Table 2 Immune-system related oncogenic mechanisms exploited by HHVs
From: Implication of human herpesviruses in oncogenesis through immune evasion and supression
| Â | Immune system-related oncogenic mechanism | HHV(s) implicated |
|---|---|---|
Tumour-promoting immuno-suppression and immune evasion mechanisms | Inhibition of antigen presentation | HSV-1, HSV-2, VZV, EBV, HCMV, HHV-8 |
vIL-10 expression or human IL-10 related immunosuppression | HSV-1, HSV-2, EBV, HCMV, HHV-6, HHV-7, HHV-8 | |
Inhibition of CTL and NK cell responses | All HHV | |
Inhibition of phagocytosis | HCMV, HHV-8 | |
Inhibition of complement response | KSHV | |
Tumour-promoting inflammation | T and B cell immune memory inflation by the presence of immunodominant epitopes | EBV, HCMV |
| Â | IL-6 induction | EBV, HCMV, HHV-6, HHV-7, HHV-8 |