- Oral presentation
- Open Access
Herpesviruses control the DNA damage response through TIP60
© Li et al; licensee BioMed Central Ltd. 2012
- Published: 19 April 2012
- Herpes Simplex
- Cold Sore
- Lytic Gene
- Host Substrate
- Substrate Conservation
1. The conserved herpesvirus kinases target the DNA damage response (DDR) pathway.
2. The EBV kinase BGLF4 induces the DDR and regulates key lytic viral genes through TIP60.
3. TIP60 knockdown impairs and γ herpesvirus replication.
4. Identification of key cellular targets of the conserved herpesvirus kinases will facilitate the development of broadly effective anti-viral strategies.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.