Table 4 Prognostic factors for OS by Cox proportional hazards regression model
Factors | Univariate | Â | Multivariate | Â |
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Gender | 2.76 (0.84–9.07) | 0.094 |  |  |
Age | 0.91 (0.44–1.87) | 0.810 |  |  |
Diabetes mellitus | 1.49 (0.69–3.23) | 0.307 |  |  |
High blood pressure | 1.51 (0.72–3.14) | 0.269 |  |  |
History of smoking | 1.85 (0.92–3.73) | 0.082 |  |  |
History of drinking | 1.25 (0.61–2.55) | 0.541 |  |  |
Cirrhosis | 2.30 (0.80–6.56) | 0.119 |  |  |
Child-Pugh class | 2.38 (1.18–4.78) | 0.014 | 0.81 (0.29–2.21) | 0.685 |
Antiviral therapy | 0.67 (0.33–1.36) | 0.273 |  |  |
Tumor number | 3.77 (1.87–7.60) | < 0.0001 | 3.05 (1.32–7.02) | 0.009 |
Tumor size | 2.24 (1.12–4.05) | 0.022 | 2.05 (0.90–4.66) | 0.084 |
Ablation method | 1.36 (0.90–2.04) | 0.137 |  |  |
etiology | 1.59 (0.97–2.60) | 0.063 |  |  |
AFP | 1.65 (0.99–2.72) | 0.050 | 1.03 (0.57–1.85) | 0.914 |
viral load | 1.22 (0.54–2.75) | 0.624 |  |  |
ALT(U/L) | 1.00 (0.98–1.01) | 0.773 |  |  |
AST(U/L) | 1.03 (1.00–1.05) | 0.007 | 1.02 (0.99–1.05) | 0.121 |
Total serum bilirubin (mg/dL) | 1.03 (1.00–1.06) | 0.040 | 1.02 (0.98–1.07) | 0.262 |
Neutrophil count (10^9/L) | 0.77 (0.60–0.99) | 0.045 | 0.65 (0.47–0.91) | 0.014 |
Lymphocyte count (10^9/L) | 0.82 (0.43–1.57) | 0.565 |  |  |
Platelet count (10^9/L) | 1.00 (0.99–1.01) | 0.797 |  |  |
Albumin | 0.88 (0.81–0.95) | 0.002 | 0.96 (0.86–1.06) | 0.441 |
Globulin | 1.05 (1.00–1.11) | 0.023 | 0.99 (0.93–1.05) | 0.841 |
Fibrinogen (mg/dL) | 1.00 (0.69–1.46) | 0.980 |  |  |
GPR | 1.34 (1.14–1.58) | < 0.0001 | 1.34 (1.00–1.81) | 0.047 |