Articles

Price and affordability of direct-acting antiviral regimens for hepatitis C virus in the United States

Hepatitis C virus is a serious infection causing cirrhosis, liver cancer, and death. The recent development of direct-acting antivirals has dramatically improved tolerability of treatment and rates of cure. Ho...

Authors: Elana S. Rosenthal and Camilla S. Graham

Cellular immune response to hepatitis-C-virus in subjects without viremia or seroconversion: is it important?

Hepatitis C Virus (HCV) causes chronic infection and represents a global health burden. To date, there is no licensed vaccine for HCV. The high viral replication rate and the existence of several HCV genotypes...

Authors: Sayed F. Abdelwahab

Detection of human papillomavirus DNA in peri-tumor tissues and pelvic lymph nodes as potential molecular marker of micrometastasis in cervical cancer

The association between high risk human papillomaviruses (HPV) and cervical cancer has been firmly established. HPV genome is present in nearly all cases of cervical cancer and detection of viral DNA could the...

Authors: Marianna Tortora, Clorinda Annunziata, Giuseppina Liguori, Simona Losito, Gerardo Botti, Stefano Greggi, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello

Prevalence of human papillomavirus types and variants and p16^INK4a expression in head and neck squamous cells carcinomas in São Paulo, Brazil

Human papillomavirus (HPV) prevalence in head and neck squamous cell carcinomas (HNSCC) diverges geographically. The reliability of using p16^INK4a expression as a marker of viral infection is controversial in HNS...

Authors: Julio C. Betiol, Laura Sichero, Henrique O. de Olival Costa, Leandro L. de Matos, Maria A. Andreoli, Silvaneide Ferreira, Sheila F. Faraj, Evandro S. de Mello, João S. Sobrinho, Lenine G. Brandão, Claudio R. Cernea, Marco A. Kulcsar, Fabio R. Pinto, Antonio J. Gonçalves, Marcelo B. Menezes, Leonardo Silva…

Concordance of oral HPV prevalence between patients with oropharyngeal cancer and their partners

Human papilloma virus (HPV) is a known causative factor in oropharyngeal squamous cell cancer (OPC). In this prospective study, we sought to define the risk of HPV transmission between OPC patients and their s...

Authors: Anne S. Tsao, Vassiliki Papadimitrakopoulou, Heather Lin, Ming Guo, J. Jack Lee, F. Christopher Holsinger, Waun Ki Hong and Erich M. Sturgis

Evaluation of the radiotherapy management of ocular surface squamous neoplasia in a high HIV prevalence setting- a retrospective review

This article evaluates a single institute’s radiotherapy management of OSSN, a previously regarded as rare malignancy, for possible future development of strategies to clearly define the role of adjuvant radio...

Authors: Ntokozo Ndlovu, Sandra Ndarukwa, Webster Kadzatsa and Simbarashe Rusakaniko

p53 expression but not p16^INK4A correlates with human papillomavirus-associated esophageal squamous cell carcinoma in Kazakh population

p16^INK4A expression has been used as a surrogate marker for human papillomavirus (HPV) infection in cervical cancer and head and neck cancer. p53 has also been reported as a feasible marker to identify HPV-positi...

Authors: Lianghai Wang, Jing Li, Jun Hou, Man Li, Xiaobin Cui, Shugang Li, Xiaodan Yu, Zhiyu Zhang, Weihua Liang, Jinfang Jiang, Lijuan Pang, Yunzhao Chen, Jin Zhao and Feng Li

Distribution of human papillomaviruses and bacterial vaginosis in HIV positive women with abnormal cytology in Mombasa, Kenya

HPV is the major etiological factor in the causal pathway for cervical cancer, which is the leading cancer among women in sub-Saharan Africa. HIV is associated with a higher prevalence and a broader range of h...

Authors: Sonia Simone Menon, Rodolfo Rossi, Ronald Harebottle, Hillary Mabeya and Davy vanden Broeck

HPV genotype distribution and anomalous association of HPV33 to cervical neoplastic lesions in San Luis Potosí, Mexico

The association of human papillomavirus (HPV) types to neoplastic lesions increase as a function of their oncogenicity and the duration of the infection since lesion severity progresses from low-grade to high-...

