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Malignant lymphoma subgroups from Zaria, Nigeria, reveal absence of HIV/AIDS-related plasmablastic lymphomas and HHV-8-related lymphoproliferative disorders

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Background

Prevalence of non-Hodgkin’s lymphoma (NHL) subgroups throughout Africa, particularly among persons with HIV/AIDS, is unknown but increases in Burkitt lymphoma, plasmablastic lymphoma, and HHV-8 proliferation disorders have been noted. SSALC, an AIDS and Cancer Specimen Resource (ACSR/NCI) project, seeks to define indigenous sub-Saharan NHL subtypes using WHO classification (2008). Omoti (Univ. Benin 2007) defined an overall malignant lymphoma (ML) rate: 13.4/100,000 (1990s) including 17% Hodgkin’s disease and 83% NHL but subgroups were not defined. Because regional HIV/AIDS prevalence is high, we subgrouped NHL and reviewed lymph node hyperplasia using stored material from Ahmadu Bello University Teaching Hospital in Zaria, Nigeria, to look for HIV/AIDS-associated lymphoid malignancies.

Materials and methods

Fifty-seven paraffin blocks were used to construct a tissue microarray (TMA), and whole tissue sections were H&E stained for morphology. TMA sections were stained using 30 monoclonal antibodies for common NHL antigens and Lana-1 for HHV-8 (immunohistochemical, IHC); in situ hybridization (ISH) for EBV-encoded RNA, kappa/lambda light chains (Ventana, Tucson, AZ), and fluorescent in situ hybridization (FISH) c-myc t(8;14) (Abbott/Vysis, Downer’s Grove, IL).

Results

There were 43 ML and 14 hyperplasic lymph nodes or reactive tissues. One lymph node was suspected for Castleman’s disease but Lana-1 was negative. Table 1 lists ML subgroups.

Table 1 Cases by diagnostic subgroup.

Conclusions

Subgrouping ML with Hodgkin's disease (12%) and NHL (88%) is similar to the 2007 report from nearby Benin University. Burkitt lymphoma was the most common NHL at 51% followed by follicular lymphoma 16% and diffuse large B-cell lymphomas 14%. With the exception of Burkitt lymphoma, which is endemic in Nigeria, other NHL commonly associated with HIV/AIDS such as plasmablastic lymphoma and HHV-8 lymphoproliferative disorders were not identified.

Acknowledgements

This article has been published as part of Infectious Agents and Cancer Volume 5 Supplement 1, 2010: Proceedings of the 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI).The full contents of the supplement are available online at http://www.biomedcentral.com/1750-9378/5?issue=S1.

Author information

Correspondence to Leona W Ayers.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Lymphoma
  • Follicular Lymphoma
  • Malignant Lymphoma
  • Lymphoproliferative Disorder
  • Burkitt Lymphoma