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Table 3 Carcinogenic mechanisms of investigated bacteria in relation to ovarian cancer

From: The potential role of infectious agents and pelvic inflammatory disease in ovarian carcinogenesis

Microorganism Suspected mechanisms Potentially associated cancers
Chlamydia trachomatis Inhibition of apoptosis
Production of reactive oxygen species
Inhibition of DDR [62, 64]
Cervical squamous cell carcinoma
Ovarian cancer
Neisseria Gonorrhoeae DNA strand breaks. Inhibition of P53.
Cell cycle disruption [68]
Bladder cancer
Prostate cancer
Ovarian cancer
Mycoplasma Genitalium Acquisition of anchorage-independent growth
Inhibition of apoptosis. Karyotypic entropy [69]
Ovarian cancer
Prostate cancer
  1. DDR Double-stranded DNA Repair