- Meeting abstracts
- Open Access
Malignant lymphoma subgroups from Zaria, Nigeria, reveal absence of HIV/AIDS-related plasmablastic lymphomas and HHV-8-related lymphoproliferative disorders
© Ayers et al; licensee BioMed Central Ltd. 2010
- Published: 11 October 2010
- Follicular Lymphoma
- Malignant Lymphoma
- Lymphoproliferative Disorder
- Burkitt Lymphoma
Prevalence of non-Hodgkin’s lymphoma (NHL) subgroups throughout Africa, particularly among persons with HIV/AIDS, is unknown but increases in Burkitt lymphoma, plasmablastic lymphoma, and HHV-8 proliferation disorders have been noted. SSALC, an AIDS and Cancer Specimen Resource (ACSR/NCI) project, seeks to define indigenous sub-Saharan NHL subtypes using WHO classification (2008). Omoti (Univ. Benin 2007) defined an overall malignant lymphoma (ML) rate: 13.4/100,000 (1990s) including 17% Hodgkin’s disease and 83% NHL but subgroups were not defined. Because regional HIV/AIDS prevalence is high, we subgrouped NHL and reviewed lymph node hyperplasia using stored material from Ahmadu Bello University Teaching Hospital in Zaria, Nigeria, to look for HIV/AIDS-associated lymphoid malignancies.
Fifty-seven paraffin blocks were used to construct a tissue microarray (TMA), and whole tissue sections were H&E stained for morphology. TMA sections were stained using 30 monoclonal antibodies for common NHL antigens and Lana-1 for HHV-8 (immunohistochemical, IHC); in situ hybridization (ISH) for EBV-encoded RNA, kappa/lambda light chains (Ventana, Tucson, AZ), and fluorescent in situ hybridization (FISH) c-myc t(8;14) (Abbott/Vysis, Downer’s Grove, IL).
Cases by diagnostic subgroup.
Lymphoblastic lymphoma: (pre-B)
Angioimmunoblastic T-cell lymphoma
Marginal zone lymphoma
Lymphoma not otherwise specified (NOS)
B-cell lymphoma, EBV+
Diffuse large B-cell lymphoma
Activated B cell
Malignant infiltrate (HHV-8 negative)
Subgrouping ML with Hodgkin's disease (12%) and NHL (88%) is similar to the 2007 report from nearby Benin University. Burkitt lymphoma was the most common NHL at 51% followed by follicular lymphoma 16% and diffuse large B-cell lymphomas 14%. With the exception of Burkitt lymphoma, which is endemic in Nigeria, other NHL commonly associated with HIV/AIDS such as plasmablastic lymphoma and HHV-8 lymphoproliferative disorders were not identified.
This article has been published as part of Infectious Agents and Cancer Volume 5 Supplement 1, 2010: Proceedings of the 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI).The full contents of the supplement are available online at http://www.biomedcentral.com/1750-9378/5?issue=S1.
This article is published under license to BioMed Central Ltd.