Table 1 NLRP3 and NLRP1 allele, genotype and haplotypes frequencies in mesothelioma patients (MM) and healthy controls (HC)
From: NLRP1 polymorphisms in patients with asbestos-associated mesothelioma
MM (n=134) | HC (N=256) | P | OR (95% CI) | ||
|---|---|---|---|---|---|
NLRP3 rs35829419 | Allele/ Genotype | ||||
A | 10 (0.04) | 30 (0.06) | |||
C | 258 (0.96) | 482 (0.94) | 0.234 | 1.61 0.75-3.74 | |
A/A | 0 | 0 | |||
C/A | 10 (0.07) | 30 (0.12) | |||
C/C | 124 (0.93) | 226 (0.88) | 0.221 | ||
NLRP3 rs10754558 | Allele/ Genotype | ||||
G | 113 (0.42) | 232 (0.45) | |||
C | 155 (0.58) | 280 (0.55) | 0.405 | 1.14 0.83-1.55 | |
G/G | 23 (0.17) | 55 (0.21) | |||
C/G | 67 (0.50) | 122 (0.48) | |||
C/C | 44 (0.33) | 79 (0.31) | 0.610 | ||
rs35829419-rs10754558 | Haplotypes | ||||
C-C | 153 (0.57) | 282 (0.55) | 0.459 | ||
C-G | 107 (0.40) | 205 (0.40) | |||
A-G | 8 (0.03) | 25 (0.05) | |||
NLRP1 rs2670660 | Allele/ Genotype | ||||
A | 131 (0.49) | 235 (0.46) | |||
G | 137 (0.51) | 277 (0.54) | 0.450 | 0.89 0.65-1.2 | |
A/A | 33 (0.25) | 52 (0.20) | |||
A/G | 66 (0.49) | 131 (0.51) | |||
G/G | 35 (0.26) | 73 (0.29) | 0.604 | ||
NLRP1 rs12150220 | Allele/ Genotype | ||||
A | 133 (0.50) | 249 (0.49) | |||
T | 135 (0.50) | 263 (0.51) | 0.821 | 0.95 0.71-1.31 | |
AA | 31 (0.23) | 60 (0.23) | |||
AT | 72 (0.54) | 129 (0.50) | |||
TT | 31 (0.23) | 67 (0.26) | 0.772 | ||
rs2670660-rs12150220 | Haplotypes | ||||
G-T | 121 (0.45) | 236 (0.46) | 0.588 | ||
A-A | 118 (0.44) | 205 (0.40) | |||
G-A | 16 (0.06) | 41 (0.08) | |||
A-T | 13 (0.05) | 30 (0.06) |