Skip to content

Advertisement

  • Review
  • Open Access

A review of the infection-associated cancers in North African countries

Infectious Agents and Cancer201611:35

https://doi.org/10.1186/s13027-016-0083-8

©  The Author(s). 2016

  • Received: 31 March 2016
  • Accepted: 9 June 2016
  • Published:

Abstract

Cancer is typically classified as a leading non-communicable disease; however, infectious agents, such as Helicobacter pylori (H. pylori), hepatitis B virus (HBV), hepatitis C virus (HCV) and human papilloma virus (HPV), contribute significantly to the pathogenesis of various cancers. Less developed countries, including countries of the North African (NA) region, endure the highest burden of infection-related cancers. The five most common infection-associated cancers in NA in order of incidence are bladder cancer, cervical cancer, liver cancer, stomach cancer, and nasopharyngeal carcinoma. This review aims to outline the epidemiologic pattern of infection-associated cancers in five NA countries (namely: Morocco, Algeria, Tunisia, Libya and Egypt) highlighting the similarities and differences across the region. The present study employed an initial literature review of peer-reviewed articles selected from PubMed, ScienceDirect and World Health Organization (WHO) databases based on key word searches without restriction on publication dates. Original research articles and reports written in French, as well as data from institutional reports and regional meeting abstracts were also included in this extensive review. Egypt, Libya, Tunisia, Algeria and Morocco were selected to be the focus of this review.

Keywords

  • Infection
  • Cancer
  • North Africa

Background

Cancer is typically classified as a non-communicable disease; however, infectious agents contribute significantly to cancer etiology [1]. The International Agency for Research on Cancer (IARC) has labelled some infectious agents as carcinogens, these include; Helicobacter pylori (H. pylori), hepatitis B virus (HBV), hepatitis C virus (HCV), Opisthorchis viverrini, Clonorchis sinensis, human papillomavirus (HPV), Epstein-Barr virus (EBV), human T-cell lymphotropic virus type 1 (HTLV-1), human herpes virus type 8 (HHV-8, also known as Kaposi’s sarcoma herpes virus; KSHV) and Schistosoma haematobium (S. haematobium) [2]. The data consistently point to an association between an infectious agent and a specific malignancy and ranges from 100 % (e.g. cervical cancer (CC) attributable to HPV) to 0.4 % (liver cancer caused by liver flukes), depending on the infectious agent, the cancer and the geographical location [3]. Persistent infection with certain types of HPV has been established as a necessary cause for CC, accounting for 100 % of these tumors. In addition to CC, oncogenic HPVs were found in approximately 88 % of anal cancers, 70 % of vaginal cancers, 50 % of penile cancers, and 43 % of vulvar cancers. Among other cancer types, HHV-8 has been found in nearly all tumors in patients with Kaposi’s sarcoma (KS). In endemic areas, all squamous cell carcinomas (SCCs) are assumed be attributed to schistosomiasis. H. pylori infection is consistently associated with gastric carcinoma and all nasopharyngeal carcinoma (NPC) cases are associated with EBV infection, while T-cell leukemia is rare in HTLV-1 negative subjects. Overall, 75 % to 80 % of cases of primary liver cancers are attributable to persistent infections with either HBV (50–55 %) or HCV (25–30 %) [1].

Malignant transformations of human cells that may be caused by infectious agents occur through different mechanisms of action [4]. These agents may act as direct carcinogens through the expression of oncogenes. The resulting onco-proteins can interact with cellular proteins leading to disruption of cell-cycle check-points, inhibition of apoptosis, and enhancement of cell immortalization. Infectious agents, such as HPV, HBV, HTLV-1, EBV and KSHV, act through this mechanism. Another mechanism of malignant transformation occurs as follows: chronic infection followed by chronic inflammation leads to the release of inflammatory mediators and the production of free oxygen radicals, which have direct mutagenic effects in addition to promoting tumor neo-vascularization and survival. Inflammation-induced cancers are associated with HCV, H. pylori and S. haematobium. Immune-suppression induced by human immunodeficiency virus (HIV-1), as well as KSHV and EBV, strongly increases the incidence of many other infection-associated cancers.

A systematic analysis by de Martel et al. from 2012 estimated that 16.1 % (about 2 million) of all new cancer cases reported during 2008, were directly attributable to infections; the majority of which (80 %, 1.6 million) originated in less developed countries. The proportion of infection-associated cancers ranged between 7.4 % and 22.9 % in developed and developing countries, respectively. According to the same study, in North African (NA) region the proportion was estimated at 12.7 %, with local variations between and within countries [1, 5].

Hepatitis B and C, HPV, and H. Pylori have been associated with about 95 % of infection-associated cancer cases. Cancer sites affected include cancers of the liver, cervix, selected head and neck cancers, and gastric cancers. These viruses differ in their contribution to cancer burden worldwide. HPV contributes equally to the cancer burden in both developed and developing countries. H. Pylori results in more cancer cases in developed countries, while HCV and HBV result in higher cancer rates in developing countries [6]. In NA, the five most common infection-related cancers in descending order are: bladder cancer, cervical cancer, liver cancer, stomach cancer, and NPC (Table 1). This review aims to demonstrate the influence of infectious agents on cancer pattern in NA countries and to summarize and provide up-to-date data in a region-specific manner.
Table 1

Total cancer incidence per 100,000 of most common infection-associated cancers in North African countriesa: Globocan, 2012 [7]

 

Morocco

Algeria

Tunisia

Libya

Egypt

Bladder (Schistosoma haematobium)

5.8

5.9

8.3

8.6

13.1

Cervix uteri (HPV)

14.3

8.5

4.8

9.7

2.3

Liver (HCV and HBV)

1.2

1.5

1.1

4.8

25.5

Stomach (Helicobacter pylori)

4.0

6.0

4.2

3.7

2.5

Nasopharyngeal (EBV)

2.3

3.2

2.3

231

0.3

aTotal cancer incidence (not only the incidence attributed to infectious agents)

Methods

The present study employed an initial literature review of peer-reviewed articles published in PubMed, ScienceDirect, and World Health Organization (WHO) databases with no restriction on publication date. Original research articles and reports written in French, as well as data from institutional reports and regional meeting abstracts were also included in this extensive review. In the articles and reports, data in the NA countries (Egypt, Libya, Tunisia, Algeria and Morocco) were considered eligible when the nature of epidemiological data, such as prevalence and incidence rates, were specified. Combinations of keywords used in the searches were: infectious agents (EBV, HCV, HBV, schistosomiasis, HPV, H. Pylori, HHV-8 and HTLV-1); country name (Egypt, Algeria, Morocco, Tunisia, Libya, NA and Maghreb); cancer type (bladder, cervical, liver, hepatocellular carcinoma (HCC), anogenital, and NPC).

Schistosomiasis and bladder cancer

Bladder cancer is the 11th most common cancer worldwide, affecting predominantly men (77 %), with an estimated 429,793 new cases in 2012 and 165,068 deaths in the same year [7, 8]. Egypt has the highest age-standardized incidence rate (ASR) of bladder cancer in men in NA (21.8/100,000 persons per year), followed by Algeria and Morocco (15.3/100,000 persons per year) and Libya and Tunisia (10.8/100,000 persons per year) (Fig. 1). Egyptian men also have the highest age standardized mortality rate in the world (11.1 per 100,000 men), which is twice the rate in Europe (5.2/100,000) and three times that in the United States (4.0/100,000) [7]. Consistent with the worldwide data, cases in men comprise a higher fraction of bladder cancer as compared to women in NA (Fig. 1). This observation is likely due to the high prevalence of urinary schistosomiasis, and the high rate of smoking among men [9].
Fig. 1
Fig. 1

Estimated age standardized incidence for bladder cancer in North African Countries: Globocan, 2012 [7]. Estimated age standardized incidence for bladder cancer in five North African Countries according to GLOBOCAN 2012 report shows that Egypt has the highest burden of bladder cancer

In the 1920s S. haematobium infection rates in Egypt were as high as 70–80 %. As a direct result of several control strategies that have been implemented throughout the country for the last two decades, Egypt has recently reached low schistosomiasis endemicity [10]. The prevalence of schistosomiasis dropped to 6.6 % in 1993 and then to 1.9 % in 2002 and 1.2 % in 2006 [11, 12]. Schistosomiasis is mostly eliminated in both Tunisia and Morocco, as no new cases were reported in these countries since 1984 and 2004, respectively [13]. The Moroccan schistosomiasis elimination strategy started in 1994 and disease transmission was curtailed by 2009 based on the absence of serum antibodies, indicating undetectable or complete absence of transmission, in a sample of 2,382 children selected from provinces with a history of high incidence [14]. In Libya, S. haematobium is endemic in some limited regions (near the Mediterranean coast, in the central part and near the southwestern border of Algeria). The estimated prevalence of Schistosoma in Libya between 2003 and 2010 was 5 %. In Algeria, S. haematobium is absent in most parts of the country and the risk of infection is localized in the province of Boumerdes [15].

