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Table 2 The associations of HPV, family history of cancer, cigarette smoking, alcohol drinking, BMI, No. full-term pregnancies, HCV, HBV infection status with the cervical cancer risk

From: Hepatitis B or C viral infection and the risk of cervical cancer

Variable

Cases

Controls

Univariable

Multivariable

(n = 838)

(n = 838)

No

%

No

%

OR

95%CI

P

AOR

95%CI

P

HPV

          

 HPV-negative

141

15.5

768

91.6

 

1(reference)

  

1(reference)

 

 HPV-positive

697

84.5

70

8.4

55.2

40.6–75.1

 < 0.001

57.5

41.8–79.2

 < 0.001

Family history of cancer

          

 No

828

98.8

819

97.7

 

1(reference)

    

 Yes

10

1.2

19

2.3

0.5

0.2–1.1

0.106

   

Cigarette smoking

          

 No

834

99.5

837

99.9

 

1(reference)

    

 Yes

4

0.5

1

0.1

4

0.4–36.6

0.214

   

Alcohol drinking

          

 No

836

99.8

838

100

 

1(reference)

    

 Yes

2

0.2

0

0

–

–

–

   

BMI

          

  < 18.5

78

9.3

67

8

 

1(reference)

    

 18.5–25

587

70

573

68.4

0.9

0.6–1.2

0.438

   

 25–30

150

17.9

163

19.5

0.8

0.5–1.2

0.215

   

  > 30

23

2.7

35

4.2

0.6

0.3–1.0

0.061

   

No.full-term pregnancies

          

 0

40

4.8

93

11.1

 

1(reference)

  

1(reference)

 

 1

243

29

366

43.7

1.9

1.2–2.8

0.004

1.7

0.9–3.2

0.091

 2

343

40.9

263

31.4

3.9

2.5–6.0

 < 0.001

4.1

2.2–7.8

 < 0.001

 3

116

13.8

63

7.5

5.7

3.4–9.6

 < 0.001

7

3.3–14.7

 < 0.001

  > 3

96

11.5

53

6.3

6.4

3.7–11.1

 < 0.001

4.1

1.8–9.3

0.001

HCV markers

          

 Anti-HCV-negative

828

98.8

838

100

 

1(reference)

    

 Anti-HCV-positive

10

1.2

0

0

–

–

–

   

HBV infection status

          

 HBsAg-negative/anti-HBc-negativea

686

81.9

740

88.3

 

1(reference)

  

1(reference)

 

 HBsAg-positive/anti-HBc-positiveb

53

6.3

37

4.4

1.6

1.0–2.4

0.041

1.3

0.7–2.6

0.402

 HBsAg-negative/anti-HBc-positivec

97

11.6

61

7.3

1.7

1.2–2.4

0.001

1.6

0.9–2.6

0.083

  1. P-values in bold denoted statistical significance for P <0.05
  2. Multivariate analyses were adjusted by age (as a continous variable), ethnicity (Han/non-Han), birth of place (Yunnan and neighboring province/Other provinces in China), HPV (negative/positive), and No. full-term pregnancies (0/1/2/3/ > 3)
  3. HPV, human papillomavirus; BMI, Body Mass Index; HCV, hepatitis C virus; HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; anti-HBc, hepatitis B core antibody; OR, odds ratio; AOR, adjusted odds ratio; CI: confidence interval.
  4. aNever exposed
  5. bChronic carrier of HBV
  6. cPast exposure to HBV