Articles

Salvage chemotherapy for adults with relapsed or refractory lymphoma in Malawi

Lymphoma is highly associated with HIV in sub-Saharan Africa (SSA), which contributes to worse outcomes relative to resource-rich settings, and frequent failure of first-line chemotherapy. However, there are n...

Authors: Bongani Kaimila, Toon van der Gronde, Christopher Stanley, Edwards Kasonkanji, Maria Chikasema, Blessings Tewete, Paula Fox and Satish Gopal

Whole-genome analysis of human papillomavirus genotypes 52 and 58 isolated from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer

Human papillomavirus genotypes 52 and 58 (HPV52/58) are frequently detected in patients with cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC) in East Asian countries including Japan....

Authors: Yuri Tenjimbayashi, Mamiko Onuki, Yusuke Hirose, Seiichiro Mori, Yoshiyuki Ishii, Takamasa Takeuchi, Nobutaka Tasaka, Toyomi Satoh, Tohru Morisada, Takashi Iwata, Shingo Miyamoto, Koji Matsumoto, Akihiko Sekizawa and Iwao Kukimoto

Six years genotype distribution of Human Papillomavirus in Calabria Region, Southern Italy: a retrospective study

Although analysis of the Human papillomavirus (HPV) genotype spread in a particular area has a crucial impact on public health and prevention programmes, there is a lack of epidemiological data regarding HPV i...

Authors: Luisa Galati, Cinzia Peronace, Maria Teresa Fiorillo, Rosanna Masciari, Cristina Giraldi, Salvatore Nisticò, Pasquale Minchella, Vincenzo Maiolo, Giorgio Settimo Barreca, Nadia Marascio, Angelo Giuseppe Lamberti, Aida Giancotti, Maria Gabriella Lepore, Francesca Greco, Maria Vittoria Mauro, Annelisa Borelli…

Interleukin-17F expression is elevated in hepatitis C patients with fibrosis and hepatocellular carcinoma

The role of interleukin (IL) 17A in chronic liver diseases had been extensively studied, but the function of IL-17F, which shares a high degree of homology with IL-17A, in the progression of chronic hepatic di...

Authors: Ming-Sian Wu, Chun-Hsiang Wang, Fan-Chen Tseng, Hsuan-Ju Yang, Yin-Chiu Lo, Yi-Ping Kuo, De-Jiun Tsai, Wan-Ting Tsai and Guann-Yi Yu

Prevalence and characteristics of Epstein–Barr virus-associated gastric carcinomas in Portugal

Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein–Barr virus (EBV) has been associated with approximately 1...

Authors: Célia Nogueira, Marta Mota, Rui Gradiz, Maria Augusta Cipriano, Francisco Caramelo, Hugo Cruz, Ana Alarcão, Francisco Castro e Sousa, Fernando Oliveira, Fernando Martinho, João Moura Pereira, Paulo Figueiredo and Maximino Leitão

Rare bacterial isolates causing bloodstream infections in Ethiopian patients with cancer

In recent years, saprophytic bacteria have been emerging as potential human pathogens causing life-threatening infections in patients with malignancies. However, evidence is lacking concerning such bacteria, p...

Authors: Balew Arega, Yimtubezinash Wolde-Amanuel, Kelemework Adane, Ezra Belay, Abdulaziz Abubeker and Daniel Asrat

Evaluation of human cytomegalovirus antigen expression in invasive breast carcinoma in a population of Iranian patients

The role of human cytomegalovirus (HCMV) in the development of breast carcinoma is questionable. The aim of this study was to evaluate the expression of the immediate early antigen (IE) of HCMV in breast carci...

Authors: Fereshteh Mohammadizadeh and Fatemeh Mahmudi

Synchronous bilateral tonsil carcinoma: case presentation and review of the literature

The incidence of synchronous bilateral tonsil carcinoma seems to be underreported. For adequate oncologic treatment, it is mandatory to remove all primaries to prevent recurrence or metachronic disease. The pu...

Authors: M-N. Theodoraki, J. A. Veit, T. K. Hoffmann and J. Greve

Erratum to: Outcome of HIV-associated lymphoma in a resource-limited setting of Jos, Nigeria

Authors: Olugbenga Akindele Silas, Chad J. Achenbach, Lifang Hou, Robert L. Murphy, Julie O. Egesie, Solomon A. Sagay, Oche O. Agbaji, Patricia A. Agaba, Jonah Musa, Agabus N. Manasseh, Ezra D. Jatau, Ayuba M. Dauda, Maxwell O. Akanbi and Barnabas M. Mandong

The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer’s disease: an overview of pre-clinical studies and translational perspectives in clinical practice

Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia characterized by cognitive and memory impairment. One of the mechanism involved in the pathogenesis of AD, is the o...