Regarding bladder cancer incidence, the Algerian cancer registry, Setif, reported an increased trend in bladder cancer during a study period of 25 years (from 1986 to 2010). Bladder cancer rates (per 100,000) increased in men from 1.6 in 1986–1990 to 10.3 in 2006–2010 [16]. Similarly, in Morocco, based on the Casablanca cancer population registry, the ASR of bladder cancer increased in men from 5.8 in 2004 to 10.2 in 2007 [17]. Different trends were observed in the other NA countries, with either a stabilized or a decreasing tendency. The incidence rates remained stable over time in Tunisia (1993–2006) [18]. Bladder cancer ASR decreased from 11.7 in 2003 to 3.2 in 2012 among men in Libya [19]. In Egypt, the relative frequency of bladder cancer dropped from 27.6 % in 1970 to 11.7 % in 2007, which correlates well with a decrease of Schistosoma association from 82.4 % to 55.3 % during the same study period. A significant rise of tobacco-associated transitional cell carcinoma (TCC) from 16 % to 65.8 % and a decrease in SCC from 75.9 % to 28.4 % was however reported for the same period [20].

Shistosomiasis-associated bladder cancer presents a distinctive clinicopathologic profile, different from that reported from the Western countries. In contrast to the Western countries, which predominantly exhibit TCC as the major form of bladder cancer (estimated at 90–95 %), Egypt has reported as much as 75 % of their cases as SCC in the past [9, 21, 22]. Between 1970 and 1974, 26.7 % of patients registered in the National Cancer Institute (NCI) at Cairo University suffered from bladder cancer attributed to schistosomiasis [21]. Another study of 2778 patients at the NCI, showed that bladder cancer patients in 2005 had a six fold increased risk of TCC vs. SCC compared with patients treated in 1980 [23]. Thus, despite the considerable elimination of S. haematobium-related infections and hence the resulting bladder cancer, the effect of that had been impeded by tobacco-related bladder cancer among Egyptian men.

Human Papilloma virus and cervical cancer

Cervical cancer is the world’s third most common cancer among women, with an ASR of 14 per 100,000 women. The main bulk of CC cases occur in developing countries (85 %), yet NA countries show an overall low incidence (ASR: 6.6 per 100,000). Despite the relatively low incidence rates, CC is the second most common cancer among women in Algeria and Morocco and the third most common cancer in Tunisia. An increasing East-West gradient exists, ranging from as low as 2.3/100,000 women in Egypt to as high as 14.3/100,000 women in Morocco (Fig. 2) [7].
Fig. 2
Fig. 2

Estimated age standardized incidence and mortality rates for cervical cancer in North African countries: Globocan, 2012 [7]. Estimated age standardized incidence and mortality rates for cervical cancer in five North African countries according to GLOBOCAN 2012 report shows an increasing East-West gradient of cervical cancer

The age specific rates in Algeria and Morocco, were found to increase rapidly with age until 50–54 or 55–59 years, and then remained constant (Algeria) or decline (Morocco). Incidence rates reached relatively high values (almost 60/100,000) in Morocco between the ages of 50–54 years and around 40/100,000 in Algeria for ages above 55 years. In Egypt, the incidence rate was lower than 10/100,000 across all age groups. No cases of CC were observed among women below 30 years of age in Algeria, Morocco, and Egypt [24].

Almost 100 % of all CC cases are caused by the HPV, which ranks as the most common sexually transmitted infection globally [3]. There are more than 150 strains of HPV with varying carcinogenic potential. HPV-16 and 18 overshadow other strains (31, 33, 35, 45, 52 and 58) contributing to over 70 % of all CC cases and being responsible for 41–67 % of high-grade cervical lesions and 16–32 % of low-grade cervical lesions [25–27]. Paucity of published data in the NA region obscure the true epidemiological picture, however it is estimated that HPV prevalence falls between 5–12 % in low-risk population groups and 20–49 % in high-risk groups, with an average of 21.3 % [28]. Data of a meta-analysis also reported that the crude and adjusted HPV prevalence among women with normal cytological findings in NA (Egypt, Tunisia, Morocco and Algeria) were estimated at 10.9 % and 9.2 %, respectively [29]. The average prevalence is slightly higher in cases of cervical intraepithelial neoplasia (CIN) and established CC cases (25–90 % and 61–98 %, respectively) [28]. Mirroring the global situation, HPV16 is the most prevalent type among diagnosed cancer cases in NA countries (59 %), followed by HPV-18 (8.6–17 %) [30]. According to data available till 2013, NA countries resemble each other in HPV prevalence, which hovers around 10.5 %, aside from Tunisia which has a higher national prevalence (14.6 %), reasons for which are presently unclear (Table 2) [31].
Table 2

HPV prevalence in North African countries among different cell types according to data available till 2013 [31]

Country

HPV prevalence in women with normal cytology

HPV 16 and/or 18 in women with

Normal cytology

Low grade lesions

High grade lesions

Cervical cancer

Egypt

10.5

5.1

18.5

40

78.4

Libya

10.7

5.1

18.5

40

78.4

Tunisia

14.6

5.2

18.5

40

78.4

Algeria

10.5

9

18.5

40

77.1

Morocco

10.5

2.9

20.9

40

79.2

Human Papilloma virus and other ano-genital cancers

While HPV is the major cause of various types of ano-genital cancers, such as anal, vulvar, vaginal, and penile cancers, few studies report this correlation perhaps due to their low incidence rates, and a focus on CC, respectively. Anal cancer has a low worldwide incidence of 1 per 100,000 in the general population. Interestingly, the majority of vulvar cases were found in developed nations. Contrary to vulvar cancer, a higher prevalence (68 %) of vaginal cancer was observed in developing nations. Equally rare is worldwide incidence of penile cancer (22,000 new cases/year), which is highly positively correlated with CC [32–34]. Low incidences of ano-genital cancers have been reported across NA countries. ASRs of ano-genital cancers in NA countries did not exceed 3.1/100,000 for anal cancers, 0.7 for vulvar cancer and 0.4 for vaginal cancer (Table 3). Libya and Morocco do not currently have any official, published data [35–37].
Table 3

Age-standardized incidence rate (ASR) of ano-genital cancers in North African countries [35–37]

 

Egypt

Tunisia

Algeria

Anal cancer

0.4

0.2

Algiers:

Male 3.1; Female 2.5

Setif region:

Male 0.1; Female 0.1

Vulvar cancer

0.7

0.3

Algiers: 0.1

Setif region: 0.0

Vaginal cancer

0.2

0.4

Algiers: 0.1

Setif region:0.2

Penile cancer

0.0

0.0

Algiers : 0.0

Setif region:0.0

The only available data on HPV in anogenital cancers from NA are from a population from west Algeria, reporting a prevalence of HPV of 40 % in vaginal cancers, 17 % in vulvar cancers and 33 % in anal cancers [38].

