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Table 1 p16INK4A expression in correlation with clinical parameters and HPV status in Kazakh patients with ESCC

From: p53 expression but not p16INK4A correlates with human papillomavirus-associated esophageal squamous cell carcinoma in Kazakh population

Clinical properties

Total

p16 expression (n/%)

Negative (%)

Positive (%)

P value

Gender

    

 Male

103

85(66.4 %)

18(60.0 %)

0.507

 Female

55

43(33.6 %)

12(40.0 %)

Age (mean)

    

  < 58

85

60(48.0 %)

13(50.0 %)

0.853

  ≥ 58

67

65(52.0 %)

13(50.0 %)

Histopathological grade

    

 Well

38

34(27.2 %)

4(13.3 %)

0.268

 Moderate

97

76(60.8 %)

21(70.0 %)

 Poor

20

15(12.0 %)

5(16.7 %)

Invasion depth

    

 T1-T2

78

63(53.8 %)

15(51.7 %)

0.838

 T3-T4

68

54(46.2 %)

14(48.3 %)

Lymphatic invasion

    

 N0

66

48(42.5 %)

18(64.3 %)

0.038

 N1-N3

75

65(57.5 %)

10(35.7 %)

TNM Staging

    

 I/II

76

59(60.8 %)

17(77.3 %)

0.147

 III/IV

43

38(39.2 %)

5(22.7 %)

HPV infection

    

 Negative

66

52(53.1 %)

14(60.9 %)

0.499

 Positive

55

46(46.9 %)

9(39.1 %)

  1. P < 0.05 indicates a significant association among the variables