Authors: Marco Cascella, Sabrina Bimonte, Maria Rosaria Muzio, Vincenzo Schiavone and Arturo Cuomo

Effect of electrochemotherapy on human herpesvirus 8 kinetics in classic Kaposi sarcoma

Electrochemotherapy (ECT) has shown to be an effective treatment for cutaneous and subcutaneous Kaposi sarcoma (KS) lesions. However, no study has investigated the impact of ECT treatment on the kinetics of hu...

Authors: Noemy Starita, Gianluca Di Monta, Andrea Cerasuolo, Ugo Marone, Anna Maria Anniciello, Gerardo Botti, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello

Outcome of HIV-associated lymphoma in a resource-limited setting of Jos, Nigeria

Lymphoma is a leading cause of cancer-related death among human immunodeficiency virus (HIV)-infected individuals in the current era of potent anti-retroviral therapy (ART). Globally, mortality after HIV-assoc...

Authors: Olugbenga Akindele Silas, Chad J. Achenbach, Lifang Hou, Robert L. Murphy, Julie O. Egesie, Solomon A. Sagay, Oche O. Agbaji, Patricia E. Agaba, Jonah Musa, Agabus N. Manasseh, Ezra D. Jatau, Ayuba M. Dauda, Maxwell O. Akanbi and Barnabas M. Mandong

Non-pulmonary cancer risk following tuberculosis: a nationwide retrospective cohort study in Lithuania

Lithuania remains one of the highest tuberculosis burden countries in Europe. Epidemiological studies have long pointed to infections as important factors of cancer aetiology, but the association between tuber...

Authors: Ruta Everatt, Irena Kuzmickiene, Edita Davidaviciene and Saulius Cicenas

Seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus among HIV-negative people in China

Little information on the prevalence of Kaposi’s sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia.

Authors: Tiejun Zhang, Zhenqiu Liu, Jun Wang, Veenu Minhas, Charles Wood, Gary M. Clifford, Na He and Silvia Franceschi

Serum EBV antibodies and LMP-1 in Polish patients with oropharyngeal and laryngeal cancer

The association between Epstein-Barr virus (EBV) and the development of head and neck cancer was reported by many researchers. The aim of the present study was to detect EBV DNA and EBV antibodies in 110 Polis...

Authors: Sylwia Fołtyn, Małgorzata Strycharz-Dudziak, Bartłomiej Drop, Anastazja Boguszewska and Małgorzata Polz-Dacewicz

LPS promotes resistance to TRAIL-induced apoptosis in pancreatic cancer

Though TRAIL has been hailed as a promising drug for tumour treatment, it has been observed that many tumour cells have developed escape mechanisms against TRAIL-induced apoptosis. As a receptor of LPS, TLR 4,...

Authors: Katharina Beyer, Lars Ivo Partecke, Felicitas Roetz, Herbert Fluhr, Frank Ulrich Weiss, Claus-Dieter Heidecke and Wolfram von Bernstorff

Prevalence and risk factors associated with sexually transmitted infections (STIs) among women of reproductive age in Swaziland

Sexually transmitted infections (STIs) remain an important public health problem with approximately half a billion new cases annually among persons aged 15–49 years. Epidemiological data on STIs among women of...

Authors: Themba G. Ginindza, Cristina D. Stefan, Joyce M. Tsoka-Gwegweni, Xolisile Dlamini, Pauline E. Jolly, Elisabete Weiderpass, Nathalie Broutet and Benn Sartorius

Association of hepatitis status with surgical outcomes in patients with dual hepatitis B and C related hepatocellular carcinoma

The conception that serological hepatitis markers determined surgical prognosis of hepatocellular carcinoma (HCC) associated with hepatitis B (HBV) or hepatitis C (HCV) has been well defined. However, little i...

Authors: Xiu-Tao Fu, Ying-Hong Shi, Jian Zhou, Yuan-Fei Peng, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Kang Song, Jia Fan and Zhen-Bin Ding

Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma

Primary hepatocellular carcinoma (HCC) mainly develops in subjects chronically infected with hepatitis B (HBV) and C (HCV) viruses through a multistep process characterized by the accumulation of genetic alter...

