Volume 7 Supplement 1

Proceedings of the 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI)

Open Access

Multicentric Castleman’s disease in HIV/AIDS patients at an urban HIV clinic in Atlanta, Georgia, in the combined antiretroviral therapy era

  • Rathi N Pillai1Email author,
  • Clifford Gunthel2,
  • Marylyn Adamski3,
  • Marina Mosunjac4 and
  • Minh Ly Nguyen2
Infectious Agents and Cancer20127(Suppl 1):P20

https://doi.org/10.1186/1750-9378-7-S1-P20

Published: 19 April 2012

Background

Multicentric Castleman’s disease (MCD), which has been associated with human herpesvirus-8 (HHV-8), is a lymphoproliferative disorder with an increased prevalence in HIV positive patients [1]. We describe our experience with MCD in a group of patients with HIV/AIDS in an urban HIV clinic.

Methods

Our clinic serves annually 5,000 patients diagnosed with AIDS. Patients with a diagnosis of multicentric Castleman’s disease between 2006 and 2010 were identified from the pathology database at Grady Memorial Hospital or referrals to the clinic. Clinic charts and medical records were abstracted. Patients’ demographics, CD4 counts, HIV viral load, HIV and MCD treatment and outcomes were recorded.

Results

Nine patients diagnosed with MCD were identified in our HIV/AIDS population. All patients were male and reported sex with men (MSM) as their risk for HIV infection. The mean age at MCD diagnosis was 39.22 ± 11.40; the mean CD4 cell count nadir was 68.33 ± 62.2 cells/mm3. 85% (7/9) were on cART (combined antiretroviral therapy) at the time of MCD diagnosis with a mean CD4 count of 233.67±157.44 cells/mm3. MCD was of the hyaline vascular variant in 3 patients, plasma cell variant in 2, transitional in 1 patient, and unspecified in 2 patients. Systemic symptoms were present in three patients. Five patients had both Kaposi sarcoma (KS) and MCD (2 with KS occurring after MCD diagnosis, 1 with KS before MCD, 2 with KS and MCD diagnosed simultaneously). Most of the patients were anemic with mean hemoglobin of 8.99±4.04 g/dL and hypoalbuminemic (2.31±0.96). 85% had anemia, hepatosplenomegaly, and low albumin at diagnosis. Treatment consisted of valgancyclovir, chemotherapy and/or rituximab. In the 5 patients who died, the mean time from MCD diagnosis was 425.2±447 days.

Conclusions

HIV-associated MCD is characterized by lymphadenopathy, splenomegaly, anemia and hypoalbuminemia. Among the diseases associated with HHV8 (KS, primary effusion lymphoma, and MCD), MCD appears to be the least affected by cART use or degree of immunosuppression [2]. In our cohort, 85% of patients had a CD4 count above 200 at MCD diagnosis.The survival with cART is still dismal, with one year survival of 50%. Larger multicenter study is needed to better understand the pathogenesis of HIV-associated MCD and its treatment.

Authors’ Affiliations

(1)
Winship Cancer Institute, Emory University
(2)
Division of Infectious Diseases, Emory University School of Medicine
(3)
Infectious Disease Program, Grady Health System
(4)
Department of Pathology, Emory University School of Medicine

References

  1. Powles T, Stebbing J, Bazeos A: The role of immunosuppresssion and HHV-8 in the increasing incidence of HIV-associated multicentric Castleman’s disease. Ann Oncol. 2009, 20 (4): 775-9. 10.1093/annonc/mdn697.View ArticlePubMedGoogle Scholar
  2. Myelona EE, Baraboutis IG, Lekakis LJ: Multicentric Castleman’s disease in HIV infection: a systematic review of the literature. AIDS Rev. 2008, 10 (1): 25-35.Google Scholar

Copyright

© Pillai et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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