Viral hepatitis and liver cancer

Globally, liver cancer or HCC is the fifth cancer among men (7.5 % of all cancers in men) and the ninth among women (3.4 % of all cancers in women). About 85 % of cases occur in developing countries with 2.4:1 male to female ratio [7, 39]. In NA, liver cancer is the most common cancer in men and the second most common one among women with an estimated ASR of 18 and 7 per 100,000 men and women, respectively. A large disparity exists with a decreasing East-West gradient observed across the region, where incidence in both sexes ranges from a lowest of 1.1/100,000 in Tunisia to a highest of 25.5/100,000 in Egypt (Fig. 3). In Egypt, the male:female ratio reaches 3.8:1, probably due to the higher prevalence of HBV and HCV among men. In addition, the relatively high rates of NHL in Egypt may be explained, in part, by the high HCV prevalence in the country [7].
Fig. 3
Fig. 3

Estimated age standardized incidence and mortality rates for liver cancer (in both sexes) in North African countries: Globocan, 2012. [7]. Estimated age standardized incidence and mortality rates for liver cancer in five North African countries according to GLOBOCAN 2012 report shows that Egypt has the highest burden of liver cancer with a decreasing East-West gradient

About 5 % of all cancers are thought to be the direct result of chronic infections with hepatitis viruses [3]. A strong geographic correlation has been found globally between the incidence of liver cancer and the prevalence of hepatitis B surface antigen (HBsAg) or hepatitis C antibody (anti-HCV) [40–43]. Chronic HCV is implicated in most HCC cases in developed countries and in one-third of cases in developing countries [44]. In NA there is a 33-fold increase in HCC with HCV infection and a 10-fold increase with HBV infection [45]. In addition, there is evidence for a causative association between chronic HCV infection and non-Hodgkin lymphoma (NHL), although the underlying mechanism is still not fully understood [46–48].

Hepatitis B

Most NA countries have an intermediate endemicity of HBV (Table 4) [49]. In Algeria, there is a significant lack of recent data on the prevalence of HbsAg in the general population, with the last publication dating back almost 20 years ago. The WHO estimates the prevalence in Algeria to stand anywhere between 2 % to 7 %, while Khelifa et al. reported it as 2.2 % in North Eastern regions in 1998 with HBV genotype D being the most common there accounting for 93 % of all HBV infections [50].
Table 4

Prevalence of HBV in North African countries according to data available till 2013 [49]

Country

HBV prevalence (%) in population

HBV prevalence (%) in Hemodialysis patients

Most common genotypes

Less common genotypes

Egypt

4

4.1

D

Subtype D1

Libya

2–7

2.6 [52]

D

 

Tunisia

2–7

No data

D

A, E

Algeria

3.6

No data

D

A, E

Morocco

1.3

2

D

A

The sero-prevalence of HBsAg in the general population in Libya varies between 1.3 % and 5.8 %. A national sero-epidemiological study conducted between 2004 and 2005 showed a prevalence of 2.2 % with 120,000–150,000 chronic HBsAg carriers [51]. A study on hemodialysis patients detected HBsAg prevalence of 2.6 % [52]. A low prevalence (1.3 %) was found among blood donors. HBV genotype D is the most prevalent in Libya [53].

Morocco has a low estimated prevalence for chronic HBV, ranging between 1 % and 3 % [54–58]. The HBsAg burden in the general population is 1.5 %, which was similar to that reported among health professionals (1 %), yet this figure increases to 1.7 % among sexually active subjects and to 2 % among hemodialysis patients [54–56, 59]. At Moroccan blood banks, the prevalence has remarkably decreased between 2000 and 2010 from 2.5–2.8 % to 0.8–1.3 % [57, 59, 60]. HBV genotype D accounts for 90 % of all HBV infections in Morocco [61].

In Tunisia, the estimated HBV prevalence ranges between 2 % and 7 %, being highest in South and Midwest regions. A survey on blood donors in 1994 revealed a prevalence of 5 % [62]. In 2010, the overall prevalence of HBsAg burden in a population of chronic carriers and of volunteers was 5.3 % and 2.9 % respectively. A large study conducted in 1997 found that 6.5 % of the study group was HBsAg positive [63]. HBV genotype D was found in 80 % of patients in Tunisia with dominant sub-genotype D7 [64, 65].

In Egypt, an earlier study reported HBsAg prevalence between 8 % and 11.7 % [66]. Recently, HBV prevalence in the general population has been varying from 1.3 % to 6.7 % [49]. Recent blood donor screening revealed a prevalence of HBsAg of 1.3–1.4 % [67, 68]. However, another cross-sectional study found that 16.6 % of blood donors were positive for total anti-HBV core antibodies of which 64 % were positive for HBsAg [69]. The prevalence of HBV among Egyptian liver cancer patients was 25.9 % and was shown to decrease over time [70]. HBV genotype D accounts for an estimated 87 % of the total infection in Egypt [71].

Hepatitis C

The global HCV prevalence is 2.35 % with estimated 160 million chronically-infected people [72]. It is a major cause of severe liver disease resulting in 0.35 million annual deaths [73]. HCV infection is a major public health issue in the NA Maghreb region (Morocco, Mauritania, Algeria, Tunisia, and Libya), where the prevalence ranges between 1–2 %. The highest prevalence however is reported in Egypt, ranging from 6 % to 28 % with an average of 14.7 % [74]. In addition, immigrants from the NA region to Europe were shown to have a higher prevalence compared to the general European Union population in host countries, raising the issue of national immigrant screening programs [75–77].

In Algeria, a survey conducted in 1995 among blood donors and pregnant women, found an HCV prevalence of 0.2 % [78]. The Algerian Ministry of Health estimated that the prevalence had reached 2.5 % in 2009 [79]. High prevalence rates, were found among hemodialysis patients (25 % to 53 %) and in hemophiliacs (31.6 %) [80]. In Algeria, subtype 1b is the most prevalent genotype (86.2 %) [81].

In the mid-1990s, the prevalence of HCV cases among Libyan general population was 8 % and was labeled as ‘community acquired’ [82]. A more recent national sero-epidemiological survey denoted that the prevalence had declined to 1.2 % [51]. Prevalence was higher among renal dialysis (20.5 %) and poly-transfused patients (11 %), transmission being mainly nosocomial [83]. Genotype 4 was the most common (35.7 %), followed by genotype 1 (32.6 %) [84].

In Morocco, the estimated prevalence among the general population and blood donors was 0.3 % and 2 % respectively [85–87]. The highest prevalence rates were observed in hemodialysis patients (34 %-68 %), hemophiliac patients (42 %), and intravenous drug users (60.1 %) [85, 88–91]. A survey conducted in 2001 in Casablanca revealed a 5 % prevalence of anti-HCV antibodies in traditional barbers. A more recent study showed a low prevalence among young army recruits (0.35 %), blood donors (0.33 %), and hospitalized patients (3.08 %) [60]. The most commonly found HCV genotypes were 1b (47.6 %), 2a/2c (37.1 %) and 1a (2.8 %) respectively [92].

In Tunisia, the average prevalence of anti-HCV antibodies is 1.6 % ranging between 0.3 % in the south and 3 % in the northwest region where several reports revealed the presence of a chronic hepatitis C cluster. An average prevalence of 0.6 % was reported in blood donors. Genotype 1b predominates and the prevalence ranges from 79 % to 90 % [62, 93–95].

The Egyptian Demographic Health Survey of 2008 estimated the prevalence of anti-HCV antibodies to be 14.7 %; the highest in the world to date. This inflated prevalence is thought to be associated with the mass parenteral anti-schistosomiasis therapy implemented during the 1950s-1980s [96–98] resulting in a large reservoir of chronic HCV. Between 2000 and 2007 the annual sero-prevalence of HCV among blood donors declined from 17.7 % to 7.4 % [67]. However, ongoing endemic transmission is suggested with an estimated incidence of nearly 6.9/1,000 persons per year [96, 99]. HCV genotype G4 is the most common genotype in Egypt [98].

A meta-analysis of 32 case-control studies reported that co-infection with HBV and HCV is strongly associated with HCC (OR = 165), compared with mono-infection with HCV (OR =17) or HBV (OR = 23) [100]. Similarly, a recent study in the NA region reported a 33-fold increase in HCC with HCV infection and a 10-fold increase with HBV infection [ 45]. This risk increased 84-fold when patients were co-infected by both viruses, suggesting a synergistic effect between the two infections, although the exact mechanism has not yet been established.

