Table 3 Carcinogenic mechanisms of investigated bacteria in relation to ovarian cancer
From: The potential role of infectious agents and pelvic inflammatory disease in ovarian carcinogenesis
| Microorganism | Suspected mechanisms | Potentially associated cancers |
|---|---|---|
| Chlamydia trachomatis |
Inhibition of apoptosis Production of reactive oxygen species Inhibition of DDR [62, 64] |
Cervical squamous cell carcinoma Ovarian cancer |
| Neisseria Gonorrhoeae |
DNA strand breaks. Inhibition of P53. Cell cycle disruption [68] |
Bladder cancer Prostate cancer Ovarian cancer |
| Mycoplasma Genitalium |
Acquisition of anchorage-independent growth Inhibition of apoptosis. Karyotypic entropy [69] |
Ovarian cancer Prostate cancer |