, Cantor A, Celestin F, Cruz-Cruz L, Fonseca S, et al. High frequency of HPV16-associated head and neck squamous cell carcinoma in the Puerto Rican population. Head Neck. 2004;26(9):778–84.
Article
PubMed
Google Scholar
IARC Monograph. Human Papillomaviruses. IARC. 2012;100B:255–313.
Google Scholar
Van Doorslaer K, Tan Q, Xirasagar S, Bandaru S, Gopalan V, Mohamoud Y, et al. The Papillomavirus Episteme: a central resource for papillomavirus sequence data and analysis. Nucleic Acids Res. 2013;41:D571–8.
Article
PubMed
Google Scholar
Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 1990;63(6):1129–36.
Article
CAS
PubMed
Google Scholar
Dyson N, Howley PM, Münger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science. 1989;243(4893):934–37.
Article
CAS
PubMed
Google Scholar
Gillison ML, Shah KV. Human papillomavirus-associated head and neck squamous cell carcinoma: Mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers. Curr Opin Oncol. 2001;13(3):183–88.
Article
CAS
PubMed
Google Scholar
Fakhry C, Zhang Q, Nguyen-Tan PF, Rosenthal D, El-Naggar A, Garden AS, et al. Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma. J Clin Oncol. 2014;32(30):3365–73.
Article
PubMed
PubMed Central
Google Scholar
Gillison ML, D’Souza G, Westra W, Sugar E, Xiao W, Begum S, et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst. 2008;100(6):407–20.
Article
PubMed
Google Scholar
Deschler DG, Richmon JD, Khariwala SS, Ferris RL, Wang MB. The “new” head and neck cancer patient-young, nonsmoker, nondrinker, and HPV positive: evaluation. Otolaryngol Head Neck Surg. 2014;151(3):375–80.
Article
PubMed
PubMed Central
Google Scholar
Goldenberg D, Begum S, Westra WH, Khan Z, Sciubba J, Pai SI, et al. Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck. 2008;30:898–903.
Article
PubMed
Google Scholar
Schwartz SR, Yueh B, McDougall JK, Daling JR, Schwartz SM. Human papillomavirus infection and survival in oral squamous cell cancer: a population-based study. Otolaryngol Head Neck Surg. 2001;125(1):1–9.
Article
CAS
PubMed
Google Scholar
Dayyani F, Etzel CJ, Liu M, Ho CH, Lippman SM, Tsao AS. Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol. 2010;2:2–15.
Article
Google Scholar
Stadler ME, Patel MR, Couch ME, Hayes DN. Molecular biology of head and neck cancer: Risks and pathways. Hematol Oncol Clin North Am. 2008;22(6):1099–124.
Article
PubMed
PubMed Central
Google Scholar
American Joint Committee on Cancer. AJCC Cancer Staging Handbook 7. 7th ed. New York: Springer; 2011.
Google Scholar
de Roda Husman AM, Walboomers JM, van den Brule AJ, Meijer CJ, Snijders PJ. The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol. 1995;76(4):1057–62.
Article
PubMed
Google Scholar
Báez A, Cantor A, Fonseca S, Marcos-Martinez M, Mathews LA, Muro-Cacho CA, et al. Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma. Clin Cancer Res. 2005;11(9):3191–7.
Article
PubMed
Google Scholar
Fonseca S. The Incidence, Prognostic and Therapeutic Significance of HPV-16 E6/E7 Oncoproteins in Head and Neck Squamous Cell Carcinoma in Puerto Ricans. [master's thesis]. San Juan: University of Puerto Rico - School of Medicine; 2006. p. 67.
Bol V, Grégoire V. Biological basis for increased sensitivity to radiation therapy in HPV-positive head and neck cancers. Biomed Res Int. 2014;2014:1–6.
Article
Google Scholar
Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, et al. Improved Survival of Patients With Human Papillomavirus – Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial. J Natl Cancer Inst. 2008;100(4):261–69.
Article
CAS
PubMed
Google Scholar
Annertz K, Rosenquist K, Andersson G, Jacobsson H, Hansson BG, Wennerberg J. High-risk HPV and survival in patients with oral and oropharyngeal squamous cell carcinoma – 5-year follow up of a population-based study. Acta Otolaryngol. 2014;134(8):843–51.
Article
PubMed
Google Scholar
Nagel R, Martens-de Kemp SR, Buijze M, Jacobs G, Braakhuis BJ, Brakenhoff RH. Treatment response of HPV-positive and HPV-negative head and neck squamous cell carcinoma cell lines. Oral Oncol. 2013;49(6):560–66.
Article
PubMed
Google Scholar
Smeets SJ, Braakhuis BJ, Abbas S, Snijders PJ, Ylstra B, van de Wiel MA, et al. Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus. Oncogene. 2006;25(17):2558–64.
Article
CAS
PubMed
Google Scholar
Sepiashvili L, Bruce JP, Huang SH, O’Sullivan B, Liu FF, Kislinger T. Novel insights into head and neck cancer using next-generation “omic” technologies. Cancer Res. 2015;75(3):480–86.
Article
CAS
PubMed
Google Scholar
Perez-Ordonez B, Beauchemin M, Jordan RC. Molecular biology of squamous cell carcinoma of the head and neck. J Clin Pathol. 2006;59(5):445–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Braakhuis BJ, Snijders PJ, Keune WJ, Meijer C, Ruijter-Schippers HJ, Leemans C, et al. Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus. J Natl Cancer Inst. 2004;96(13):998–1006.
Article
CAS
PubMed
Google Scholar
Ramshankar V, Krishnamurthy A. Human papilloma virus in head and neck cancers-role and relevance in clinical management. Indian J Surg Oncol. 2013;4(1):59–66.
Article
PubMed
Google Scholar
Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010;363(1):24–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rieckmann T, Tribius S, Grob TJ, Meyer F, Busch CJ, Petersen C, et al. HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity. Radiother Oncol. 2013;107(2):242–46.
Article
CAS
PubMed
Google Scholar
Smith EM, Rubenstein LM, Haugen TH, Pawlita M, Turek LP. Complex etiology underlies risk and survival in head and neck cancer human papillomavirus, tobacco, and alcohol: a case for multifactor disease. J Oncol. 2012;2012(57):1–9.
Article
Google Scholar
Young RJ, Rischin D, Fisher R, McArthur GA, Fox SB, Peters LJ, et al. Relationship between epidermal growth factor receptor status, p16(INK4A), and outcome in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2011;20(6):1230–37.
Article
CAS
PubMed
Google Scholar