Human papillomavirus prevalence in invasive cervical carcinoma by HIV Status
© De Vuyst et al; licensee BioMed Central Ltd. 2012
Published: 19 April 2012
Data on the prevalence of human papillomavirus (HPV) types in invasive cervical carcinoma (ICC) in women with HIV are scarce but are essential to elucidate the influence of immunity on the carcinogenicity of different HPV types, and the potential impact of prophylactic HPV vaccines in populations with high HIV prevalence.
To compare the prevalence of HPV types in ICC by HIV status.
From 2007 to 2009, a multicentre case-case study was conducted at two referral hospitals in Nairobi, Kenya, and in Durban, South Africa. Women over 18 years of age presenting with ICC were recruited, and frozen biopsies were obtained and tested for HPV DNA using GP5+/6+-PCR methodology. The present analysis was limited to the 235 squamous cell cancers (SCC) detected.
Overall, our data suggest that current prophylactic HPV vaccines against HPV16 and 18 may prevent similar proportions of cervical SCC in HIV-positive as in HIV-negative women provided that vaccine-related protection is sustained after HIV infection.
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