The impact of the HIV epidemic on U.S. anal cancer rates, 1980-2007
© Shiels et al; licensee BioMed Central Ltd. 2012
Published: 19 April 2012
U.S. incidence rates of anal cancer have increased steadily over time, and are generally higher in women than men. It has been proposed that the HIV epidemic may have influenced U.S. anal cancer trends. Compared to the general population, anal cancer rates are strongly elevated in HIV-infected individuals. Anal cancer rates in HIV-infected individuals have also increased over time. We estimated the impact of the HIV epidemic on U.S. anal cancer trends during 1980-2007.
Data on anal cancer incidence rates were obtained from the HIV/AIDS Cancer Match Study, which links 14 U.S. HIV/AIDS and cancer registries. We estimated incidence rates with anal cancer cases and person-years for the general population, and then subtracted 2 groups of cases in people with AIDS: cases that occurred after AIDS diagnosis (incident) and within 5 years prior to AIDS (prevalent). All rates were standardized to the 2000 U.S. population by age, sex and race. Poisson regression was used to estimate changes in rates over time.
During 1980-2007, the U.S. anal cancer epidemic in young men was strongly influenced by the HIV epidemic; however, among women, the anal cancer epidemic was independent of HIV. Effective anal cancer prevention in HIV-infected men would have a substantial impact on U.S. anal cancer rates.
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