A multicenter case-control study conducted between 2002 and 2005 in patients with HCC from Algeria, Morocco and Tunisia, reported that 60 % of HCC patients were positive for anti-HCV and 18 % for HBsAg [45]. In Egypt, there was a significant increase in the annual proportion of patients with HCC among chronic liver disease patients attending the Cairo liver center, during a study period ranging from 4.0 % in 1993 to 7.2 % in 2002, with a significant drop of HBsAg positivity among HCC patients from 38.6 % to 20.5 % and a slight increase of HCV positivity from 85.6 % to 87.9 % [101].

The Algerian Cancer Registry in Setif was the only one that could provide longitudinal data on HCC over a 25-year period (from 1986 to 2010). The liver cancer rate was found to increase since 1996–2000 after a decrease for both sexes (annual percent changes of +8.9 % in men and +5.4 % in women) [16]. In Libya, no significant change in liver cancer incidence was observed between 2003 (ASR = 3.3) and 2012 (ASR = 4)) [19].

H. Pylori and stomach cancer

Stomach cancer is the 4th common cancer in men and the 6th in women worldwide with an ASR of 17.4 and 7.5 per 100,000 respectively. Stomach cancer incidence is much less in NA (ASR: 4.3 and 2.7 per 100,000 in men and women, respectively) with an increasing East- West gradient (Fig. 4) [7].
Fig. 4
Fig. 4

Estimated age standardized incidence and mortality rates for stomach cancer (in both sexes) in North African countries: Globocan, 2012 [7]. Estimated age standardized incidence and mortality rates for stomach cancer in five North African countries according to GLOBOCAN 2012 report shows that Algeria has the highest burden of stomach cancer

H. pylori infection is the etiological agent in various gastric pathologies and the disease severity has been attributed to some H. pylori genotypes [102]. It is estimated that H. pylori infection increases the risk of stomach cancer by nearly six times. Prevalence rates differ by age, ethnicity and socioeconomic characteristics, being higher in developing countries [103].

In Morocco, a 69 % prevalence of H. pylori infection was found among patients with digestive complaints. Commonly infected sites were the atrium (73 %), the corpus (21 %) and the pylorus (6 %). The potentially carcinogenic cagA antigen was detected in 42.3 % of cases [104]. In Egypt, several studies showed high prevalence of infection in various settings. H. pylori IgG antibodies were detected in 68 % of a group of women with primary fibromyalgia [105]. H. pylori prevalence of 72.38 % was found among school children [106]. In Tunisia, 66.7 % of a group of symptomatic patients were seropositive for H. pylori compared to 64 % of a group of blood-donors [107]. The prevalence of H. pylori infection reached 51.4 % among six-year old children [108]. The estimated prevalence of H. pylori infection in Algeria was over 70 % [109]. In 1989, a sero-epidemiological study found that the prevalence among children in the first decade of life was 45 % which rose steadily to reach 92 % among those in the fifth decade [110]. Despite the high infection rates in NA countries, stomach cancer remains relatively low, indicating that other determinants such as genetic factors or virulence of the organism influence the carcinogenic potential and ultimate cancer development.

Epstein-Barr virus associated cancers

NPC is the 22nd most common cancer worldwide, but it is the 6th most common cancer in NA. In addition to NA it is prevalent in Southern China, Southeast Asia, Japan and the Middle East [111, 112]. EBV is a group I carcinogen, implicated in NPC, Burkitt’s Lymphoma, Hodgkin’s, non-Hodgkin’s and T cell lymphoma [113].

EBV infects over 95 % of the global adult population [114], yet NPC results from an interaction between EBV infection and environmental/genetic factors [112]. The highest observed incidence of NPC in NA is in Algeria (3.2/100,000) and the lowest is in Egypt with 0.3/100,000 (Fig. 5). Interestingly, some typical NA foods seem to be associated with increased risk of NPC [115, 116]. A study conducted over 4 years (2002–2005), in Morocco, Algeria and Tunisia reported that the consumption of butyric acid (found in rancid butter (smen), rancid sheep fat, and dried mutton stored in oil (quaddid)) was significantly associated with an increased risk of NPC, with the presence of butyric acid in these traditional foods acting as a potential EBV activator [116].
Fig. 5
Fig. 5

Estimated age standardized incidence and mortality rates for NPC (in both sexes) in North African Countries: Globocan, 2012 [7]. Estimated age standardized incidence and mortality rates for NPC in five North African countries according to GLOBOCAN 2012 report shows highest levels of NPC in Algeria

HHV8 and Kaposi’s sarcoma

Kaposi’s sarcoma (KS) does not appear in the top 25 cancers in the world, however, it is the 10th most common cancer in Africa, with an ASR of 4.7/100,000 probably due to the high prevalence of HIV [7]. In Morocco, anti-HHV8 antibody was found in 92 % of KS cases, mostly affecting males [117, 118]. Kaposi sarcoma was the cause of death in 6 % of a sample of HIV-positive patients [119].

In Tunisia, the sero-prevalence of HHV8 was 13.8 % in blood donors, 13 % in pregnant women, and 12 % in children [120]. HHV8 was found in 17 % of kidney transplant patients [121]. Another study noted that 7 % of adult renal transplant recipients developed various cancers, of which 41.6 % developed KS [122]. Kaposi sarcoma was found in 4.5 % of skin cancer patients registered in southern Tunisia over a period of 24 years (1979–2002) [123]. In a small cohort with acquired immunodeficiency syndrome (AIDS), KS emerged in 22.7 % of cases within 0 to 10 years. This time frame was similar in the neighboring Morocco [124]. In Egypt, a prospective study on 1–4 year old children with febrile syndrome showed that 41.9 % were seropositive for HHV-8 [125]. There is a general lack of data on this subject in Algeria.

HTLV-1 and T-cell Leukemia

There is a close association between T-cell Leukemia and the presence of antibodies to HTLV-I [126]. However, few studies have been carried out in the last decade in Africa and the number of tested individuals is limited. Sero-positivity for HTLV-I in Morocco is 0.6 %. In Tunisia, Algeria and Egypt, HTLV-I/II infections were not observed in blood donors or recipients [127].

Conclusion

Differences in the rates of infection-related cancers across NA countries are manifested in the high incidence of bladder and liver cancers and NHL in Egypt versus the remarkably increasing East-West gradient of CC. Rates of NPC were also high in all the NA countries except Egypt.

The burden of infection-related cancers is still underestimated worldwide and associations with new infectious agents remain yet to be explored. If infectious diseases associated with cancers were prevented, it is estimated that there would be 26.3 % fewer cancer cases in developing countries and 7.7 % in developed countries.

The administration of the HBV vaccine in addition to the routine screening of blood and blood products for HBV and HVC have resulted in a reduced incidence of liver cancer. Furthermore, HPV vaccines which protect against HPV-16 & 18 are now available and have the potential to reduce the incidence of CC. A paradox is the incidence of SCC of bladder cancer, which markedly decreased in Egypt as a result of the success of schistosomiasis control, although increased smoking doubtless is a factor contributing to the increased proportion of TCC bladder cancer in Egypt. The intermediate prevalence of many communicable diseases in NA requires a constant epidemiological surveillance and the rapid adoption of available preventative vaccines in addition to health education about region-specific risk factors. Therefore the strategy should shift from a therapy-based one which is employed after the development of a specific malignancy is linked to an infectious agent to a preventative one based on national vaccination campaigns, population education on risk factors and other lifestyle-related preventative measures.

Abbreviations

AIDS, Acquired immunodeficiency syndrome; ASR, Age standardized incidence rate; CC, Cervical cancer; EBV, Epstein-Barr virus; H. pylori, Helicobacter pylori; HBsAg, Hepatitis B surface antigen; HBV, Hepatitis B Virus; HCC, Hepatocellular carcinoma; HCV, Hepatitis C Virus; HHV-8, Human herpes virus type 8; HIV-1, Human immunodeficiency virus; HPV, Human papillomavirus; HTLV-1, Human T-cell lymphotropic virus type 1; IARC, International Agency for Research on Cancer; IgG, Immunoglobulin G; KS, Kaposi’s sarcoma; KSHV, Kaposi sarcoma- associated herpes virus; NA countries, North African countries (Egypt, Libya, Tunisia, Algeria and Morocco); NA, North Africa; NCI, National Cancer Institute at Cairo University; NHL, Non-Hodgkin lymphoma; NPC, Nasopharyngeal carcinoma; OR, Odds ratio; S. haematobium, Schistisoma haematobium; SCC, Squamous cell carcinoma; TCC, Transitional cell carcinoma; WHO, World Health Organization

Declarations

Acknowledgement

This study was financially supported by the European Union, EU FP7/2007-2013 grant 260715. The funders had no role in study design, decision to publish, or preparation of the manuscript.

