Skip to main content

Advertisement

Table 1 Associations between Merkel cell polyomavirus and cutaneous squamous cell carcinoma

From: Merkel cell polyomavirus (MCV) T-antigen seroreactivity, MCV DNA in eyebrow hairs, and squamous cell carcinoma

MCV biomarker Controls SCC Cases Controls SCC Cases OR (95 % CI) p-value
N = 300 N = 171 N = 300 N = 171
n (%) n (%) n (%) n (%)
Seropositivity to MCV T-Ag Cut points based on reference sample* Cut point of > 50 MFI   
MCV small T 1 (0.3) 0 (0) 7 (2.3) 2 (1.2) 0.31 (0.06–1.62) 0.164
MCV large T exon 1 2 (0.7) 0 (0) 3 (1) 1 (0.6) 0.56 (0.05–5.93) 0.633
MCV large T exon 2 2 (0.7) 1 (0.6) 18 (6) 16 (9.4) 1.22 (0.57–2.62) 0.611
MCV large T 3 (1.0) 2 (1.2) 22 (7.3) 16 (9.4) 0.99 (0.48–2.08) 0.988
    Controls (n = 292) Cases (n = 169) OR (95 % CI) p-value
n(%) n(%)
Presence of MCV DNA in eyebrow hairs    109 (37.3) 82 (48.5) 1.17 (0.76–1.78) 0.478
  1. MCV Merkel cell polyomavirus, SCC cutaneous squamous cell carcinoma. *MFI cutoff for seropositivity based on MCC patients: 200 for small T, 200 for large T exon 1,400 for large T exon 2 and 400 for large T. Odds ratios (OR) and Wald 95 % confidence intervals (CI) calculated using alternative cutoff of >50 MFI and logistic regression, adjusting for age and gender