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Table 5 The time and average of patients’ overall survival according to PIK3CA mutation status

From: PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome

Groups     Time   
Variable Total N events 6 months 1 year 3 years 5 years Median survival p-value
CM/ESCC WT 13 10 79.4% 72.2% 43.3% 28.9% 2 years < 0.001 *
MUT 5 5 20.0% 0.0% 0.0% 0.0% 5 months
ESCC WT 24 22 82.6% 64.7% 32.6% 14.5% 2 years 0.405
MUT 4 4 80.0% 80.0% 60.0% 0.0% 2.5 years
  1. *Log-rank test. CM/ESCC – chagasic megaesophagus associated with esophageal squamous cell carcinoma; ESCC – esophageal squamous cell carcinoma without chagasic megaesophagus; WT – wild-type; MUT – mutated; Bold numbers - statistical significance