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Table 1 Characteristics of the included studies, 2011–18

From: HPV E6/E7 mRNA test for the detection of high grade cervical intraepithelial neoplasia (CIN2+): a systematic review

Author (s), YearCountry#Partici-pantsAge group, medianStudy population characteristicsHistology profiles
Ratnam, 2011Canada141815–80, 30.6Women referred to colposcopy and those routinely screenedNormal = 651, CIN1 = 366, CIN2 = 120, CIN2 + =401, CIN3 = 281
Waldstrom, 2011Denmark40516–65, 32Three years archived liquid-based samples, all with a diagnosis of LSILCIN2 + =67, CIN3 + =33
Fan, 2018China192No dataPatients with abnormal cytology results and/or high-risk HPV infectionCIN1- = 41, CIN1 = 54, CIN2 = 28, CIn3 = 53, cancer = 16
Han,2018China197No dataWomen with abnormal cytological or HPV test resultsCIN1- = 80, CIN1 = 16, CIN2/3 = 50, Caner = 51
Binnicker,2014USA350No dataResidual specimens with a cytologic result of ≥ atypical squamous cells of undetermined significance (ASC-US)CIN2 + =81, CIN3 + =41
Broccolo,2013Italy30820–65A retrospective study on cervical cytology specimensNormal = 70, CIN1 = 159, CIN2 + =79
Waldstrom, 2012Denmark23530–69, 42.2Women with ASC-US cytologyNormal = 86, CIN1 = 35, CIN2 = 21, CIN3 = 26, Cancer = 1
Li,2017China318No dataWomen with ASCUS cytology attending routine outpatient primary cervical screeningNormal = 169, CIN1 = 74, CIn2 = 40, CIN3 = 16, cancer = 19
Benevolo,2011Italy46417–78, 32Hybrid Capture 2 (HC2)-positive patients, who underwent colposcopy<CIN2 = 49, CIN2 + =49, SCC = 9
Wang, 2019Korea56320–84, noLiquid-based cytology samplesNormal = 51, CIN1 = 75, CIN2 = 16, CIN3 = 40, cancer = 38
Liu, 2014China335No dataWomen who underwent outpatient hospital-based gynecological screeningNormal = 30, CIN1 = 5, CIN2 = 1,CIn3 = 15, Cancer 41
Iftner, 2015Germany945130–60Women undergoing routine cervical screening<CIN2 = 513, CIN2 = 47, CIN3 + =43
Sorbye, 2011Norway52025–69Post-colposcopy follow-up of women with negative or low-grade biopsyCIN2- = 396, CIN2 + = 124
Duvlis, 2015Macedonian41319–78Women that come for cervical cancer screeningNormal = 10, CIN1 = 22, CIN2 = 20, CIN3 = 9
Castro, 2013Spain16518–75, 34.8Women with endocervical samples harboring HPV 16 and/or 18 DNACIN2- = 93, CIN2 + = 72
Pierry, 2012USA24619–75Women in a higher risk urban screening populationNormal = 137, CIN1 = 64, CIN2 = 25, CIN3 = 20
Alaghehbandan, 2013Canada136015–80, 30.7women with a history of abnormal cytology referred to colposcopyNormal = 635, CIN1 = 345, CIN2 + =380, Cancer = 10
Clad, 2011Germany424No dataWomen referred to colposcopy due to an abnormal Pap smearNormal = 108, CIN1 = 64, CIN2 = 89, CIN3 = 150, Cancer = 13
Varnai, 2018Germany6621–66, 34.6Office based screening population who were HPV-DNA positive for at least one of the following HR- HPV types: HPV 16, 18, 31, 33 and 45Normal = 6, CIN2 = 5, CIN3 = 22
Coquillard, 2011USA2049No dataWomen both low and high riskNormal = 1694, CIN1 = 78 CIN2 + =73
Shen, 2013China27216–77, 37Women with abnormal colposcopyCIN1- = 80, CIN2 = 6, CIN3 + =25
Li, 2016China18622–68Patients underwent colposcopyNormal = 32, CIN1 = 51, CIN2/3 = 71, cancer = 32
Liu, 2017China380> 30Women who were associated with high risk of cervical virus infectionNormal = 159, CIN1 = 68, CIN2 = 74, CIN3 = 68, cancer = 11
Benevolo, 2011Italy161018–83, 39.5Retrospective analysis of women underwent an E6/E7 mRNA test on cervical samplesNormal = 74, CIN1 = 282, CIN2 = 120, CIN3 = 86, cancer = 24
Liu, 2018Japan17122–76, 33Women with pathologically-diagnosed CIN or cervical carcinomaCIN1 = 16, CIN2 = 33, CIN3 = 83, SCC = 39
Persson, 2014Sweden21923–60, 32HR-HPV-positive women diagnosed with atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesions (LSIL)Normal = 56, CIN1 = 69, CIn2 = 37, CIN3+ 36
Sorbye, 2011Norway29725–69Women with ASC-US and LSCIN1- = 53, CIN2 + =69
Andersson, 2011Sweden20421–79, 32Women who were undergoing gynecological screening or had been admitted to a referral centerNormal = 45, CIN1 = 33, CIn2 = 28, CIN3 = 31, Cancer 28
Oliveira, 2013Portugal55418–73, 33Women were referred for opportunistic screening and for evaluation of HPV associated lesionsNormal = 131, CIN1 = 128, CIn2 = 129, CIN3 = 146, Cancer = 14