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Table 1 p16INK4A expression in correlation with clinical parameters and HPV status in Kazakh patients with ESCC

From: p53 expression but not p16INK4A correlates with human papillomavirus-associated esophageal squamous cell carcinoma in Kazakh population

Clinical properties Total p16 expression (n/%)
Negative (%) Positive (%) P value
Gender     
 Male 103 85(66.4 %) 18(60.0 %) 0.507
 Female 55 43(33.6 %) 12(40.0 %)
Age (mean)     
  < 58 85 60(48.0 %) 13(50.0 %) 0.853
  ≥ 58 67 65(52.0 %) 13(50.0 %)
Histopathological grade     
 Well 38 34(27.2 %) 4(13.3 %) 0.268
 Moderate 97 76(60.8 %) 21(70.0 %)
 Poor 20 15(12.0 %) 5(16.7 %)
Invasion depth     
 T1-T2 78 63(53.8 %) 15(51.7 %) 0.838
 T3-T4 68 54(46.2 %) 14(48.3 %)
Lymphatic invasion     
 N0 66 48(42.5 %) 18(64.3 %) 0.038
 N1-N3 75 65(57.5 %) 10(35.7 %)
TNM Staging     
 I/II 76 59(60.8 %) 17(77.3 %) 0.147
 III/IV 43 38(39.2 %) 5(22.7 %)
HPV infection     
 Negative 66 52(53.1 %) 14(60.9 %) 0.499
 Positive 55 46(46.9 %) 9(39.1 %)
  1. P < 0.05 indicates a significant association among the variables