Authors: Raúl DelaRosa-Martínez, Mireya Sánchez-Garza and Rubén López-Revilla

Cervical cancer survival in a resource-limited setting-North Central Nigeria

Organized cervical cancer screening services are presently lacking in Nigeria contributing to late presentation and diagnosis of invasive cervical cancer cases (ICCs) at advanced stages in most gynecologic uni...

Authors: Jonah Musa, Joseph Nankat, Chad J. Achenbach, Iornum H. Shambe, Babafemi O. Taiwo, Barnabas Mandong, Patrick H. Daru, Robert L. Murphy and Atiene S. Sagay

Use of swabs for dry collection of self-samples to detect human papillomavirus among Malagasy women

Most women in developing countries have never attended cervical screening programmes and often little information exists on type-specific human papillomavirus (HPV) prevalence among these populations. Self-sam...

Authors: Pierre Vassilakos, Rosa Catarino, Stephanie Bougel, Maria Munoz, Caroline Benski, Ulrike Meyer-Hamme, Jeromine Jinoro, Josea Lea Heriniainasolo and Patrick Petignat

Human papillomavirus infection and risk of breast cancer: a meta-analysis of case-control studies

Although systematic reviews (SR) report that human papillomavirus (HPV) increases the risk of breast cancer, there are still disputes regarding this association. In particular, it has been argued that the risk...

Authors: Jong-Myon Bae and Eun Hee Kim

Non-typhoidal Salmonella DNA traces in gallbladder cancer

We earlier proposed a genetic model for gallbladder carcinogenesis and its dissemination cascade. However, the association of gallbladder cancer and ‘inflammatory stimulus’ to drive the initial cascade in the ...

Authors: Prajish Iyer, Savio George Barreto, Bikram Sahoo, Pratik Chandrani, Mukta R. Ramadwar, Shailesh V. Shrikhande and Amit Dutt

Erratum to: Human papillomavirus types in non-cervical high-grade intraepithelial neoplasias and invasive carcinomas from San Luis Potosí, Mexico: a retrospective cross-sectional study

Authors: Claudia Magaña-León, Cuauhtémoc Oros and Rubén López-Revilla

Influence of insulin resistance on the development of hepatocellular carcinoma after antiviral treatment for non-cirrhotic patients with chronic hepatitis C

Insulin resistance is considered to be an important factor in the progression of fibrosis and the enhancement of the risk of hepatocellular carcinoma (HCC) for chronic hepatitis C patients. The aim of this stu...

Authors: Takeo Hayashi, Eiichi Ogawa, Norihiro Furusyo, Masayuki Murata and Jun Hayashi

Prevalence of human papilloma virus (HPV) and its genotypes in cervical specimens of Egyptian women by linear array HPV genotyping test

The association of human papillomavirus (HPV) with cervical cancer is well established.

Authors: Mohamed A. Youssef, Lobna Abdelsalam, Reem Abdelhameed Harfoush, Iman Mamdouh Talaat, Eman Elkattan, Abeer Mohey, Rana M. A. Abdella, Marwa Salah Farhan, Hany Ahmed Foad, Abeer Mostafa Elsayed, Naglaa A. Elkinaai, Doaa Ghaith, Mohamed Elsayed Rashed, Mohamed Abd-El Ghafar, Yasser Khamis and Ahmed N. Hosni

Infectious Agents and Cancer reviewer acknowledgement 2015

The editors of Infectious Agents and Cancer would like to thank all our reviewers who have contributed their time and expertise to the journal in Volume 10 (2015).

Authors: Franco M. Buonaguro, Sam M. Mbulaiteye and Maria Lina Tornesello

Patterns of human herpesvirus-8 oral shedding among diverse cohorts of human herpesvirus-8 seropositive persons

Human herpesvirus-8 (HHV-8), the etiologic agent of Kaposi sarcoma (KS), establishes lifelong latent infection with periodic lytic replication (“shedding”) at mucosal sites, especially the oropharynx. Patterns...