Authors’ contributions

WAA, MK, MA and AF planned the study. WAA, WMH, LM and MK performed the literature search. WAA, MK, LM and MA evaluated research articles included. WMH and RDT wrote review sections, figures and tables. WAA, LM, AF, MK, and RDT revised and edited to obtain the final format. All authors read and approved the final manuscript.

Authors’ information

WMH is a research assistant with a Master’s degree in public health and M.B.B.Ch degree in Medicine.

WAA is a professor of public health with a broad experience in epidemiology and mutagenesis research.

MA is a researcher with a broad experience in cancers associated with viruses.

LM is a researcher with background in stem cell research and oncogenesis.

AF is a scientist with a great experience in research on cancer epidemiology and cancer risk factors and prevention.

RDT holds a BSc in Molecular Biology and an MSc in Biotechnology; her work focuses on virology and epidemiological research.

MK is a researcher with a great experience in infectious diseases and cancer research.

Competing interests

The authors declare that they have no competing interests.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Community, Environmental and Occupational Medicine, Faculty of Medicine, Ain ShamsUniversity, Cairo, Egypt
(2)
Biology and Medical Research Unit, National Center of Energy, Sciences and Nuclear Technics, Rabat, Morocco
(3)
Laboratory of Onco-virology, Institut Pasteur du Maroc, Casablanca, Morocco
(4)
Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(5)
Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden

