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Table 3 Rare variant burden analysis for nonsynonymous variants within all types of HPV for the cervicitis, LSIL and HSIL groups

From: Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai

  

N Controls

  

N LSIL

  

N HSIL

  

Viral

Number

with

% of

Number

with

% of

Number

with

% of

 

Gene

IF

Variants

Controls

LSIL

Variants

Controls

HSIL

Variants

Controls

P Value

E6

86

55

64.0

63

32

50.8

84

45

53.6

0.215

E7

73

53

72.6

58

31

53.4

81

32

39.5

3.17 × 10–4*

Total

159

108

67.9

121

63

52.1

165

77

46.7

3.83 × 10–4*

  1. HPV Human papillomavirus; IF cervicitis; LSIL low-grade squamous intraepithelial lesion; HSIL high-grade squamous intraepithelial lesion;*P values remain significant after Bonferroni adjustment for multiple tests
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Infectious Agents and Cancer

ISSN: 1750-9378

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