Authors: Francesca Pezzuto, Luigi Buonaguro, Franco M. Buonaguro and Maria Lina Tornesello

Differences in age-specific HPV prevalence between self-collected and health personnel collected specimen in a cross-sectional study in Ghana

HPV infections are ubiquitous and particularly common among sexually active young women. However, there are regional and national variations in age-specific HPV prevalence, which have implications for cervical...

Authors: Adolf K. Awua, Richard M. K. Adanu, Edwin K. Wiredu, Edwin A. Afari and Alberto Severini

The potential role of infectious agents and pelvic inflammatory disease in ovarian carcinogenesis

The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis.

Authors: Kasper Ingerslev, Estrid Hogdall, Tine Henrichsen Schnack, Wojciech Skovrider-Ruminski, Claus Hogdall and Jan Blaakaer

Mouse mammary tumour virus (MMTV) and human breast cancer with neuroendocrine differentiation

Mouse mammary tumour viruses (MMTVs) may have a role in a subset of human breast cancers. MMTV positive human breast cancers have similar histological characteristics to neuroendocrine breast cancers and to MM...

Authors: Lawson JS, Ngan CC, Glenn WK and Tran DD

Major and ancillary magnetic resonance features of LI-RADS to assess HCC: an overview and update

Liver Imaging Reporting and Data System (LI-RADS) is a system for interpreting and reporting of imaging features on multidetector computed tomography (MDCT) and magnetic resonance (MR) studies in patients at r...

Authors: Vincenza Granata, Roberta Fusco, Antonio Avallone, Orlando Catalano, Francesco Filice, Maddalena Leongito, Raffaele Palaia, Francesco Izzo and Antonella Petrillo

Protein signature characterizing Helicobacter pylori strains of patients with autoimmune atrophic gastritis, duodenal ulcer and gastric cancer

Helicobacter pylori (H. pylori) represents a key factor in the etiology of autoimmune atrophic gastritis (AAG), duodenal ulcer (DU) and gastric cancer (GC). The aim of this study was t...

Authors: Valli De Re, Ombretta Repetto, Stefania Zanussi, Mariateresa Casarotto, Laura Caggiari, Vincenzo Canzonieri and Renato Cannizzaro

Predominance and association risk of Blastocystis hominis subtype I in colorectal cancer: a case control study

Blastocystis, a genetically diverse intestinal parasite with controversial pathogenic potential, has increasingly been incriminated for diarrheal illness in immunocompromised individua...

Authors: Amr Mohamed Mohamed, Mona Abdelfattah Ahmed, Sabah Abdelghany Ahmed, Sherif Ahmed Al-Semany, Saad Saed Alghamdi and Dina Abdulla Zaglool

Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar

Human mammary tumor virus (HMTV) is 90–95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors. HMTV (MMTV-like) sequences were reported to be present in human bre...

Authors: Thar Htet San, Masayoshi Fujisawa, Soichiro Fushimi, Teizo Yoshimura, Toshiaki Ohara, Lamin Soe, Ngu Wah Min, Ohnmar Kyaw, Xu Yang and Akihiro Matsukawa

Estimation of the overall burden of cancers, precancerous lesions, and genital warts attributable to 9-valent HPV vaccine types in women and men in Europe

In addition to cervical cancer, human papillomavirus (HPV) is responsible for a significant proportion of cancers and precancerous lesions of the vulva, vagina, anus, penis, head and neck, as well as genital w...

Authors: Susanne Hartwig, Jean Lacau St Guily, Géraldine Dominiak-Felden, Laia Alemany and Silvia de Sanjosé

The effects of antiviral treatment on breast cancer cell line

Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack o...

Authors: Madina Shaimerdenova, Orynbassar Karapina, Damel Mektepbayeva, Kenneth Alibek and Dana Akilbekova

Aflatoxin B₁ inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma

Aflatoxin B₁ (AFB₁) contamination of food is very high in most sub-Saharan African countries. AFB₁ is known to cause hepatocellular carcinoma (HCC) by inducing mutation in the tumour suppressor gene TP53. The num...

Authors: Patrick W. Narkwa, David J. Blackbourn and Mohamed Mutocheluh

Erratum to: Mouse mammary tumor-like virus (MMTV) is present in human breast tissue before development of virally associated breast cancer

Authors: Teiko Nartey, Chiara M. Mazzanti, Stella Melana, Wendy K. Glenn, Generoso Bevilacqua, James F. Holland, Noel J. Whitaker, James S. Lawson and Beatriz G. T. Pogo

Genetic variability in E6, E7 and L1 genes of Human Papillomavirus 62 and its prevalence in Mexico

Human papillomavirus (HPV) is the main etiological agent of cervical cancer, the third most common cancer among women globally and the second most frequent in Mexico. Persistent infection with high-risk HPV ge...

