MCV biomarker

Controls

SCC Cases

Controls

SCC Cases

OR (95 % CI)

pvalue


N = 300

N = 171

N = 300

N = 171


n (%)

n (%)

n (%)

n (%)


Seropositivity to MCV TAg

Cut points based on reference sample*

Cut point of > 50 MFI
  
MCV small T

1 (0.3)

0 (0)

7 (2.3)

2 (1.2)

0.31 (0.06–1.62)

0.164

MCV large T exon 1

2 (0.7)

0 (0)

3 (1)

1 (0.6)

0.56 (0.05–5.93)

0.633

MCV large T exon 2

2 (0.7)

1 (0.6)

18 (6)

16 (9.4)

1.22 (0.57–2.62)

0.611

MCV large T

3 (1.0)

2 (1.2)

22 (7.3)

16 (9.4)

0.99 (0.48–2.08)

0.988

  
Controls (n = 292)

Cases (n = 169)

OR (95 % CI)

pvalue

n(%)

n(%)

Presence of MCV DNA in eyebrow hairs
  
109 (37.3)

82 (48.5)

1.17 (0.76–1.78)

0.478


MCV Merkel cell polyomavirus, SCC cutaneous squamous cell carcinoma. *MFI cutoff for seropositivity based on MCC patients: 200 for small T, 200 for large T exon 1,400 for large T exon 2 and 400 for large T. Odds ratios (OR) and Wald 95 % confidence intervals (CI) calculated using alternative cutoff of >50 MFI and logistic regression, adjusting for age and gender