Table 1 MDM2 (rs2278744) polymorphism in patients with HPV and cervical lesions of low degree (LSIL) and high degree (HSIL) and healthy patients
Cases | Normal cytology | p-value; OR [95% C.I.] | ||||||
|---|---|---|---|---|---|---|---|---|
Total SILa | LSILb | HSILc | Controld | Total SIL vs. C | LSIL vs. C | HSIL vs. C | HSIL vs. LSIL | |
SNP309 rs2278744 | ||||||||
Alelles | ||||||||
T | 265 (0.62) | 165 (0.63) | 100 (0.61) | 95 (0.63) | Reference | Reference | Reference | Reference |
G | 156 (0.38) | 95 (0.37) | 61 (0.39) | 55 (0.37) | 0.80; 1.04 [0.71-1.54] | 0.97; 0.99 [0.65-1.50] | 0.67; 1.11 [0.70-1.75] | 0.55; 1.14 [0.74-1.75] |
Genotypes | ||||||||
TT | 80 (0.37) | 54 (0.42) | 26 (0.30) | 30 (0.40) | Reference | Reference | Reference | Reference |
TG | 105 (0.51) | 57 (0.44) | 48 (0.61) | 35 (0.47) | 0.83; 0.85 [0.48-1.49] | 0.92; 1.11 [0.60-2.04] | 0.33; 1.58 [0.80-3.13] | *0.11; 1.75 [0.95-3.20] |
GG | 27 (0.12) | 19 (0.15) | 8 (0.09) | 10 (0.13) | 0.83; 0.99 [0.43-2.28] | 0.92; 0.95 [0.39-2.30] | 0.33; 0.92 [0.32-2.69] | 0.33; 0.92 [0.32-2.69] |