Authors: Rachel A. Bender Ignacio, Jason D. Goldman, Amalia S. Magaret, Stacy Selke, Meei-Li Huang, Soren Gantt, Christine Johnston, Warren T. Phipps, Joshua T. Schiffer, Richard A. Zuckerman, R. Scott McClelland, Connie Celum, Larry Corey, Anna Wald and Corey Casper

Erratum to: Impact of human papillomavirus on head and neck squamous cell cancers in Gabon

Authors: Ingrid Labouba, Chloé Bertolus, Hervé I. Koumakpayi, Ernest Belembaogo, Jérôme Miloundja and Nicolas Berthet

Predictors of immune reconstitution inflammatory syndrome associated with Kaposi’s sarcoma: a case report

We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi’s sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseli...

Authors: Anna Maria Cattelan, Adriana Mattiolo, Angela Grassi, Maria Assunta Piano, Lolita Sasset, Marco Trevenzoli, Paola Zanovello and Maria Luisa Calabrò

Prevalence of human papillomavirus genotypes among women with cervical cancer in Ghana

Human Papillomavirus (HPV) infections have been shown to be a necessary risk factor for the development of cervical cancer. However, HPV genotype distribution varies geographically, both in type and relative p...

Authors: A. K. Awua, S. T. Sackey, Y. D. Osei, R. H. Asmah and E. K. Wiredu

Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer

Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas g...

Authors: Shegan Gao, Shuoguo Li, Zhikun Ma, Shuo Liang, Tanyou Shan, Mengxi Zhang, Xiaojuan Zhu, Pengfei Zhang, Gang Liu, Fuyou Zhou, Xiang Yuan, Ruinuo Jia, Jan Potempa, David A. Scott, Richard J. Lamont, Huizhi Wang…

Human papillomavirus genotypes distribution among Gabonese women with normal cytology and cervical abnormalities

Cervical cancer is one of the most common tumors affecting women with a disproportionate mortality occurring in developing countries. Despite the high prevalence of cervical cancer and cervical neoplasia in Ga...

Authors: Samira Zoa Assoumou, Angelique Ndjoyi Mbiguino, Barthelemy Mabika Mabika, Sidonie Nguizi Ogoula, Mohammed El Mzibri, Abdelkrim Khattabi and My Mustapha Ennaji

Molecular diagnosis and phylogenetic analysis of human papillomavirus type-16 from suspected patients in Pakistan

Human Papillomavirus (HPV) is well known pathogen that can cause benign and malignant tumors in humans, yet there is very little information regarding HPV types prevalent in Pakistan.

Authors: Abdullah Abdullah, Muhammad Qasim, Muhammad Shafiq, Muhammad Ijaz, Shamsa Parveen, Shahnaz Murtaza, Qamar Javed, Salman Akbar Malik, Shahida Husain Tarar, Sajid Mehmood, Abdul Sami, Syed Muhammad Saqlan Naqvi and Muhammad Zeeshan Hyder

Pathology and oncology in Africa: education and training for the future in cancer research– East African Regional Meeting

According to the World Health Organisation (WHO), deaths from non-communicable diseases (NCDs) will increase globally, with the largest increase being on the African continent. On our continent, projections ha...

Authors: D. C. Stefan, N. Masalu, L. Ngendahayo, D. Amadori, M. Botteghi, M. Mendy, N. A. Othieno-Aabinya, T. Ngoma, F. Asirwa, O. Balogun, W. Ngwa, E. Vuhahula and A Adesina

Relationship between CK19 expression, deregulation of normal keratinocyte differentiation pattern and high risk-human papilloma virus infection in oral and oropharyngeal squamous cell carcinoma

Simple epithelial keratins appear early during embryonic development and are expressed in non-stratified, ductal and pseudo-stratified epithelial tissues. CK19, the lowest molecular weight keratin, is also exp...

