Four year survival in untreated AIDS related-Kaposi sarcoma (AIDS-KS) in Jos, Nigeria
© Agaba et al; licensee BioMed Central Ltd. 2009
Published: 17 June 2009
AIDS-KS remains a significant cause of morbidity and mortality especially in sub-Saharan Africa in the face of ART scale-up. We compare survival over a four-year period between HIV-infected men and women with untreated AIDS-KS receiving care in Jos, Nigeria.
Patients and methods
One hundred and three (58.8%) were females while 72 (41.2%) were males, giving a male: female ratio of 1:1.6. The mean age was 35 ± 7 and 40 ± 7 for females and males respectively (p < 0.001). Median CD4 count was 105 and 114 cells/mm3 (p, 0.76) while HIV RNA was 43,113 and 80,310 (p, 0.01) median copies/ml for females and males respectively at baseline. Mean duration of observation was similar for both sexes (2.3 ± 0.9 years) with 18.4% of females and 13.9% of males having history of use of HAART. Seventy-five percent (75%) of the females and 80 percent of the males had disseminated cutaneous disease and more than 40 percent of the male had nodular lesions compared with 25.5 percent of the females. The probability of survival was similar for both sexes.
Despite the availability of HAART, AIDS-KS continues to significantly affect morbidity and mortality in HIV-infected patients in our setting. Provision of specific treatment for AKS may improve overall outcome.
This article is published under license to BioMed Central Ltd.