Authors: Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, María Teresa Magaña-Torres, María Guadalupe López-Cardona, Yelda Aurora Leal-Herrera, Patricia Piña-Sánchez, Luis Felipe Jave-Suárez and Adriana Aguilar-Lemarroy

Worldwide malaria incidence and cancer mortality are inversely associated

Investigations on the effects of malaria infection on cancer mortality are limited except for the incidence of Burkitt’s lymphoma (BL) in African children. Our previous murine lung cancer model study demonstra...

Authors: Li Qin, Changzhong Chen, Lili Chen, Ran Xue, Ming Ou-Yang, Chengzhi Zhou, Siting Zhao, Zhengxiang He, Yu Xia, Jianxing He, Pinghua Liu, Nanshan Zhong and Xiaoping Chen

An update on the management of breast cancer in Africa

There is limited information about the challenges of cancer management and attempts at improving outcomes in Africa. Even though South and North Africa are better resourceds to tackle the burden of breast canc...

Authors: V. Vanderpuye, S. Grover, N. Hammad, PoojaPrabhakar, H. Simonds, F. Olopade and D. C. Stefan

Safety of new DAAs for chronic HCV infection in a real life experience: role of a surveillance network based on clinician and hospital pharmacist

Direct Antiviral Agents (DAAs) for HCV therapy represents a step ahead in the cure of chronic hepatitis C. Notwithstanding the promising results in several clinical trials, few data are available on adverse ef...

Authors: A. Nappi, A. Perrella, P. Bellopede, A. Lanza, A. Izzi, M. Spatarella and C. Sbreglia

Randomized trial evaluating self-sampling for HPV DNA based tests for cervical cancer screening in Nigeria

Cervical cancer incidence and mortality rates in Sub-Saharan Africa (SSA) remain high due to several factors including low levels of uptake of cervical cancer screening. Self-collection of cervicovaginal sampl...

Authors: Fatima Modibbo, K. C. Iregbu, James Okuma, Annemiek Leeman, Annemieke Kasius, Maurits de Koning, Wim Quint and Clement Adebamowo

Review on the role of the human Polyomavirus JC in the development of tumors

Almost one fifth of human cancers worldwide are associated with infectious agents, either bacteria or viruses, and this makes the possible association between infections and tumors a relevant research issue. W...

Authors: Serena Delbue, Manola Comar and Pasquale Ferrante

Hepatitis C virus seroprevalence in the general female population of 9 countries in Europe, Asia and Africa

New oral treatments with very high cure rates have the potential to revolutionize global management of hepatitis C virus (HCV), but population-based data on HCV infection are missing in many low and middle-inc...

Authors: Gary M. Clifford, Tim Waterboer, Bolormaa Dondog, You Lin Qiao, Dimitri Kordzaia, Doudja Hammouda, Namory Keita, Nahid Khodakarami, Syed Ahsan Raza, Ang Tshering Sherpa, Witold Zatonski, Michael Pawlita, Martyn Plummer and Silvia Franceschi

Human papillomavirus genotypes associated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China

The mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China.

Authors: Jin Zhao, Zhong Guo, Qiang Wang, Tianbin Si, Shuyan Pei, Chenjing Wang, Hongmei Qu, Jianbin Zhong, Ying Ma, Cong Nie and Dan Zhang

Clinical and prognostic analysis of 78 patients with human immuno-deficiency virus associated non-Hodgkin’s lymphoma in Chinese population

Human Immuno-deficiency Virus (HIV) associated non-Hodgkin’s lymphoma (NHL) was a special group of disease, which manifests distinct clinical features and prognosis as compared with NHLs in patients without HI...

Authors: Yang Shen, Renfang Zhang, Li Liu, Yinzhong Shen, Wei Song, Tangkai Qi, Yang Tang, Zhenyan Wang, Liqian Guan and Hongzhou Lu

The surgical pathology laboratory in Mwanza, Tanzania: a survey on the reproducibility of diagnoses after the first years of autonomous activity

In 2000, an Italian non-governmental organisation (NGO) began a 9-year project to establish a surgical pathology laboratory at the Bugando Medical Centre (BMC) in Mwanza, Tanzania, a country with a low Human D...