Authors: Angela Santoro, Giuseppe Pannone, Rossella Ninivaggi, Massimo Petruzzi, Andrea Santarelli, Giuseppe Maria Russo, Silvia Lepore, Michele Pietrafesa, Ilaria Laurenzana, Rosalia Leonardi, Paolo Bucci, Maria Iole Natalicchio, Alberta Lucchese, Silvana Papagerakis and Pantaleo Bufo

The DC-SIGN-CD56 interaction inhibits the anti-dendritic cell cytotoxicity of CD56 expressing cells

This study aimed to clarify interactions of the pattern-recognition receptor DC-SIGN with cells from the HIV-infected peripheral blood lymphocyte cultures.

Authors: Alexey A. Nabatov and Ivan S. Raginov

Human papillomavirus genotypes among women with or without HIV infection: an epidemiological study of Moroccan women from the Souss area

Data on Human PapillomaVirus (HPV) infection are scarce in Morocco. The objective of the study was to determine the prevalence of HPV and cervical cytology abnormalities in women from the Souss area, Morocco.

Authors: Essaada Belglaiaa, Hicham Elannaz, Bouchra Mouaouya, Mohamed Aksim, Mariette Mercier, Jean-Luc Prétet, Said Chouham and Christiane Mougin

Cytomegalovirus reactivation and its clinical impact in patients with solid tumors

Cytomegalovirus reactivation can be life threatening. However, little evidence on its incidence in solid cancers is available. Therefore our single center Cytomegalovirus polymerase chain reaction database wit...

Authors: Konstantin Schlick, Michael Grundbichler, Jutta Auberger, Jan Marco Kern, Markus Hell, Florian Hohla, Georg Hopfinger and Richard Greil

miR-23b as a potential tumor suppressor and its regulation by DNA methylation in cervical cancer

The aberrant expression of miR-23b is involved in the development and progression of cancer. The aim of this study was to evaluate the potential role of methylation in the silencing of miR-23b in cervical canc...

Authors: Gabriela Elizabeth Campos-Viguri, Hilda Jiménez-Wences, Oscar Peralta-Zaragoza, Gricenda Torres-Altamirano, Diana Guillermina Soto-Flores, Daniel Hernández-Sotelo, Luz Del Carmen Alarcón-Romero, Marco Antonio Jiménez-López, Berenice Illades-Aguiar and Gloria Fernández-Tilapa

HPV16/18 genotyping for the triage of HPV positive women in primary cervical cancer screening in Chile

We previously conducted a population-based screening trial of high-risk human papillomavirus (hrHPV) testing and conventional cytology, demonstrating higher sensitivity (92.7 % vs 22.1 % for CIN2+) but lower p...

Authors: Marcela Lagos, Vanessa Van De Wyngard, Helena Poggi, Paz Cook, Paola Viviani, María Isabel Barriga, Martha Pruyas and Catterina Ferreccio

A prospective randomized study on limits of colposcopy and histology: the skill of colposcopist and colposcopy-guided biopsy in diagnosis of cervical intraepithelial lesions

The main objective of our study was to evaluate the colposcopist ability to correctly identify the worst area of a cervical lesion where biopsy should be performed; the secondary objective was to investigate t...

Authors: Giuseppe Bifulco, Nicoletta De Rosa, Giada Lavitola, Roberto Piccoli, Alessandra Bertrando, Valentina Natella, Costantino Di Carlo, Luigi Insabato and Carmine Nappi

Cross-sectional study about primary health care professionals views on the inclusion of the vaccine against human papillomavirus in the vaccine schedules

Although the inclusion of the HPV vaccine has been registered in Spain since 2007, vaccination rates are lower than expected. The patients wish to be vaccinated is heavily influenced by information they have r...

Authors: M. Reyes Oliver Pérez, Victoria Bravo Violeta, Ana Vazquez del Campo, Cristina Ruiz, Sonia Yáñez Castaño, Laura P. Pérez Conde and Jesús S. Jiménez López

Impact of human papillomavirus on head and neck squamous cell cancers in Gabon

Head and neck squamous cell cancers are among the most aggressive. Their incidence and mortality rates are relatively lower in Middle Africa than worldwide, but in Gabon, these rates tend to be 2–3 fold higher...

