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Table 2 Adjusted OR’s and 95 % CIs of HNSCC patients according to HPV-16 status and clinicopathological parameters

From: HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients

Variable HPV-16 + (N = 97) HPV-16 - (N = 88) OR value, 95 % CI P value
  No. Percent No. Percent   
Age (y)
  ≤ 60 45 46.4 38 43.2   
  > 60 52 53.6 50 56.8 1.14 [0.637 – 2.035] 0.767
Sex
 Male 89 91.8 75 85.2   
 Female 8 8.2 13 14.8 1.93 [0.759 – 4.902] 0.173
Tumor site
 Larynx 41 42.3 42 47.7 0.866 [0.304 – 2.470] 0.788
 Oral Cavity 36 37.1 32 36.4 0.998 [0.338 – 2.942] 0.996
 Pharynx 20 20.6 14 15.9 1.675 [0.420 – 6.681] 0.465
Stage of Disease
 I,II 30 30.9 17 19.3   
 III,IV 67 69.1 71 80.7 1.87 [0.945 – 3.700] 0.091
Tumor grade
 SCC 11 11.3 8 9.1   
 Well 22 22.7 21 23.9 0.875 [0.226 – 3.385] 0.847
 Moderate 55 56.7 52 59.1 0.729 [0.269 – 1.973] 0.534
 Poor 9 9.3 7 7.9 0.720 [0.240 – 2.161] 0.558
Nodal involvement
 Yes 30 16.2 34 18.4   
 No 67 36.2 54 29.2 0.711 [0.387-1.306] 0.272
Tobacco status
 Yes 88 90.7 75 85.2   
 No 9 9.3 13 14.8 1.70 [0.686 – 4.186] 0.265
Alcohol status
 Yes 82 84.5 72 81.8   
 No 15 15.5 16 18.2 1.22 [0.561 – 2.630] 0.695
  1. HPV-16 + human papillomavirus type 16 positive, HPV-16 - human papillomavirus type 16 negative, OR odds ratio, 95 % CI 95 % confidence interval