Table 1 The significant biological pathways enriched by hub genes of DEMs
Row | miRNA | Enriched terms |
|---|---|---|
1 | hsa-let-7a | Endometrial cancer, Colorectal cancer, Renin secretion, Cocaine addiction, TNF signaling pathway, Human T-cell leukemia virus 1 infection, Thyroid hormone signaling pathway, Human cytomegalovirus infection, Renal cell carcinoma, Cortisol synthesis and secretion |
2 | hsa-let-7g | Endometrial cancer, Colorectal cancer, Human T-cell leukemia virus 1 infection, Circadian rhythm, Thyroid hormone signaling pathway, Toxoplasmosis, TNF signaling pathway, Hedgehog signaling pathway, Human cytomegalovirus infection, Chronic myeloid leukemia |
3 | hsa-mir-181b | Endocrine and other factor-regulated calcium reabsorption, Endometrial cancer, TNF signaling pathway, Renal cell carcinoma, Acute myeloid leukemia, Thyroid hormone signaling pathway, Human T-cell leukemia virus 1 infection, Toll-like receptor signaling pathway, Small cell lung cancer, Graft-versus-host disease |
4 | hsa-mir-26b | Endometrial cancer, Small cell lung cancer, Renal cell carcinoma, Melanoma, Amyotrophic lateral sclerosis (ALS), Chronic myeloid leukemia, Human T-cell leukemia virus 1 infection, Renin secretion, Cocaine addiction, Colorectal cancer |
5 | hsa-mir-30c | Renin secretion, Endocrine and other factor-regulated calcium reabsorption, TNF signaling pathway, Osteoclast differentiation, Endometrial cancer, Th17 cell differentiation, Human T-cell leukemia virus 1 infection, Cocaine addiction, Aldosterone-regulated sodium reabsorption, Renal cell carcinoma |
6 | hsa-mir-186 | Endocrine and other factor-regulated calcium reabsorption, Endometrial cancer, Renal cell carcinoma, Acute myeloid leukemia, Thyroid hormone signaling pathway, Salmonella infection, Chronic myeloid leukemia, Pancreatic cancer, Colorectal cancer, Th17 cell differentiation |
7 | hsa-mir-10a | TNF signaling pathway, Cocaine addiction, Circadian rhythm, Small cell lung cancer, Endocrine and other factor-regulated calcium reabsorption, Endometrial cancer, Renal cell carcinoma, Chronic myeloid leukemia, Cortisol synthesis and secretion, Parathyroid hormone synthesis, secretion and action |
8 | hsa-mir-30b | Endocrine and other factor-regulated calcium reabsorption, Endometrial cancer, Cocaine addiction, Thyroid hormone signaling pathway, Chronic myeloid leukemia, Human cytomegalovirus infection, Long-term depression, Salivary secretion, Renin secretion, Salmonella infection |
9 | hsa-let-7f | Endometrial cancer, Renin secretion, Renal cell carcinoma, Colorectal cancer, Human cytomegalovirus infection, Thyroid hormone signaling pathway, Long-term depression, Cocaine addiction, Prostate cancer, Neurotrophin signaling pathway |