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Table 1 MDM2 (rs2278744) polymorphism in patients with HPV and cervical lesions of low degree (LSIL) and high degree (HSIL) and healthy patients

From: MDM2 polymorphism associated with the development of cervical lesions in women infected with Human papillomavirus and using of oral contraceptives

  Cases Normal cytology p-value; OR [95% C.I.]
  Total SILa LSILb HSILc Controld Total SIL vs. C LSIL vs. C HSIL vs. C HSIL vs. LSIL
SNP309 rs2278744         
Alelles         
T 265 (0.62) 165 (0.63) 100 (0.61) 95 (0.63) Reference Reference Reference Reference
G 156 (0.38) 95 (0.37) 61 (0.39) 55 (0.37) 0.80; 1.04 [0.71-1.54] 0.97; 0.99 [0.65-1.50] 0.67; 1.11 [0.70-1.75] 0.55; 1.14 [0.74-1.75]
Genotypes         
TT 80 (0.37) 54 (0.42) 26 (0.30) 30 (0.40) Reference Reference Reference Reference
TG 105 (0.51) 57 (0.44) 48 (0.61) 35 (0.47) 0.83; 0.85 [0.48-1.49] 0.92; 1.11 [0.60-2.04] 0.33; 1.58 [0.80-3.13] *0.11; 1.75 [0.95-3.20]
GG 27 (0.12) 19 (0.15) 8 (0.09) 10 (0.13) 0.83; 0.99 [0.43-2.28] 0.92; 0.95 [0.39-2.30] 0.33; 0.92 [0.32-2.69] 0.33; 0.92 [0.32-2.69]
  1. p < 0.05 – statistically significant.
  2. aSIL: Squamous intraepithelial lesions.
  3. bLSIL: Low-grade squamous intraepithelial lesions.
  4. cHSIL: High-grade squamous intraepithelial lesions.
  5. dC: Control - Normal cytology.
  6. *In overdominant model the risk to TG genotype was 1.81 (1.03-3.16, 95% CI).