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Table 4 Concordance values between LQ, RH and PS techniques for HPV DNA detection using HC2/LA as reference values

From: Performance of the digene LQ, RH and PS HPVs genotyping systems on clinical samples and comparison with HC2 and PCR-based Linear Array

  ASSAY
NEGATIVE vs. POSITIVE LQ (N = 265+/40-) RH (N = 263+/42-) PS (N = 91/214-)
% concordance (95% CI) 98.69 (96.68-99.64) 98.03 (95.77-99.27) 91.80 (88.14-94.62)
Kappa index (95% CI) 0.94 (0.88-0.99) 0.91 (0.84-0.98) 0.81 (0.75-0.88)
Agreement among positives (95% CI) 98.88 (96.75-99.77) 98.13 (95.68-99.39) 80.00 (71.30-87.02)
Agreement among negatives (95% CI) 97.37 (86.19-99.93) 97.37 (86.19-99.93) 98.46 (95.57-99.68)
NEGATIVE vs. POSITIVE SINGLE vs. POSITIVE MULTIPLE LQ RH PS
% concordance 75.74 (70.53-80.44) 75.08 (69.83-79.84) 89.84 (85.88-92.99)
Kappa index (95% CI) 0.59 (0.50-0.67) 0.57 (0.48-0.66) 0.78 (0.71-0.85)
Agreement among positives single infection (95% CI) 82.89 (75.95-88.51) 89.47 (83.47-93.86) 78.22 (68.90-85.82)
Agreement among positives multiple infection (95% CI) 59.13 (49.57-68.21) 48.70 (39.27-58.19) 33.33 (7.48-70.07)
  1. "CI": Confidence Interval; "% Concordance" and "Kappa index (95% CI)": referred to HC2 result.