Authors: Ingrid Labouba, Chloé Bertolus, Hervé I. Koumakpayi, Ernest Belembaogo, Jérôme Miloundja and Nicolas Berthet

Patterns of HIV viremia and viral suppression before diagnosis of non-AIDS-defining cancers in HIV-infected individuals

The association between HIV viremia and non-AIDS-defining cancers (NADCs) is not well characterized. Viremia may contribute directly or indirectly to cancer development and may have a differential impact on va...

Authors: David J. Riedel, Anne F. Rositch and Robert R. Redfield

Inconclusive role of human papillomavirus infection in breast cancer

Epidemiological studies have examined the association between human papillomavirus (HPV) and breast cancer, but the findings are inconclusive. This study aimed to detect the prevalence of HPV in breast cancer ...

Authors: Yi Zhou, Jinyuan Li, Yuting Ji, Ming Ren, Bo Pang, Ming Chu and Lanlan Wei

Merkel cell polyomavirus (MCV) T-antigen seroreactivity, MCV DNA in eyebrow hairs, and squamous cell carcinoma

The role of Merkel cell polyomavirus (MCV) infection in the etiology of non-melanoma skin cancers, other than Merkel cell carcinoma, is unclear. Previously, we reported a significant association between seropo...

Authors: Shalaka S. Hampras, Angelika Michel, Markus Schmitt, Tim Waterboer, Lena Kranz, Tarik Gheit, Kate Fisher, Vernon K. Sondak, Jane Messina, Neil Fenske, Basil Cherpelis, Massimo Tommasino, Michael Pawlita and Dana E. Rollison

Prevalence of Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in oral and oropharyngeal squamous cell carcinoma in south-eastern Poland

The aim of this study was to analyze the prevalence of HPV and EBV in oral and oropharyngeal squamous cell carcinoma in south-eastern Poland. The correlation between viral infection, OSCC, alcohol use, tobacco...

Authors: Dorota Polz-Gruszka, Kamal Morshed, Agnieszka Stec and Małgorzata Polz-Dacewicz

The predictive role of NLR and PLR for solid non-AIDS defining cancer incidence in HIV-infected subjects: a MASTER cohort study

The neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), two low cost, routinely available inflammatory indices, have been found to be associated with risk of death in patients with sol...

Authors: Elena Raffetti, Francesco Donato, Francesco Castelli, Franco Maggiolo, Giampiero Carosi and Eugenia Quiros-Roldan

Epidemiological patterns of cervical human papillomavirus infection among women presenting for cervical cancer screening in North-Eastern Nigeria

Sub-Saharan countries including Nigeria have the highest burden of Human Papillomavirus (HPV) infection in the world. Most studies on HPV surveillance in Nigeria were done in the southern part of the country. ...

Authors: Mohammed Mohammed Manga, Adeola Fowotade, Yusuf Mohammed Abdullahi, Aliyu Usman El-nafaty, Danladi Bojude Adamu, Hamidu Umar Pindiga, Rasheed Ajani Bakare and Abimbola Olu Osoba

Human papillomavirus types in non-cervical high-grade intraepithelial neoplasias and invasive carcinomas from San Luis Potosí, Mexico: a retrospective cross-sectional study

Viral infections and the burden of high-grade intraepithelial neoplasias (HIN) and invasive carcinomas (IC) associated to infections by human papillomavirus (HPV) types may be prevented by type-specific anti-H...

Authors: Claudia Magaña-León, Cuauhtémoc Oros and Rubén López-Revilla

Rural-urban differences in the clinico-pathologic profiles of Jamaican men with prostate cancer

Prostate cancer causes the highest number of cancer-related deaths in Jamaican men. It is not known whether rural-dwelling men present with worse disease than urban-dwelling men at initial presentation. Since ...

