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Table 1 Univariate analysis of the impact of hepatitis B virus and tumor-related factors on the formation of MVI

From: Effect of hepatitis B virus DNA replication level and anti-HBV therapy on microvascular invasion of hepatocellular carcinoma

Factors MVI P
Yes No
Patient demographics
 Age > 50 years 211 272 0.008
<=50 years 98 79
 Gender Male 262 272 0.017
Female 47 79
 Antivirus treatment Yes 67 105 0.016
No 242 246
Preoperative laboratory test
 HBsAg Positive 278 297 0.041
Negative 31 54
 HBsAb Positive 31 23 0.104
Negative 278 328
 HBeAg Positive 77 86 0.901
Negative 232 265
 HBeAg Positive 126 142 0.933
Negative 183 209
 HBcAb Positive 300 337 0.527
Negative 9 14
 Pre-S1Ag Positive 234 268 0.851
Negative 75 83
 HBV DNA load > 100 IU/ml 166 145 0.001
<=100 IU/ml 143 206
 AFP > 7.2 ng/ml 259 203 0.001
<=7.2 ng/ml 50 148
 CEA > 3.4 ng/mL 71 81 0.976
<=3.4 ng/mL 238 270
 CA125 > 35 U/mL 43 27 0.010
<=35 U/mL 266 324
 CA19–9 > 39 U/mL 69 69 0.400
<=39 U/mL 240 282
 CA24–2 > 15 U/mL 13 13 0.842
<=15 U/mL 296 338
 ALB > 35 g/L 258 311 0.057
<= 35 g/L 51 40
 TBIL > 22 umol/L 127 116 0.032
<=22 umol/L 182 235
 ALT > 50 U/mL 78 79 0.410
<=50 U/mL 231 272
 AST > 40 U/mL 111 75 0.001
<=40 U/mL 198 276
 GGT > 60 U/mL 133 97 0.001
<=60 U/mL 176 254
Pathological findings
 Edmonson grading Grades III/IV 168 100 0.001
Grades I/II 141 251
 Diameter > 3 cm 224 196 0.001
<=3 cm 85 155
 Number of lesions Multiple 56 34 0.002
Single 253 317
 Encapsulation Incomplete 203 147 0.001
Complete 106 204
 Presence of cirrhosis Yes 219 213 0.006
No 90 138
 Satellite nodules Yes 73 21 0.001
No 236 330