Table 4 Concordance values between LQ, RH and PS techniques for HPV DNA detection using HC2/LA as reference values
ASSAY | |||
|---|---|---|---|
NEGATIVE vs. POSITIVE | LQ (N = 265+/40-) | RH (N = 263+/42-) | PS (N = 91/214-) |
% concordance (95% CI) | 98.69 (96.68-99.64) | 98.03 (95.77-99.27) | 91.80 (88.14-94.62) |
Kappa index (95% CI) | 0.94 (0.88-0.99) | 0.91 (0.84-0.98) | 0.81 (0.75-0.88) |
Agreement among positives (95% CI) | 98.88 (96.75-99.77) | 98.13 (95.68-99.39) | 80.00 (71.30-87.02) |
Agreement among negatives (95% CI) | 97.37 (86.19-99.93) | 97.37 (86.19-99.93) | 98.46 (95.57-99.68) |
NEGATIVE vs. POSITIVE SINGLE vs. POSITIVE MULTIPLE | LQ | RH | PS |
% concordance | 75.74 (70.53-80.44) | 75.08 (69.83-79.84) | 89.84 (85.88-92.99) |
Kappa index (95% CI) | 0.59 (0.50-0.67) | 0.57 (0.48-0.66) | 0.78 (0.71-0.85) |
Agreement among positives single infection (95% CI) | 82.89 (75.95-88.51) | 89.47 (83.47-93.86) | 78.22 (68.90-85.82) |
Agreement among positives multiple infection (95% CI) | 59.13 (49.57-68.21) | 48.70 (39.27-58.19) | 33.33 (7.48-70.07) |