References

  1. de Martel C, Farley J, Franceschi S, Bray F, Forman D, Plummer M. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012;13(6):607–15.PubMedView ArticleGoogle Scholar
  2. Jemal A, Center MM, DeSantis C, Ward EM. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 2010;19(8):1893–907.PubMedView ArticleGoogle Scholar
  3. Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006;118(12):3030–44.PubMedView ArticleGoogle Scholar
  4. World Health Organization, International Agency for Rresearch on Cancer, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Biological agents, 2012; 100 B: 39-40. [http://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Evaluation-Of-Carcinogenic-Risks-To-Humans/Biological-Agents-2012]. Accessed 1 Mar 2016.
  5. Zanetti R, Tazi MA, Rosso S. New data tells us more about cancer incidence in North Africa. Eur J Cancer. 2010;46(3):462–6.PubMedView ArticleGoogle Scholar
  6. Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132(5):1133–45.PubMedView ArticleGoogle Scholar
  7. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010 [http://globocan.iarc.fr, Accessed on 25/12/2013., 2013].
  8. Parkin D. The global burden of urinary bladder cancer. Scand J Urol Nephrol. 2008;42 Suppl 218:12–20.View ArticleGoogle Scholar
  9. Khaled H. Schistosomiasis and Cancer in Egypt: Review. J Adv Res. 2013;4(5):461–6.PubMedPubMed CentralView ArticleGoogle Scholar
  10. Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J. Schistosomiasis and water resources development: Systematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis. 2006;6(7):411–25.PubMedView ArticleGoogle Scholar
  11. El Khoby T, Galal N, Fenwick A. The USAID/Government Egypt’s Schistosomiasis Research Project (SRP). Parasitol Today. 1998;14:92–6.PubMedView ArticleGoogle Scholar
  12. World Bank. Egypt-National Schistosomiasis Control Project. Washington, DC: World Bank; 2008. [http://documents.worldbank.org/curated/en/2008/06/9689864/egypt-national-schistosomiasis-controlproject]. Accessed 1 Mar 2016.Google Scholar
  13. WHO. Schistosomiasis number of people treated 2009. Wkly Epidemiol Rec. 2011;86:73–80.Google Scholar
  14. Amarir F, El Mansouri B, Fellah H, Sebti F, Mohammed L, Handali S, et al. National serologic survey of Haematobium schistosomiasis in Morocco evidence for elimination. Am J Trop Med Hyg. 2011;84(1):15–9.PubMedPubMed CentralView ArticleGoogle Scholar
  15. 15. Barakat R, El Morshedy H, Farghaly A. Human Schistosomiasis in the Middle East and North Africa Region. In: Neglected tropical diseases – Middle East and North Africa. Mary Ann McDowell, Sima Rafati: Springer- Verlag Wien; 2014. [http://link.springer.com/book/10.1007/978-3-7091-1613-5]. Accessed 1 Mar 2016.
  16. Hamdi Cherif M, Serraino D, Mahnane A, Laouamri S, Zaidi Z, Boukharouba H, et al. Time trends of cancer incidence in Setif, Algeria, 1986–2010. BMC Cancer. 2014;14:637.PubMedPubMed CentralView ArticleGoogle Scholar
  17. Obtel M, Lyoussi B, Tachfouti N, Mathoulin Pelissier N, Nejjari C. Using surveillance data to understand cancer trends: an overview in Morocco. Archives of Public Health. 2015;73:45–51.PubMedPubMed CentralView ArticleGoogle Scholar
  18. Missaoui N, Trabelsi A, Parkin DM, Jaidene L, Chatti D, Mokni M, et al. Trends in the incidence of cancer in the Sousse region, Tunisia, 1993–2006. Int J Cancer. 2010;127:2669–77.PubMedView ArticleGoogle Scholar
  19. Bodalal Z, Azzuz R, Bendardaf R. Cancers in Eastern Libya: First results from Benghazi Medical Center. World J Gastroenterol. 2014;20:6293–301.PubMedPubMed CentralView ArticleGoogle Scholar
  20. Gouda I, Mokhtar N, Bilal D, El-Bolkainy T, El-Bolkainy MN. Bilharziasis and bladder cancer: a time trend analysis of 9843 patients. J Egypt Nat Cancer Inst. 2007;19(2):158–62.PubMedGoogle Scholar
  21. El Sebaie I, El Bolkainy M, Hussein M. Cancer Institute registry. Med J Cairo Univ. 1973;41:175–82.Google Scholar
  22. Lamm DL, Tori FM. Bladder Cancer. Cancer J Clin. 1996;46:93–113.View ArticleGoogle Scholar
  23. Felix AS, Soliman AS, Khaled H, Zaghloul MS, Banerjee M, El-Baradie M, et al. The changing pattern of bladder cancer in Egypt over the past 26 years. Cancer Causes Control. 2008;19(4):421–9.PubMedPubMed CentralView ArticleGoogle Scholar
  24. Vaccarella S, Bruni L, Seoud M. Burden of human papilloma virus infections and related diseases in the extended Middle East and North Africa region. Vaccine. 2013;315:G32–44.View ArticleGoogle Scholar
  25. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12–9.PubMedView ArticleGoogle Scholar
  26. Clifford G, Franceschi S, Diaz M, Muñoz N, Villa LL. Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases. Vaccine. 2006;31(24):26–34.View ArticleGoogle Scholar
  27. Bosch FX, Lorincz A, Muñoz N, Meijer CJ, Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol. 2002;55(4):244–65.PubMedPubMed CentralView ArticleGoogle Scholar
  28. Seoud MA, Seoud KM, Lindely S, Anis S. Human papillomavirus (HPV): Burden of the disease in cervical cancer in the extended Middle East and North Africa. A comprehensive review. J Clin Oncol 2009; 27 (suppl; abstr e16577) meeting report (2009 Asco Annual meeting).Google Scholar
  29. Bruni L, Diaz M, Catellsague X, Ferrer E, Bosch X, de Sanjose S. Cervical Human Papillomavirus Prevalence in 5 Continents: Meta-Analysis of 1 Million Women with Normal Cytological Findings. J Infect Dis. 2010;202(12):1789–99.PubMedView ArticleGoogle Scholar
  30. Castellsagué X, de Sanjosé S, Aguado T, Louie K.S, Bruni L, Muñoz J, Diaz M, Irwin K, Gacic M, Beauvais O, Albero G, Ferrer E, Byrne S, Bosch F X. HPV and Cervical Cancer in the World 2007 Report. WHO/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre) [http://www.hpvcentre.net/hpvpublications.php]. Accessed 12 Dec 2016.
  31. Bruni L, Barrionuevo-Rosas L, Serrano B, Brotons M, Cosano R, Muñoz J, Bosch F, de Sanjosé S, X. C. ICO Information Centre on HPV and Cancer (HPV Information Centre). Summary Report 2013-12-16 [Data Accessed] 2013.Google Scholar
  32. Palefsky JM. HPV infection in men. Dis Markers. 2007;23(4):261–72.PubMedPubMed CentralView ArticleGoogle Scholar
  33. Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer. 2002;2(5):342–50.PubMedView ArticleGoogle Scholar
  34. Chin-Hong PV, Palefsky JM. Natural history and clinical management of anal human papillomavirus disease in men and women infected with human immunodeficiency virus. Clin Infect Dis. 2002;35(9):1127–34.PubMedView ArticleGoogle Scholar
  35. Parkin DM, et al., Cancer Incidence in Five Continents. IARC Scientific Publications No. 155, 2002. VIII.Google Scholar
  36. Curado MP, et al., Cancer Incidence in Five Continents. IARC Scientific Publications No. 160, 2007. IX.Google Scholar
  37. UNESCO Institute for Statistics Data Centre [online database]. Montreal, UNESCO Institute for Statistics, 2012. Available at: http://stats.uis.unesco.org [Accessed on Jan 2013].
  38. Nahet A, Boublenza L, Hassaine H, Masdoua N, Prétet JL, Belglaiaa E, et al. HPV DNA genotyping: A study of anogenital, head and neck and skin cancers in a population from west Algerian. HPV detection in different cancers from an Algerian population. Bull Cancer. 2016;103:455–60.Google Scholar
  39. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90.PubMedView ArticleGoogle Scholar
  40. Lu SN, Su WW, Yang SS, Chang TT, Cheng KS, Wu JC, et al. Secular trends and geographic variations of hepatitis B virus and hepatitis C virus-associated hepatocellular carcinoma in Taiwan. Int J Cancer. 2006;119:1946–52.PubMedView ArticleGoogle Scholar
  41. Huang YH, Wu JC, Chau GY, Tsay SH, King KL, Sheng WY, Lui WY, Lee SD. Detection of serum hepatitis B, C, and D viral nucleic acids and its implications in hepatocellular carcinoma patients. J Gastroenterol. 1998;33:512–6.PubMedView ArticleGoogle Scholar
  42. Lee SD, Lee FY, Wu JC, Hwang SJ, Wang SS, Lo KJ. The prevalence of anti-hepatitis C virus among Chinese patients with hepatocellular carcinoma. Cancer. 1992;69:342–5.PubMedView ArticleGoogle Scholar
  43. Bosch FX, Ribes J, Díaz M, Cléries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology. 2004;127(5 Suppl 1):S5–16.PubMedView ArticleGoogle Scholar
  44. Dhanasekaran R, Limaye A, Cabrera R. Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics. Hepat Med. 2012;4:19–37.PubMedPubMed CentralGoogle Scholar
