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Table 1 Cohort, participant, and shedding characteristics

From: Patterns of human herpesvirus-8 oral shedding among diverse cohorts of human herpesvirus-8 seropositive persons

Participant Location, N (%)a USA Peru Cameroon Uganda Kenya Total
102 (41 %) 7 (3 %) 32 (13 %) 68 (27 %) 39 (16 %) 248 (100 %)
Participant Demographic and Clinical Data:
Male, n (%) 101 (99 %) 7 (100 %) 0 (0 %) 44 (65 %) 0 (0 %) 152 (61 %)
 HIV-infected, n (%) 46 (46 %) 7 (100 %) 32 (100 %) 37 (54 %) 21 (54 %) 143 (58 %)
CD4 countb
 CD4 < 200 9 (20 %) 0 (0 %) 0 (0 %)  --  -- 9 (6 %)
 CD4 200–499 17 (37 %) 1 (14 %) 13 (41 %)  --  -- 31 (22 %)
 CD4 500+ 12 (26 %) 0 (0 %) 5 (16 %)  --  -- 17 (12 %)
 Unknown 8 (17 %) 6 (86 %) 14 (44 %) 37 (100 %) 21 (100 %) 86 (60 %)
HIV-1 RNAb
 <104 12 (26 %) 4 (57 %)  -- 7 (18 %)  -- 23 (16 %)
 ≥104 22 (48 %) 3 (43 %)  -- 25 (68 %)  -- 50 (35 %)
 Unknown 12 (26 %) 0 (0 %) 32 (100 %) 5 (14 %) 21 (100 %) 70 (49 %)
Kaposi sarcoma: 2 (2 %) 0 (0 %) 0 (0 %) 34 (50 %) 0 (0 %) 36 (15 %)
 HIV-associated: 1 (1 %)  --  -- 19 (28 %)  -- 20 (8 %)
HSV-2 seropositive, n/tested (%) 62/97 (64 %) 7 (100 %) 31 (97 %) ND ND 100/135 (74 %)
Cohort Shedding Characteristics:
Sessions,
Number: 152 7 32 68 39 298
Observations per session:
 Median # of days (range) 33 (15–136) 56 (27–57) 19 (14–23) 29 (14–32) 29 (26–29) 30 (14–136)
Overall shedding:
 Positive swabs: 2,213 75 183 389 263 3,123
 Total swabs: 6,660 359 590 1834 1,114 10,557
 Percent positive: (33 %) (21 %) (31 %) (21 %) (24 %) (30 %)
Participant shedding rate per session,
 Median % (IQR) 7 (0, 73) 0 (0, 33) 18 (0, 56) 0 (0, 34) 7 (0, 43) 4 (0, 54)
Persons with any shedding 60 (59 %) 3 (43 %) 21 (66 %) 26 (38 %) 27 (69 %) 137 (55 %)
Quantity, median (IQR) of positive swabs, log10 copies/mL 4.8 (3.9–5.6) 7.4 (5.0–7.8) 3.2 (2.7–3.8) 5.2 (3.9–6.0) 4.4 (3.5–5.5) 4.7 (3.7–5.6)
  1. Abbreviations. US United States, ND Not determined, IQR Interquartile Range, HSV Herpes simplex virus
  2. aPercentages are out of those within the given country
  3. bPercentages for CD4 count and HIV RNA are of HIV-infected participants