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Table 2 Estimated mean annual number of new HPV-attributable cancer cases in women and men in Europe

From: Estimation of the overall burden of cancers, precancerous lesions, and genital warts attributable to 9-valent HPV vaccine types in women and men in Europe

Cancer site

New cancers

N, (95% bound)

New cancers attributable to all HPV types

N, (95% bound)a

New cancers attributable to 9-valent HPV vaccine types (6/11/16/18/31/33/45/52/58)

N, (95% bound)a

Cervical cancer

34,939

(32,863 – 37,032)

34,939

(32,863 – 37,032)

31,130

(28,800 – 33,495)

Vulvar cancer

9,776

(8,727 – 10,841)

1,554

(1,135 – 2,044)

1,466

(1,008 – 1,994)

Vaginal cancer

2,224

(1,723 – 2,744)

1,562

(1,058 – 2,134)

1,360

(827 – 1,980)

Anal cancer (F)

4,663

(3,968 – 5,375)

4,062

(3,203 – 4,940)

3,834

(2,851 – 4,818)

Head and neck cancers (F)

18,052

(13,977 – 22,183)

1,396

(728 – 2,592)

1,301

(586 – 2,574)

Total (women)

69,654

(61,754 – 77,609)

43,512

(39,256 – 48,387)

39,091

(34,320 – 44,513)

Anal cancer (M):

2,801

(2,260 – 3,359)

2,440

(1,822 – 3,088)

2,303

(1,621 – 3,012)

Penile cancer

4,231

(3,543 – 4,937)

1,227

(845 – 1,697)

1,113

(707 – 1,619)

Head and neck cancers (M)

81,989

(73,563 – 90,469)

5,834

(3,729 – 9,735)

5,485

(2,923 – 9,680)

Total (men)

89,021

(79,558 – 98,543)

9,501

(6,502 – 14,376)

8,901

(5,348 – 14,168)

Total (both sexes)

158,675

(141,617 – 175,815)

53,013

(45,886 – 62,589)

47,992

(39,785 – 58,511)

  1. HPV human papillomavirus, N number, CI confidence interval, F female, M male
  2. aExcept for cervical cancer, prevalence is based on oncogenically-active HPV infections only (i.e., HPV DNA detection plus either E6aI mRNA expression or p16 overexpression)