Epstein-Barr virus BART microRNAs in EBV- associated Hodgkin lymphoma and gastric cancer

Table 1 Protein patterns distinguishing different EBV states

Cell type	EBV state	BZLF1	BARF-1^a	miR-	miR-	EBNA proteins						LMP
				BARTs	BHRF1s	1	2	3A	3B	3C	LP	1	2A	2B	EBER
Plasma cell	Lytic	+	+	+	+#	–	–	–	–	–	–	–	–	–	+
PEL, NPC
Memory B cell	Latency 1	–	–	+	−/+	+	–	–	–	–	–	–	–	–	+
Germinal center B	Latency 2	–	–	+	−/+	+	–	–	–	–	+	+	+	+	+
cell, HD, NPC, BL
Naïve B cell, LCBL	Latency 3	–	–	+	+	+	+	+	+	+	+	+	+	+	+
Gastric carcinoma	Latency 1–2	–	+	+	–	+	–	–	–	–	+	–	+	+	+

^a BARF1 promoter is cell-type specific: in viral latency, BARF1 is exclusively expressed in epithelial tumors such as nasopharyngeal and gastric carcinoma but not in lymphoma. # miR-BHRF1s are restricted to lymphoblastoid cell lines (LCL) and nasal NK/T cell lymphoma. BARF and EBER, RNA; BL Burkitt lymphoma, DLCBL Diffuse large B-cell lymphoma; EBNA EBV nuclear antigen; HD Hodgkin disease; LMP Latent membrane proteins; NPC Nasopharyngeal carcinoma; PEL Reactivity of peripheral blood lymphocytes

ISSN: 1750-9378