Merkel cell polyomavirus (MCV) T-antigen seroreactivity, MCV DNA in eyebrow hairs, and squamous cell carcinoma

Table 1 Associations between Merkel cell polyomavirus and cutaneous squamous cell carcinoma

MCV biomarker	Controls	SCC Cases	Controls	SCC Cases	OR (95 % CI)	p-value
	N = 300	N = 171	N = 300	N = 171
	n (%)	n (%)	n (%)	n (%)
Seropositivity to MCV T-Ag	Cut points based on reference sample*		Cut point of > 50 MFI
MCV small T	1 (0.3)	0 (0)	7 (2.3)	2 (1.2)	0.31 (0.06–1.62)	0.164
MCV large T exon 1	2 (0.7)	0 (0)	3 (1)	1 (0.6)	0.56 (0.05–5.93)	0.633
MCV large T exon 2	2 (0.7)	1 (0.6)	18 (6)	16 (9.4)	1.22 (0.57–2.62)	0.611
MCV large T	3 (1.0)	2 (1.2)	22 (7.3)	16 (9.4)	0.99 (0.48–2.08)	0.988
			Controls (n = 292)	Cases (n = 169)	OR (95 % CI)	p-value
			n(%)	n(%)	OR (95 % CI)	p-value
Presence of MCV DNA in eyebrow hairs			109 (37.3)	82 (48.5)	1.17 (0.76–1.78)	0.478

MCV Merkel cell polyomavirus, SCC cutaneous squamous cell carcinoma. *MFI cutoff for seropositivity based on MCC patients: 200 for small T, 200 for large T exon 1,400 for large T exon 2 and 400 for large T. Odds ratios (OR) and Wald 95 % confidence intervals (CI) calculated using alternative cutoff of >50 MFI and logistic regression, adjusting for age and gender

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