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Table 4 Randomized clinical trials of HCC treatment with SA monotherapy

From: The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets

Publication

Type of study

Number of enrolled patients and controls

Type of Cancer

SA used for treatment

Response to treatment-outcome

  

Patients

Controls

   

Kourumalis 1998[220]

RCT

28*

30#

Advanced HCC

OCT SC (500 μg/d)

↓AFP,↑S, ↑QoL

Yuen 2002[221]

RCT

35*

35°

Advanced HCC

OCT LAR (30 mg/28d)

None

Dimitroulopoulos 2007[166]

RCT

24* (Octreoscan +)

30° (Octreoscan +)

Advanced HCC

OCT LAR (20 to 30 mg/28d)

↑S, ↑QoL

66# (Octreoscan -)

Becker 2007[223]

RCT

60*

59°

Advanced HCC

OCT LAR (30 mg/28d)

None

Barbare 2009[224]

RCT

135*

137°

Advanced HCC

OCT LAR (30 mg/28d)

=S, ↓QoL

  1. RCT, Randomized clinical trial.
  2. AFP, Alpha fetoprotein.
  3. S, Survival.
  4. QoL, Quality of life.
  5. *: treated patients.
  6. #: untreated patients.
  7. °: placebo controls.