The impact of aging on cancer burden in people with HIV/AIDS
© Polesel et al; licensee BioMed Central Ltd. 2010
Published: 11 October 2010
People with HIV/AIDS (PWHA) have higher risk of some cancers compared to the general population, with an approximately 2-fold increase for all non-AIDS-defining cancers (NADC). The widespread use of highly active antiretroviral therapy (HAART) has improved life expectancy of PWHA, exposing them to both aging and the prolonged exposure to cancer risk factors. A linkage study was therefore conducted to evaluate the impact of aging on the burden of cancer in this population.
Materials and methods
We performed an anonymous record linkage between Italian AIDS (21,951 cases) and Cancer Registries (17.3 million people, covering 30% of the general population). Crude incidence rates (IR), IRs directly standardized by sex and age, and age-specific IRs were estimated for NADCs in the pre-HAART (1986-1996) and in the HAART (1997-2004) periods.
All non-AIDS-defining cancers.
Age Group (years)
Incidence Rates (per 100,000)
General Population People With HIV/AIDS
Incidence Rate Ratio (people with AIDS vs. general population) IR Ratio
The lack of any change in standardized IRs of NADCs across periods highlights the strong influence of PWHA aging on the observed upward trends of crude IRs. The aging of PWHA in HAART period, together with the age-related increase of cancer incidence, points to cancer as an increasing medical priority for this population in the near future. This calls for the intensification of cancer prevention strategies, notably smoking cessation and screening programs.
This article has been published as part of Infectious Agents and Cancer Volume 5 Supplement 1, 2010: Proceedings of the 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI).The full contents of the supplement are available online at http://www.biomedcentral.com/1750-9378/5?issue=S1.
This article is published under license to BioMed Central Ltd.