  45. Bahri O, Ezzikouri S, Alaya-Bouafif NB, Iguer F, Feydi AE, Mestiri H, et al. First multicenter study for risk factors for hepatocellular carcinoma development in North Africa. World J Hepatol. 2011;3(1):24–30.PubMedPubMed CentralGoogle Scholar
  46. Gisbert JP, García-Buey L, Pajares JM, Moreno-Otero R. Prevalence of hepatitis C virus infection in B-cell non-Hodgkin’s lymphoma: systematic review and meta-analysis. Gastroenterology. 2003;125(6):1723–32.PubMedView ArticleGoogle Scholar
  47. Matsuo K, Kusano A, Sugumar A, Nakamura S, Tajima K, Mueller NE. Effect of hepatitis C virus infection on the risk of non-Hodgkin’s lymphoma: a meta-analysis of epidemiological studies. Cancer Sci. 2004;95(9):745–52.PubMedView ArticleGoogle Scholar
  48. Dal Maso L, Franceschi S. Hepatitis C virus and risk of lymphoma and other lymphoid neoplasms: a meta-analysis of epidemiologic studies. Cancer Epidemiol Biomarkers Prev. 2006;15(11):2078–85.PubMedView ArticleGoogle Scholar
  49. Gasim IG. Hepatitis B, virus in the Arab world: Where do we stand? Arab J Gastroenterol. 2013;14:35–43.PubMedView ArticleGoogle Scholar
  50. Khelifa F, Thibault V. Characteristics of hepatitis B viral strains in chronic carrier patients from North-East Algeria. Pathol Biol. 2009;57(1):107–13.PubMedView ArticleGoogle Scholar
  51. Elzouki A, Hepatitis B. C and HIV infection in Libya. Libyan J Infect Dis. 2007;1:132–3.Google Scholar
  52. Alashek WA, McIntyre CW, Taal MW. Hepatitis B and C infection in haemodialysis patients in Libya: prevalence, incidence and risk factors. BMC Infect Dis. 2012;12:265.PubMedPubMed CentralView ArticleGoogle Scholar
  53. Salem MA, EM Elnifro EM, Alshuwen F. Molecular Analysis of Hepatitis B Virus Isolates in Libya: Predominant Circulation of Hepatitis B Virus Genotype D. J Gastroenterol Hepatol Res. 2012;1(7):119–21.Google Scholar
  54. Ezzikouri S, Chemin I, Chafik A, Wakrim L, Nourlil J, Malki AE, et al. Genotype determination in Moroccan hepatitis B chronic carriers. Infect Genet Evol. 2008;8(3):306–12.PubMedView ArticleGoogle Scholar
  55. Djeriri K, Laurichesse H, Merle JL, Charof R, Abouyoub A, Fontana L, et al. Hepatitis B in Moroccan health care workers. Occup Med. 2008;58(6):419–24.View ArticleGoogle Scholar
  56. Sbai A, Baha W, Ougabrai H, Allalia T, Dersi N, Lazaar F, et al. Hepatitis B prevalence and risk factors in Morocco. Pathol Biol. 2012;60(5):3.View ArticleGoogle Scholar
  57. Zohoun A, Hadef R, Zahid H, Benkirane M. Seroprevalence of HBV and HCV in blood donors at the Blood Transfusion Center of Mohammed V Military Teaching Hospital in Rabat Morocco. Med Trop. 2011;71(5):513–4.Google Scholar
  58. Heikel J, Sekkat S, Bouqdir F, Rich H, Takourt B, Radouani F, et al. The prevalence of sexually transmitted pathogens in patients presenting to a Casablanca STD clinic. Eur J Epidemio. 1999;15(8):711–5.View ArticleGoogle Scholar
  59. Benjelloun S, Bennani A, Sekkat S, Benslimane A. Les hépatites virales au Maroc. Aspects épidémiologique et moléculaire [Abstract]. Journées scientifiques de medecine. 2002;60–4:60–4.Google Scholar
  60. Aqodad N, Lahbabi M, Elyousfi M, Mellouki I, Benajah D, Elabkari M, et al. Prevalence of VHC-Ab and HBsAg among blood donors in Guelmim in the south of Morocco. Hep Intl. 2011;5(1):96.Google Scholar
  61. Baha W, Ennajib MM, Lazara F, Melloulc M, El Fahimec E, El Malkia A, et al. HBV genotypes prevalence, precore and basal core mutants in Morocco. Infect Genet Evol. 2012;12(6):1157–62.Google Scholar
  62. Jemni S, Ikbel K, Kortas M, Mahjoub J, Ghachem L, Bidet JM, et al. Seropositivity to hepatitis C virus in Tunisian haemodialysis patients. Nouv Rev Fr Hemato. 1994;36(5):349–51.Google Scholar
  63. Triki H, Said N, Ben Salah A, Arrouji A, Ben Ahmed F, Bouguerra A, et al. Seroepidemiology of hepatitis B, C and delta viruses in Tunisia. Trans R Soc Trop Med Hyg. 1997;91(1):11–4.PubMedView ArticleGoogle Scholar
  64. Bahri O, Cheikh I, Hajji N, Djebbi A, Maamouri N, Sadraoui A, et al. Hepatitis B genotypes, precore and core promoter mutants circulating in Tunisia. J Med Virol. 2006;78(3):353–7.Google Scholar
  65. Meldal BH, Moula NM, Barnes IH, Boukef K, Allain JP. A novel hepatitis B virus subgenotype, D7, in Tunisian blood donors. J Gen Virol. 2009;90(Pt 7):1622–8.PubMedView ArticleGoogle Scholar
  66. Sherif MM, Abou-Aita BA, Abou-Elew MH, el-Kafrawi AO. Hepatitis B virus infection in upper and lower Egypt. J Med Virol. 1985;15(2):129–35.PubMedView ArticleGoogle Scholar
  67. Ismail AM, Ziada HN, Sheashaa HA, Shehab El-Din AB. Decline of viral hepatitis prevalence among asymptomatic Egyptian blood donors: a glimmer of hope. Eur J Intern Med. 2009;20(5):490–3.PubMedView ArticleGoogle Scholar
  68. Wasfi OA, Sadek NA. Prevalence of hepatitis B surface antigen and hepatitis C virus antibodies among blood donors in Alexandria. Egypt East Mediterr Health J. 2011;17(3):238–42.PubMedGoogle Scholar
  69. Said ZN, Sayed MH, Salama II, Aboel-Magd EK, Mahmoud MH, Setouhy ME, et al. Occult hepatitis B virus infection among Egyptian blood donors. World J Hepatol. 2013;5(2):64–73.PubMedPubMed CentralView ArticleGoogle Scholar
  70. Lehman EM, Wilson ML. Epidemiology of hepatitis viruses among hepatocellular carcinoma cases and healthy people in Egypt: a systematic review and meta-analysis. Int J Cancer. 2009;124(3):690–7.PubMedView ArticleGoogle Scholar
  71. Khaled IA, Mahmoud OM, Saleh AF, Bioumie EE. Prevalence of HBV genotypes among Egyptian hepatitis patients. Mol Biol Rep. 2011;38(7):4353–7.PubMedView ArticleGoogle Scholar
  72. Lavanchy D. Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect. 2011;17(2):107–15.PubMedView ArticleGoogle Scholar
  73. Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol. 2006;45(4):529–38.PubMedView ArticleGoogle Scholar
  74. Guerra J, Garenne M, Mohamed MK, Fontanet A. HCV burden of infection in Egypt: results from a nationwide survey. J Viral Hepat. 2012;19(8):560–7.PubMedView ArticleGoogle Scholar
  75. Roudot-Thoraval F, Deforges L, Girollet PP, Maria B, Milliez J, Pathier D, Duval J, Dhumeaux D. Prevalence of hepatitis C virus antibodies (tests ELISA 2 and RIBA 2) in a population of pregnant women in France. Gastroenterol Clin Biol. 1992;16(3):255–9. Article in French.PubMedGoogle Scholar
  76. Chiaramonte M, Pupo A, Menegon T, Baldo V, Malatesta R, Trivello R. HBV and HCV infection among non-European Union immigrants in North-East Italy. Epidemiol Infect. 1998;121(1):179–83.PubMedPubMed CentralView ArticleGoogle Scholar
  77. Hemminki K, Mousavi SM, Brandt A, Ji J, Sundquist J. Liver and gallbladder cancer in immigrants to Sweden. Eur J Cancer. 2010;46(5):926–31.PubMedView ArticleGoogle Scholar
  78. Ayed Z, Houinato D, Hocine M, Ranger-Rogez S, Denis F. Prevalence of serum markers of hepatitis B and C in blood donors and pregnant women in Algeria. Bull Soc Pathol Exot. 1995;88(5):225–8.PubMedGoogle Scholar
  79. National Travel Health Network, C., Country Information, Algeria, Tunisia, Morocco, 2009.Google Scholar
  80. Berkane S. French Luncheon comment prendre en charge les patients atteints d’hépatite C avec les médicaments disponibles en Algérie, 2009.Google Scholar
  81. Rouabhia S, Sadelaoud M, Chaabna-Mokrane K, Toumi W, Abenavoli L. Hepatitis C virus genotypes in north eastern Algeria: A retrospective study. World J Hepatol. 2013;5(7):393–7.PubMedPubMed CentralView ArticleGoogle Scholar
  82. Saleh MG, Pereira LM, Tibbs CJ, Ziu M, al-Fituri MO, Williams R, McFarlane IG. High prevalence of hepatitis C virus in the normal Libyan population. Trans R Soc Trop Med Hyg. 1994;88(3):292–4.Google Scholar
  83. Daw MA, Elkaber MA, Drah AM, Werfalli MM, Mihat AA, Siala IM. Prevalence of hepatitis C virus antibodies among different populations of relative and attributable risk. Saudi Med J. 2002;23(11):1356–60.PubMedGoogle Scholar
  84. Elasifer HA, Agnnyia YM, Al-Alagi BA, Daw MA. Epidemiological manifestations of hepatitis C virus genotypes and its association with potential risk factors among Libyan patients. Virol J. 2010;7(317):7–317.Google Scholar
  85. Benjelloun S, Bahbouhi B, Sekkat S, Bennani A, Hda N, Benslimane A. Anti-HCV seroprevalence and risk factors of hepatitis C virus infection in Moroccan population groups. Res Virol J. 1996;147:247–55.View ArticleGoogle Scholar
  86. Benouda A, Boujdiya Z, Ahid S, Abouqal R, Adnaoui M. Prevalence of hepatitis C virus infection in Morocco and serological tests assessment of detection for the viremia prediction. Pathol Biol. 2009;57(5):368–72.PubMedView ArticleGoogle Scholar
