Figure 2
A schema showing studies of multi-factorial etiology of Burkitt lymphoma (BL). Descriptive epidemiological studies have demonstrated sex, age, and geography as risk factors. Immunological and biomarker studies have demonstrated increased risk related to infections that disrupt immunity, such as malaria, human immunodeficiency virus, and use of solid organ transplantation as risk factors. The genetic basis of BL remains largely explored and represents the next frontier in BL research.