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Table 2 Distribution of HPV52/58 variant sublineages according to cervical histology status

From: Whole-genome analysis of human papillomavirus genotypes 52 and 58 isolated from Japanese women with cervical intraepithelial neoplasia and invasive cervical cancer

 

Variant

Total

CIN1

CIN2

CIN3

ICC

Adjusted ORa

(95% CI)

HPV52

A1

2

0

0

2

0

-

A2

0

0

0

0

0

-

B1

0

0

0

0

0

-

B2

31

9

9

6

7

-

C

0

0

0

0

0

-

D

0

0

0

0

0

-

HPV58

A1

13

6

3

2

2

1.0 (reference)

A2

19

7

5

4

3

1.47 (0.35–6.17)

A3

3

1

0

1

1

1.71 (0.12–23.9)

B

0

0

0

0

0

ND

C

1

0

1

0

0

ND

D

0

0

0

0

0

ND

  1. Restricted to cases with HPV52 or HPV58 single infection
  2. OR odds ratio, CI confidence interval, ND not determined
  3. arelative risk for progression from CIN1 to CIN2/3/ICC compared to HPV58 sublineage A1