Table 3 Carcinogenic mechanisms of investigated bacteria in relation to ovarian cancer
From: The potential role of infectious agents and pelvic inflammatory disease in ovarian carcinogenesis
Microorganism | Suspected mechanisms | Potentially associated cancers |
|---|---|---|
Chlamydia trachomatis | Inhibition of apoptosis Production of reactive oxygen species | Cervical squamous cell carcinoma Ovarian cancer |
Neisseria Gonorrhoeae | DNA strand breaks. Inhibition of P53. Cell cycle disruption [68] | Bladder cancer Prostate cancer Ovarian cancer |
Mycoplasma Genitalium | Acquisition of anchorage-independent growth Inhibition of apoptosis. Karyotypic entropy [69] | Ovarian cancer Prostate cancer |