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Figure 5 | Infectious Agents and Cancer

Figure 5

From: Evaluation of a combined triple method to detect causative HPV in oral and oropharyngeal squamous cell carcinomas: p16 Immunohistochemistry, Consensus PCR HPV-DNA, and In Situ Hybridization

Figure 5

ISH techniques for HPV show the morphological context of viral DNA location. Representative case of HPV-DNA positive tumor without virus integration in cancer cells. In spite of positivity for two HPV viruses (HR-HPV 31 and LR-HPV 44 viruses) this case of OSCC showed no integration but cytoplasmic localization in cancer cells as evaluated by two commercially available in situ hybridization techniques; note the cytoplasmic virus location in autolytic cancer cells (All the pictures in this panel were selected from different fields of a single case. A, x40), B, x40), DAKO ISH, brown DAB signals stain the viral DNA; C, x60), D, x60), Ventana ISH, tetrazole blue signals stain the viral DNA).

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Infectious Agents and Cancer

ISSN: 1750-9378

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