Volume 4 Supplement 2

Proceedings of the 11th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research

Open Access

Preliminary findings on cancer incidence in HIV-infected persons from six countries in Central and South America and the Caribbean

  • DR Masys1,
  • F Fang1,
  • I Ye1,
  • V Fink2,
  • E Gotuzzo3,
  • D Padgett4,
  • JW Pape5,
  • C Cortes6,
  • M Bacon7 and
  • M Schechter8
Infectious Agents and Cancer20094(Suppl 2):O18

https://doi.org/10.1186/1750-9378-4-S2-O18

Published: 17 June 2009

Background

The Caribbean, Central and South America network (CCASAnet) is one of seven regions funded by the International Epidemiologic Databases to Evaluate AIDS (IeDEA) program sponsored by the National Institute of Allergy & Infectious Diseases and National Cancer Institute [1]. CCASAnet performs analyses using HIV epidemiology data from clinical care sites in Argentina, Brazil, Chile, Haiti, Honduras, Mexico and Peru. In August of 2007, with a funding supplement provided by NCI, six participating sites in the network began a project to determine the incidence, treatment and outcomes of cancer occurring in HIV-infected individuals in the region.

Methods

A total of approximately 13,000 HIV-positive individuals followed at the participating sites formed the study cohort. Chart reviews began in fall 2007 and are continuing at present. A standardized cancer case abstract form was developed by the Vanderbilt data coordination center and its use was validated by Fundación Huésped in Buenos Aires. English and Spanish language versions of the case report form and instructions for its use were created, along with a secure online Web interface for capturing data in computerized format, Table 1.
Table 1

Preliminary results *

Site – Country

FH – Argentina

UFRJ – Brazil

FA – Chile

GHESKIO – Haiti

IHSS – Honduras

Total adult patients

2000

2800

2400

4000

1000

Adult patients reviewed to date for cancer diagnoses

1200

620

2400

450

946

Cancer cases identified as of May, 2008

107

36

125

27

51

Current cancer incidence estimate in HIV cohort

8.9%

5.8%

5.2%

6%

5.4%

Method of diagnosis (Clinical/Histopathological)

Histopathological 90%

Clinical 10%

Histopathological 100%

Histopathological 100%

Histopathological 40%

Clinical 60%

Histopathological 80%

Clinical 20%

Cancer types found to date

71 KS

22 NHL

2 HL

1 breast

1 cervix

TBD

70 KS

28 NHL

6 HL

13 solid tumors:

3 anorectal,

4 in situ cervical neoplasias (CIN),

1 non KS sarcoma,

1 basal cell Ca

3 testicle,

1 prostate,

1 colon

9 KS

5 Cervical Cancer

2 Lymphoma

2 Hodgkin

1 Ovarian

2 Breast

1 Colon

2 Oro-pharyngeal

1 Right eye

1 Liver

1 Pancreas

Case reviews and confirmations in progress. To date, 5 NHL cases found (2 Burkitt, 1 small cell, 2 NHL not otherwise specified)

*Updated incidence figures and characterization of cases will be presented at the conference.

Conclusion

The preliminary incidence and cancer types occurring in selected cohorts in the Caribbean, Central and South America are consistent with previously reported cancer findings in HIV-infected populations.

Authors’ Affiliations

(1)
Vanderbilt University School of Medicine
(2)
Fundación Huésped (FH) and Hospital Fernández
(3)
Universidad Peruana Cayetano Heredia and Instituto de Medicina Tropical Alexander von Humboldt (IMTAvH)
(4)
Instituto Hondureño de Seguridad Social (IHSS) and Universidad Nacional Autόnoma de Honduras
(5)
Les Centres GHESKIO
(6)
Fundaciόn Arriarán (FA)
(7)
National Institute of Allergy & Infections Diseases, National Institute of Health
(8)
Universidade Federal do Rio de Janeiro (UFRJ)

References

  1. McGowan CC, Cahn P, Gotuzzo E, Padgett D, Pape JW, Wolff M, Schechter M, Masys DR: Cohort Profile: Caribbean, Central and South America Network for HIV research (CCASAnet) collaboration within the International Epidemiologic Databases to Evaluate AIDS (IeDEA) programme. Int J Epidemiol. 2007, 36 (5): 969-76. 10.1093/ije/dym073. Epub 2007 Sep 10.View ArticlePubMedGoogle Scholar

Copyright

© Masys et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

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