Authors: R. Tumino, P. F. Rambau, F. Callea, L. Leoncini, R. Monaco, J. Kahima, V. Stracca Pansa, L. Viberti, D. Amadori, P. Giovenali and K. A. Mteta

Human papillomavirus infection in anal intraepithelial lesions from HIV infected Cuban men

An association between HPV infection and progression to anal squamous intraepithelial lesions (ASIL) has been established, specifically in high-risk populations such as HIV-infected men. In this population, an...

Authors: Celia M. Limia, Yudira Soto, Yanara García, Orestes Blanco, Vivian Kourí, María V. López, María E. Toledo, Lissette Pérez, Yoanna Baños, Yaniris Caturla and Francisco Aguayo

Characterisation of microbial communities within aggressive prostate cancer tissues

An infectious aetiology for prostate cancer has been conjectured for decades but the evidence gained from questionnaire-based and sero-epidemiological studies is weak and inconsistent, and a causal association...

Authors: Melissa A. Yow, Sepehr N. Tabrizi, Gianluca Severi, Damien M. Bolton, John Pedersen, Graham G. Giles and Melissa C. Southey

Frequency of Chlamydia trachomatis infection in cervical intraepithelial lesions and the status of cytological p16/Ki-67 dual-staining

Chlamydia trachomatis (Ct) is not a disease subject to mandatory reporting in Brazil, and the prevalence rate of this genital infection varies according to the region in which studies ...

Authors: R. Robial, A. Longatto-Filho, C. M. Roteli-Martins, M. F. Silveira, D. Stauffert, G. G. Ribeiro, I. M. Linhares, M. Tacla, M. A. Zonta and E. C. Baracat

Multiple HPV infections in female sex workers in Western Kenya: implications for prophylactic vaccines within this sub population

Whilst the imputed role of High Risk (HR) HPV infection in the development of cervical lesions and cancer has been established, the high number of HPV genotypes that Female Sex workers (FSW) harbour warrants ...

Authors: Sonia Menon, Davy van den Broeck, Rodolfo Rossi, Emilomo Ogbe and Hillary Mabeya

Mouse mammary tumor-like virus (MMTV) is present in human breast tissue before development of virally associated breast cancer

There is substantial evidence that a virus homologous to mouse mammary tumor virus (MMTV) may have a role in human breast cancer. The present study indicates that those who developed breast cancer associated w...

Authors: Teiko Nartey, Chiara M. Mazzanti, Stella Melana, Wendy K. Glenn, Generoso Bevilacqua, James F. Holland, Noel J. Whitaker, James S. Lawson and Beatriz G.T. Pogo

African Organization for Research and Training in Cancer: position and vision for cancer research on the African Continent

The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa including informa...

Authors: J. Olufemi Ogunbiyi, D. Cristina Stefan and Timothy R. Rebbeck

Induction of VX2 para-renal carcinoma in rabbits: generation of animal model for loco-regional treatments of solid tumors

Animal models of para-renal cancer can provide useful information for the evaluation of tumor response to loco-regional therapy experiments in solid tumors. The aim of our study was to establish a rabbit para-...

Authors: Sabrina Bimonte, Maddalena Leongito, Mauro Piccirillo, Maria Luisa Tamma, Marianna Vallifuoco, Adele Bracco, Antonio Mancini, Daniele Di Napoli, Sigismondo Castaldo, Santolo Cozzolino, Francesca Iacobellis, Roberto Grassi, Vincenza Granata, Secondo Lastoria, Steven Curley and Francesco Izzo

Human papillomavirus genotypes and HPV-16 variants distribution among Tunisian women with normal cytology and squamous intraepithelial lesions

Little is known about the epidemiological characteristics of papillomavirus (HPV) infection among North African countries. Herein, we conducted a molecular epidemiological study to investigate prevalence of HP...

Authors: R. Ghedira, W. Mahfoudh, S. Hadhri, S. Gabbouj, I. Bouanene, H. Khairi, A. Chaieb, R. Khelifa, N. Bouaouina, S. Remadi, A. A. Elmi, D. Bansal, A. A. Sultan, R. Faleh, A. Zakhama, L. Chouchane…

Erratum to: Molecular Detection of Epstein - Barr virus in Nasopharyngeal Carcinoma among Sudanese population

Authors: Ali Edris, Mona Ali Mohamed, Nouh S. Mohamed and Emmanuel E. Siddig

Molecular mechanisms of HPV mediated neoplastic progression

Human Papillomavirus is the major etiological agent in the development of cervical cancer but not a sufficient cause. Despite significant research, the underlying mechanisms of progression from a low-grade squ...

Authors: Rashmirani Senapati, Nihar Nalini Senapati and Bhagirathi Dwibedi