A suggested model in which environmental xenobiotics are involved in EBV-mediated cancers: 1. Xenobiotics promote EBV lytic cycle leading to cell lysis and virus dissemination from B cells; 2. Xenobiotics promote the abortive lytic infection, which involves the expression of some latent and lytic genes although without viral maturation; 3. Xenobiotics promote DNA damage which can lead to mutations facilitating EBV genome maintenance and latency in epithelial cells; 4. EBV and xenobiotics promote synergism or additive effects for cancer initiation and progression. Created with BioRender.com.