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Table 2 Course characteristics and infection outcomes according to acute myeloid leukemia protocol type (N = 157)

From: Infections in children with down syndrome and acute myeloid leukemia: a report from the Canadian infections in AML research group

  DS-specific AML protocol (N = 59) Non-DS AML protocol (N = 98)
Course characteristics   
Number with neutropenia (ANC <0.5 x109) at start of course (%) 5 (8.4) 12 (12.5)a
Median days with neutropenia (IQR) 11.0 (3.0, 21.0) 16.0 (7.0, 25.0)
Median days receiving steroids (IQR) 0.0 (0.0, 2.0) 2.0 (0.0, 5.0)
Supportive care   
Co-trimoxazole prophylaxis (%) 41 (69.5) 66 (67.4)
Fluconazole prophylaxis (%) 28 (47.5) 39 (39.8)
Infection outcomes b   
Microbiologically documented sterile site infection (%) 7 (11.9) 14 (14.3)
Bacteremia (%) 6 (10.2) 10 (10.2)
  Sterile site Gram-positive bacteria (%) 5 (8.5) 9 (9.2)
  Sterile site Gram-negative bacteria (%) 2 (3.4) 6 (6.1)
  Sterile site fungus (%) 0 (0.0) 1 (1.0)
Clinically documented infection (%) 7 (11.9) 29 (29.6)
Sepsis (%) 1 (1.7) 3 (3.1)
Infectious death (%) 0 (0.0) 0 (0.0)
  1. Abbreviations: ANC absolute neutrophil count, IQR interquartile range, AML acute myeloid leukemia, DS Down syndrome.
  2. aANC not available at start of 2 courses.
  3. bInfection outcomes represent at least one event per course.