Table 3 Unadjusted and adjusted results from the Cox proportional hazard models investigating the association between time from cancer diagnosis to death, dichotomizing HIV-1 viral load
From: Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America
Unadjusted | Adjusted | |||||
|---|---|---|---|---|---|---|
Covariate | HR | 95% CI | P | HR | 95% CI | P |
Sex | 0.41 | 0.22 | ||||
Female (ref) | 1.00 | 1.00 | ||||
Male | 0.87 | (0.61–1.22) | 0.81 | (0.57–1.14) | ||
Cancer diagnosis relative to cART initiation | 0.61 | 0.41 | ||||
Cancer diagnosis after cART initiation (ref) | 1.00 | 1.00 | ||||
Cancer diagnosis before/at cART initiation/Did not start cART | 0.93 | (0.70–1.23) | 0.87 | (0.62–1.22) | ||
CD4 count (cells/μL) at cancer diagnosis | 0.06 | 0.80 | ||||
100 | 1.18 | (0.96–1.44) | 0.99 | (0.82–1.21) | ||
200 | 1.03 | (0.91–1.17) | 0.98 | (0.86–1.12) | ||
350 (ref) | 1.00 | 1.00 | ||||
500 | 1.03 | (0.89–1.19) | 1.03 | (0.90–1.17) | ||
HIV-1 RNA at cancer diagnosis | 0.21 | 0.02 | ||||
Undetectable (ref) | 1.00 | 1.00 | ||||
Detectable (> 400 copies/mL) | 1.28 | (0.87–1.88) | 1.63 | (1.08–2.47) | ||
Years from HIV diagnosis to cancer diagnosis | 1.03 | (1.01–1.06) | 0.01 | 1.03 | (1.01–1.06) | 0.01 |
Age at cancer diagnosis (per year) | 1.02 | (1.01–1.03) | 0.003 | 1.02 | (1.01–1.03) | 0.002 |