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Table 2 Distribution of the PreS1 mutation prevalent among chronic hepatitis B patients according to clinical status

From: Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo

Amino acid substitutions Number of isolates(%) Genotype ASC CAH LC HCC Type of Epitope
K13E 8 E 0 2 2 4  
N14K 5 E 1 2 2 0  
H15Y 5 E 1 2 2 0  
N19T 5 E 0 2 1 2 B and T-cell
P25L 6 E 0 1 1 2 &
N29K 8 A 1 2 2 3 Hepatocyte-binding site
P30Q 7 A 2 2 2 3  
A35E 8 E 0 0 5 3  
R38K 14 E 2 3 5 4  
R38G 4 E 1 0 1 2  
W42G 4 E 0 1 0 3  
H44L 11 E 2 1 4 4  
V49A 6 A 0 3 1 2  
T52R 5 E 1 1 1 2  
P64S 4 E 1 1 2 0 S promoter (nt 3019-3201)
V80I 7 A 2 0 2 3  
K85Q 4 E 2 1 1 0  
S90T 6 A 1 3 0 2  
S100V 4 E 1 1 2 0  
  1. ASC asymptomatic carriers, CAH chronic active hepatitis, LC liver cirrhosis, HCC hepatocellular carcinoma (HCC), nt nucleotide