Table 1 Univariate analysis of the impact of hepatitis B virus and tumor-related factors on the formation of MVI
Factors | MVI | P | ||
|---|---|---|---|---|
Yes | No | |||
Patient demographics | ||||
Age | > 50 years | 211 | 272 | 0.008 |
<=50 years | 98 | 79 | ||
Gender | Male | 262 | 272 | 0.017 |
Female | 47 | 79 | ||
Antivirus treatment | Yes | 67 | 105 | 0.016 |
No | 242 | 246 | ||
Preoperative laboratory test | ||||
HBsAg | Positive | 278 | 297 | 0.041 |
Negative | 31 | 54 | ||
HBsAb | Positive | 31 | 23 | 0.104 |
Negative | 278 | 328 | ||
HBeAg | Positive | 77 | 86 | 0.901 |
Negative | 232 | 265 | ||
HBeAg | Positive | 126 | 142 | 0.933 |
Negative | 183 | 209 | ||
HBcAb | Positive | 300 | 337 | 0.527 |
Negative | 9 | 14 | ||
Pre-S1Ag | Positive | 234 | 268 | 0.851 |
Negative | 75 | 83 | ||
HBV DNA load | > 100 IU/ml | 166 | 145 | 0.001 |
<=100 IU/ml | 143 | 206 | ||
AFP | > 7.2 ng/ml | 259 | 203 | 0.001 |
<=7.2 ng/ml | 50 | 148 | ||
CEA | > 3.4 ng/mL | 71 | 81 | 0.976 |
<=3.4 ng/mL | 238 | 270 | ||
CA125 | > 35 U/mL | 43 | 27 | 0.010 |
<=35 U/mL | 266 | 324 | ||
CA19–9 | > 39 U/mL | 69 | 69 | 0.400 |
<=39 U/mL | 240 | 282 | ||
CA24–2 | > 15 U/mL | 13 | 13 | 0.842 |
<=15 U/mL | 296 | 338 | ||
ALB | > 35 g/L | 258 | 311 | 0.057 |
<= 35 g/L | 51 | 40 | ||
TBIL | > 22 umol/L | 127 | 116 | 0.032 |
<=22 umol/L | 182 | 235 | ||
ALT | > 50 U/mL | 78 | 79 | 0.410 |
<=50 U/mL | 231 | 272 | ||
AST | > 40 U/mL | 111 | 75 | 0.001 |
<=40 U/mL | 198 | 276 | ||
GGT | > 60 U/mL | 133 | 97 | 0.001 |
<=60 U/mL | 176 | 254 | ||
Pathological findings | ||||
Edmonson grading | Grades III/IV | 168 | 100 | 0.001 |
Grades I/II | 141 | 251 | ||
Diameter | > 3 cm | 224 | 196 | 0.001 |
<=3 cm | 85 | 155 | ||
Number of lesions | Multiple | 56 | 34 | 0.002 |
Single | 253 | 317 | ||
Encapsulation | Incomplete | 203 | 147 | 0.001 |
Complete | 106 | 204 | ||
Presence of cirrhosis | Yes | 219 | 213 | 0.006 |
No | 90 | 138 | ||
Satellite nodules | Yes | 73 | 21 | 0.001 |
No | 236 | 330 | ||