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Fig. 6 | Infectious Agents and Cancer

Fig. 6

From: The m6A methyltransferase METTL3 affects autophagy and progression of nasopharyngeal carcinoma by regulating the stability of lncRNA ZFAS1

Fig. 6

ZFAS1 affects the level of autophagy by regulating the expression of miR-100-3p. A The expression of ATG10 in 53 pairs of patient samples. B, C The expression of ATG10 gene (B) and protein (C) in each treatment group. D Dual luciferase report verifies the targeting of ATG10 and miR-100-3p. The binding site prediction comes from the starbase database. E RIP assay verifies the targeting of ATG10 and miR-100-3p. F QRT-PCR detects the expression of autophagy-related genes (LC3, Beclin1, p62) in different treatment groups. G Immunofluorescence was used to detect the expression of LC3II label in each treatment group. H WB detected the expression of PI3K/AKT signaling pathway in different treatment groups. *p < 0.05, compared with NC group, #p < 0.05, compared with mimics group. NC: normal control, oe-ZFAS1: over-expression ZFAS1

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Infectious Agents and Cancer

ISSN: 1750-9378

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