Figure 2From: Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with HPV16 E7 oncoproteinLabeling indexes immunoreactivity for HIF-1α in paraffin sections from oral squamous cell carcinomas. A lower HIF-1α protein expression was observed in tumors negative for HPV DNA in comparison with those positive for HPV16 DNA (37.24 ± 25.95 vs. 58.85 ± 22.17; p < .001). Differences were analyzed by the Mann-Whitney test; statistical results were considered significant for p values < .05.Back to article page