Table 2 Adjusted OR’s and 95 % CIs of HNSCC patients according to HPV-16 status and clinicopathological parameters
From: HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients
Variable | HPV-16 + (N = 97) | HPV-16 - (N = 88) | OR value, 95 % CI | P value | ||
|---|---|---|---|---|---|---|
No. | Percent | No. | Percent | |||
Age (y) | ||||||
≤ 60 | 45 | 46.4 | 38 | 43.2 | ||
> 60 | 52 | 53.6 | 50 | 56.8 | 1.14 [0.637 – 2.035] | 0.767 |
Sex | ||||||
Male | 89 | 91.8 | 75 | 85.2 | ||
Female | 8 | 8.2 | 13 | 14.8 | 1.93 [0.759 – 4.902] | 0.173 |
Tumor site | ||||||
Larynx | 41 | 42.3 | 42 | 47.7 | 0.866 [0.304 – 2.470] | 0.788 |
Oral Cavity | 36 | 37.1 | 32 | 36.4 | 0.998 [0.338 – 2.942] | 0.996 |
Pharynx | 20 | 20.6 | 14 | 15.9 | 1.675 [0.420 – 6.681] | 0.465 |
Stage of Disease | ||||||
I,II | 30 | 30.9 | 17 | 19.3 | ||
III,IV | 67 | 69.1 | 71 | 80.7 | 1.87 [0.945 – 3.700] | 0.091 |
Tumor grade | ||||||
SCC | 11 | 11.3 | 8 | 9.1 | ||
Well | 22 | 22.7 | 21 | 23.9 | 0.875 [0.226 – 3.385] | 0.847 |
Moderate | 55 | 56.7 | 52 | 59.1 | 0.729 [0.269 – 1.973] | 0.534 |
Poor | 9 | 9.3 | 7 | 7.9 | 0.720 [0.240 – 2.161] | 0.558 |
Nodal involvement | ||||||
Yes | 30 | 16.2 | 34 | 18.4 | ||
No | 67 | 36.2 | 54 | 29.2 | 0.711 [0.387-1.306] | 0.272 |
Tobacco status | ||||||
Yes | 88 | 90.7 | 75 | 85.2 | ||
No | 9 | 9.3 | 13 | 14.8 | 1.70 [0.686 – 4.186] | 0.265 |
Alcohol status | ||||||
Yes | 82 | 84.5 | 72 | 81.8 | ||
No | 15 | 15.5 | 16 | 18.2 | 1.22 [0.561 – 2.630] | 0.695 |