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Table 3 Unadjusted and adjusted results from the Cox proportional hazard models investigating the association between time from cancer diagnosis to death, dichotomizing HIV-1 viral load

From: Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America

  Unadjusted Adjusted
Covariate HR 95% CI P HR 95% CI P
Sex    0.41    0.22
 Female (ref) 1.00    1.00   
  Male 0.87 (0.61–1.22)   0.81 (0.57–1.14)  
Cancer diagnosis relative to cART initiation    0.61    0.41
 Cancer diagnosis after cART initiation (ref) 1.00    1.00   
 Cancer diagnosis before/at cART initiation/Did not start cART 0.93 (0.70–1.23)   0.87 (0.62–1.22)  
CD4 count (cells/μL) at cancer diagnosis    0.06    0.80
 100 1.18 (0.96–1.44)   0.99 (0.82–1.21)  
 200 1.03 (0.91–1.17)   0.98 (0.86–1.12)  
 350 (ref) 1.00    1.00   
 500 1.03 (0.89–1.19)   1.03 (0.90–1.17)  
HIV-1 RNA at cancer diagnosis    0.21    0.02
 Undetectable (ref) 1.00    1.00   
 Detectable (> 400 copies/mL) 1.28 (0.87–1.88)   1.63 (1.08–2.47)  
Years from HIV diagnosis to cancer diagnosis 1.03 (1.01–1.06) 0.01 1.03 (1.01–1.06) 0.01
Age at cancer diagnosis (per year) 1.02 (1.01–1.03) 0.003 1.02 (1.01–1.03) 0.002