  87. Lahlou Amine I, Zouhair S, Chegri M, L’kassmi H. Seroprevalence of anti-HCV in patients of the Military Hospital Moulay Ismail (Meknes, Morocco): Data analysis of the medical biology laboratory (2002-2005). Bull Soc Pathol Exot. 2010;103(4):255–8. [Article in French.PubMedView ArticleGoogle Scholar
  88. Boulaajaj K, Elomari Y, Elmaliki B, Madkouri B, Zaid D, Benchemsi N. Prevalence of hepatitis C, hepatitis B and HIV infection among haemodialysis patients in Ibn-Rochd university hospital, Casablanca]. Nephrol Ther. 2005;1(5):274–84.PubMedView ArticleGoogle Scholar
  89. Sekkat S, Kamal N, Benali B, Fellah H, Amazian K, Bourquia A, El Kholti A, Benslimane A. Prevalence of anti-HCV antibodies and seroconversion incidence in five haemodialysis units in Morocco. Nephrol Ther. 2008;4(2):105–10. Article in French.PubMedView ArticleGoogle Scholar
  90. Bahadi A, Maoujoud O, Hassani K, Akhmouch I, Doblali T, El Allam M, et al. L’hépatite C virale en hémodialyse: étude multicentrique ambispective de séroconversion et de prévalene. Néphrologie Thérapeutique. 2011;7:399–406.View ArticleGoogle Scholar
  91. Trimbitas RD, Serghini FZ, Lazaar F, Baha W, Foullous A, Essalhi M, et al. The “hidden” epidemic: a snapshot of Moroccan intravenous drug users. Virol J. 2014;11(43):11–43.Google Scholar
  92. Benani A, El-Turk J, Benjelloun S, Sekkat S, Nadifi S, Hda N, et al. HCV genotypes in Morocco. J Med Virol. 1997;52(4):396–8.Google Scholar
  93. Hannachi N, Boughammoura L, Marzouk M, Tfifha M, Khlif A, Soussi S, et al. Viral infection risk in polytransfused adults: seroprevalence of seven viruses in central Tunisia. Bull Soc Pathol Exot. 2011;104(3):220–5.PubMedView ArticleGoogle Scholar
  94. Ben Alaya Bouafif N, Triki H, Mejri S, Bahri O, Chlif S, Bettaib J, et al. A case control study to assess risk factors for hepatitis C among a general population in a highly endemic area of northwest Tunisia. Arch Inst Pasteur Tunis. 2007;84(1-4):21–7.PubMedGoogle Scholar
  95. Mejri S, Mhalla S, Ben Yahia A, Triki H. Molecular and phylogenetic analyses of Tunisian hepatitis C virus strains subtype 1b. Ann Biol Clin. 2012;70(6):707–16.Google Scholar
  96. Frank C, Mohamed MK, Strickland GT, Lavanchy D, Arthur RR, Magder LS, et al. The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet. 2000;355(9207):887–91.PubMedView ArticleGoogle Scholar
  97. El-Zanaty F. Egypt Demographic and Health Survey 2008. Cairo, Egypt: Ministry of Health, El-Zanaty and Associates and Macro International. 2009.Google Scholar
  98. Mohamoud YA, Mumtaz GR, Riome S, Miller D, Abu-Raddad LJ. The epidemiology of hepatitis C virus in Egypt: a systematic review and data synthesis. BMC Infect Dis. 2013;13:288–308.PubMedPubMed CentralView ArticleGoogle Scholar
  99. DeWolfe Miller F, Abu-Raddad LJ. Evidence of intense ongoing endemic transmission of hepatitis C virus in Egypt. Proc Natl Acad Sci U S A. 2010;107(33):14757–62.PubMedPubMed CentralView ArticleGoogle Scholar
  100. Donato F, Boffetta P, Puoti M. A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma. Int J Cancer. 1998;75(3):347–54.PubMedView ArticleGoogle Scholar
  101. El-Zayadi AR, Badran HM, Barakat EM, Attia M-D, Shawky S, Mohamed MK, et al. Hepatocellular carcinoma in Egypt: a single center study over a decade. World J Gastroenterol. 2005;11:5193–8.Google Scholar
  102. Forman D. Helicobacter pylori and gastric cancer. Scand J Gastroenterol Suppl. 1996;220:23–6.PubMedView ArticleGoogle Scholar
  103. Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut. 2001;49(3):347–53.View ArticleGoogle Scholar
  104. Alaoui Boukhris S, Benajah DA, El Rhazi K, Ibrahimi SA, Nejjari C, Amarti A, et al. Prevalence and distribution of Helicobacter pylori cagA and vacA genotypes in the Moroccan population with gastric disease. Eur J Clin Microbiol Infect Dis. 2012;31(8):1775–81.PubMedView ArticleGoogle Scholar
  105. Olama SM, El-Arman M. Helicobacter pylori in Egyptian patients with fibromyalgia syndrome. Egyptian Rheumatologist. 2013;35(3):167–73.View ArticleGoogle Scholar
  106. Mohammad MA, Hussein L, Coward A, Jackson SJ. Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth. Public Health Nutr. 2008;11(3):230–6.PubMedView ArticleGoogle Scholar
  107. Mansour KB, Keita A, Zribi M, Masmoudi A, Zarrouk S, Labbene M, et al. Seroprevalence of Helicobacter pylori among Tunisian blood donors (outpatients), symptomatic patients and control subjects. Gastroenterol Clin Biol. 2010;34(1):75–82.PubMedView ArticleGoogle Scholar
  108. Siai K, Ghozzi M, Ezzine H, Medjahed N, Azzouz MM. Prevalence and risk factors of Helicobacter pylori infection in Tunisian children: 1055 children in Cap-Bon (northeastern Tunisia). Gastroenterol Clin Biol. 2008;32(11):881–6.PubMedView ArticleGoogle Scholar
  109. Sixième colloque sur Helocobacter Pylori, L.A.d.R.s.H.-A., Palais de la Culture Moufdi Zakaria, 20 Feb 2011.Google Scholar
  110. Mégraud F, Brassens-Rabbé MP, Denis F, Belbouri A, Hoa DQ. Seroepidemiology of Campylobacter pylori infection in various populations. J Clin Microbiol. 1989;27(8):1870–3.PubMedPubMed CentralGoogle Scholar
  111. Zhou X, Cui J, Macias V, Kajdacsy-Balla AA, Ye H, Wang J, Rao PN. The progress on genetic analysis of nasopharyngeal carcinoma. Comp Funct Genomics. 2007;57513(10):57513.Google Scholar
  112. Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2006;15(10):1765–77.PubMedView ArticleGoogle Scholar
  113. IARC, Lyon, France: World Health Organization. Epstein-Barr Virus and Kaposi’s Sarcoma Herpesvirus/Human Herpesvirus 8. 1997.Google Scholar
  114. Rickinson AB, Kieff E. Epstein-Barr Virus. Virology. 2007;5:2655–700.Google Scholar
  115. Belbaraka R, Lalya I, Boulaamane L, Tazi M, Benjaafar N, Errihani H. Dietary risk factors of undifferenced nasopharyngeal carcinoma : a case-control study. Tunis Med. 2013;91(6):406–9.PubMedGoogle Scholar
  116. Feng BJ, Jalbout M, Ayoub WB, Khyatti M, Dahmoul S, Ayad M, et al. Dietary risk factors for nasopharyngeal carcinoma in Maghrebian countries. Int J Cancer. 2007;121(7):1550–5.PubMedView ArticleGoogle Scholar
  117. El Kassimi B, Benchemsi N, Mikou O, El Ouazzani T, Lakhdar H. Maladie de Kaposi et anticorps anti-herpès virus-8 au Maroc. Med Mal Infect. 2003;33(4):226–8.View ArticleGoogle Scholar
  118. Errihani H, Berrada N, Raissouni S, Rais F, Mrabti H, Rais G. Classic Kaposi’s sarcoma in Morocco: clinico-epidemiological study at the National Institute of Oncology. BMC Dermatol. 2011;11:15–20.PubMedPubMed CentralView ArticleGoogle Scholar
  119. Sodqi M, Marih L, Lahsen AO, Bensghir R, Chakib A, Himmich H, et al. Causes of death among 91 HIV-infected adults in the era of potent antiretroviral therapy. Presse Med. 2012;41(7-8):e386–90.Google Scholar
  120. Hannachi N, Ben Fredj N, Samoud S, Ferjani A, Khlif A, Boughammoura L, et al. Seroprevalence and risk factors of human herpes virus 8 infection in Central-East Tunisia. Pathol Biol. 2012;60(5):282–6.PubMedView ArticleGoogle Scholar
  121. Lahlaoui H, Niija H, Ben Moussa M. Seroprevalence of human herpesvirus 8 in kidney transplant recipients in a single-center study from Tunisia. Iran J Kidney Dis. 2012;6(1):14–6.PubMedGoogle Scholar
  122. Harzallah K, Abderrahim E, Chareffedine K, Yeich S, Belhadj R, Skhiri H, et al. Cancers after renal transplantation: multicenter experience. Saudi J Kidney Dis Transpl. 2008;19(5):825–30.PubMedGoogle Scholar
  123. Mseddi M, Marrekchi S, Abdelmaksoud W, Bouassida S, Meziou TJ, Boudaya S, et al. Epidemio-clinical profile of skin cancer in southern Tunisia. Tunis Med. 2007;85(6):505–8.PubMedGoogle Scholar
  124. Dhrif AS, Kilani B, Ammari L, Kanoun F, Tiouri H, Ben CT. AIDS-associated Kaposi’s sarcoma: 22 cases. Tunis Med. 2007;85(6):494–9.PubMedGoogle Scholar
  125. Andreoni M, Sarmati L, Nicastri E, El Sawaf G, El Zalabani M, Uccella I, et al. Primary human herpesvirus 8 infection in immunocompetent children. JAMA. 2002;287(10):1295–300.PubMedView ArticleGoogle Scholar
  126. Blattner W, Takatsuki K, Gallo R. Human T-cell leukemia lymphoma virus and adult T-cell leukemia. JAMA. 1983;250:1074–80.PubMedView ArticleGoogle Scholar
  127. De-The G, Gessain A, Gazzolo L. Comparative seroepidemiology of HTLV-I and HTLV-II in the French West Indies and some African countries. Cancer Res. 1985;45(9):S4633–6.Google Scholar

Copyright

© The Author(s). 2016

Advertisement

Infectious Agents and Cancer

ISSN: 1750-9378

Contact us