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Figure 1 | Infectious Agents and Cancer

Figure 1

From: Peripheral blood lymphocytes from low-grade squamous intraepithelial lesions patients recognize vaccine antigens in the presence of activated dendritic cells, and produced high levels of CD8 + IFNγ + T cells and low levels of IL-2 when induced to proliferate

Figure 1

Response of PBL from LSIL patients and normal donors to already known antigens. A) PBL from LSIL patients (LSIL) (n = 20), normal donors (Normal) (n = 20), and women vaccinated with Gardasil® (Gsl) (n = 5), were incubated with antigens from Infanrix Hexa®, a vaccine containing antigens of diphtheria, tetanus, pertussis, hepatitis B and poliovirus, which is administered during childhood. B) PBL from LSIL patients (LSIL) (n = 20), normal donors (Normal) (n = 20), and women vaccinated with Gardasil® (Gsl) (n = 5) were incubated with Gardasil® a recombinant vaccine containing capsid antigens from HPV16, and HPV18. Proliferation was determined by means of thymidine incorporation after 5 days incubation, and the proliferation index corresponded to cpm in the presence of antigen/cpm control without antigen. A statistical significant difference was found between LSIL and normal groups (* p < 0.005).

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Infectious Agents and Cancer

ISSN: 1750-9378

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