Authors: William D. Aiken, Kieron S. Jones, Camille Ragin and Kenneth James

Human papilloma virus is not detectable in samples of urothelial bladder cancer in a central European population: a prospective translational study

Previous investigations on the association of human papillomavirus (HPV) and human bladder cancer have led to conflicting results. The aim of this study was to determine if low and high risk HPV play a role in...

Authors: Sebastian C. Schmid, Leonore Thümer, Tibor Schuster, Thomas Horn, Florian Kurtz, Julia Slotta-Huspenina, Judith Seebach, Michael Straub, Tobias Maurer, Michael Autenrieth, Hubert Kübler, Margitta Retz, Ulrike Protzer, Jürgen E. Gschwend and Dieter Hoffmann

The significance of Bartonella henselae bacterias for oncological diagnosis in children

Cat-scratch disease (CSD) is a common infection in children; however, the wide spectrum of its clinical picture may lead to delayed diagnosis. An unusual presentation of CSD includes in the differential diagno...

Authors: Katarzyna Mazur-Melewska, Katarzyna Jończyk-Potoczna, Anna Mania, Paweł Kemnitz, Jarosław Szydłowski, Wojciech Służewski and Magdalena Figlerowicz

Frequency of Human Papilloma Virus (HPV) subtypes 31,33,35,39 and 45 among Yemeni women with cervical cancer

Identification of different HPV subtypes in unidentified communities provides sufficient information for screening and monitoring potential impact of a vaccination program. Therefore, the aim of this study was...

Authors: Hussain Gadelkarim Ahmed, Saleh Hussein Bensumaidea and Ibraheem M. Ashankyty

Viral infections in prostate carcinomas in Chilean patients

A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of hum...

Authors: Hector Rodríguez, Jorge Levican, Juan P. Muñoz, Diego Carrillo, Mónica L. Acevedo, Aldo Gaggero, Oscar León, Tarik Gheit, Omar Espinoza-Navarro, Jorge Castillo, Iván Gallegos, Massimo Tommasino and Francisco Aguayo

A review of the pattern of AIDS defining, HIV associated neoplasms and premalignant lesions diagnosed from 2000–2011 at Kenyatta National Hospital, Kenya

Sub-Sahara Africa hosts up to 71 % of all HIV infected people in the world. With this high incidence of Human immunodeficiency virus ( HIV) comes the burden of co-morbidities such as malignant and premalignant...

Authors: Emily A. Rogena, Kenneth O. Simbiri, G. De Falco, L. Leoncini, Leona Ayers and J. Nyagol

p16^INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya

The identification of suited early detection tests is one among the multiple requirements to reduce cervical cancer incidence in developing countries.

Authors: Caroline Wangari Ngugi, Dietmar Schmidt, Karanja Wanyoro, Hamadi Boga, Peter Wanzala, Anne Muigai, John Mbithi, Magnus von Knebel Doeberitz and Miriam Reuschenbach

Human papillomavirus infection and immunohistochemical expression of cell cycle proteins pRb, p53, and p16^INK4a in sinonasal diseases

We aimed to clarify the possible role of human papillomavirus (HPV) infection in the malignant transformation of sinonasal inverted papilloma (IP).

Authors: Yukashi Yamashita, Masahiro Hasegawa, Zeyi Deng, Hiroyuki Maeda, Shunsuke Kondo, Asanori Kyuna, Sen Matayoshi, Shinya Agena, Takayuki Uehara, Hideaki Kouzaki, Takeshi Shimizu, Taro Ikegami, Akira Ganaha and Mikio Suzuki

NLRP1 and NLRP3 polymorphisms in mesothelioma patients and asbestos exposed individuals a population-based autopsy study from North East Italy

NRLP1 (rs12150220, rs9889625, rs9900356, rs6502867, rs2670660) and NLRP3 (rs35829419, rs10754558) polymorphisms have been analyzed in 69 subjects with documented asbestos exposure and dea...

Authors: Violetta Borelli, Ronal R Moura, Elisa Trevisan and Sergio Crovella