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Table 3 Rare variant burden analysis for nonsynonymous variants within all types of HPV for the cervicitis, LSIL and HSIL groups

From: Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai

  N Controls  N LSIL  N HSIL  
ViralNumberwith% ofNumberwith% ofNumberwith% of 
GeneIFVariantsControlsLSILVariantsControlsHSILVariantsControlsP Value
E6865564.0633250.8844553.60.215
E7735372.6583153.4813239.53.17 × 10–4*
Total15910867.91216352.11657746.73.83 × 10–4*
  1. HPV Human papillomavirus; IF cervicitis; LSIL low-grade squamous intraepithelial lesion; HSIL high-grade squamous intraepithelial lesion;*P values remain significant after Bonferroni adjustment for multiple tests