A prospective randomized study on limits of colposcopy and histology: the skill of colposcopist and colposcopy-guided biopsy in diagnosis of cervical intraepithelial lesions

Table 2 Histological diagnosis of specimen A and B resulted from the routine analysis and from the revision analysis performed by an experienced gynecologic pathologist

Hystological Diagnosis	Specimen A N (%)			Specimen B N (%)
	Routine Analysis	Revision Analysis^a	p Value	Routine Analysis	Revision Analysis^a	p Value
Negative	18 (7.2)	40 (15.9)	.34	35 (13.9)	51 (20.3)	.03
Cervicites / Metaplasia	116 (46.2)	96 (38.2)		95 (37.8)	102 (40.6)
CIN1 / Koilocytosis / Condylomatosis	71 (28.3)	65 (25.9)		73 (29.1)	52 (20.7)
CIN2	20 (8.0)	14 (5.6)		24 (9.6)	10 (4.0)
CIN3	26 (10.4)	36 (14.3)		24 (9.6)	36 (14.3)

^aRevision analysis: analysis performed by experienced pathologist. In uncertain cases immunohistochemical stains were used, particularly, antibody against ki67 to evaluate the proliferative activity and p16 protein expression to determine the different degrees of CIN

ISSN: 1750-9378